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Paracrine function amplifies pro-tumor electrochemical signal within neuron-glioma synapses

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Science China(Life Sciences) 2024年第6期67卷 1318-1320页

作者： Yan hu Peishan hu Xiaozhong Peng Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE State Key Laboratory of BiotherapyWest China Second University HospitalSichuan UniversityChengdu 610041China Guangdong Institute of Gastroenterology Department of General SurgeryGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China Department of Molecular Biology and Biochemistry Institute of Basic Medical SciencesMedical Primate Research CenterNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100730China State Key Laboratory of Respiratory Health and Multimorbidity Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100730China Institute of Laboratory Animal Science Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Neuronal activity plays a pivotal role in various physiological processes,including tissue development,homeostasis,and *** in recent years have improved our understanding of neuronal activity in brain cancers,such as glioblastoma(GBM)and diffuse midline gliomas(DMG),which are among the most prevalent and lethal cancers affecting children and ***,the neurons regulate brain cancers via two routes.

关键词： glioma homeostasis function

Antibodies elicited by Newcastle disease virus-vectored H7N9 avian influenza vaccine are functional in activating the complement system

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Journal of Integrative Agriculture 2024年第6期23卷 2052-2064页

作者： Zenglei hu Ya huang Jiao hu Xiaoquan Wang Shunlin hu Xiufan Liu Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China Yangzhou UniversityYangzhou 225009China Animal Infectious Disease Laboratory School of Veterinary MedicineYangzhou UniversityYangzhou 225009China Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou UniversityYangzhou 225009China

H7N9 subtype avian influenza virus poses a great challenge for poultry *** disease virus(NDV)-vectored H7N9 avian influenza vaccines(NDV_(vec)H7N9)are effective in disease control because they are protective and allow mass *** note,these vaccines elicit undetectable H7N9-specific hemagglutination-inhibition(HI)but high IgG antibodies in ***,the molecular basis and protective mechanism underlying this particular antibody immunity remain ***,immunization with an NDV_(vec)H7N9 induced low anti-H7N9 HI and virus neutralization titers but high levels of hemagglutinin(HA)-binding IgG antibodies in *** residues(S150,G151 and S152)in HA of H7N9 virus were identified as the dominant epitopes recognized by the NDV_(vec)H7N9 immune *** transferred NDV_(vec)H7N9 immune serum conferred complete protection against H7N9 virus infection in *** NDV_(vec)H7N9 immune serum can mediate a potent lysis of HA-expressing and H7N9 virus-infected cells and significantly suppress H7N9 virus *** activities of the serum were significantly impaired after heat-inactivation or treatment with complement inhibitor,suggesting the engagement of the complement ***,mutations in the 150-SGS-152 sites in HA resulted in significant reductions in cell lysis and virus neutralization mediated by the NDV_(vec)H7N9 immune serum,indicating the requirement of antibody-antigen binding for complement ***,antibodies induced by the NDV_(vec)H7N9 can activate antibody-dependent complement-mediated lysis of H7N9 virus-infected cells and complement-mediated neutralization of H7N9 *** findings unveiled a novel role of the complement in protection conferred by the NDV_(vec)H7N9,highlighting a potential benefit of engaging the complement system in H7N9 vaccine design.

关键词： H7N9 subtype avian influenza virus NDV vector vaccine antibody immunity complement protection

Epidemiology and current management of cerebrovascular disease in China

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Journal of Geriatric Cardiology 2024年第5期21卷 465-474页

作者： Sheng-Shou hu The Writing Committee of the Report on Cardiovascular Health and Diseases in China

The Annual Report on Cardiovascular Health and Diseases in China(2022)intricate landscape of cardiovascular health in *** connection with the previous section,this fifth section of the report continues the dissection on the manage-ment of cardiovascular diseases(CVD).Cerebrovascular disease is the leading cause of death and loss of healthy life among Chinese *** on the results of GBD 2019,from 1990 to 2019,the years of life lost due to premature death caused by stroke showed a decreasing trend,while the years lived with disability still increased *** present,national mortal-ity surveillance system can provide national and provincial representative annual death data on cerebrovascular disease,but the national representative data on some other important epidemiological indicators(such as incidence,prevalence,disability rate,and case fatality rate)are scarce in *** the construction of large cohort population and extension of follow-up time,re-search on stroke-related risk factors is increasing,providing a basis for the prevention and control of risk *** to limited large-scale population-based intervention studies,there is a lack of epidemiological evidence to transform into feasible interven-tion strategies and *** recent years,great progress in endovascular treatment for basilar-artery occlusion has been achieved in China,but there is still much room for improvement of guideline-based anticoagulant treatment and lipid-lowering treatment,as well as standardized diagnosis and treatment among patients with ischemic stroke.

