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Superparamagnetic iron oxide nanoparticles assembled magnetic nanobubbles and their application for neural stem cells labeling

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Journal of Materials Science & Technology 2021年第4期63卷 124-132页

作者： Jing Li zhenqiang Feng ning Gu Fang Yang State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Sciences and Medical EngineeringSoutheast UniversityNanjing 210096China

Micro/nanobubbles for use as ultrasound contrast agents have been fabricated with different shell *** various biomedical nanoparticles have been embedded in the shells of bubbles,the composite structures have shown promising applications in multi-modal imaging,drug/gene delivery,and biomedical *** this study,we developed a new gas-liquid interface self-assembly method to prepare magnetic nanobubbles embedded with superparamagnetic iron oxide nanoparticles(SPIONs).The diameter of the generated assembled nanobubbles was 227.40±87.21 nm with a good polydispersity index(PDI)of *** the condition of 150 compression cycles,the nanobubble concentration could reach about 6.12×10^(9)/*** electron microscopy(TEM)and scanning electronic microscopy(SEM)demonstrated that the assembled nanobubbles had a hollow gas core with SPIONs adsorbed on the ***(US)imaging and magnetic resonance imaging(MRI)experiments indicated that the assembled magnetic nanobubbles exhibited good US and MR contrast ***,the assembled magnetic nanobubbles were used to label neural stem cells under ultrasound *** 40 s US exposure,the magnetic nanobubbles could be delivered into cells with 2.80 pg Fe per cell,which could be observed in the intracellular endosome by *** with common incubation methods,the ultrasound exposure method did not introduce the potential cytotoxicity of transfection reagents and the efficiency was about twice as high as the efficiency of ***,the assembled magnetic nanobubbles prepared through the pressure-driven gas-liquid interface assembly approach could be a potential US/MRI dual model imaging nanocarrier for regenerative applications.

关键词： magnetic shells bubble

IgG4相关性疾病表现为输尿管肿物1例报告

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中华泌尿外科杂志 2024年第5期45卷 395-396页

作者：何龙芝葛玉成赵振强刘宇坤齐思宇宁晨王文营首都医科大学附属北京友谊医院泌尿外科北京100050

IgC4相关性疾病(IgC4-RD)累及输尿管表现为输尿管肿物罕见,本文报道1例女性患者,因体检发现左肾盂输尿管连接处肿物1周就诊。超声及MRI检查示左肾盂输尿管连接处有一长径约3cm的肿物,伴左肾积水,血清IgG4浓度升高。行B超引导下肿物穿刺... 详细信息

IgC4相关性疾病(IgC4-RD)累及输尿管表现为输尿管肿物罕见,本文报道1例女性患者,因体检发现左肾盂输尿管连接处肿物1周就诊。超声及MRI检查示左肾盂输尿管连接处有一长径约3cm的肿物,伴左肾积水,血清IgG4浓度升高。行B超引导下肿物穿刺活检,病理提示淋巴浆细胞浸润,IgG4/IgG>0.5,考虑为IgG4-RD。患者接受糖皮质激素治疗1个月后复查CT见肿物明显缩小,IgG4浓度下降至正常。

关键词：输尿管疾病 IgG4相关性疾病肿物

Studies on abacavir-induced hypersensitivity reaction:a successful example of translation of pharmacogenetics to personalized medicine

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Science China(Life Sciences) 2013年第2期56卷 119-124页

作者： GUO YongLi SHI LeMing HONG HuiXiao SU zhenqiang FUSCOE James ning BaiTang Division of Systems Biology National Center for Toxicological Researchthe US Food and Drug Administration Division of Bioinformatics and Biostatistics National Center for Toxicological Researchthe US Food and Drug Administration

Abacavir is an effective nucleoside analog reverse transcriptase inhibitor used to treat human immunodeficiency virus(HIV) infected *** main side effect is hypersensitivity reaction(HSR).The incidence of the HSR is associated with ethnicity among patients exposed to abacavir,and retrospective and prospective studies show a significantly increased risk of abacavir-induced HSR in human leukocyte antigen(HLA)-B*57:01-carrying *** studies indicated that abacavir interacts specifically with HLA-B*57:01 and changed the binding specificity between the HLA molecule and the HLA-presented endogenous peptide repertoire,leading to a systemic autoimmune ***-B*57:01 screening,combined with patch testing,had clinically predictive value and cost-effective impact in reducing the incidence of abacavir-induced HSR regardless of the HLA-B*57:01 prevalence in the ***,the US Food and Drug Administration(FDA) and international HIV treatment guidelines recommend a routine HLA-B*57:01 screening prior to abacavir treatment to decrease false positive diagnosis and prevent abacavir-induced *** studies of abacavir-induced HSR and the implementation of the HLA-B*57:01 screening in the clinic represent a successful example of the use of pharmacogenetics for personalized diagnosis and therapy.

