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金属加工（热加工） 2024年第7期 89-93页

作者：郝丰林钟兴刘涛王正起纪仕超张希平浙江双环传动机械股份有限公司杭州管理总部浙江杭州311100 江苏双环齿轮有限公司江苏淮安223200 青岛钲瑞热处理有限公司山东青岛266109

针对某低碳合金钢齿轮渗碳淬火后因齿轮平面扭曲变形大而报废的现象,通过变形检测,对热处理工装、毛坯原材料及正火工艺等影响因素进行分析,表明正火预处理不合格是造成齿轮变形的重要原因。阐述了等温正火预处理对防止齿轮热处理变形... 详细信息

针对某低碳合金钢齿轮渗碳淬火后因齿轮平面扭曲变形大而报废的现象,通过变形检测,对热处理工装、毛坯原材料及正火工艺等影响因素进行分析,表明正火预处理不合格是造成齿轮变形的重要原因。阐述了等温正火预处理对防止齿轮热处理变形所具有重要的作用。

关键词：渗碳淬火贝氏体变形混晶二次正火

Compatibility evaluation between waterborne epoxy resin and SBR latex modified asphalt emulsion

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 160-171页

作者： Jianhua Yang zhengqi Zhang Ying Fang Key Laboratory for Special Area Highway Engineering of Ministry of Education Chang'an UniversityXi'an 710064China

Good compatibility between waterborne epoxy resin(WER)modifier and styrene-butadiene rubber(SBR)latex modified asphalt emulsion(SBRE)is an essential premise for good pavement performance of WER and SBR latex compositely modified asphalt emulsion(WSAE).This study aims to explore the compatibility between WER modifier and *** achieve the goal,several WER modifiers produced by two methods were first selected to modify SBRE,thus the WSAEs were ***,storage stability and workability of the WSAEs themselves,and high-temperature performance,rheological behavior and temperature sensitivity of their evaporated residues were compared and evaluated via performing a series of experiments,respectively,thus the WER modifier possessing an optimal modification effect was *** show that the storage stability of WSAEs is sensitive to the amount of *** incorporation of 1%WERs by the mass of SBRE improves the storage stability of SBRE,while WERs that exceed 1%weaken its storage *** the WERs reach 3%and 4%,the 5 d storage stability of prepared WSAEs will be beyond the limitation of *** WERs into SBRE negatively affects the workability of SBRE,and the workability of WSAEs is adversely influenced by the WERs content and the storage *** ensure the construction,the WSAEs with 3%and 4%WERs should not be stored for more than 36 h and 48 h,*** WERs effectively improve the high-temperature performance of SBRE residue,especially the 3%***,the WERs notably enhance the rheological property and thermal stability of SBRE *** contrast,the WER modifier produced by chemically modified method has a smaller adverse impact on the storage stability and workability of WSAE,and a larger enhancement on the high-temperature performance,rheological property and thermal stability of SBRE residue,which is thus recommended to modify SBRE.

关键词： Waterborne epoxy resin SBR modified asphalt emulsion Workability Rheological property Temperature sensitivity Compatibility evaluation

Analysis on patents of health care products with substances of medicine food homology in China

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Chinese Herbal Medicines 2024年第3期16卷 412-421页

作者： Haibo Liu Yanfeng wang Jiali Huang zhengqi Dong Peigen Xiao Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China Key Laboratory of Traditional Chinese Medicine Patent Information Resources State Administration of Traditional Chinese MedicineBeijing 100080China Beijing Academy of Science and Technology Beijing 100048China

Objective:The concept of substances of medicine food homology(SMFH)has garnered significant attention in recent *** study conducts a systematic analysis of patent literature related to SMFH,and elucidates the development trends,technical hotspots,and the overall patent protection landscape of SMFH in China over the past two ***:The patent search focused on the SMFH varieties as the objects of inquiry,with retrieval conducted in patent ***,the acquired data underwent processing,analysis,and ***:While the technical threshold for pharmaceutical applications surpasses that of the food service sector,the former may assume a prominent role in the *** and development(R&D)activities in the southeast of China demonstrate robust activity than other *** and scientific research institutions exhibit substantial advantages in patent applications compared with individuals and hold greater potential for future ***:The findings of this patent analysis indicate that China’s SMFH industry are presently undergoing a transition from an extensive model to a high-quality *** quality and technical standards of SMFH products are consistently ***,there is a need for more stringent patent application requirements to align with the evolving development needs.

