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An Evaluation on the Effects of the Policy of the Great Campaign of Western Development of China in the First 10 Years Based on the Kuznets Regional Inverted-U Theory

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Chinese Business Review 2013年第10期12卷 661-672页

作者： huan zheng Xingming fang Southwestern University of Finance and Economics Chengdou China

In order to reduce the regional differentials or narrow the gap in economic development between eastern and western areas and prevent the intensification of contradictions resulting from the regional inequality during the development process, the government of China launched the Great Campaign of Western Development （GCWD） in 2000. In this paper, we will evaluate the effects of the first 10 years＇ GCWD and use the latest Chinese annual data from 1978 to 2010 to investigate the problem of regional differentials in the development process, evaluate the effects of GCWD policy and test whether there is a regional Kuznets inverted-U curve in the regional development of China. The result shows that there are both good and bad news： the good news is that the inverted U-shaped curve of absolute differential between eastern and western areas finally emerges （the previous studies showed that the inverted-U curve did not appear and the differentials between eastern and western areas became worse） and the bad news is that the differential is in the first half of the inverted U-shaped curve in our choice of time span （1978-2010）, that is, it is still in the situation of deterioration, and the turning better point will emerge in 2025. Although the western areas have benefitted from GCWD, the absolute gap has been still widened. To narrow the gap, the western areas should accelerate the industrial development and the government should adjust the policy and make more efforts to support the development of the industry in the western areas, especially cultivate and support the development of the western characteristic and advantageous industry rather than just supporting the construction of infrastructure in the western areas.

关键词： Great Campaign of Western Development (GCWD) the gap between eastern and western areas regional inequality or differential inverted-U curve

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GCH1 variants contribute to the risk and earlier age-at-onset of Parkinson's disease:a two-cohort case-control study

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Translational Neurodegeneration 2020年第3期9卷 409-420页

作者： Hong-xu Pan Yu-wen Zhao Jun-pu Mei zheng-huan fang Yige Wang Xun Zhou Yang-jie Zhou Rui Zhang Kai-lin Zhang Li Jiang Qian Zeng Yan He zheng Wang Zhen-hua Liu Qian Xu Qi-ying Sun Yang Yang Ya-cen Hu Ya-se Chen Juan Du Li-fang Lei Hai-nan Zhang Chun-yu Wang Xin-xiang Yan Lu Shen Hong Jiang Jie-qiong Tan Jin-chen Li Bei-sha Tang Ji-feng Guo Department of Neurology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Centre for Medical Genetics and Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangsha 410008China Department of Geriatrics Xiangya HospitalCentral South UniversityChangsha 410008China Department of Neurology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Department of Neurology The Second Xiangya HospitalCentral South UniversityChangsha 410011China Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South UniversityChangsha 410008China

Background:Common and rare variants of guanosine triphosphate cyclohydrolase 1(GCH1)gene may play important roles in Parkinson's disease(PD).However,there is a lack of comprehensive analysis of GCH1 genotypes,especially in non-coding *** aim of this study was to explore the genetic characteristics of GCH1,including rare and common variants in coding and non-coding regions,in a large population of PD patients in Chinese mainland,as well as the phenotypic characteristics of GCH1 variant ***:In the first cohort of this case-control study,we performed whole-exome sequencing in 1555 patients with early-onset or familial PD and 2234 healthy controls;then in the second cohort,whole-genome sequencing was performed in sporadic late-onset PD samples(1962 patients),as well as 1279 *** at target GCH1 regions were extracted,and then genetic and detailed phenotypic data were analyzed using regression models and the sequence kernel association *** also performed a meta-analysis to correlate deleterious GCH1 variants with age at onset(AAO)in PD ***:For coding variants,we identified a significant burden of GCH1 deleterious variants in early-onset or familial PD cases compared to controls(1.2%VS 0.1%,P<0.0001).In the analysis of possible regulatory variants in GCH1 non-coding regions,rs12323905(P=0.001,odds ratio=1.19,95%CI 1.07-1.32)was significantly associated with PD,and variant sets in untranslated regions and intron regions,GCH1 brain-specific expression quantitative trait loci,and two possible promoter/enhancer(GH14J054857 and GH14J054880)were suggestively associated with *** phenotype correlation analysis revealed that the carriers of GCH1 deleterious variants manifested younger AAO(P<0.0001),and had milder motor symptoms,milder fatigue symptoms and more autonomic nervous ***-analysis of six studies demonstrated 6.4-year earlier onset in GCH1 deleterious variant carriers(P=0.0009).Conclusions:The results

