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Chinese Chemical Letters 2024年第6期35卷 353-357页

作者： Jinyan Zhang Fen Liu Qian Jin Xueyi Li Qiong Zhan Mu Chen Sisi Wang zhenlong wu Wencai Ye Lei Wang State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Center for Bioactive Natural Molecules and Innovative Drugs and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchJinan UniversityGuangzhou 510632China College of Pharmacy Jinan UniversityGuangzhou 510632China

The first phloroglucinol-triterpenoid hybrids,myrtphlotritins A-E(1-5),were rapidly recognized and isolated from two species of Myrtaceae by employing the building blocks-based molecular network(BBMN)*** 1-5 featured new carbon skeletons in which phloroglucinol derivatives were coupled with lupane-and dammarane-type triterpenoids through different linkage *** structures and absolute configurations were elucidated by comprehensive analysis of spectroscopic data and quantum chemical *** pathways for compounds 1-5 were proposed on the basis of the coexisting *** by the biogenetic pathways,the biomimetic synthesis of compound 1 was also ***,compounds 2,3,and 5 exhibited potent antiviral activities against herpes simplex virus type-1(HSV-1)infection,and compounds 2 and 5 displayed significant anti-inflammatory activities on RAW264.7 cells.

关键词： Phloroglucinol-triterpenoid adduct Myrtaceae Building blocks-based molecular network Biomimetic synthesis Antiviral activity Anti-inflammatory activity

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猫胰腺炎成因及其营养调控

动物营养学报 2024年第6期36卷 3500-3506页

作者：常城贺马纪然杨鹰武振龙中国农业大学动物科学技术学院北京100193

胰腺炎是猫的一种常见病,其发病原因复杂,临床症状比较严重,死亡率高,但目前还没有针对猫胰腺炎的特效治疗方法。胰腺炎患病动物的试验和临床数据都证明营养管理措施对治疗猫胰腺炎的重要意义,营养调控不仅有助于预防营养不良,也是降低... 详细信息

胰腺炎是猫的一种常见病,其发病原因复杂,临床症状比较严重,死亡率高,但目前还没有针对猫胰腺炎的特效治疗方法。胰腺炎患病动物的试验和临床数据都证明营养管理措施对治疗猫胰腺炎的重要意义,营养调控不仅有助于预防营养不良,也是降低全身炎症、并发症和死亡率的关键。猫胰腺炎营养调控的研究主要是添加营养素如蛋白质、脂肪、维生素和矿物质等。本文综述了关于猫急性与慢性胰腺炎的发病原因及其营养调控的相关研究,旨在为猫胰腺炎的临床治疗提供参考。

关键词：猫急性胰腺炎慢性胰腺炎发病原因营养调控

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基于预期动态方程的含高比例可再生能源孤岛运行微电网负荷频率控制

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上海交通大学学报 2024年第6期58卷 954-964,I0009页

作者：吴振龙刘艳红薛亚丽李东海 CHEN Yangquan 郑州大学电气与信息工程学院郑州450001 清华大学能源与动力工程系北京100084 加州大学默塞德分校工程学院美国默塞德CA 95343

针对高比例可再生能源并入微电网带来的负荷频率控制问题,提出基于预期动态方程的比例-积分-微分(PID)控制策略.在分析微电网负荷频率控制模型和控制难点的基础上,设计基于预期动态方程的PID控制策略,采用单一变量法分析控制器参数对控... 详细信息

针对高比例可再生能源并入微电网带来的负荷频率控制问题,提出基于预期动态方程的比例-积分-微分(PID)控制策略.在分析微电网负荷频率控制模型和控制难点的基础上,设计基于预期动态方程的PID控制策略,采用单一变量法分析控制器参数对控制效果的影响,总结了简单、实用的参数整定流程,并在微电网负荷频率控制系统中应用.在不同工况下与多种控制器进行仿真对比,结果表明:所提控制策略能够在保证鲁棒性的前提下取得最佳控制效果,展现出很高的工程应用价值.

