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Influence of cerium and yttrium addition on strength and electrical conductivity of pure aluminum alloys

Journal of Rare Earths 2024年第3期42卷 600-611,I0006页

作者： guojian Lin Lu Li zhengwei guo Xianjun Jia Xiao Wang Zhentao Yuan guoxing Zhang Yun Zhan Quan Shan Zulai Li Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming650093China Research Center for Analysis and Measurement Kunming University of Science and TechnologyKunming650093China City College Kunming University of Science and TechnologyKunming650051China

To develop pure aluminum alloys with high conductivity and strength, Al-0.2Ce and Al-0.2Ce-0.1Y alloys were prepared by rolling and annealing processes in this study. The effects of trace rare earth elements on the strength and electrical conductivity of the pure aluminum alloys were investigated. It is revealed that the addition of Ce and Y to pure aluminum can effectively enhance the strength and electrical conductivity of the alloys. In Al-0.2Ce, the addition of Ce can effectively refine the grain size of a-Al, with an average grain size of 90.68 μm in the as-cast state. The grain size of the alloy is further reduced to 87.55 μm by the simultaneous addition of Y. The synergistic addition of Ce and Y changes the properties of the alloy. The addition of Ce and Y also produces the Al_(11)Ce_(3) and Al_(3)Y second phases, which have coherent relationship with a-Al. The two-dimensional mismatch degree was calculated to be only 4.43%and 0.85%, respectively, which can provide a certain amount of nucleation substrate for a-Al in the incubation stage. The interfacial match between the L1_(2)structure of Al_(3)Y and a-Al was calculated using first-principles simulations. The results indicate that Al_(3)Y has a strong bonding effect with a-Al. Nanoscale second phases at grain boundaries can be effective in reducing resistivity due to dislocation *** second phases with better matching interfaces to the substrate have no positive effect on the scattering motion of electrons.

关键词： Pure aluminum Rare earths Impurity purification First-principles calculations Strength-conductivity contradiction

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Synthesis of reversible PAD4 inhibitors via copper-catalyzed C-H arylation of benzimidazole

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Science China Chemistry 2019年第5期62卷 592-596页

作者： zhengwei guo Lai Shi Bo Wang Gang He Yanming Wang Gong Chen State Key Laboratory and Institute of Elemento-Organic Chemistry College of ChemistryNankai University School of Life Sciences Henan University Department of Biochemistry and Molecular Biology The Pennsylvania State University

PAD4 is a promising epigenetic drug target for various cancers and immune diseases. In this work, we applied a Cu-catalyzed C–H arylation reaction of N-heteroarene to the synthesis of complex non-covalent PAD4 inhibitors bearing a bi-heteroaryl pharmacophore. This strategy allowed us to access various analogs of C_2-aryl substituted benzimidazoles from a common benzimidazole core and easily accessible aryl iodides. Preliminary SAR studies revealed the indole motif of GSK-484 is critical to its activity. Replacing the N-cyclopropylmethyl group to N-benzyl group on the indole ring of GSK-484 resulted in more than5-fold increase in cell killing efficacy against 4T1 cell line.

关键词： C–H arylation benzimidazoles PAD4 inhibitor copper catalysis

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Numerical study of the influence of the atmospheric pressure on the thermal environment in the passenger cabin

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Building Simulation 2024年第2期17卷 253-265页

作者： Xin Su Yu guo zhengwei Long Yi Cao Tianjin Key Lab.of Indoor Air Environmental Quality Control School of Environmental Science and EngineeringTianjin UniversityTianjin300072China Shanghai Aircraft Design and Research Institute Jinke RoadPudong DistrictShanghai201210China