关键词： Parkinson's disease Age at onset GCH1 Deleterious variants Non-coding variants

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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期 369-376页

作者： Song-Meng Wang Hao Nian Yan-fang Wang Li-Shuo zheng Yu-Tao zheng Yi-Wei Dong Liping huang Xiaoping Wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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The low-latitude sodium layer:comparative data from lidar observations at Hainan,China and São Paulo,Brazil

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Earth and Planetary Physics 2025年第1期9卷 39-53页

作者： fang Wu Jing Jiao GuoTao Yang Lifang Du zhengKuan Liu HaoRan zheng JiXin Guo ShaoHua Gong YaJun Zhu State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Hainan National Field Science Observation and Research Observatory for Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China China-Brazil Joint Laboratory for Space Weather NSSC/INPESão Josédos Campos 12227-010Brazil School of Physics and Electronics Engineering Hainan Normal UniversityHaikou 571158China

Physical and chemical processes observed in the mesosphere and thermosphere above the Earth’s low latitudes are complex and highly interrelated to activity in the low-latitude *** sodium detected by lidar can yield clues to dynamic and chemical processes in these spatial layers above the Earth’s *** paper is based on sodium layer data collected at two low-latitude stations,one in the northern hemisphere and one in the *** low-latitude sodium layer exhibits conspicuous seasonal variations in shape,density,and altitude;these variations are similar between Earth’s hemispheres:sodium layer density at both stations reaches its seasonal maximum in autumn and minimum in ***,maximal Na density over Brazil is greater than that over *** variations of Na density above the two low-latitude stations are also similar;at both,maxima are observed before *** variations of the Na layer over Brazil that differ from those observed in the northern hemisphere may be related to the South Atlantic Magnetic Anomaly(SAMA)or fountain *** suggest that low-latitude Na layer data may provide useful additional evidence that could significantly improve the low-latitude part of the WACCM-Na model.

关键词： metallic sodium layer seasonal variation nocturnal variation lidar

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Engineering high-performance chemiluminescent probes via enzymatic pocket targeting: high-throughput screening for ultralong afterglow imaging of orthotopic hepatocellular carcinoma

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Science China Chemistry 2025年

作者： Shuai huang Shuaige Bai Ting Luo Bin Feng Min Liu Fan zheng Shuang huang Yanpeng fang Dan Ding Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South University College of Life Sciences Nankai University

Hepatocellular carcinoma （HCC） is a highly aggressive liver malignancy and the main form of liver cancer. Early diagnosis and treatment of HCC can effectively reduce mortality. Carboxylesterase （CE）-specific detection and imaging can be used for early diagnosis and image-guided surgical of HCC. However, traditional optical probes suffer from poor selectivity and low imaging signal-to-noise ratio. Here, we have constructed a series of chemiluminescent probes for carboxylesterase detection based on the strategy of enzymatic pocket-oriented steric tailoring techniques. The probes with different unique and excellent properties have been obtained through the structure-based steric hindrance adjustment on the recognition site. Here, CE-2 has been successfully used for high-throughput screening of rapid carboxylesterase inhibitors due to its extremely low detection limit (2.5×10-4U mL-1) and fast recognition ability. CE-3 has been successfully used for image-guided surgery of orthotopic hepatocellular carcinoma due to its ultra-long chemiluminescence imaging （over 12 h） of hepatocellular carcinoma. This study may promote advances in the rapid detection and screening of inhibitory drugs for CE and the field of surgical navigation in HCC.