关键词：微电网负荷频率控制预期动态方程比例-积分-微分参数整定

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通过多学科融合提升动物营养与饲料科学专业博士生创新能力的探索与实践

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创新创业理论研究与实践 2024年第3期7卷 125-130页

作者：季昀杨鹰武振龙中国农业大学动物科学技术学院北京100193

随着科学技术的不断发展,动物营养与饲料科学学科在过去几十年中取得了长足的进步。为了更好地适应时代发展对科技创新的新要求,需要培养具备创新思维和跨学科解决问题能力的专业人才。博士生作为专业人才的高水平后备军,是提高我国各... 详细信息

随着科学技术的不断发展,动物营养与饲料科学学科在过去几十年中取得了长足的进步。为了更好地适应时代发展对科技创新的新要求,需要培养具备创新思维和跨学科解决问题能力的专业人才。博士生作为专业人才的高水平后备军,是提高我国各学科创新水平的核心力量。现代动物营养与饲料科学与其他学科具有明显的融合特征,充分利用跨学科专业的知识和方法有助于大幅提高动物营养与饲料科学专业博士生创新能力。博士生课程建设和以兴趣为导向的多学科研究能力培养、借助跨学科专家指导的学术能力培养保障机制以及跨学科学术交流平台对博士生创新思维的锻炼等多项举措,对于提升动物营养与饲料科学专业博士生创新能力具有重要意义,有利于提高博士生培养质量,促进新农科背景下动物营养与饲料科学专业的高质量发展。

关键词：多学科融合动物营养与饲料科学创新博士生研究生培养新农科

Design and examination of a turboprop inlet with scavenge duct

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Chinese Journal of Aeronautics 2023年第8期36卷 32-42页

作者： Gaojie ZHENG zhenlong wu Huijun TAN Yue ZHANG Kun WANG College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

The inlet with scavenge duct is an important part of turboprop aircraft *** type of inlet normally has a complex shape,of which the design is challenging and directly affects the flow field quality of the engine entrance and thus the engine *** this paper,the parametric design method of a turboprop aircraft inlet with scavenge duct is established by extracting and controlling the transition law of the critical characteristic *** inlet’s performance and internal flow characteristics are examined by wind-tunnel experiment and numerical *** results indicate that a flow tendency of winding up on both sides is formed due to the induction of the inlet profile,as well as a vortex pair on the back side of the power output *** vortex pair dominates the pressure distortion index on the Aerodynamic Interface Plane(AIP).In addition,with the increase of freestream angle of attack,the total-pressure recovery coefficient of the inlet increases gradually while the total pressure distortion index decreases *** the basis of the experimental results under different working conditions,the parametric design method proposed in this paper is feasible.

关键词： Design methord Flowcharacteristics Inlet performance Scavengeduct Turbopropaircraft

Dihydroartemisinin ameliorates innate inflammatory response induced by Streptococcus suis-derived muramidase-released protein via inactivation of TLR4-dependent NF-kB signaling

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Journal of Pharmaceutical Analysis 2023年第10期13卷 1183-1194页

作者： Yun Ji Kaiji Sun Ying Yang zhenlong wu State Key Laboratory of Animal Nutrition and Feeding China Agricultural UniversityBeijing100193China Beijing Advanced Innovation Center for Food Nutrition and Human Health China Agricultural UniversityBeijing100193China

Muramidase-released protein(MRP)is now being recognized as a critical indicator of the virulence and pathogenicity of Streptococcus suis(***).However,the identification of viable therapeutics for *** infection was hindered by the absence of an explicit mechanism for MRP-actuated ***(DhA)is an artemisinin derivative with potential anti-inflammatory *** modulatory effect of DhA on the inflammatory response mediated by the virulence factor MRP remains *** research aimed to identify the signaling mechanism by which MRP triggers the innate immune response in mouse spleen and cultured *** the candidate mechanism in mind,we investigated DhA for its ability to dampen the pro-inflammatory response induced by *** innate immune response in mice was drastically triggered by MRP,manifesting as splenic and systemic inflammation with splenomegaly,immune cell infiltration,and an elevation in pro-inflammatory cytokines.A crucial role for Toll-like receptor 4(TLR4)in coordinating the MRP-mediated inflammatory response via nuclear factor-kappa B(NF-kB)activation was revealed by TLR4 *** addition,NFkB-dependent transducer and activator of transcription 3(STAT3)and mitogen-activated protein kinases(MAPKs)activation was required for the inflammatory signal transduction engendered by ***,we observed an alleviation effect of DhA on the MRP-induced immune response,which referred to the suppression of TLR4-mediated actuation of NF-kB-STAT3/MAPK *** inflammatory response elicited by MRP is relevant to TLR4-dependent NF-kB activation,followed by an increase in the activity of STAT3 or *** mitigates the inflammation process induced by MRP via blocking the TLR4 cascade,highlighting the therapeutic potential of DhA in targeting *** infection diseases.