The cabin air pressure remains lower than the horizontal atmospheric pressure when the airplane is in *** pressure is one of the parameters that must be taken into consideration while studying the thermal environment of an airplane *** are still no reference values for aircraft cabins despite the fact that numerous studies on low pressure heat transfer have demonstrated the connection between convective heat transfer coefficient(CHTC)and air *** this paper,a correction method for CHTC under low pressure conditions was established by using the dummy heat dissipation in the low-pressure cabin *** this basis,a thermal environment simulation model was developed,then was applied to the simulation of a seven-row aircraft cabin containing 42 passengers,and the CHTC and heat loss of dummy surface in the cabin were ***,the results of PMV calculated by using heat dissipation and air parameters at sampling points were *** results show that the modified CHTC can accurately reflect the cabin thermal environment under low pressure conditions,and the correction of CHTC can be realized by adjusting the turbulent Prandtl number,which is nonlinear correlated with the *** simulation results of the thermal environment in the seven-row cabin show that the CHTC changes by about 42%before and after *** air pressure decreases during take-off,which reduces the average CHTC of the crew surface from 5.09 W/(m^(2)·K)to 4.56 W/(m^(2)·K),but the air temperature rises by about 0.2°C as a *** deviation of PMV results calculated by using simulated heat loss data and using air parameters of measuring points in space is up to 0.5,but the latter is representative for calculating the thermal comfort level of the whole cabin.

关键词： low pressure aircraft cabin simulation heat dissipation convective heat transfer coefficient

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Study of the multi-physics field-coupled model of the two-stage electrostatic precipitator

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Building Simulation 2024年第3期17卷 387-398页

作者： Wenjia Hao Yu guo Yukun Wang Tao Yu Hao Gao zhengwei Long Tianjin Key Laboratory of Indoor Air Environmental Quality Control School of Environmental Science and EngineeringTianjin UniversityWeijin Road 92Tianjin300072China Wuhan Second Ship Design and Research Institute WuhanChin

The two-stage electrostatic precipitator is widely used to purify oil mist ***,there is limited research on the influences of relative humidity,particle deposition characteristics,and the generation of gaseous ***,this paper established a numerical model of the electrostatic oil mist purifier and applied it to a two-stage electrostatic *** the model was used to investigate the corona discharge characteristics under different relative humidity conditions in the charged zone,the particle deposition characteristics,the purification efficiency,the ozone concentration distribution,and the oil vapor concentration distribution in the collection *** results indicate that,with a constant temperature,the corona current decreases as relative humidity increase,and there is a quadratic relationship between relative humidity and *** variation in relative humidity has little impact on the purification *** maximum ozone concentration occurs near the electrode line,and its concentration is influenced by the discharge current and inlet airflow *** oil vapor concentration reaches its maximum value at the side plates,with a value of 19 ppb,while it reaches the minimum value at the collecting zone electrode plate,with a value of 2 *** temperature is the main factor affecting the volatilization of the oil film,with higher temperatures resulting in higher oil vapor.

关键词： two-stage ESPs particle deposition corona discharge oil vapor

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Bioactive Hydrogels with Pro-coagulation Effect for Hemostasis

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Chinese Journal of Chemistry 2024年第1期42卷 87-103,I0004页

作者： Quanshi guo Yihang Ding Lisha Yu Zongrui Tong zhengwei Mao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhouZhejiang 310058China Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310009China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province HangzhouZhejiang 310009China

Hemostatic hydrogels are widely applied for wound management of damaged tissues,traumatic wounds,and surgical *** hydrogels composed of bioactive components,including fibrin and thrombin,showed great promise in the clinic due to their good pro-coagulation *** the expanding knowledge of cascade reaction of blood coagulation and emerging bioactive substances,massive bioactive hydrogels consisting of peptides,hemocoagulase,polyphosphate(polyP),etc.,have been developed as effective hemostatic *** on the coagulation process and mechanism,we summarize the role of reported bioactive hydrogels in hemostasis in this *** conclude the key points in the coagulation process,including activation of coagulation factors,fibrinogen polymerization,etc.,then discuss how to design bioactive hydrogels to accelerate coagulation targeted to these ***,we conclude the progress and propose a perspective of bioactive hydrogels with a pro-coagulation effect for hemostasis.