关键词： prevention diagnosis Epidemiology

强极化衬底下不同堆垛方式双层石墨烯能隙的研究

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南开大学学报（自然科学版） 2020年第5期53卷 56-61页

作者：郝家磊曹学伟胡振芃南开大学物理科学学院天津300071

基于第一性原理计算,以强极性极化材料作为衬底,提出一种打开双层石墨烯能隙的有效方法.应用表面功能化的氮化硼极性材料为衬底,使以AA和转角形式堆垛的双层石墨烯,其能隙打开到0.0339eV和0.0325 eV.当以AB方式堆垛双层石墨烯时,在该衬... 详细信息

基于第一性原理计算,以强极性极化材料作为衬底,提出一种打开双层石墨烯能隙的有效方法.应用表面功能化的氮化硼极性材料为衬底,使以AA和转角形式堆垛的双层石墨烯,其能隙打开到0.0339eV和0.0325 eV.当以AB方式堆垛双层石墨烯时,在该衬底下其能隙可达到0.430 eV左右;且此能隙随衬底与双层石墨烯之间的堆垛方式的不同而发生微小变化.这表明该方法一方面能够通过改变双层石墨烯自身的堆垛方式来有效的改变其能隙大小;另一方面在AB堆垛情况下通过调整衬底与相邻石墨烯的堆垛方式可以对其能隙在0.430eV附近进行微调.该方法在完美的保持双层石墨烯结构完整性的前提下,能够获得适用于光电子器件的能隙.相较于其他方法,该方法更加切实可行,能够促进石墨烯在半导体器件中的应用以及石墨烯技术的发展.

关键词：第一性原理双层石墨烯氮化硼能隙

Cloud-Type-Dependent 1DVAR Algorithm for Retrieving Hydrometeors and Precipitation in Tropical Cyclone Nanmadol from GMI Data

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Advances in Atmospheric Sciences 2024年第3期41卷 407-419页

作者： Linjun HAN Fuzhong WENG Hao hu Xiuqing hu School of the Environment China University of Geosciences(Wuhan)Wuhan 430074China Chinese Academy of Meteorological Sciences Beijing 100081China CMA Earth System Modeling and Prediction Centre Beijing 100081China Key Laboratory of Radiometric Calibration and Validation for Environmental Satellites National Satellite Meteorological Center(National Center for Space Weather)of CMABeijing 100081China

Understanding the structure of tropical cyclone(TC)hydrometeors is crucial for detecting the changes in the distribution and intensity of *** this study,the GMI brightness temperature and cloud-dependent 1DVAR algorithm were used to retrieve the hydrometeor profiles and surface rain rate of TC Nanmadol(2022).The Advanced Radiative Transfer Modeling System(ARMS)was used to calculate the Jacobian and degrees of freedom(△DOF)of cloud water,rainwater,and graupel for different channels of GMI in convective *** retrieval results were compared with the Dual-frequency Precipitation Radar(DPR),GMI 2A,and IMERG *** is shown that from all channels of GMI,rain water has the highest△DOF,at *** to the radiance Jacobian to atmospheric state variables,cloud water emission dominates its *** rain water,the emission of channels 1–4 dominates *** with the GMI 2A precipitation product,the 1DVAR precipitation rate has a higher correlation coefficient(0.713)with the IMERG product and can better reflect the location of TC *** the TC eyewall,the highest radar echo top indicates strong *** the melting layer where Ka-band attenuation is strong,the double frequency difference of DPR data reflects the location of the *** DPR drop size distribution(DSD)product shows that there is a significant increase in particle size below the melting layer in the spiral rain ***,the particle size may be one of the main reasons for the smaller rain water below the melting layer retrieved from 1DVAR.

关键词： cloud-dependent 1DVAR hydrometeor precipitation GMI DPR

Quantitative estimation of global mean precipitation throughout the Phanerozoic era

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Science China Earth Sciences 2024年第5期67卷 1616-1624页

作者： Xiujuan BAO Yongyun hu Laboratory for Climate and Ocean-Atmospheric Studies Department of Atmospheric and Oceanic SciencesSchool of PhysicsPeking UniversityBeijing 100871China

Quantitatively estimating the global mean precipitation(GMP)throughout Earth's history is crucial for enhancing our understanding of long-term climate evolution and the hydrological ***,currently there is no established methodology for estimating global mean ***,we present the first study that estimates GMP in the Phanerozoic *** relationship between GMP and global mean surface temperature(GMST)is investigated by analyzing data from 23 models in the Coupled Model Intercomparison Project phase 6(CMIP6).The result reveals consistent and significant impact of temperature on precipitation,with a sensitivity range of 2–3%K^(-1).Additionally,we propose a method for accessing latitudinal variations in precipitation caused by land area distributions and paleo-Koppen climatic *** climatic belts are determined based on geological indicators such as coals,evaporites,and glacial *** GMP is thus quantitatively estimated by combining variations in GMST,land area distributions,and paleo-koppen climatic belts,spanning from 540 Ma to the present *** quantitative GMP curve demonstrates fluctuations in GMP about 500 mm yr^(-1),with values ranging from 948 to1442 mm yr-1over the Phanerozoic *** curve aligns closely with findings derived from numerical *** presented paleoprecipitation variations facilitate a more comprehensive understanding of the interconnected geological and paleoclimatic developments.

