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南京铁路枢纽总图规划深化研究

中国铁路 2024年第6期 141-146页

作者：黄鹏郑洪中铁第四勘察设计院集团有限公司湖北武汉430063

以《交通强国建设纲要》等上位规划为引领,从国际运输、国内中长途运输、南京都市圈、枢纽客货运输体系建设的角度,提出目前南京铁路枢纽存在的问题。通过分析枢纽近远期客流情况,介绍路网构成,从国际运输、国内运输、过江通道、客运站... 详细信息

以《交通强国建设纲要》等上位规划为引领,从国际运输、国内中长途运输、南京都市圈、枢纽客货运输体系建设的角度,提出目前南京铁路枢纽存在的问题。通过分析枢纽近远期客流情况,介绍路网构成,从国际运输、国内运输、过江通道、客运站分工调整等方面提出南京铁路枢纽总图规划优化方案,以期打造国内领先、国际一流的铁路枢纽。通过定量分析可知,枢纽优化后,相关车站、区间线路、过江通道的能力满足远期运输需求,并且对国际国内运输体系建设、都市圈城市发展都具有显著促进作用。

关键词：南京铁路枢纽总图规划国际运输过江通道空铁联运海铁联运

Mechanical response and dilatancy characteristics of deep marble under different stress paths:A sight from energy dissipation

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Journal of Central South University 2024年第6期31卷 2070-2086页

作者： LIU Xiao-hui HAO Qi-jun zheng Yu ZHANG Zhao-peng XUE Yang Key Laboratory of Fluid and Power Machinery Ministry of EducationXihua UniversityChengdu 610039China School of Energy and Power Engineering Xihua UniversityChengdu 610039China College of Water Resource and Hydropower Sichuan UniversityChengdu 610065China State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering Sichuan UniversityChengdu 610065China Southwest Municipal Engineering Design&Research Institute of China Chengdu 610036China MOE Key Laboratory of Deep Earth Science and Engineering Sichuan UniversityChengdu 610065China

Dilatancy is a fundamental volumetric growth behavior observed during loading and serves as a key index to comprehending the intricate nonlinear behavior and constitutive equation structure of *** study focuses on Jinping marble obtained from the Jinping Underground Laboratory in China at a depth of 2400 *** uniaxial and triaxial tests at different strain rates,along with constant confining pressure tests and reduced confining pressure tests under different confining pressures were conducted to analyze the mechanical response and dilatancy characteristics of the marble under four stress ***,a new empirical dilatancy coefficient is proposed based on the energy dissipation *** results show that brittle failure characteristics of marble under uniaxial compression are more obvious with the strain rate increasing,and plastic failure characteristics of marble under triaxial compression are gradually ***,compared to the constant confining pressure,the volume expansion is relatively lower under unloading *** energy dissipation is closely linked to the process of dilatancy,with a rapid increase of dissipated energy coinciding with the beginning of dilatancy.A new empirical dilatancy coefficient is defined according to the change trend of energy dissipation rate curve,of which change trend is consistent with the actual dilatancy response in marble under different stress *** existing empirical and theoretical dilatancy models are analyzed,which shows that the empirical dilatancy coefficient based on the energy background is more universal.

关键词： deep marble stress paths dilatancy energy dissipation empirical dilatancy coefficient

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密闭管道内非连续分布甲烷/空气爆炸特性

消防科学与技术 2024年第8期43卷 1059-1065页

作者：郑凯周朋常州大学安全科学与工程学院江苏常州213164

在长度900 mm、截面为100 mm×100 mm的矩形密闭管道内开展预混气体非连续分布对甲烷/空气爆炸影响的试验研究。通过分段通入甲烷体积分数为9.5%的预混气体,形成甲烷/空气-空气和甲烷/空气-空气-甲烷/空气两种非连续分布模式。研究发现... 详细信息

在长度900 mm、截面为100 mm×100 mm的矩形密闭管道内开展预混气体非连续分布对甲烷/空气爆炸影响的试验研究。通过分段通入甲烷体积分数为9.5%的预混气体,形成甲烷/空气-空气和甲烷/空气-空气-甲烷/空气两种非连续分布模式。研究发现,随着空气区域缩短,火焰传播距离、火焰尖端速度和爆炸超压均增大。特别是在甲烷/空气-空气-甲烷/空气分布中,当中间空气区域小于500 mm时,火焰会穿越并引发二次爆炸,且其超压随空气区域减小而增加。研究结果可为天然气爆炸事故防控提供理论支持。

