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Jianpi-Huatan-Huoxue-Anshen formula ameliorates gastrointestinal inflammation and microecological imbalance in chemotherapytreated mice transplanted with H22 hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4209-4231页

作者： Ya-Nan Wang Xiang-Yang Zhai zheng Wang Chun-Ling Gao Sui-Cai Mi Wen-Li Tang Xue-Min Fu Huai-Bang Li Li-Feng Yue peng-Fei Li Sheng-Yan Xi Department of TCM Xiang’an HospitalSchool of MedicineXiamen UniversityXiamen 361102Fujian ProvinceChina Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao 999078China Department of Radiotherapy Chenggong Hospital of Xiamen UniversityPLA 73rd Army HospitalXiamen 361003Fujian ProvinceChina Department of Oncology Xiamen Hospital of Traditional Chinese MedicineXiamen 361015Fujian ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China

BACKGROUND Jianpi-Huatan-Huoxue-Anshen formula[Tzu-Chi cancer-antagonizing&lifeprotecting II decoction(TCCL)]is a Chinese medical formula that has been clinically shown to reduce the gastrointestinal side effects of chemotherapy in cancer patients and improve their quality of ***,its effect and mechanism on the intestinal microecology after chemotherapy are not yet *** To discover the potential mechanisms of TCCL on gastrointestinal inflammation and microecological imbalance in chemotherapy-treated mice transplanted with hepatocellular carcinoma(HCC).METHODS Ninety-six mice were inoculated subcutaneously with HCC *** week later,the mice received a large dose of 5-fluorouracil by intraperitoneal injection to establish a HCC chemotherapy ***-six mice were randomly selected before administration,and feces,ileal tissue,and ileal contents were collected from each *** remaining mice were randomized into normal saline,continuous chemotherapy,Yangzheng Xiaoji capsulestreated,and three TCCL-treated *** treatment,feces,tumors,liver,spleen,thymus,stomach,jejunum,ileum,and colon tissues,and ileal contents were *** changes,serum levels of IL-1β,IL-6,IL-8,IL-10,IL-22,TNF-α,and TGF-β,intestinal SIgA,and protein and mRNA expression of ZO-1,NF-κB,Occludin,MUC-2,Claudin-1,and IκB-αin colon tissues were *** effect of TCCL on the abundance and diversity of intestinal flora was analyzed using 16S rDNA *** TCCL treatment improved thymus and spleen weight,thymus and spleen indexes,and body weight,decreased tumor volumes and tumor tissue cell density,and alleviated injury to gastric,ileal,and colonic mucosal *** proteins and genes associated with inflammation,IL-10,TGF-β,SIgA,ZO-1,MUC-2,and Occludin were upregulated,whereas NF-κB,IL-1β,IL-6,TNF-α,IL-22,IL-8,and IκB-αwere ***,TCCL increased the proportions of fecal Actinobacteria,AF12,Adlercreutzia,Clostridium,Coriobac

关键词： Chinese medicine Chemotherapy H22 hepatocellular carcinoma Intestinal barrier function Intestinal microecological balance

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以金融与产业高质量融合发展助推中国式现代化

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工信财经科技 2024年第2期 90-98页

作者：郑鹏西南财经大学工商管理学院成都银行股份有限公司长顺支行

中央经济工作会议指出:“必须把推进中国式现代化作为最大的政治。”加快建设现代化产业体系,离不开金融与产业的高质量融合发展。本文认为,坚持政治性和人民性是金融与产业高质量融合发展的逻辑起点;尊重市场意识、遵守契约精神、尊重... 详细信息

中央经济工作会议指出:“必须把推进中国式现代化作为最大的政治。”加快建设现代化产业体系,离不开金融与产业的高质量融合发展。本文认为,坚持政治性和人民性是金融与产业高质量融合发展的逻辑起点;尊重市场意识、遵守契约精神、尊重发展规律是金融与产业高质量融合发展的基本原则;补齐短板、打通堵点、守正创新是金融与产业高质量融合发展的有效手段;增强双向黏性、提升产业吸引、激活发展韧劲是金融与产业高质量融合发展的必要通道;强化金融监管、加强法律建设、防范系统性风险是金融与产业高质量融合发展的重要底线。

