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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第1期25卷 83-90页

作者： Zhikun LIU Yichao WU Abid Ali KHAN Lun LU Jianguo WANG Jun CHEN Ningyang JIA Shusen zheng xiao xu Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou310006China Zhejiang University School of Medicine Hangzhou310058China Department of Radiology Easter Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai200438China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou310003China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalHangzhou310022China

Hepatocellular carcinoma(HCC)is one of the most common malignancies and is a major cause of cancer-related mortalities worldwide(Forner et al.,2018;He et al.,2023).Sarcopenia is a syndrome characterized by an accelerated loss of skeletal muscle(SM)mass that may be age-related or the result of malnutrition in cancer patients(Cruz-Jentoft and Sayer,2019).Preoperative sarcopenia in HCC patients treated with hepatectomy or liver transplantation is an independent risk factor for poor survival(Voron et al.,2015;van Vugt et al.,2016).

关键词： cancer patients

Stabilization or degradation?Post-translational modifications of JAZ proteins in plants

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Molecular Plant 2024年第7期17卷 1002-1004页

作者： xiaoyan xu Jianping Hu zheng Yuan Joint International Research Laboratory of Metabolic&Developmental Sciences School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai200240China Department of Energy Plant Research Laboratory and Plant Biology Department Michigan State UniversityEast LansingMI 48824USA

Jasmonates(JAs)are essential hormones that regulate plant responses to biotic and abiotic stresses and are involved in various developmental processes,including flowering time control,floral organ development,and fertility of male and female gametes(Howe et al.,2018).However,our understanding of the mechanisms by which JAs integrate multiple signals to regulate diverse physiological processes remains *** the canonical JA signaling pathway,activated JAs are perceived by the F-box protein receptor CORONATINE INSENSITIVE 1(COl1),which induces the interaction between COl1 and the Jas domain of the repressor proteins JASMONATE-ZIM DOMAIN PROTEINs(JAZs),leading to the ubiquitination and degradation of JAZ *** proteolytic destruction of the JAZ repressors is a crucial step that releases the inhibition of JAZs on the JA response transcription factor MYC2,allowing MYC2 to activate the expression of downstream genes(Howe et al.,2018).Therefore,the stability and specific spatiotemporal expression pattern of the JAZ proteins are critical for the regulation of JA signaling output,as they determine the activation and repression of JA responses.

关键词： translational fertility release

Surface diffraction beamline at the SSRF

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Nuclear Science and Techniques 2024年第7期35卷 47-57页

作者： Yue-Liang Gu xu zheng Xing-Min Zhang Bin Zhao Guang-Zhi Yin Da-Ming Zhu Yuan-He Sun Xing-Yu Gao xiao-Long Li Shanghai Advanced Research Institute Chinese Academy of Sciences239 Zhangheng RoadPudong DistrictShanghai201204China

BL02U2 of the Shanghai Synchrotron Radiation Facility is a surface diffraction beamline with a photon flux of 5.5×10^(12) photons/s at 10 keV and a beam size of 160µm×80µm at the sample *** is dedicated to studying surfaces(solid-vacuum,solid-gas)and interfaces(solid-solid,solid-liquid,and liquid-liquid)in nanoscience,condensed matter,and soft matter systems using various surface scattering techniques over an energy range of 4.8-28 keV with transmission and reflection ***,BL02U2 has a high energy resolution,high angular resolution,and low beam divergence,which can provide excellent properties for X-ray diffraction experiments,such as grazing incident X-ray diffraction,X-ray reflectivity,crystal truncation rods,and liquid X-ray *** of in situ environments can also be provided for the samples *** paper describes the setup of the new beamline and its applications in various fields.

关键词： Surface and interface Beamline Surface diffraction Microstructure

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Quantitative Analysis of Seeing with Height and Time at Muztagh-Ata Site Based on ERA5 Database

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Research in Astronomy and Astrophysics 2024年第1期24卷 87-95页

作者： xiao-Qi Wu Cun-Ying xiao Ali Esamdin Jing xu Ze-Wei Wang Luo xiao Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Department of Astronomy Beijing Normal UniversityBeijing 100875China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China

Seeing is an important index to evaluate the quality of an astronomical *** estimate seeing at the Muztagh-Ata site with height and time quantitatively,the European Centre for Medium-Range Weather Forecasts reanalysis database(ERA5)is *** calculated from ERA5 is compared consistently with the Differential Image Motion Monitor seeing at the height of 12 *** show that seeing decays exponentially with height at the Muztagh-Ata *** decays the fastest in fall in 2021 and most slowly with height in *** seeing condition is better in fall than in *** median value of seeing at 12 m is 0.89 arcsec,the maximum value is1.21 arcsec in August and the minimum is 0.66 arcsec in *** median value of seeing at 12 m is 0.72arcsec in the nighttime and 1.08 arcsec in the *** is a combination of annual and about biannual variations with the same phase as temperature and wind speed indicating that seeing variation with time is influenced by temperature and wind *** Richardson number Ri is used to analyze the atmospheric stability and the variations of seeing are consistent with Ri between *** quantitative results can provide an important reference for a telescopic observation strategy.