关键词： Dihydroartemisinin Inflammation Muramidase-released protein Streptococcus suis Toll-like receptor 4

Hydroxyproline alleviates 4-hydroxy-2-nonenal-induced DNA damage and apoptosis in porcine intestinal epithelial cells

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Animal Nutrition 2022年第2期9卷 7-15页

作者： Yun Ji Yu He Ying Yang Zhaolai Dai zhenlong wu State Key Laboratory of Animal Nutrition Department of Animal Nutrition and Feed ScienceChina Agricultural UniversityBeijing 100193China Beijing Advanced Innovation Center for Food Nutrition and Human Health China Agricultural UniversityBeijing 100193China

Oxidative stress has been confirmed in relation to intestinal mucosa damage and multiple bowel *** (Hyp) is an imino acid abundant in sow's milk. Compelling evidence has beengathered showing the potential antioxidative properties of Hyp. However, the role and mechanism ofHyp in porcine intestinal epithelial cells in response to oxidative stress remains unknown. In this study,small intestinal epithelial cell lines of piglets (IPEC-1) were used to evaluate the protective effects of Hypon 4-hydroxy-2-nonenal (4-HNE)-induced oxidative DNA damage and apoptosis. IPEC-1 pretreated with0.5 to 5 mmol/L Hyp were exposed to 4-HNE (40 mmol/L) in the presence or absence of Hyp. Thereafter,the cells were subjected to apoptosis detection by Hoechst staining, flow cytometry, and Western blot orDNA damage analysis by comet assay, immunofluorescence, and reverse-transcription quantitative PCR(RT-qPCR). Cell apoptosis and the upregulation of cleaved-caspase-3 induced by 4-HNE (40 mmol/L) wereinhibited by 5 mmol/L of Hyp. In addition, 5 mmol/L Hyp attenuated 4-HNE-induced reactive oxygenspecies (ROS) accumulation, glutathione (GSH) deprivation and DNA damage. The elevation in transcriptionof GADD45a (growth arrest and DNA-damage-inducible protein 45 alpha) and GADD45b(growth arrest and DNA-damage-inducible protein 45 beta), as well as the phosphorylation of H2AX(H2A histone family, member X), p38 MAPK (mitogen-activated protein kinase), and JNK (c-Jun N-terminalkinase) in cells treated with 4-HNE were alleviated by 5 mmol/L Hyp. Furthermore, Hyp supplementationincreased the protein abundance of Krüppel like factor 4 (KLF4) in cells exposed to *** of KLF4 expression by kenpaulone impeded the resistance of Hyp-treated cells to DNAdamage and apoptosis induced by 4-HNE. Collectively, our results indicated that Hyp serves to protectagainst 4-HNE-induced apoptosis and DNA damage in IPEC-1 cells, which is partially pertinent with theenhanced expression of KLF

关键词： Hydroxyproline Apoptosis DNA damage 4-Hydroxy-2-nonenal Oxidative stress

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线性自抗扰控制系统的稳定性分析方法

控制工程 2024年第1期31卷 95-102页

作者：刘艳红李朋真李汇来吴振龙李兆阳郑州大学电气与信息工程学院河南郑州450001 河南科技大学国际教育学院河南洛阳471027

针对二阶线性系统和二阶线性自抗扰控制,提出了基于误差的稳定性分析方法。该方法通过观测误差、跟踪误差状态量建立闭环系统状态空间模型,借助状态空间模型的特征值分析闭环系统的收敛性,并运用李雅普诺夫法判断系统的稳定性。与基于... 详细信息

针对二阶线性系统和二阶线性自抗扰控制,提出了基于误差的稳定性分析方法。该方法通过观测误差、跟踪误差状态量建立闭环系统状态空间模型,借助状态空间模型的特征值分析闭环系统的收敛性,并运用李雅普诺夫法判断系统的稳定性。与基于劳斯判据的稳定性分析方法相比较,二者的分析结论一致,算例和仿真结果验证了所提方法的简单性和有效性。此外,通过仿真和蒙特卡洛实验验证了自抗扰控制相比于PID控制在跟踪性能、抗扰能力和鲁棒性等方面的优势。

关键词：线性自抗扰控制稳定性状态空间跟踪误差蒙特卡洛

Glycine represses endoplasmic reticulum stress-related apoptosis and improves intestinal barrier by activating mammalian target of rapamycin complex 1 signaling

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Animal Nutrition 2022年第1期8卷 1-9页

作者： Ying Yang Xiaoxiao Fan Yun Ji Ju Li Zhaolai Dai zhenlong wu State Key Laboratory of Animal Nutrition China Agricultural UniversityBeijing100193China Henan Yinfa Animal Husbandry Co. XinzhengHenan451100China