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基于粒子群算法的纯电动商用车转矩分配策略

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江苏大学学报（自然科学版） 2025年第1期46卷 1-8,27页

作者：田韶鹏方正武汉理工大学汽车工程学院湖北武汉430070

针对纯电动商用车采用双电动机驱动时存在的转矩分配问题,提出基于粒子群算法的模糊控制策略.首先在Simulink/Stateflow软件中搭建整车动力系统物理模型,以粒子群算法为基础,进行整车转矩分配.由于计算量大,无法运用于实车,故根据粒子... 详细信息

针对纯电动商用车采用双电动机驱动时存在的转矩分配问题,提出基于粒子群算法的模糊控制策略.首先在Simulink/Stateflow软件中搭建整车动力系统物理模型,以粒子群算法为基础,进行整车转矩分配.由于计算量大,无法运用于实车,故根据粒子群算法的结果,结合传统项目经验,设计一个参数实时调节模糊控制器来进行转矩分配.该方法运行速度快,且基本达到粒子群全局优化的效果.验证与分析结果表明:与原车单电动机动力系统相比,采用该方法的双电动机动力系统能量消耗减少了12.08%;在双电动机动力系统下,该方法与平均分配控制策略相比,电动机总能量损失降低了13.09%.

关键词：纯电动商用车双电动机驱动转矩分配粒子群算法模糊控制策略

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分子标记在大豆种质和分离群体中对SMV抗性基因的选择效果研究

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大豆科学 2018年第1期37卷 14-21页

作者：刘士超任锐王丽群王涛落金艳郑欢芳智海剑李凯南京农业大学大豆研究所/农业部大豆生物学与遗传育种重点实验室/国家大豆改良中心/作物遗传与种质创新国家重点实验室江苏南京210095

大豆花叶病毒(Soybean mosaic virus,SMV)病是我国大豆生产上最主要的病毒病害之一。本研究用与SMV株系SC15和SC18抗病基因Rsc15和Rsc18紧密连锁的5个分子标记(Satt246、Satt286和Satt634、BARCSOYSSR-02-0667和Satt266)对来自国内外的50份大豆种质以及杂交组合"科丰1号×RN-9"后代进行了针对SC15和SC18株系的抗病性评价和选择。经接种验证后结果表明:Sat-246和Satt286对抗病基因Rsc15的选择平均符合率分别为63.89%和66.67%;Satt634、BARCSOYSSR-02-0667和Satt266对Rsc18选择的平均符合率分别为67.92%、68.09%和63.10%;共选出抗SC15的材料34份,抗SC18的材料27份,对SC15和SC18均抗病的材料25份。通过对杂交组合"科丰1号×RN-9"衍生的F_2、F_3和F_4代分离群体进行标记选择和接种SMV的表型验证,发现标记Sat-246和Satt286在3个分离世代对SC15抗性基因筛选的符合率分别为72.13%、68.83%和84.25%。用与Rsc15和Rsc18连锁的5个分子标记,对F_2、F_3和F_4代分离群体进行抗性基因的选择,在F4就筛选到18个对SC15和SC18均为抗病且标记带型完全纯合的抗病家系。本研究结果表明这些分子标记可有效用于种质资源和杂交后代群体对SMV抗性的选择。

关键词：分子标记大豆大豆花叶病毒抗病基因选择符合率

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On Maximum Elastic Scheduling in Cloud-Based Data Center Networks for Virtual Machines with the Hose Model

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Journal of Computer Science & Technology 2019年第1期34卷 185-206页

作者： Shuai-Bing Lu Jie Wu huan-Yang zheng Zhi-Yi fang College of Computer Science and Technology Jilin UniversityChangchun 13012China Department of Computer and Information Sciences Temple UniversityPhiladelphiaPA19122U.S.A.