关键词： site testing atmospheric effects methods:data analysis telescopes Earth

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Adsorption and sensing characteristics of insulating gas C4F7N on 3d late transition metal-phthalocyanine:Theoretical and experimental study

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High Voltage 2024年第4期9卷 870-878页

作者： Dachang Chen Ziang zheng Cong Zhang Yi Luo Song xiao Qing Miao Ke Liu Beibei xiao School of Electrical and Electronic Engineering Wuhan Polytechnic UniversityWuhanChina Beijing International S&T Cooperation Base for Plasma Science and Energy Conversion Institute of Electrical EngineeringChinese Academy of SciencesBeijingChina School of Electrical Engineering and Automation Wuhan UniversityWuhanChina School of Energy and Power Engineering Jiangsu University of Science and TechnologyZhenjiangChina

Heptafluoroisobutyronitrile(C_(4)F_(7)N)is being considered as a promising alternative to the greenhouse gas SF6 in the electrical ***,its biotoxicity necessitates the development of gas sensing technology to detect leaked C_(4)F_(7)N.A combination of density functional theory and experiments was employed to evaluate the adsorption and sensing performance of different metal-phthalocyanines as potential sensing materials for C_(4)F_(7)N *** study included exploring adsorption configurations with adsorption energies,electron transfer,and adsorption distance,as well as comparisons of electronic properties,electron distribution,and density of states(DOS)among the ***,gas sensing experiments were conducted using different MPcs to detect 25-100 ppm C_(4)F_(7)*** results revealed that Mn-Pc,Fe-Pc,Co-Pc,and Zn-Pc exhibited considerable chemical interactions,while Ni-Pc and Cu-Pc showed weaker adsorption *** findings were further elucidated based on the electron density and DOS of atomic ***,gas sensing experiments indicated that Co-Pc demonstrated a higher response compared to Fe-Pc at the same concentration of C_(4)F_(7)***,the theoretical and experimental insights offer valuable guidance for C_(4)F_(7)N detection and provide a systematic approach to screen and explore organometallic polymer-based gas sensors applicable in various fields.

关键词： adsorption phthalocyanine Adsorption

RNase P:Beyond Precursor tRNA Processing

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 19-28页

作者： Peipei Wang Juntao Lin Xiangyang zheng Xingzhi xu Guangdong Key Laboratory for Genome Stability&Disease Prevention and Marshall Laboratory of Biomedical Engineering Shenzhen University Medical SchoolShenzhen UniversityShenzhen 518060China Department of Urology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000China Shenzhen University General Hospital-Dehua Hospital Joint Research Center on Precision Medicine Dehua HospitalDehua 362500China

Ribonuclease P(RNase P)was first described in the 1970’s as an endoribonuclease acting in the maturation of precursor transfer RNAs(tRNAs).More recent studies,however,have uncovered non-canonical roles for RNase P and its ***,we review the recent progress of its involvement in chromatin assembly,DNA damage response,and maintenance of genome stability with implications in *** possibility of RNase P as a therapeutic target in cancer is also discussed.

关键词： RNase P Chromatin assembly DNA damage response Genome stability Tumorigenesis

HCRVD: A Vulnerability Detection System Based on CST-PDG Hierarchical Code Representation Learning

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Computers, Materials & Continua 2024年第6期79卷 4573-4601页

作者： Zhihui Song Jinchen xu Kewei Li zheng Shan School of Cyberspace Security Information Engineering UniversityZhengzhou450001China

Prior studies have demonstrated that deep learning-based approaches can enhance the performance of source code vulnerability detection by training neural networks to learn vulnerability patterns in code ***,due to limitations in code representation and neural network design,the validity and practicality of the model still need to be ***,due to differences in programming languages,most methods lack cross-language detection *** address these issues,in this paper,we analyze the shortcomings of previous code representations and neural *** propose a novel hierarchical code representation that combines Concrete Syntax Trees(CST)with Program Dependence Graphs(PDG).Furthermore,we introduce a Tree-Graph-Gated-Attention(TGGA)network based on gated recurrent units and attention mechanisms to build a Hierarchical Code Representation learning-based Vulnerability Detection(HCRVD)*** system enables cross-language vulnerability detection at the *** experiments show that HCRVD surpasses many competitors in vulnerability detection *** benefits from the hierarchical code representation learning method,and outperforms baseline in cross-language vulnerability detection by 9.772%and 11.819%in the C/C++and Java datasets,***,HCRVD has certain ability to detect vulnerabilities in unknown programming languages and is useful in real open-source *** shows good validity,generality and practicality.

