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Intracellular codelivery of anti-inflammatory drug and anti-miR 155 to treat inflammatory disease

Acta Pharmaceutica Sinica B 2020年第8期10卷 1521-1533页

作者： Chao Teng Chenshi Lin Feifei Huang Xuyang Xing Shenyu Chen Ling Ye Helena S.Azevedo Chenjie Xu zhengfeng wu Zhongjian Chen Wei He School of Pharmacy China Pharmaceutical UniversityNanjing 210009China School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China School of Engineering and Materials Science Institute of BioengineeringUniversity of LondonLondon E14NSUK Department of Biomedical Engineering City University of Hong KongKowloonHong KongChina Key Laboratory of Modern Preparation of TCM Ministry of EducationJiangxi University of Traditional Chinese MedicineNanchang 330004China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Atherosclerosis(AS) is a lipid-driven chronic inflammatory disease occurring at the arterial subendothelial space. Macrophages play a critical role in the initiation and development of AS. Herein,targeted codelivery of anti-miR 155 and anti-inflammatory baicalein is exploited to polarize macrophages toward M2 phenotype, inhibit inflammation and treat AS. The codelivery system consists of a carrier-free strategy(drug-delivering-drug, DDD), fabricated by loading anti-miR155 on baicalein nanocrystals,named as baicalein nanorods(BNRs), followed by sialic acid coating to target macrophages. The codelivery system, with a diameter of 150 nm, enables efficient intracellular delivery of anti-miR155 and polarizes M1 to M2, while markedly lowers the level of inflammatory factors in vitro and in vivo. In particular, intracellular fate assay reveals that the codelivery system allows for sustained drug release over time after internalization. Moreover, due to prolonged blood circulation and improved accumulation at the AS plaque, the codelivery system significantly alleviates AS in animal model by increasing the artery lumen diameter, reducing blood pressure, promoting M2 polarization, inhibiting secretion of inflammatory factors and decreasing blood lipids. Taken together, the codelivery could potentially be used to treat vascular inflammation.

关键词： miR155 inflammatory sustained

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Current Situations and Development Strategies for Integration of Peanut Agronomy and Agricultural Machinery in China

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Asian Agricultural Research 2015年第12期7卷 77-81,89页

作者： zhengfeng wu Junhua LIU Hao FENG Dianxu CHEN Caibin WANG Shandong Peanut Research Institute Binzhou University

The mechanization level of peanut production is the bottleneck restricting the development of peanut production in China,while integration of agronomy and agricultural machinery is an essential approach for improving mechanization level of peanut production. This paper elaborated requirements of peanut agronomy for agricultural machinery from peanut planting modes,land cultivation,sowing,harvesting,picking,and shelling,etc. Besides,it discussed requirements of agricultural machinery for agronomy from peanut seed quality,variety characteristics,planting modes,and soil condition. In addition,it analyzed existing problems and restricting factors of integration of peanut agronomy and agricultural machinery. Finally,it came up with recommendations for development strategies including increasing government fund input,optimizing industrial distribution,and multidisciplinary joint research.

关键词： Peanut Agronomy Agricultural machinery Simplified cultivation Development strategies

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论湘西少数民族文学与湘楚文化的关系

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中国文学研究 2021年第2期 170-176页

作者：吴正锋湖南城市学院人文学院湖南益阳413000

湘西少数民族文学与湘楚文化具有十分紧密的关系。湘西少数民族文学扎根于深厚的湘楚文化传统,湘楚文化反过来使湘西少数民族文学呈现出浓郁的湘楚文化特色。湘西少数民族文学呈现出湘西神秘魔幻的巫傩文化特征,表现了浪漫传奇精神与楚... 详细信息

湘西少数民族文学与湘楚文化具有十分紧密的关系。湘西少数民族文学扎根于深厚的湘楚文化传统,湘楚文化反过来使湘西少数民族文学呈现出浓郁的湘楚文化特色。湘西少数民族文学呈现出湘西神秘魔幻的巫傩文化特征,表现了浪漫传奇精神与楚人的悲剧意识,表达了炽热的爱国爱民情怀以及对独立人格精神的坚守,表现了少数民族独有的民情风俗与民歌民谣。湘西少数民族文学是巫楚地域文化与湘西少数民族文化的复合表现,它是中国南方少数民族文学的重要代表,为中国文学的多样艺术色彩作出了重要贡献。

关键词：湘西少数民族文学湘楚文化巫傩文化地域文化少数民族文化

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论凌宇先生的学术思想

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南方文坛 2023年第1期 75-80页

作者：吴正锋湖南城市学院人文学院

凌宇先生是沈从文研究的全国著名的专家。在20世纪末80年代初期,沈从文研究还是一个颇为敏感的研究领域之时,凌宇先生便像发掘文物一样,将沈从文作品从故纸堆中收集整理出来,并进行深入的研究,先后出版了专著《从边城走向世界》(生活·... 详细信息