关键词： personalized medicine pharmacogenetics drug safety abacavir hypersensitivity reaction (HSR) HLA-B*57:01 HLA-B*57-01 screening

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盆腔异位前列腺1例报告

中华泌尿外科杂志 2024年第8期45卷 631-632页

作者：何龙芝葛玉成赵振强刘宇坤齐思宇宁晨王文营首都医科大学附属北京友谊医院泌尿外科北京100050

异位前列腺临床罕见。本文报道1例男性患者,因体检发现盆腔肿物20d就诊。超声、CT、MRI检查提示盆腔肿物,大小约4cm×5cm,总前列腺特异性抗原(tPSA)6.09ng/ml,游离PSA1.97ng/ml。行B超引导下前列腺和肿物穿刺活检,病理检查提示前列腺良... 详细信息

异位前列腺临床罕见。本文报道1例男性患者,因体检发现盆腔肿物20d就诊。超声、CT、MRI检查提示盆腔肿物,大小约4cm×5cm,总前列腺特异性抗原(tPSA)6.09ng/ml,游离PSA1.97ng/ml。行B超引导下前列腺和肿物穿刺活检,病理检查提示前列腺良性增生,免疫组化染色检查P504S(弱+),34βE12(+);盆腔肿物为前列腺组织,P504S(-),34βE12(+),考虑盆腔肿物为异位前列腺。尽管罕见,异位前列腺也应被考虑为盆腔肿瘤的鉴别诊断之一。

关键词：前列腺异位盆腔

Coordination cage with structural “defects” and open metal sites catalyzes selective oxidation of primary alcohols

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Science China Chemistry 2023年第6期66卷 1714-1721页

作者： Tian-Pu Sheng Ying Wei Parvathi Jampani Chang Li Feng-Rong Dai Shuping Huang zhenqiang Wang Zhong-ning Chen State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Chemistry Fuzhou UniversityFuzhou 350108China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry&Center for Fluorinated Functional Materials University of South DakotaVermillionSDUSA

Coordination cages with intrinsic enzyme-like activity are a class of promising catalysts for improving the efficiency of organic *** present herein a viable strategy to conveniently construct multimetallic active sites into a coordination cage via self-assembly of a pre-formed sulfonylcalix[4]arene-based tetranuclear copper(II)precursor and an amino-functionalized dicarboxylate *** cage exhibits a“defective”,partially open cylindrical structure and features coordinatively labile dimetallic Cu(II)*** by this unique inner cavity environment,promising catalytic activity toward selective oxidation of primary alcohols to carboxylic acids at room temperature is *** studies reveal that the coordinatively labile dimetallic Cu(II)sites can efficiently capture and activate the substrate and oxidant to catalyze the reaction,while the confined nano-cavity environment modulates substrate binding and enhances the catalytic *** study provides a new approach to designing biomimetic multifunctional coordination cages and environmentally friendly supramolecular catalysts.

关键词： coordination cages open metal sites alcohol oxidation host-guest systems supramolecular chemistry

Critical role of bioinformatics in translating huge amounts of next-generation sequencing data into personalized medicine

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Science China(Life Sciences) 2013年第2期56卷 110-118页

作者： HONG HuiXiao ZHANG WenQian SHEN Jie SU zhenqiang ning BaiTang HAN Tao PERKINS Roger SHI LeMing TONG WeiDa Division of Bioinformatics and Biostatistics National Center for Toxicological ResearchUS Food and Drug Administration Beijing Genomic Institute Beishan Industrial Zone Division of Systems Biology National Center for Toxicological ResearchUS Food and Drug Administration

Realizing personalized medicine requires integrating diverse data types with *** most vital data are genomic information for individuals that are from advanced next-generation sequencing(NGS) technologies at *** technologies continue to advance in terms of both decreasing cost and sequencing speed with concomitant increase in the amount and complexity of the *** prodigious data together with the requisite computational pipelines for data analysis and interpretation are stressors to IT infrastructure and the scientists conducting the work *** is increasingly becoming the rate-limiting step with numerous challenges to be overcome for translating NGS data for personalized *** review some key bioinformatics tasks,issues,and challenges in contexts of IT requirements,data quality,analysis tools and pipelines,and validation of biomarkers.