关键词： Hemostasis Biological activity Biomaterials Enzyme catalysis Composites

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Inhalable iron redox cycling powered nanoreactor for amplified ferroptosis-apoptosis synergetic therapy of lung cancer

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Nano Research 2024年第6期17卷 5435-5451页

作者： Linjing Wu Wenhao Wang Mengqin guo Fangqin Fu Wenhua Wang Tszching Sung Meihong Zhang Ziqiao Zhong Chuanbin Wu Xin Pan zhengwei Huang College of Pharmacy Jinan UniversityGuangzhou 511436China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China

Fenton reaction centered ferroptosis-apoptosis synergetic therapy has emerged as a promising tumor elimination ***,the low intracellular Fenton level and accumulation of therapeutics at the lesion site greatly limit the efficacy of ferroptosis *** overcome these two bottlenecks,an inhalable metal polyphenol network(MPN)-hybrid liposome,encoded as LDG,was proposed for enhancing the intracellular Fenton reaction level by co-delivering the ferroptosis inducer dihydroartemisinin(DHA)and the ferrous ion(Fe2+)donor *** synthesized LDG had excellent nebulization performance which significantly improved the accumulation in the lungs,about 8.2 times of intravenous *** terms of anticancer mechanisms,MPN raised the intracellular level of Fe2+by constructing iron cycling in the weakly acidic environment of *** by Fe2+,DHA with peroxide-bridge structure underwent a high level of Fenton-like reaction,promoted the production of intracellular reactive oxygen species(ROS)and induced strong ferroptosis while cooperating with *** exhibited extraordinary antitumor ability in an orthotopic lung tumor model,whose tumor inhibition efficiency was 1.53(P=0.0014)and 1.32(P=0.0183)times of the LG group(liposomes coated with gallic acid(GA)-Fe MPN)and LD group(liposomes loaded with DHA),respectively,showing the strongest anticancer *** conclusion,the constructed MPN-hybrid liposomes could be a potent custom nanoplatform for pulmonary delivery and underscored the great potential of ferroptosis-apoptosis synergetic therapy.

关键词： lung cancer pulmonary delivery ferroptosis metallic polyphenol network

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Unveiling the innovative green synthesis mechanism of selenium nanoparticles by exploiting intracellular protein elongation factor Tu from Bacillus paramycoides

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第9期25卷 789-795页

作者： Pei LIU Haiyu LONG Shuai HE Han CHENG Erdong LI Siyu CHENG Mengdi LIANG zhengwei LIU Zhen guo Hao SHI Faculty of Life Science and Food Engineering Huaiyin Institute of TechnologyHuai’an223003China Jiangsu Provincial Key Construction Laboratory of Probiotics Preparation Huaiyin Institute of TechnologyHuai’an223003China

Selenium nanoparticles(SeNPs)have garnered extensive research interest and shown promising applications across diverse fields owing to their distinctive properties,including antioxidant,anticancer,and antibacterial activity(Ojeda et al.,2020;Qu et al.,2023;Zambonino et al.,2021,2023).Among the various approaches employed for SeNP synthesis,green synthesis has emerged as a noteworthy and eco-friendly *** et al.(2023)underscored the significance of green-synthesized SeNPs,presenting a compelling avenue in this *** innovative strategy harnesses the potential of natural resources,such as plant extracts or microorganisms,to facilitate the production of SeNPs.

关键词： synthesis mechanism nanoparticles

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采用压顶梁抗浮的地铁车站主体结构整体响应分析

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城市轨道交通研究 2016年第3期19卷 71-76页

作者：郭正伟中铁工程设计咨询集团有限公司郑州设计院郑州工程师450001

在明挖地铁车站抗浮设计中越来越多地采用的压顶梁抗浮型式。该型式具有易于与围护结构结合使用、施工简便、抗浮性能可靠等优点。将压顶梁和围护结构二者结合作为抗浮压重措施,对地铁车站主体结构利用有限元软件建立足尺三维荷载-结构... 详细信息

在明挖地铁车站抗浮设计中越来越多地采用的压顶梁抗浮型式。该型式具有易于与围护结构结合使用、施工简便、抗浮性能可靠等优点。将压顶梁和围护结构二者结合作为抗浮压重措施,对地铁车站主体结构利用有限元软件建立足尺三维荷载-结构模型,从理论上对抗浮工况下地铁车站主体结构进行受力分析,揭示压顶梁作用下地铁车站结构的一系列力学响应。研究表明:在浮力和压顶梁共同作用下,车站结构顶板呈下沉状态,浮力影响主要通过侧墙传递至顶板,结构抗浮满足要求;底板位移呈山峰状分布,底板中部为结构抗浮不利部位,宜增设必要的抗浮措施,如抗拔桩等;底板配重可较好地约束浮力作用下底板结构的上浮变形,且变形更均匀;车站结构局部出现裂缝,但通过配筋设计可使裂缝控制在规范允许的范围内,满足正常使用要求。