关键词：中国式现代化金融与产业融合发展

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Perioperative toripalimab plus neoadjuvant chemotherapy might improve outcomes in resectable esophageal cancer:an interim analysis of a phase Ⅲ randomized clinical trial

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Cancer Communications 2024年第10期44卷 1214-1227页

作者： Yan zheng Guanghui Liang Dongfeng Yuan Xianben Liu Yufeng Ba Zimin Qin Sining Shen Zhenxuan Li Haibo Sun Baoxing Liu Quanli Gao peng Li Zongfei Wang Shilei Liu Jianping Zhu Haoran Wang Haibo Ma Zhenzhen Liu Fei Zhao Jun Zhang He Zhang Daoyuan Wu Jinrong Qu Jie Ma peng Zhang Wenjie Ma Ming Yan Yongkui Yu Qing Li Jiangong Zhang Wenqun Xing Department of Thoracic Surgery The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Immunotherapy The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Endoscopy The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Pathology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Radiology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Biobank The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Strategic Development The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Statistics LinkDoc Technology Co.LtdBeijingP.R.China Department of Cancer Epidemiology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouP.R.China

Background:In the era of immunotherapy,neoadjuvant immunochemotherapy(NAIC)for the treatment of locally advanced esophageal squamous cell carcinoma(ESCC)is used clinically but lacks of high-level clinical *** study aimed to compare the safety and long-term efficacy of NAIC followed byminimally invasive esophagectomy(MIE)with those of neoadjuvant chemotherapy(NAC)followed by ***:A prospective,single-center,open-label,randomized phase Ⅲ clinical trial was conducted at Henan Cancer Hospital,zhengzhou,*** were randomly assigned to receive either neoadjuvant toripalimab(240mg)plus paclitaxel(175 mg/m^(2))+cisplatin(75 mg/m^(2))(toripalimab group)or paclitaxel+cisplatin alone(chemotherapy group)every 3 weeks for 2 *** surgery,the toripalimab group received toripalimab(240 mg every 3 weeks for up to 6 months).The primary endpoint was event-free survival(EFS).The pathological complete response(pCR)and overall survival(OS)were key secondary *** events(AEs)and quality of life were also ***:Between May 15,2020 and August 13,2021,252 ESCC patients ranging fromT1N1-3M0 to T2-3N0-3M0were enrolled for interim analysis,with 127 in the toripalimab group and 125 in the chemotherapy *** 1-year EFS rate was 77.9%in the toripalimab group compared to 64.3%in the chemotherapy group(hazard ratio[HR]=0.62;95%confidence interval[CI]=0.39 to 1.00;P=0.05).The 1-year OS rates were 94.1%and 83.0%in the toripalimab and chemotherapy groups,respectively(HR=0.48;95%CI=0.24 to 0.97;P=0.037).The patients in the toripalimab group had a higher pCR rate(18.6%vs.4.6%;P=0.001).The rates of postoperative Clavien-Dindo grade Ⅲb or higher morbidity were 9.8%in the toripalimab group and 6.8%in the chemotherapy group,with no significant difference observed(P=0.460).The rates of grade 3 or 4 treatment-related AEs did not differ between the two groups(12.5%versus 12.4%).Conclusions:The interim results of this ongoing trial showed that in resec

关键词： esophageal squamous cell carcinoma minimally invasive esophagectomy neoadjuvant chemotherapy neoadjuvant immunochemotherapy survival

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Extracorporeal membrane oxygenation states basilar artery thrombectomy and left posterior cerebral artery stent thrombectomy:A case report

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World Journal of Clinical Cases 2024年第18期12卷 3589-3595页

作者： Li-Shan Ding Hao Liang Ming zheng Meng Shen Zhao-Jun Li Rui-peng Song Qing-Liang Chen Department of Radioactive Intervention Henan University of Traditional Chinese MedicineZhengzhou 450099Henan ProvinceChina Department of Radioactive Intervention Henan No.3 Provincial People’s HospitalZhengzhou 450006Henan ProvinceChina Department of Endocrinology Henan No.3 Provincial People’s HospitalZhengzhou 450000Henan ProvinceChina