关键词： patent analysis patent pattern substances of medicine food homology traditional Chinesemedicine

Faster structured illumination microscopy using complementary encoding-based compressive imaging

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Photonics Research 2024年第4期12卷 740-748页

作者： zhengqi HUANG YUNHUA YAO YILIN HE YU HE CHENGZHI JIN MENGDI GUO DALONG QI LIANZHONG DENG ZHENRONG SUN ZHIYONG wang SHIAN ZHANG State Key Laboratory of Precision Spectroscopy School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China School of Mathematical Sciences University of Electronic Science and Technology of ChinaChengdu 611731China Joint Research Center of Light Manipulation Science and Photonic Integrated Chip of East China Normal University and Shandong Normal University East China Normal UniversityShanghai 200241China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Structured illumination microscopy (SIM) has been widely applied to investigate intricate biological dynamics due to its outstanding super-resolution imaging speed. Incorporating compressive sensing into SIM brings the possibility to further improve the super-resolution imaging speed. Nevertheless, the recovery of the superresolution information from the compressed measurement remains challenging in experiments. Here, we report structured illumination microscopy with complementary encoding-based compressive imaging (CECI-SIM) to realize faster super-resolution imaging. Compared to the nine measurements to obtain a super-resolution image in a conventional SIM, CECI-SIM can achieve a super-resolution image by three measurements;therefore, a threefold improvement in the imaging speed can be achieved. This faster imaging ability in CECI-SIM is experimentally verified by observing tubulin and actin in mouse embryonic fibroblast cells. This work provides a feasible solution for high-speed super-resolution imaging, which would bring significant applications in biomedical research.

关键词： illumination complementary faster

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基于先验显著性信息的道路场景目标检测

计算机工程与应用 2023年第21期59卷 251-257页

作者：王钲棋邵洁上海电力大学电子与信息工程学院上海201306

在自动驾驶领域中,道路目标检测与识别是关键一环,直接关系到智能汽车的行车安全。在驾驶场景下目标种类多,大小差距大,导致卷积网络无法充分提取目标的位置信息,是道路场景检测准确率较低的主要原因,针对该问题,提出一种基于显著性信... 详细信息

在自动驾驶领域中,道路目标检测与识别是关键一环,直接关系到智能汽车的行车安全。在驾驶场景下目标种类多,大小差距大,导致卷积网络无法充分提取目标的位置信息,是道路场景检测准确率较低的主要原因,针对该问题,提出一种基于显著性信息改进的Sa-YOLOV5s算法。利用改进的语义分割网络(SaNet)充分提取语义信息,获取显著性图像。将显著性图像与不同尺度的卷积层特征进行融合,增强背景与目标的辨别性。利用DIoU-NMS充分计算所有检测框的位置,进一步减少误检和漏检的情况。通过与BshapeNet+算法及DIDN算法进行对比实验,验证了该方法在Cityscapes数据集上检测性能优于BshapeNet+算法及DIDN算法,平均检测精度分别上升了0.024和0.072;检测实时性方面,推理速度为33 FPS,达到了实时检测24 FPS的标准。

关键词：道路场景目标检测显著性信息 YOLOV5

Fuzzing:Progress,Challenges,and Perspectives

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Computers, Materials & Continua 2024年第1期78卷 1-29页

作者： Zhenhua Yu zhengqi Liu Xuya Cong Xiaobo Li Li Yin Institute of Systems Security and Control College of Computer Science and TechnologyXi'an University of Science and TechnologyXi'an710054China School of Mathematics and Information Science Baoji University of Arts and SciencesBaoji721013China Institute of Systems Engineering Macao University of Science and TechnologyTaipaMacaoChina