关键词：非连续分布甲烷/空气火焰行为火焰尖端速度爆炸超压

LiDar点云指导下特征分布趋同与语义关联的3D目标检测

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电子学报 2024年第5期52卷 1700-1715页

作者：郑锦蒋博韬彭微王森北京航空航天大学计算机学院北京100191 虚拟现实技术与系统全国重点实验室北京100191

针对现有基于伪点云的3D目标检测算法精度远低于基于真实激光雷达(Light Detection and ranging,LiDar)点云的3D目标检测,本文研究伪点云重构,并提出适合伪点云的3D目标检测网络.考虑到由图像深度转换得到的伪点云稠密且随深度增大逐渐... 详细信息

针对现有基于伪点云的3D目标检测算法精度远低于基于真实激光雷达(Light Detection and ranging,LiDar)点云的3D目标检测,本文研究伪点云重构,并提出适合伪点云的3D目标检测网络.考虑到由图像深度转换得到的伪点云稠密且随深度增大逐渐稀疏,本文提出深度相关伪点云稀疏化方法,在减少后续计算量的同时保留中远距离更多的有效伪点云,实现伪点云重构.本文提出LiDar点云指导下特征分布趋同与语义关联的3D目标检测网络,在网络训练时引入LiDar点云分支来指导伪点云目标特征的生成,使生成的伪点云特征分布趋同于LiDar点云特征分布,从而降低数据源不一致造成的检测性能损失;针对RPN(Region Proposal Network)网络获取的3D候选框内的伪点云间语义关联不足的问题,设计注意力感知模块,在伪点云特征表示中通过注意力机制嵌入点间的语义关联关系,提升3D目标检测精度.在KITTI 3D目标检测数据集上的实验结果表明:现有的3D目标检测网络采用重构后的伪点云,检测精度提升了2.61%;提出的特征分布趋同与语义关联的3D目标检测网络,将基于伪点云的3D目标检测精度再提升0.57%,相比其他优秀的3D目标检测方法在检测精度上也有提升.

关键词： 3D目标检测伪点云语义关联分布趋同注意力感知

scRNA-seq reveals that origin recognition complex subunit 6 regulates mouse spermatogonial cell proliferation and apoptosis via activation of Wnt/β-catenin signaling

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Asian Journal of Andrology 2024年第1期26卷 46-56页

作者： Shi-Wei Liu Jia-Qiang Luo Liang-Yu Zhao Ning-Jing Ou Chao-Yang Yu-Xiang Zhang Hao-Wei Bai Hong-Fang Sun Jian-Xiong Zhang Chen-Cheng Yao peng Li Ru-Hui Tian zheng Li Zi-Jue Zhu Department of Andrology Center for Men's HealthUrologic Medical CenterShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China State Key Lab of Reproductive Medicine Nanjing Medical UniversityNanjing 211166China Shanghai Key Lab of Reproductive Medicine Shanghai Jiao Tong University School of MedicineShanghai 200080China Department of Urology Guangdong Provincial Key Laboratory of Biomedical ImagingThe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Urology First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

The regulation of spermatogonial proliferation and apoptosis is of great significance for maintaining *** single-cell RNA sequencing(scRNA-seq)analysis of the testis was performed to identify genes upregulated in *** scRNAseq analysis,we identified the spermatogonia upregulated gene origin recognition complex subunit 6(Orc6),which is involved in DNA replication and cell cycle regulation;its protein expression in the human and mouse testis was detected by western blot and *** explore the potential function of Orc6 in spermatogonia,the C18-4 cell line was transfected with control or Orc6 ***,5-ethynyl-2-deoxyuridine(EdU)and terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assays,flow cytometry,and western blot were used to evaluate its effects on proliferation and *** was revealed that ORC6 could promote proliferation and inhibit apoptosis of C18-4 *** RNA sequencing and bioinformatics analysis indicated that Orc6 was involved in the activation of wingless/integrated(Wnt)/β-catenin *** blot revealed that the expression ofβ-catenin protein and its phosphorylation(Ser675)were significantly decreased when silencing the expression of *** findings indicated that Orc6 was upregulated in spermatogonia,whereby it regulated proliferation and apoptosis by activating Wnt/β-catenin signaling.