BACKGROUND Extracorporeal membrane oxygenation(ECMO)is a new type of extracorporeal respiratory and circulatory assistance *** can drain venous blood out of the body and inject it into veins or arteries after being oxygenated by an oxygenator(membrane lung)to replace lung and heart functions in a short *** can provide tissue blood perfusion and gas exchange almost equivalent to cardiac output and extend the effective treatment time window for patients with acute circulatory failure to restore cardiopulmonary *** SUMMARY We report a case of an 81-year-old woman who underwent whole cerebral angiography,basilar artery thrombectomy and stent thrombectomy in the posterior artery of the left brain after implantation of *** patient was admitted to the hospital due to myocardial *** that the cause of the patient’s disturbance of consciousness was unknown and cerebrovascular accident could not be ruled out after the implantation of ECMO,the department of Radioactive Intervention performed cerebral *** the result of the angiography indicated vascular *** the basilar artery thrombectomy and stent thrombectomy in the posterior artery of the left brain,the patency of the occlusive vessel was *** Although the patient eventually died of circulatory failure,the result of this case verifies the feasibility of cerebral angiography and thrombectomy in patients with implanted ECMO in the intubated state.

关键词： Extracorporeal membrane oxygenation Blood circulation failure Nerve intervention Stent thrombectomy Case report

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Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma

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Frontiers of Medicine 2024年第2期18卷 375-393页

作者： Fu’an Xie Yujia Niu Lanlan Lian Yue Wang Aobo Zhuang Guangting Yan Yantao Ren Xiaobing Chen Mengmeng Xiao Xi Li Zhe Xi Gen Zhang Dongmei Qin Kunrong Yang Zhigang zheng Quan Zhang Xiaogang Xia peng Li Lingwei Gu Ting Wu Chenghua Luo Shu-Hai Lin Wengang Li Cancer Research Center Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen361102China Xiamen University Research Center of Retroperitoneal Tumor Committee of Oncology Society of Chinese Medical Association Xiamen UniversityXiamen361102China Department of Laboratory Medicine Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China Department of Retroperitoneal Tumor Surgery Peking University International HospitalBeijing102206China School of Public Health Harvard UniversityBostonMA02115USA Laboratory of Biochemistry and Molecular Biology Research Department of Clinical LaboratoryFujian Medical University Cancer HospitalFuzhou350014China Surgery Department Affiliated Fuzhou First Hospital of Fujian Medical UniversityFuzhou350009China National Institute for Data Science in Health and Medicine Xiamen UniversityXiamen361102China Department of Hepatobiliary Surgery Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China

Retroperitoneal liposarcoma(RLPS)is the main subtype of retroperitoneal soft sarcoma(RSTS)and has a poor prognosis and few treatment options,except for *** proteomic and metabolic profiles of RLPS have remained *** aim of our study was to reveal the metabolic profile of ***,we performed proteomic analysis(n=10),metabolomic analysis(n=51),and lipidomic analysis(n=50)of retroperitoneal dedifferentiated liposarcoma(RDDLPS)and retroperitoneal well-differentiated liposarcoma(RWDLPS)tissue and paired adjacent adipose tissue obtained during *** analysis mainly revealed that glycolysis,purine metabolism,pyrimidine metabolism and phospholipid formation were upregulated in both RDDLPS and RWDLPS tissue compared with the adjacent adipose tissue,whereas the tricarboxylic acid(TCA)cycle,lipid absorption and synthesis,fatty acid degradation and biosynthesis,as well as glycine,serine,and threonine metabolism were *** particular importance,the glycolytic inhibitor 2-deoxy-D-glucose and pentose phosphate pathway(PPP)inhibitor RRX-001 significantly promoted the antitumor effects of the MDM2 inhibitor RG7112 and CDK4 inhibitor *** study not only describes the metabolic profiles of RDDLPS and RWDLPS,but also offers potential therapeutic targets and strategies for RLPS.