关键词：地铁车站压顶梁抗浮围护结构力学响应

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联合变化检测与子带对消技术的SAR图像干扰抑制方法

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系统工程与电子技术 2021年第9期43卷 2484-2492页

作者：李宁吕宗森郭拯危河南大学计算机与信息工程学院河南开封475004 河南大学河南省大数据分析与处理重点实验室河南开封475004 河南大学河南省智能技术与应用工程技术研究中心河南开封475004

子带对消(subband spectral cancellation,SSC)法是一种有效的合成孔径雷达(synthetic aperturEradar,SAR)射频干扰(radiOfrequency interference,RFI)抑制方法,但其在消除干扰的同时容易损失图像细节信息,影响后续图像解译。为此,在SSC方法的基础上,联合变化检测技术,提出一种改进的SAR图像干扰抑制方法。根据改进的对数比变化检测算子,所提方法实现了干扰二次检测,消除了干扰图像中的虚警信息,避免了图像中有用信号的损失。基于欧空局Sentinel-1A卫星干涉宽幅模式受干扰SAR图像,开展了干扰抑制与效果评估。实验结果表明,所提方法能够在有效抑制干扰的同时尽可能保留SAR图像细节信息,证明了所提方法的有效性。

关键词：合成孔径雷达射频干扰抑制子带对消变化检测

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基于Sentinel-1/2遥感数据的冬小麦覆盖地表土壤水分协同反演

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电子与信息学报 2021年第3期43卷 692-699页

作者：赵建辉张蓓李宁郭拯危河南大学河南省大数据分析与处理重点实验室开封475004 河南大学河南省智能技术与应用工程技术研究中心开封475004 河南大学计算机与信息工程学院开封475004

冬小麦是我国重要粮食作物之一,对冬小麦覆盖地表土壤水分进行监测有助于解决因土壤供水导致的冬小麦歉收和农业用水浪费等问题。为了降低冬小麦覆盖地表土壤水分微波遥感反演过程中冬小麦对雷达后向散射系数的影响,该文基于Sentinel-1... 详细信息

冬小麦是我国重要粮食作物之一,对冬小麦覆盖地表土壤水分进行监测有助于解决因土壤供水导致的冬小麦歉收和农业用水浪费等问题。为了降低冬小麦覆盖地表土壤水分微波遥感反演过程中冬小麦对雷达后向散射系数的影响,该文基于Sentinel-1携带的合成孔径雷达(SAR)数据和Sentinel-2携带的多光谱成像仪(MSI)数据,结合水云模型,开展冬小麦覆盖地表土壤水分协同反演研究。首先,基于MSI数据,该文定义了一种新的植被指数,即融合植被指数(FVI),用于冬小麦含水量反演;然后,该文发展了一种基于主被动遥感数据的冬小麦覆盖地表土壤水分反演半经验模型,校正冬小麦在土壤水分反演过程中对雷达后向散射系数的影响;最后,以河南省某地冬小麦农田为研究区域,开展归一化水体指数(NDWI)和FVI两种指数与VV,VH,VV/VH 3种极化组合而成的6种反演方式下的土壤水分反演对比实验。结果表明:以FVI为植被指数,能够更好地去除冬小麦在土壤水分反演过程中对雷达后向散射系数的影响;6种反演方式中,FVI与VV/VH组合下的反演效果最优,其决定系数为0.7642,均方根误差为0.0209 cm^(3)/cm^(3),平均绝对误差为0.0174 cm^(3)/cm^(3),展示了该文所提土壤水分反演模型的研究价值和应用潜力。

关键词：雷达土壤水分反演水云模型融合植被指数 Sentinel-1/2

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