凌宇先生是沈从文研究的全国著名的专家。在20世纪末80年代初期,沈从文研究还是一个颇为敏感的研究领域之时,凌宇先生便像发掘文物一样,将沈从文作品从故纸堆中收集整理出来,并进行深入的研究,先后出版了专著《从边城走向世界》(生活·读书·新知三联书店1985年版)和《沈从文传》(北京十月文艺出版社1988年版),此外,凌宇先生还发表了一系列具有重要影响力的沈从文研究论文,在学术界引起强烈的反响。

关键词：沈从文研究沈从文作品凌宇从边城走向世界三联书店学术思想收集整理

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论张枣诗歌的对话性

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中国文学研究 2023年第4期 193-199页

作者：吴正锋湖南城市学院人文学院湖南益阳413000

张枣诗歌的对话性主要体现在:“对话式”地展开社会人生的探讨,表现诗人强烈的寻觅知音的意识;分裂的主体戏剧化地展示内在矛盾的情思,在二元对立中体现诗人元诗创作的特点;抒叙主体的独白话语中出现另一主体的声音,形成复调的艺术。张... 详细信息

张枣诗歌的对话性主要体现在:“对话式”地展开社会人生的探讨,表现诗人强烈的寻觅知音的意识;分裂的主体戏剧化地展示内在矛盾的情思,在二元对立中体现诗人元诗创作的特点;抒叙主体的独白话语中出现另一主体的声音,形成复调的艺术。张枣诗歌的对话性的形成与张枣寻求中国文化的“知音乐趣”、荒原式的生命体验以及他对元诗创作理念的追求等方面都有紧密的联系。

关键词：张枣对话性知音复调元诗

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Study on Physiological Characteristics and Supporting Techniques of Huayu 22 Peanut

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Asian Agricultural Research 2015年第10期7卷 74-76 82,82页

作者： Yaping ZHENG Yongmei ZHENG zhengfeng wu Xuewu SUN Caibin WANG Shandong Peanut Research Institute

Huayu 22 Peanut( Arachis hypogaea L.) belongs to ordinary large variety of peanut with high quality,high yield potential and high stress resistance. Study on nutrition characteristics,stress physiology and supporting techniques of Huayu 22 Peanut is conducive to further developing its application value in breeding and exploiting its high yield potential. Compared with Baisha 1016 Peanut,Huayu 22 Peanut has greater shade tolerance. In weak light,both the leaf area and rate of photosynthesis of Huayu 22 Peanut decline slightly,and damage of chloroplast ultramicrostructure is less,light compensation point and chloroplast a / b are lower,and capturing and utilization efficiency of weak light are higher; after removal of shade,Huayu 22 Peanut plant gets recovered quickly with higher growth compensation effect but slight dropping of yield. Characteristics of N supply for Huayu 22 Peanut at different growth stages are as follows: N supply intensity of root nodule takes on unimodal curve with peak at pod bearing stage. The N supply intensity of soil takes on N shape with higher value at pegging stage and pod filling stage; N supply intensity takes on unimodal curve with peak at pegging stage. At seedling stage and pod filling stage,N is mainly supplied by soil; at pegging stage and pod bearing stage,N is supplied by root nodule. At whole growth stage,root nodule has the largest contribution to N supply,accounting for 50. 0%,followed by soil and fertilizer,and the proportion is about 5: 3: 2. The study established standardized supporting technique for simple cultivation of Huayu 22 Peanut with " single-seed planting,high effective fertilizer application,and three sprays and multi-prevention".

关键词： Peanut Huayu 22 Shade tolerance physiology Nutriti

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论沈从文小说与中国传统叙事艺术的关系

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中国文学研究 2016年第3期 96-101页

作者：吴正锋湖南省社会科学院文学研究所湖南长沙410003

沈从文小说创作植根于深厚的中国传统叙事艺术传统基础上,其叙事艺术吸收与借鉴了中国史传叙事艺术、唐传奇叙事艺术、话本拟话本叙事艺术,以及章回小说叙事艺术等中国传统叙事艺术的有益成分,具有鲜明的民族特征和民族风格,为世界叙事... 详细信息

沈从文小说创作植根于深厚的中国传统叙事艺术传统基础上,其叙事艺术吸收与借鉴了中国史传叙事艺术、唐传奇叙事艺术、话本拟话本叙事艺术,以及章回小说叙事艺术等中国传统叙事艺术的有益成分,具有鲜明的民族特征和民族风格,为世界叙事艺术的殿堂增添了中国因素和中国色彩。以此同时,沈从文结合新的时代特点,对中国传统叙事艺术进行了革新与转化,推动了中国传统叙事艺术的现代发展。