关键词： RLPS proteomics metabolomics lipidomics metabolism

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Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2970-2983页

作者： Qi Yang Bao Xue Fengjiang Liu Yongzhi Lu Jielin Tang Mengrong Yan Qiong Wu Ruyi Chen Anqi Zhou Lijie Liu Junjun Liu Changbin Qu Qingxin Wu Muqing Fu Jiayi Zhong Jianwei Dong Sijie Chen Fan Wang Yuan Zhou Jie zheng Wei peng Jinsai Shang Xinwen Chen Guangzhou National Laboratory Guangzhou 510005China State Key Laboratory of Respiratory Disease Guangzhou Medical UniversityGuangzhou 511436China Wuhan Institute of Virology Chinese Academy of SciencesWuhan 430071China School of Basic Medical Sciences Guangzhou Medical UniversityGuangzhou 511436China GMUGIBH Joint School of Life Sciences Guangzhou Medical UniversityGuangzhou 511436China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China School of Pharmaceutical Science and Technology Hangzhou lnstitute for Advanced StudyUCASHangzhou 310024China

Respiratory syncytial virus(RSV)is the major cause of bronchiolitis and pneumonia in young children and the *** are currently no approved RSV-specific therapeutic small molecules *** high-throughput antiviral screening,we identified an oral drug,the prenylation inhibitor lonafarnib,which showed potent inhibition of the RSV fusion *** exhibited antiviral activity against both the RSV A and B genotypes and showed low cytotoxicity in HEp-2 and human primary bronchial epithelial cells(HBEC).Time-of-addition and pseudovirus assays demonstrated that lonafarnib inhibits RSV entry,but has farnesyltransferase-independent antiviral ***-electron microscopy revealed that lonafarnib binds to a triple-symmetric pocket within the central cavity of the RSV F metastable pre-fusion *** at the RSV F sites interacting with lonafarnib showed resistance to lonafarnib but remained fully sensitive to the neutralizing monoclonal antibody ***,lonafarnib dose-dependently reduced the replication of RSV in BALB/c ***,lonafarnib could be a potential fusion inhibitor for RSV infection.

关键词： neutral metastable approved

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An integrated electronic textile system capable of displaying full-color images and videos

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Science China Materials 2024年第9期67卷 3021-3028页

作者： Junyi Zou Guodong Feng Jiaqi Wu Yuanyuan zheng Yue Liu Yulu Ai Zhen Wang Huisheng peng Peining Chen State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceInstitute of Fiber Materials and Devicesand Laboratory of Advanced MaterialsFudan UniversityShanghai200438China

Smart electronic textiles with electronic functions like displaying can provide transformative opportunities for wearable devices that traditional rigid devices are hard to realize.A general strategy of enabling textiles to display is weaving light-emitting fibers into textiles and designing control ***,it remains challenging for the current electronic textiles to display full-color images and ***,we demonstrate a large-area integrated electronic textile system(with a size of 72 cm×50 cm)by weaving light-emitting diode(LED)fibers,touch-sensing fibers and polyester fibers,which could display full-color images(with a gamut of 117.6%NTSC)and continuous videos(with a refresh rate of 11.7 Hz)by designing low-voltage supply mode and parallelly transmitting *** integration of touch-sensing fibers,such textile system could achieve various touch display and interactive functions like smart phones or computers,including hand input of text,hand painting,computing and playing *** stability and durability of textile system withstanding 5000 bending cycles was also demonstrated for wearable *** integrated electronic textile system shows similar flexibility and breathability with regular textiles,which is promising to serve as new human-machine interface to change the way in which people interact with electronics.

关键词： electronic textile display refresh rate integration system

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热压制备Ni/Al微叠层复合板的协调变形行为和气压胀形成形性

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Transactions of Nonferrous Metals Society of China 2024年第3期34卷 786-797页

作者：鲁羽鹏殷宏亮席先铮孟令健林鹏梁伟太原理工大学材料科学与工程学院太原030024 太原理工大学先进金属复合材料成形技术与装备教育部工程研究中心太原030024

为了制造NiAl合金复杂薄壁构件,采用真空热压法制备一种新型Ni/Al微叠层复合板(NAMCS)。基于不同温度的单向拉伸试验,研究Ni/Al微叠层复合板的力学性能。为了阐明Ni/Al微叠层复合板的单向拉伸协调变形机制,通过扫描电子显微镜对不同拉... 详细信息