关键词： cell proliferation ORCG scRNA-seq analysis spermatogonia Wnt/β-catenin signaling

胃肠道解痉药匹维溴铵对表皮葡萄球菌的体外和体内抗菌活性研究

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中国感染控制杂志 2024年第9期23卷 1077-1083页

作者：彭程彭聪侯正利湖南师范大学附属长沙医院检验科湖南长沙410006 长沙市第四医院检验科湖南长沙410006

目的研究匹维溴铵(PVB)对表皮葡萄球菌(表葡)的体外和体内抗菌活性。方法收集长沙市某医院2022年1-12月住院患者血液分离的表葡。采用微量肉汤稀释试验和纸片扩散法检测表葡对PVB的敏感性,通过时间-杀菌曲线检测PVB抗菌效果的时间和浓... 详细信息

目的研究匹维溴铵(PVB)对表皮葡萄球菌(表葡)的体外和体内抗菌活性。方法收集长沙市某医院2022年1-12月住院患者血液分离的表葡。采用微量肉汤稀释试验和纸片扩散法检测表葡对PVB的敏感性,通过时间-杀菌曲线检测PVB抗菌效果的时间和浓度依赖性,透射电镜观察PVB处理后细菌的超微结构改变,结晶紫染色试验检测PVB对表葡生物膜的抑制和清除效果,采用棋盘稀释法研究PVB与抗菌药物的联合抗菌效果。构建皮肤脓肿感染模型,检测PVB的体内抗菌活性。结果药敏试验结果显示,PVB对表葡标准菌株RP62A、ATCC 12228的最低抑菌浓度(MIC)、最低杀菌浓度(MBC)均分别为8、16μg/mL;对表葡临床菌株的MIC、MBC分别为4~8μg/mL、8~16μg/mL。纸片扩散法结果显示,与未加药的对照组(0.60±0)cm相比,0.2 mg PVB出现明显抑菌圈[(2.26±0.09)cm;t=45.34,P<0.001],且抑菌圈直径随着PVB药量增加而增大。时间-杀菌曲线结果提示,PVB具有杀菌活性,且随着药物浓度和作用时间的增加而增强。透射电镜观察发现PVB可明显破坏表葡的正常结构,导致细菌水肿和裂解。此外,1×MIC的PVB还可显著抑制表葡生物膜的形成,使其生物膜的形成量(A 570 nm)从(2.30±0.18)减少到(0.47±0.11;t=14.85,P<0.001)。同时,1×MIC的PVB还可有效破坏已形成的生物膜,使生物膜的量从(2.64±0.10)减少到(1.77±0.30;t=4.76,P=0.009)。PVB与阿米卡星和庆大霉素联用具有协同抗菌活性,其协同抑菌指数分别为0.50、0.31。动物模型发现10 mg/kg体重的PVB可使脓肿面积从(68.83±10.68)mm 2减少到(35.50±10.58)mm 2(t=6.52,P<0.001),且使脓肿中的活菌量从(6.11±0.55)lg(CFU/脓肿)减少到(3.60±0.34)lg(CFU/脓肿)(t=3.08,P=0.014)。苏木精-伊红染色发现PVB用药组皮肤脓肿中的炎性细胞浸润相比对照组明显减少,趋于正常。结论PVB对表葡具有明显的体外和体内抗菌活性,有望成为表葡相关感染的替代治疗途径。

关键词：匹维溴铵药物重利用表皮葡萄球菌生物膜脓肿感染模型抗菌活性

Ancient DNA unravels species identification from Laosicheng site,Hunan Province,China,and provides insights into maternal genetic history of East Asian leopards

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Zoological Research 2024年第1期45卷 226-229页

作者： Ming Zhang Cai-Hui Wang Yu-Xin zheng Qi-Gao Jiangzuo Ye-Mao Hou peng Cao Qing-Yan Dai Ruo-Wei Yang Feng Liu Xiao-Tian Feng Lin-Heng Mo Qiao-Mei Fu China-Central Asia"the Belt and Road"Joint Laboratory on Human and Environment Research Key Laboratory of Cultural Heritage Research and ConservationSchool of Culture HeritageNorthwest UniversityXi’anShaanxi 710127China Shanghai Qi Zhi Institute Shanghai 200232China College of Life Sciences Northwest UniversityXi’anShaanxi 710127China Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyCenter for Excellence in Life and PaleoenvironmentChinese Academy of SciencesBeijing 100044China Cultural Relics and Archaeology Institute of Hunan ChangshaHunan 410083China University of the Chinese Academy of Sciences Beijing 100049China

DEAR EDITOR,The Laosicheng site in Yongshun County,Hunan Province,China,plays an important role in elucidating the animal population composition of the region prior to the middle Qing Dynasty(approximately 300 years ago).This site has yielded a substantial number of animal bones,11960 of which have been identified to the species level,serving as direct evidence of ancient animal populations(Hunan Provincial Institute of Cultural Relics and Archaeology,2018).