Endoplasmic reticulum(ER)stress has been associated with the dysfunction of intestinal barrier in humans and *** have previously shown that oral administration of glycine to suckling-piglets improves ER stress-related intestinal mucosal barrier impairment and jejunal epithelial ***,the underlying mechanism remains *** this study,the protective effect and the mechanism of glycine on apoptosis and dysfunction in intestinal barrier induced by brefeldin A(BFA),an ER stress inducer,was explored in porcine intestinal epithelial cells(IPEC-1).The results showed that BFA treatment led to enhanced apoptosis and upregulation of proteins involved in ER stress signaling,including inositol-requiring enzyme 1a(IRE1a),activating transcription factor 6a(ATF6a),c-Jun N-terminal kinase(JNK),and C/EBP-homologous protein(CHOP).In addition,BFA induced a dysfunction in intestinal epithelial barrier,as evidenced by the increased paracellular permeability,decreased transepithelial electrical resistance(TEER),and reduced abundance of tight junction proteins(occludin,claudin-1,zonula occludens[ZO]-1,and ZO-2).These alterations triggered by BFA were significantly abolished by glycine treatment(P<0.05),indicating a protective effect of glycine on barrier function impaired by ER ***,we found that the regulatory effect of glycine on intestinal permeability,proteins implicated in ER stress and apoptosis,as well as the morphological alterations of the ER were reversed by *** summary,our results indicated that glycine alleviates ER stress-induced apoptosis and intestinal barrier dysfunction in IPEC-1 cells in a mammalian target of rapamycin complex 1(mTORC1)-dependent *** data provides in vitro evidence and a mechanism for the protective effect of glycine against the disruption of intestinal barrier integrity induced by ER stress.

关键词： Glycine ER stress Apoptosis mTORC1 Intestinal barrier

Glutamic acid supplementation recovers the reduced performance of weanling pigs fed reduced crude protein diets

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Animal Nutrition 2022年第1期8卷 249-255页

作者： Santi D.Upadhaya Sang Seon Lee Young Hwa Kim zhenlong wu In Ho Kim Department of Animal Resource and Science Dankook UniversityNo.29 AnseodongCheonanChoongnam 31116South Korea National Institute of Animal Science 114 Sinbangro-1 GilSeongjwan-eupSeobuk-guCheonan-si31000South Korea State Key Laboratory of Animal Nutrition Department of Animal Nutrition and Feed ScienceChina Agricultural UniversityBeijing 100193China

This study was conducted to evaluate the supplementation of glutamic acid(Glu)to reduced protein diets on the performance of weanling *** hundred and eighty crossbred weanling pigs([YorkshireLandrace]Duroc,21 d old)having similar body weight(BW)of 6.45 kg were randomly allotted to 1 of 6 dietary treatments(5 pigs per pen[2 barrows and 3 gilts];6 pens per treatment)based on BW and sex during a 6-week *** treatments consisted of positive control(PC)diet formulated to have 226.9,205.6,and 188.8 g crude protein(CP)during phases 1,2,and 3,respectively,and negative control(NC)diets with 20 g CP reduction from PC diets and addition of Glu with increasing levels,resulting in the calculated Lys-to-Glu ratios of 1:2.25,1:2.30.1:2.35,1:2.40,and 1:2.45,designated as NC,NC1,NC2,NC3,and NC4,*** BW of pigs receiving PC diet was higher(P<0.05)than those receiving NC diet at d 7,21 and 42.A higher(P<0.05)average daily gain(ADG)from d 1 to 7,8 to 21,22 to 42 and during the overall experiment period was observed in pigs fed PC than NC *** fed NC diets including the graded level of Glu linearly increased(P<0.05)BW at d 42,ADG and gain-to-feed ratio(G:F)during the overall experimental *** addition,trends in linear increase in BW(P=0.056)at d 7 and ADG from d 1 to 7 and d 22 to 42(linear effect,P=0.081,P=0.058 respectively)were observed.A tendency in the linear increment of NH3(P=0.082)at d 21 and linear reduction in methyl mercaptans(P=0.054)emission at d 42 was observed in pigs fed NC diets supplemented with graded level of *** conclusion,supplementing the reduced protein diet with Glu enhanced the growth performance in weanling pigs suggesting that supplementation of Glu can compensate the reduction of 2%CP in the basal diets.

关键词： Glu Growth performance Reduced protein diet Weanling pig