As one of the most effective techniques for finding software vulnerabilities,fuzzing has become a hot topic in software *** feeds potentially syntactically or semantically malformed test data to a target program to mine vulnerabilities and crash the *** recent years,considerable efforts have been dedicated by researchers and practitioners towards improving fuzzing,so there aremore and more methods and forms,whichmake it difficult to have a comprehensive understanding of the *** paper conducts a thorough survey of fuzzing,focusing on its general process,classification,common application scenarios,and some state-of-the-art techniques that have been introduced to improve its ***,this paper puts forward key research challenges and proposes possible future research directions that may provide new insights for researchers.

关键词： Fuzzing vulnerability software testing software security

Assessing the sensitivity of RegCM4 to cumulus and ocean surface schemes over the Southeast Asia domain of the coordinated regional climate downscaling experiment

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Atmospheric and Oceanic Science Letters 2020年第1期13卷 71-79页

作者： wang zhengqi GAO Xuejie HAN Zhenyu WU Jia XU Ying JUNENG Liew Climate Change Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina National Climate Center China Meteorological AdministrationBeijingChina Faculty of Science and Technology Universiti Kebangsaan MalaysiaUKM BangiMalaysia

东南亚地区开展的区域气候模式模拟较少。为评估并确认RegCM4最新版本(4.7)在这一地区的模式配置,本文进行了三组水平分辨率为25km的多年模拟试验,分别为使用Emanuel和使用Tiedtke (Tiedtke-1)对流参数化方案,以及引入了海表面蒸发效应... 详细信息

东南亚地区开展的区域气候模式模拟较少。为评估并确认RegCM4最新版本(4.7)在这一地区的模式配置,本文进行了三组水平分辨率为25km的多年模拟试验,分别为使用Emanuel和使用Tiedtke (Tiedtke-1)对流参数化方案,以及引入了海表面蒸发效应的Tiedtke (Tiedtke-2)方案,模拟范围为CORDEX-东南亚区域。分析表明,模式对该区域当代DJF和JJA陆地气温的气候态特征具有较好的模拟能力;冷偏差在两个季节均普遍存在,但冬季模拟中部分地区存在暖偏差。对降水而言,各个试验均能够在整体上再现不同季节降水的空间分布,降水量以及季节演变特征,但Tiedtke-1与Tiedtke-2的模拟结果均要明显的好于Emanuel,特别是在海上。这一区域的RegCM4设置由此确认为使用Tiedtke-2及其他模式缺省的物理参数化过程,并将应用于未来的气候变化模拟之中。

关键词：区域气候模式联合区域降尺度对流参数化方案东南亚

THE ABSENCE OF SINGULAR CONTINUOUS SPECTRUM FOR PERTURBED JACOBI OPERATORS

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Acta Mathematica Scientia 2024年第2期44卷 515-531页

作者：傅钲淇黎雄 Department of Basic Sciences Naval Submarine AcademyQingdao266199China Laboratory of Mathematics and Complex Systems(Ministry of Education) School of Mathematical SciencesBeijing Normal UniversityBeijing100875China

This paper is mainly about the spectral properties of a class of Jacobi operators(H_(c,b)u)(n)=c_(n)u(n+1)+c_(n-1)u(n-1)+b_(n)u(n),.where∣c_(n)−1∣=O(n^(−α))and b_(n)=O(n^(−1)).We will show that,forα≥1,the singula... 详细信息

关键词： Jacobi operator singular continuous spectrum Prüfer variables

Genetic and immunologic characteristics of colorectal cancer patients with KRAS mutations and predictive significance of tumor immune microenvironment in adjuvant chemotherapy

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Genes & Diseases 2024年第3期11卷 43-46页