为了制造NiAl合金复杂薄壁构件,采用真空热压法制备一种新型Ni/Al微叠层复合板(NAMCS)。基于不同温度的单向拉伸试验,研究Ni/Al微叠层复合板的力学性能。为了阐明Ni/Al微叠层复合板的单向拉伸协调变形机制,通过扫描电子显微镜对不同拉伸应变下的变形组织进行表征。结果表明,在5%应变、室温和300℃条件下,NiAl_(3)层和Ni_(2)Al_(3)层中形成了一些裂纹。在600℃和20%应变条件下,在NiAl3层观察到一些微孔。样品在78.7%的拉伸应变断裂时,Ni_(2)Al_(3)层也未出现裂纹,表现出良好的协调变形能力。Ni/Al微叠层复合板的高温自由气压胀形试验表明,600℃时其极限胀形比(极限胀形高度与凹模直径之比)达到33.3%,表现出良好的成形性。

关键词： Ni/Al微叠层复合板力学性能协调变形机制气压胀形成形性

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大数据驱动的产品创新商务智能——基于SSP框架的分析

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财经问题研究 2024年第4期 33-44页

作者：谢康卢鹏夏正豪中山大学管理学院广东广州510000

人工智能改变产品创新主体,引发产品创新战略与流程变革。本文依据大数据合作资产理论,从企业与用户互动的适应性创新视角,通过逻辑推演分析提出大数据驱动的产品创新商务智能主体—战略—流程框架,以探讨人工智能影响制造产品创新的新... 详细信息

人工智能改变产品创新主体,引发产品创新战略与流程变革。本文依据大数据合作资产理论,从企业与用户互动的适应性创新视角,通过逻辑推演分析提出大数据驱动的产品创新商务智能主体—战略—流程框架,以探讨人工智能影响制造产品创新的新机制。研究表明:首先,人与人工智能双向卷入形成要素组合与知识积累的双向反馈式增强机制,促使创新主体发生结构性改变,形成产品创新战略与流程变革的新基础。其次,企业人工智能认知战略与竞争战略、组织文化、商业模式和生态系统的匹配,共同影响人工智能在创新流程中的一体化应用。最后,模糊前端的全流程扩散、需求—解决方案对的非线性迭代和智能制造的生成式自测构成大数据驱动的产品创新流程的新特征。研究表明,主体—战略—流程框架适合分析大数据驱动的产品创新商务智能的新机制,可为人工智能与产品创新的关系研究提供新视角。

关键词：人工智能产品创新商务智能大数据合作资产 SSP框架

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锑污染土壤修复技术研究进展与发展趋势

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稀有金属 2024年第3期48卷 411-426页

作者：郑鹏崔兴兰李红霞车小奎史新悦王雷郑其中国有研科技集团有限公司高品质有色金属绿色特种冶金国家工程研究中心北京101407 有研资源环境技术研究院(北京)有限公司北京101407 北京有色金属研究总院北京100088 战略性有色金属绿色制造技术北京市工程研究中心北京101407 有研工程技术研究院有限公司北京101407

锑是一种具有潜在毒性和致癌性的元素,采矿和金属冶炼等人类活动导致锑被大量的释放,造成严重的环境污染,威胁人类健康,引起各国学者的广泛关注。对国内外锑污染的现状和锑在大气、水和土壤环境中分布特征进行了介绍;归纳了锑在迁移转... 详细信息

锑是一种具有潜在毒性和致癌性的元素,采矿和金属冶炼等人类活动导致锑被大量的释放,造成严重的环境污染,威胁人类健康,引起各国学者的广泛关注。对国内外锑污染的现状和锑在大气、水和土壤环境中分布特征进行了介绍;归纳了锑在迁移转化过程中形态、氧化还原过程、吸附和沉淀规律;并总结了翻土和客土法、土壤淋洗技术、固定/稳定化技术、植物修复技术和微生物修复技术目前的研究进展;在此基础上对各种土壤修复技术的优缺点和应用场景进行比较分析,并对锑污染土壤修复技术未来发展趋势进行展望。相比而言,土壤淋洗技术和固定/稳定化技术已经有较成熟的应用,而植物修复技术和微生物修复技术具有绿色、低成本的特点,能够广泛地同其他修复技术联合使用,已逐渐成为目前的研究重点。

关键词：锑迁移转化土壤污染修复技术

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