关键词： Hunan Ancient insight

Relationship Between Climate Change and Marmot Plague of Marmota himalayana Plague Focus—the Altun Mountains of the Qinghai-Xizang Plateau,China,2000–2022

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China CDC weekly 2024年第4期6卷 69-74,I0006页

作者： Qun Duan Xiaojin zheng Zhiqiang Gan Dongyue Lyu Hanyu Sha Xinmin Lu Xiaoling Zhao Asaiti Bukai Ran Duan Shuai Qin Li Wang Jinxiao Xi Di Wu peng Zhang Deming Tang Zhaokai He Huaiqi Jing Biao Kan Xin Wang National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Akesai Kazak Autonomous County Center for Disease Control and Prevention Jiuquan CityGansu ProvinceChina Jiuquan Center for Disease Control and Prevention Jiuquan CityGansu ProvinceChina Gansu Provincial Center for Disease Control and Prevention Lanzhou CityGansu ProvinceChina

Introduction:Plague is a zoonotic disease that occurs naturally in specific geographic *** change can influence the populations of the plague host or vector,leading to variations in the occurrence and epidemiology of plague in ***:In this study,we collected meteorological and plague epidemiological data from the Marmota himalayana plague focus in the Altun Mountains of the Qinghai-Xizang *** data spanned from 2000 to *** describe the climatic factors and plague epidemic conditions and we describe their analysis by Pearson’s ***:During the period from 2000 to 2022,the isolation rates of Yersinia pestis(***)from marmots and fleas were 9.27%(451/4,864)and 7.17%(118/1,646),***,we observed a positive rate of F1 antibody of 11.25%(443/3,937)in marmots and 18.16%(142/782)in *** regards to climate,there was little variation,and a decreasing trend in blowing-sand days was *** temperature in the previous year showed a negative correlation with the *** isolation rate in marmots(r=−0.555,P=0.011)and the positive rate of F1 antibody in marmots(r=−0.552,P=0.012)in the current *** average annual precipitation in the previous two years showed a positive correlation with marmot density(r=0.514,P=0.024),while blowingsand days showed a negative correlation with marmot density(r=−0.701,P=0.001).Furthermore,the average annual precipitation in the previous three years showed a positive correlation with the isolation rate of *** from marmots(r=0.666,P=0.003),and blowing-sand days showed a negative correlation with marmot density(r=−0.597,P=0.009).Conclusions:The findings of this study indicate that there is a hysteresis effect of climate change on the prevalence of ***,monitoring climate conditions can offer significant insights for implementing timely preventive and control measures to combat plague epidemics.

关键词： Plague epidemiology Plateau

基于多方向自适应感知网络的高光谱遥感图像分类

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遥感学报 2024年第1期28卷 168-186页

作者：刘倩吴泽彬徐洋郑鹏郑尚东韦志辉南京理工大学计算机科学与工程学院南京210014

高光谱遥感能够同步获取目标场景的光谱数据和空间图像,满足对目标物体成分组成和形貌特征的探测需求,已被广泛应用于精准农业、地质勘察、环境监测和生物医学等领域。近几年,得益于优秀的空谱信息表征能力,基于卷积神经网络的高光谱图... 详细信息

高光谱遥感能够同步获取目标场景的光谱数据和空间图像,满足对目标物体成分组成和形貌特征的探测需求,已被广泛应用于精准农业、地质勘察、环境监测和生物医学等领域。近几年,得益于优秀的空谱信息表征能力,基于卷积神经网络的高光谱图像分类方法取得了优于传统方法的分类精度。然而,基于一定规则和固定方形窗口的卷积运算无法满足不同对象、不同分布的空谱特征提取需求,当像素位于类别边缘时该模式无法避免其他类别的无关信息,导致类别间的信息扩散以及跨类别像素的误分和错分。针对上述问题,本文提出了一种基于多方向自适应感知的高光谱图像空谱联合分类方法,并通过联合不同邻域范围的空谱上下文信息来改善模型的局部空谱建模能力。具体研究过程如下:首先,将常规卷积网络的全窗口滤波器拆分为不同方向的半窗滤波器,从而设计出侧窗卷积以捕捉具有方向性的空谱特征;然后,在此基础上进一步将不同方向的侧窗滤波核整合到统一的卷积架构中构造空谱分离多方向卷积,并设计方向自适应感知模块,以密集连接构建基于高光谱图像的多方向自适应感知分类网络,赋予模型自适应学习多种空谱结构特征的能力,弥补常规卷积和侧窗卷积只能建模单一方向空谱关系的不足,提升模型对复杂空谱结构的刻画能力。在3个公开数据集上的实验结果表明,本文提出的多方向自适应感知分类方法较常规卷积方法具有更优的分类性能,能增强边缘样本的表征准确性,改善分类中的边缘混淆现象。

关键词：遥感高光谱图像深度学习多方向自适应感知空谱结构建模空谱联合分类