作者： zhengqi Wen Wenliang Li Chengmin Shi Junrui Ma Sihui Zhao Ruize Zhou Xihong Liu Rong Yang Zhiping Zhang Hushan Zhang Bo Li Department of Oncology The First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China The Third Affliated Hospital of Kunming Medical University(Yunnan Cancer Center) KunmingYunnan 650021China Gastrointestinal and Hernia Surgery The First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China School of Nursing Yunnan University of Chinese MedicineKunmingYunnan 650022China Department of General Surgery The First People's Hospital of Yunnan ProvinceKunmingYunnan 650000China Department of General Surgery The Affiliated Hospital of Yunnan UniversityYunnan 650011China Medical Department 3D Medicines Inc.Shanghai 201114China Zhaotong Health Vocational College ZhaotongYunnan 657000China

Colorectal cancer(CRC)is one of the most common cancers around the world,and it is one of the leading causes of cancer-related death.1 Although anti-EGFR therapy and immune checkpoint inhibitor(ICl)therapy are becoming more and more important for colorectal therapy,however,clinical outcomes of current treatments for metastatic CRC,especially with ICls,have been shown to be affected by the status of ***,KRAS mutation status detection has become a very important diagnostic factor for managing metastatic CRC patients.

关键词： KRAS colorectal patients

Self-adjuvant Astragalus polysaccharide-based nanovaccines for enhanced tumor immunotherapy:a novel delivery system candidate for tumor vaccines

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Science China(Life Sciences) 2024年第4期67卷 680-697页

作者： Nan Li Yun Zhang Miaomiao Han Tian Liu Jinjia Wu Yingxia Xiong Yikai Fan Fan Ye Bing Jin Yinghua Zhang Guibo Sun Xiaobo Sun zhengqi Dong State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Chinese Academy of Medical Sciences&Peking Union Medical College(CAMS)Institute of Medicinal Plant Development(IMPLAD)Beijing 100193China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine from Ministry of Education Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine(Natural Medicine)and Translational MedicineKey Laboratory of New Drug Discovery Based on Classic Chinese Medicine Prescription from Chinese Academy of Medical SciencesCAMSIMPLADBeijing 100193China Department of Pharmaceutics School of Pharmaceutical SciencesHeilongjiang University of Chinese MedicineHarbin 150036China Jilin Academy of Chinese Medicine Sciences Changchun 130012China Joint Research Center for Chinese Medicinal Herbs IMPLADABRC&ACCLBeijing 100193China

The study of tumor nanovaccines(NVs)has gained interest because they specifically recognize and eliminate tumor ***,the poor recognition and internalization by dendritic cells(DCs)and insufficient immunogenicity restricted the vaccine ***,we extracted two molecular-weight Astragalus polysaccharides(APS,12.19 k D;APSHMw,135.67 k D)from Radix Astragali and made them self-assemble with OVA257–264directly forming OVA/APS integrated nanocomplexes through the microfluidic *** nanocomplexes were wrapped with a sheddable calcium phosphate layer to improve *** in the formed nanocomplexes served as drug carriers and immune adjuvants for potent tumor *** optimal APS-NVs were approximately 160 nm with uniform size distribution and could remain stable in physiological saline *** FITC-OVA in APS-NVs could be effectively taken up by DCs,and APS-NVs could stimulate the maturation of DCs,improving the antigen cross-presentation efficiency in *** possible mechanism was that APS can induce DC activation via multiple receptors such as dectin-1 and Toll-like receptors 2 and *** accumulation of APS-NVs both in draining and distal lymph nodes were observed following *** APS-NVs could easily access the lymph ***,APS-NVs could markedly promote antigen delivery efficiency to DCs and activate cytotoxic T *** addition,APS-NVs achieve a better antitumor effect in established B16-OVA melanoma tumors compared with the OVA+Alum treatment *** antitumor mechanism correlated with the increase in cytotoxic T cells in the tumor ***,the poor tumor inhibitory effect of APS-NVs on the nude mouse model of melanoma also confirmed the participation of antitumor adaptive immune response induced by ***,this study developed a promising APS-based tumor NV that is an efficient tumor immunotherapy without systemic side effects.

关键词： Astragalus polysaccharides nanovaccines OVA immunotherapy self-adjuvant

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