关键词： personalized medicine next-generation sequencing bioinformatics short reads alignment assemble data analysis

Sanguinarine suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma via inhibiting mTOR signaling

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Journal of Traditional Chinese Medicine 2022年第5期42卷 687-692页

作者： YANG Mengzhe ZHANG Beibei LIANG zhenqiang CHENG Nannan LüAnqiao YANG Jianyu GUO Xingzhe BAI Xianyu HUANG Yuanjiao JIAO Aijun XU ning School of Basic Medical Sciences Guangxi Medical UniversityNanning 530021China Institute of Biomedical Research Yunnan UniversityKunming 650500China Department of Otolaryngology-Head and Neck Surgery the Affiliated Tumor Hospital of Guangxi Medical UniversityNanning 530021China Life Science Institute Guangxi Medical UniversityNanning 530021China Pharmaceutical College Guangxi Medical UniversityNanning 530021China Department of Neurology the Fifth Affiliated Hospital of Guangxi Medical UniversityNanning 530021China

OBJECTIVE: To confirm the anti-NPC effect of sanguinarine(SA) through a series of wet ***: NPC cell viability was determined by proliferation experiment. Cell clone formation experiment, cell scratch test, transwell migration and invasion experiment and flow cytometry-based cell apoptosis assay were further performed. In addition, Western blotting was performed to investigate the cell signaling pathway. All the relevant experimental data were statistically processed using SPSS 16.0 ***: The results showed that sanguinarine represented a time and dose dependent inhibition effects on NPC cell proliferation including the low differentiated CNE2 cells and high metastatic 5-8F cells, along with the cell cloning ability reduction. In addition, sanguinarine has a certain inhibitory effect on the invasion and migration of NPC cells. Mechanistically, sanguinarine displayed the anti-NPC effects mainly involved into the suppression of m TOR signaling and cell apoptosis, which is closely associated with the tumor growth and metastatic malignancy. CONCLUSIONS: Collectively, we discover that sanguinarine is a new high-efficiency anti-NPC monomer of Chinese medicine, with a value for the follow-up preclinical research.

关键词： nasopharyngeal carcinoma sanguinarine TOR serine-threonine kinases apoptosis

Precise Assembly and Supramolecular Catalysis of Tetragonal-and Trigonal-Elongated Octahedral Coordination Containers

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CCS Chemistry 2022年第3期4卷 1098-1107页

作者： Tian-Pu Sheng Can He zhenqiang Wang Guo-Zong Zheng Feng-Rong Dai Zhong-ning Chen State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002 University of Chinese Academy of Sciences Beijing 100049 Churchill-Haines Laboratories Department of ChemistryCenter for Fluorinated Functional MaterialsUniversity of South DakotaVermillionSD 57069-2390

The construction of distorted or irregular coordination polyhedrons with specific shapes and functionalities is highly ***,we demonstrate a viable strategy for attaining a severely distorted octahedral coordination container through precise geometrical manipulation of its nanocavity along the C_(3) or C4 axis to turn on its supramolecular *** constructed a tetragonal-elongated octahedral coordination container utilizing sulfonylcalix[4]arene-capped Co4 units as six vertexes and tetragonalelongated from single-arm lengthened 5-[(4-carboxybenzyl)amino]isophthalate(L)as eight triangular *** the concomitant introduction of C_(3)-symmetry cyclohexane-1,3,5-tricarboxylate as a secondary linker to construct two equilateral triangular base surfaces and L to build six isosceles triangular side planes,trigonal antiprismatic architecture(trigonal-elongated octahedron)was *** elongated octahedral containers exhibited distinctly higher binding capacity and stronger binding affinity toward reaction substrates than that of regular octahedral containers;thus,promoting geometry-dependent catalytic *** geometrical manipulation strategy provides a viable approach for the convenient design of metal–organic materials with specific functionalities.

关键词： coordination containers host-guest interaction supramolecular catalysis acid-base dual catalysis Knoevenagel condensation elongated coordination octahedron

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微纳卫星编队的欠采样传输无源定位方法

清华大学学报（自然科学版） 2016年第6期56卷 650-655页

作者：李振强黄振陈曦葛宁清华大学电子工程系.北京100084 清华大学宇航技术研究中心北京100084

基于微纳卫星编队的到达时差(TDOA)/到达频差(FDOA)无源定位系统中,定位精度的提高需大幅度增加链路传输数据量,在星间链路带宽受限情况下将严重制约系统的工作效率。该文提出了一种欠采样传输时频差估计方法,在不增加传输数据量条件下... 详细信息

基于微纳卫星编队的到达时差(TDOA)/到达频差(FDOA)无源定位系统中,定位精度的提高需大幅度增加链路传输数据量,在星间链路带宽受限情况下将严重制约系统的工作效率。该文提出了一种欠采样传输时频差估计方法,在不增加传输数据量条件下,保持TDOA估计精度不变,且FDOA估计精度随欠采样所形成的时间扩展显著提升。分析了欠采样传输的时差估计精度,以及最大欠采倍数约束条件。仿真表明:对于宽带信号,该方法在传输数据量相同条件下,定位性能相对于压缩感知(CS)方法可提升6倍以上。

关键词：无源定位到达时差到达频差欠采样压缩感知