关键词： Paleoprecipitation Paleoclimate K?ppen climatic belts Global mean precipitation Hydrological cycle

BSIN: A Behavior Schema of Information Networks Based on Approximate Bisimulation

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Tsinghua Science and Technology 2024年第4期29卷 1092-1104页

作者： Wujie hu Jinzhao Wu School of Electrical Engineering Guangxi UniversityNanning 530004China

Information networks are becoming increasingly important in practice. However, their escalating complexity is gradually impeding the efficiency of data mining. A novel network schema called the Behavior Schema of Information Networks (BSIN) is proposed to address this issue. This work defines the behavior of nodes as connected paths in BSIN, proposes a novel function distinguish behavior differences, and introduces approximate bisimulation into the acquisition of quotient sets for node types. The major highlight of BSIN is its ability to directly obtain a high-efficiency network on the basis of approximate bisimulation, rather than reducing the existing information network. It provides an effective representation of information networks, and the resulting novel network has a simple structure that more efficiently expresses semantic information than current network representations. The theoretical analysis of the connected paths between the original and the obtained networks demonstrates that errors are controllable;and semantic information is approximately retained. Case studies show that BSIN yields a simple network and is highly cost-effective.

关键词： data mining information network approximate bisimulation controllable error

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一种演绎金融数据沙堆演化过程的新方法

数量经济技术经济研究 2016年第5期33卷 122-142页

作者：郭兆纲魏宝社胡振鹏南昌大学管理学院东北财经大学社会与行为跨学科研究中心

用递归图方法演绎金融数据的沙堆演化过程是我们为了研究金融数据中所蕴含的沙崩和跃升现象而提出的一种创新方法。该方法基于重构相空间理论,通过对比分析递归图中类分形自相似结构的演化过程与沙堆堆积过程之间的相似性,从直观分析沙... 详细信息

用递归图方法演绎金融数据的沙堆演化过程是我们为了研究金融数据中所蕴含的沙崩和跃升现象而提出的一种创新方法。该方法基于重构相空间理论,通过对比分析递归图中类分形自相似结构的演化过程与沙堆堆积过程之间的相似性,从直观分析沙堆堆积、滑落及坍塌的特征入手,构建类分形自相似结构的沙堆演化模型,提出了驻留比率、滑落比率及时间间隔的边界点等概念工具,研究金融数据中所蕴含的沙崩和跃升现象。本文重点介绍该方法提出的思路和模型的构建过程,并以上证综合指数为例验证了方法的有效性。

关键词：递归图类分形自相似结构沙堆模型沙崩跃升

气候变化对鄱阳湖赣江流域水文情势影响的实证研究

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水利水电技术（中英文） 2021年第11期52卷 39-49页

作者：肖农闫峰胡振鹏雷苏琪国家能源集团江西电力有限公司万安水利发电厂江西万安343800 南昌大学鄱阳湖环境与资源利用教育部重点实验室江西南昌330031 南昌大学建筑工程学院江西南昌330031

为了解气候变化对鄱阳湖赣江流域不同区域水文情势的影响,选择栋背、吉安、峡江、外洲等代表性水文站,将赣江流域进一步划分为赣江上游、坝吉区间、吉峡区间、峡外区间等4个子区域,结合长系列的水文资料,从气候变化下的降雨演变、径流... 详细信息

为了解气候变化对鄱阳湖赣江流域不同区域水文情势的影响,选择栋背、吉安、峡江、外洲等代表性水文站,将赣江流域进一步划分为赣江上游、坝吉区间、吉峡区间、峡外区间等4个子区域,结合长系列的水文资料,从气候变化下的降雨演变、径流演变、洪水时空分布演变、干旱及旱涝急转事件发生频率演变4个方面进行实证研究,并提出相应的对策建议。结果表明:气候变化对赣江流域不同区域的水文情势影响有一定区别。(1)相比于1960—2001年,赣江上游、吉峡区间、峡外区间2002—2020年的年平均降水量和年降雨天数均有减少;而坝吉区间的年降雨天数有一定减少,但年平均降水量则增大了6.4%。(2)降水方面,4个区域的年均降雨天数都处于减少状态。相比于1960—2001年,赣江上游的年平均流量和大于2 a一遇洪水的发生频率均有大幅下降;而中下游的峡江站和外洲站年平均流量则分别增加了3.6%和1.0%。除此之外,大于5 a一遇的典型洪水来水区域和主雨带总体也呈由上游向下游转移的趋势。(3)相比于1960—2001年,2002—2020年流域级旱涝急转事件频率由2.5%上升至10.5%;但赣江上游的气象干旱频率变化不大,而中下游吉安、南昌的气象干旱频率有明显提升。

关键词：鄱阳湖赣江气候变化水文情势实证分析