关键词： Vulnerability detection deep learning CST-PDG code representation tree-graph-gated-attention network cross-language

Influence of crystal-transforming agent on the performance and mechanism ofα-high-strength gypsum prepared from FGD gypsum

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Particuology 2024年第4期87卷 37-45页

作者： Zhuoyue xu xiao Wang Biao Jin Dawang Zhang Hui Li College of Materials Science and Engineering Xi'an University of Architecture and TechnologyXi'an710055China Schoolof Materials and Chemical Engineering Henan University of Urban ConstructionPingdingshan46736China

This paper investigates the impact of flue gas desulfurization(FGD)gypsum's crystal modifier on the characteristics and microcosmic mechanism ofα-high strength *** results demonstrate that all three crystal modifiers can convert FGD gypsum toα-high-strength *** acid(CA)has the most significant influence onα-high-strength gypsum,and the preparedα-high-strength gypsum is short columnar,with an aspect ratio in the range of 1-3,and has a faster setting time,a larger specific surface area,and a smaller standard consistency,higher compressive strength,greater surface hardness,and smaller crystal particle *** initial setting time of theα-high-strength gypsum manufactured with CA crystal modifier was decreased by 36%compared to the blank sample,the final setting time was lowered by 37.5%,and the water consumption of the standard consistency was reduced by 8%.The maximum strength is 32 MPa after 2 h,the absolute dry compressive strength is up to 38 MPa,and the surface hardness is improved by 24.43%.

关键词： Flue gas desulfurization gypsum Crystal modifier Microscopic mechanism α-high-strength gypsum

Echo State Network Based on Improved Knowledge Distillation for Edge Intelligence

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Chinese Journal of Electronics 2024年第1期33卷 101-111页

作者： Jian ZHOU Yuwen JIANG Lijie xu Lu ZHAO Fu xiao College of Computer Nanjing University of Posts and Telecommunications Jiangsu High Technology Research Key Laboratory for Wireless Sensor Networks

Echo state network(ESN) as a novel artificial neural network has drawn much attention from time series prediction in edge intelligence. ESN is slightly insufficient in long-term memory, thereby impacting the prediction performance. It suffers from a higher computational overhead when deploying on edge devices. We firstly introduce the knowledge distillation into the reservoir structure optimization, and then propose the echo state network based on improved knowledge distillation(ESN-IKD) for edge intelligence to improve the prediction performance and reduce the computational overhead. The model of ESN-IKD is constructed with the classic ESN as a student network, the long and short-term memory network as a teacher network, and the ESN with double loop reservoir structure as an assistant network. The student network learns the long-term memory capability of the teacher network with the help of the assistant network. The training algorithm of ESN-IKD is proposed to correct the learning direction through the assistant network and eliminate the redundant knowledge through the iterative pruning. It can solve the problems of error learning and redundant learning in the traditional knowledge distillation process. Extensive experimental simulation shows that ESN-IKD has a good time series prediction performance in both long-term and short-term memory, and achieves a lower computational overhead.

关键词： Knowledge engineering Training Performance evaluation Computational modeling Time series analysis Artificial neural networks Reservoirs

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Pannexins in the musculoskeletal system:new targets for development and disease progression

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Bone Research 2024年第2期12卷 255-269页

作者： Yan Luo Shengyuan zheng Wenfeng xiao Hang Zhang Yusheng Li Department of Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Clinical Medicine Xiangya Medicine SchoolCentral South UniversityChangshaHunan 410008China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China

During cell differentiation,growth,and development,cells can respond to extracellular stimuli through communication ***(Panx)family and connexin(Cx)family are two important types of channel-forming *** family contains three members(Panx1-3)and is expressed widely in bone,cartilage and *** there is no sequence homology between Panx family and Cx family,they exhibit similar configurations and *** to Cxs,the key roles of Panxs in the maintenance of physiological functions of the musculoskeletal system and disease progression were gradually revealed ***,we seek to elucidate the structure of Panxs and their roles in regulating processes such as osteogenesis,chondrogenesis,and muscle *** also focus on the comparison between Cx and *** a new key target,Panxs expression imbalance and dysfunction in muscle and the therapeutic potentials of Panxs in joint diseases are also discussed.

关键词： skeletal diseases system

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