With the growing popularity of cloud-based data center networks (DCNs),task resource allocation has become more and more important to the efficient use of resource in *** paper considers provisioning the maximum admissible load (MAL)of virtual machines (VMs)in physical machines (PMs)with underlying tree-structured DCNs using the hose model for *** limitation of static load distribution is that it assigns tasks to nodes in a once-and-for-all manner,and thus requires a priori knowledge of program *** avoid load redistribution during runtime when the load grows,we introduce maximum elasticity scheduling,which has the maximum growth potential subject to the node and link *** paper aims to find the schedule with the maximum elasticity across nodes and *** first propose a distributed linear solution based on message passing,and we discuss several properties and extensions of the *** on the assumptions and conclusions,we extend it to the multiple paths case with a fat tree DCN,and discuss the optimal solution for computing the MAL with both computation and communication *** that,we present the provision scheme with the maximum elasticity for the VMs,which comes with provable optimality guarantee for a fixed flow scheduling strategy in a fat tree *** conduct the evaluations on our testbed and present various simulation results by comparing the proposed maximum elastic scheduling schemes with other *** simulations validate the effectiveness of the proposed policies,and the results are shown from different perspectives to provide solutions based on our research.

关键词： data center network (DCN) cloud distributed algorithm elasticity hose model optimization

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Highly Efficient Base Editing in Viral Genome Based on Bacterial Artificial Chromosome Using a Cas9-Cytidine Deaminase Fused Protein

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Virologica Sinica 2020年第2期35卷 191-199页

作者： Ke zheng fang-fang Jiang Le Su Xin Wang Yu-Xin Chen huan-Chun Chen zheng-Fei Liu State Key Laboratory of Agricultural Microbiology and Key Laboratory of Preventive Veterinary Medicine in Hubei Province.College of Veterinary Medicine.Huazhong Agricultural University Wuhan 430070China Gene Editing Research Center Hebei University of Science and Technology.Shijiazhuang 050018China

Viruses evolve rapidly and continuously threaten animal health and economy,posing a great demand for rapid and efficient genome editing technologies to study virulence mechanism and develop effective *** present a highly efficient viral genome manipulation method using CRISPR-guided cytidine *** cloned pseudorabies virus genome into bacterial artificial chromosome,and used CRISPR-guided cytidine deaminase to directly convert cytidine(C)to uridine(U)to induce premature stop mutagenesis in viral *** editing efficiencies were 100%.Comprehensive bioinformatic analysis revealed that a large number of editable sites exist in pseudorabies virus(PRV)***,in our study viral genome exists as a plasmid in ***,suggesting that this method is virus *** application of base-editing provided an alternative approach to generate mutant virus and might accelerate study on virulence and vaccine development.

关键词： Pseudorabies virus(PRV) Bacterial artificial chromosome(BAC) Base-editing CRISPR7Cas9 Genome editing

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Pairing effects on the fragment mass distribution of Th,U,Pu,and Cm isotopes

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Nuclear Science and Techniques 2023年第11期34卷 128-139页

作者： Xin Guan Jin‑huan zheng Mei‑Yan zheng Department of Physics Liaoning Normal UniversityDalian 116029China

In this article,a comprehensive study of the fission process of Th,U,Pu,and Cm isotopes using a Yukawa-folded meanfield plus standard pairing model is *** study focused on analyzing the effects of the pairing interaction on the fragment mass distribution and its dependence on nuclear *** significant role of pairing interactions in the fragment mass distributions of^(230)Th,^(234)U,^(240)Pu,and^(246)Cm was *** analysis revealed that increasing the pairing interaction strength decreased the asymmetric fragment mass distribution and increased the symmetric ***,the odd-even mass differences at symmetric and asymmetric fission points were examined,highlighting their sensitivity to changes in the pairing interaction *** analysis of the Th,U,Pu,and Cm isotope fragment mass distributions demonstrated the effectiveness of the model in reproducing the experimental *** addition,the effects of the zero-point energy and half-width parameter on the fragment mass distribution for^(240)Pu were ***,this study provides valuable insights into the fission process by emphasizing the importance of pairing interactions and their relationship with nuclear elongation.

关键词： Nuclear fission Pairing interaction Fragment mass distribution Actinide nuclei

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