关键词：沈从文叙事艺术史记唐传奇话本拟话本章回小说

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论沈从文对湘西民族命运的思考

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民族文学研究 2006年第2期24卷 153-157页

作者：吴正锋湖南师范大学文学院

作为“湘西世界”歌者的沈从文同时也是湘西民族情绪的伟大表达者,湘西民族在长期历史中所遭受的悲惨命运以及他们在现代社会所面临的“覆灭”的生存危机,使沈从文感到“沉郁隐痛”,并在整体上拥有一种深深的“悲悯感”。沈从文对湘西... 详细信息

作为“湘西世界”歌者的沈从文同时也是湘西民族情绪的伟大表达者,湘西民族在长期历史中所遭受的悲惨命运以及他们在现代社会所面临的“覆灭”的生存危机,使沈从文感到“沉郁隐痛”,并在整体上拥有一种深深的“悲悯感”。沈从文对湘西民族命运进行了独特的思考和探索,不仅显示出他作为一个少数民族作家独到的思想特色,更重要的是沈从文以一种现代的开放性的视野看待湘西民族的现实遭遇及其未来命运。沈从文是湘西民族之魂。

关键词：沈从文湘西民族命运思考

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Physiological Characteristics of Nitrogen Nutrition in Peanut and Efficient Nitrogen Application Technology

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Asian Agricultural Research 2022年第7期14卷 47-50页

作者： Chunxiao WANG Changsong JIANG Ke ZHAO Xiaoping ZHANG zhengfeng wu Yongmei ZHENG Tianyi YU Yaping ZHENG Yantai Academy of Agricultural Sciences Yantai 265500China Haiyang City Agricultural Technology Extension Center Haiyang 265100China Sichuan Agricultural University Ya'an 625014China Shandong Peanut Research Institute Qingdao 266100China

Nitrogen plays a very important role in peanut nutrition and *** peanuts,the nitrogen nutrition comes from root nodules,soil and fertilizer,which are separately referred to as root nodule nitrogen,soil nitrogen and fertilizer *** research obtained following findings.(ⅰ)The nitrogen supply ratio of the three nitrogen sources for peanut is about 5∶3∶*** are significant differences in the nitrogen supply capacity of the three nitrogen *** root nodules have the largest variation in nitrogen fixation and have a high potential for *** fixation in root nodules is closely related to carbon metabolism indicators such as photosynthesis in peanut *** application could increase the accumulation of three nitrogen sources,and the increase in nodule nitrogen accumulation is greater than that of soil nitrogen and fertilizer nitrogen.(ⅱ)Nitrogen fertilizer has a significant effect on nitrogen nutrition of *** forms of nitrogen fertilizers,such as amide nitrogen,ammonium nitrogen,nitrate nitrogen and mixed ammonium nitrate nitrogen,have significant effects on nitrogen metabolism and nitrogen accumulation in *** nitrogen fertilizer is beneficial to improving the activity of enzymes related to nitrogen metabolism and nitrogen ***-release fertilizer can significantly increase the content of soluble protein and improve the activities of NRase,GDH,GS,GPT,*** roots and leaves at the pod setting and mature stages of peanuts,which is favorable for delaying the plant senescence and increasing the yield of *** application of common nitrogen fertilizer and slow-release fertilizer can increase the soil nitrate nitrogen level at the later growth stage,which is beneficial to the development of the root system at the later stage of growth,increasing the distribution ratio of nitrogen in the pods,and also favorable for increasing the yield and nitrogen utilization rate.(ⅲ)Increa

关键词： Peanuts Nitrogen Physiological characteristics Efficient fertilization

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Simple and Efficient Cultivation Technology for the Peanut under the Standardization Mode of Single-seed Sowing

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Asian Agricultural Research 2016年第6期8卷 61-64页

作者： Hao FENG zhengfeng wu Jiancai LIN Tianyi YU Yongmei ZHENG Xuewu SUN Pu SHEN Chengren SHI Caibin WANG Shandong Peanut Research Institute Yantai Agricultural Technology Extension Center

Single-seed sowing is a new,simple and efficient cultivation mode for peanut that realized from cultivation of healthy individual and construction of high-yielding population. The cultivation mode has the obvious advantages in uniform seedling,strong sprouting,seed saving and cost saving,thus it is considered as one of the effective ways for high-yield and high-efficient peanut cultivation in China in the *** integrating with other high-efficiency and simple cultivation measures,the single-seed sowing technology system has made conforming to China's national standardization cultivations of peanut and the technology was already applied in the main producing areas of peanut and gained the significant efficiency and abroad application prospects. Based on many years of researches in single-seed sowing technology,high-efficiency fertilization and scientific chemical control in the research team,by combining with the latest research results in plant protection and machinery,this paper described the key points and matters needing attentions from variety selection,planting mode,rational fertilization,planting specifications and field management.

关键词： Peanut Single-seed sowing High efficient cultivation Technical points

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