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Emerging delivery systems based on aqueous two-phase systems:A review

Acta Pharmaceutica Sinica B 2024年第1期14卷 110-132页

作者： Yaowen Zhang Yankun luo Jingqi Zhao Wenzhuo zheng Jun Zhan Huaping zheng Feng luo State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China School of StomatologySichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610041China Department of Dermatology Rare Diseases CenterInstitutes for Systems GeneticsFrontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

The aqueous two-phase system(ATPS)is an all-aqueous system fabricated from two immiscible aqueous *** is spontaneously assembled through physical liquid-liquid phase separation(LLPS)and can create suitable templates like the multicompartment of the intracellular *** structures containing multiple compartments make it possible to endow materials with advanced *** to the properties of ATPSs,ATPS-based drug delivery systems exhibit excellent biocompatibility,extraordinary loading efficiency,and intelligently controlled content release,which are particularly advantageous for delivering drugs in ***,we will systematically review and evaluate ATPSs as an ideal drug delivery *** on the basic mechanisms and influencing factors in forming ATPSs,the transformation of ATPSs into valuable biomaterials is ***,we concentrate on the most recent cutting-edge research on ATPS-based delivery ***,the potential for further collaborations between ATPS-based drug-carrying biomaterials and disease diagnosis and treatment is also explored.

关键词： Aqueous two-phase systems Drug delivery systems Biomaterials Microcapsules Microparticles Cell therapy Cancer treatment Organ regeneration

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Spatiotemporal Prediction of Urban Traffics Based on Deep GNN

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Computers, Materials & Continua 2024年第1期78卷 265-282页

作者： Ming luo Huili Dou Ning zheng School of Computer Science Hangzhou Dianzi UniversityHangzhou310018China Zhejiang Institute of Communications Hangzhou310012China School of Cyberspace Security Hangzhou Dianzi UniversityHangzhou310018China

Traffic prediction already plays a significant role in applications like traffic planning and urban management,but it is still difficult to capture the highly non-linear and complicated spatiotemporal correlations of traffic *** well as to fulfil both long-termand short-termprediction objectives,a better representation of the temporal dependency and global spatial correlation of traffic data is *** order to do this,the Spatiotemporal Graph Neural Network(S-GNN)is proposed in this research as amethod for traffic *** S-GNN simultaneously accepts various traffic data as inputs and investigates the non-linear correlations between the *** terms of modelling,the road network is initially represented as a spatiotemporal directed graph,with the features of the samples at the time step being captured by a convolution *** order to assign varying attention weights to various adjacent area nodes of the target node,the adjacent areas information of nodes in the road network is then aggregated using a graph *** data is output using a fully connected layer at the *** findings show that S-GNN can improve short-and long-term traffic prediction accuracy to a greater extent;in comparison to the control model,the RMSE of S-GNN is reduced by about 0.571 to 9.288 and the MAE(Mean Absolute Error)by about 0.314 to *** experimental results on two real datasets,Pe MSD7(M)and PEMS-BAY,also support this claim.

关键词： Urban traffic traffic temporal correlation GNN prediction

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Genes controlling grain chalkiness in rice

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The Crop Journal 2024年第4期12卷 979-991页

作者： luo Chen Xiumei Li Minhua zheng Rui Hu Jingfang dong Lingyan Zhou Wuge Liu Dilin Liu Wu Yang Rice Research Institute Guangdong Academy of Agricultural SciencesGuangdong Key Laboratory of New Technology in Rice BreedingGuangdong Rice Engineering LaboratoryKey Laboratory of Genetics and Breeding of High Quality Rice in Southern China(Co-construction by Ministry and Province)Ministry of Agriculture and Rural AffairsGuangzhou 510640GuangdongChina College of Agriculture and Biology Zhongkai University of Agriculture and EngineeringGuangzhou 510225GuangdongChina Guangdong Provincial Key Laboratory for Crop Germplasm Resources Preservation and Utilization Agro-biological Gene Research CenterGuangdong Academy of Agricultural SciencesGuangzhou 510640GuangdongChina

With rising living standards,there is an increasing demand for high-quality *** quality is mainly defined by milling quality,appearance quality,cooking and eating quality,and nutrition *** them,chalkiness is a key trait for appearance quality,which adversely affects cooking and eating quality,head rice yield,and commercial ***,chalkiness is undesirable,and reducing chalkiness is a major goal in rice quality ***,chalkiness is a complex trait jointly influenced by genetic and environmental factors,making its genetic study and precision improvement a huge *** the rapid development of molecular techniques,much knowledge has been gained about the genes and molecular networks involved in chalkiness *** present review describes the major environmental factors affecting chalkiness and summarizes the quantitative trait loci(QTL)associated with *** than 150 genes related to chalkiness formation have been *** functions of the genes regulating chalkiness,primarily those involved in starch synthesis,storage protein synthesis,transcription regulation,organelle development,grain shape regulation,and hightemperature response,are ***,we identify the challenges associated with genetic improvement of chalkiness and suggest potential ***,the review offers insight into the molecular dynamics of chalkiness and provides a strong basis for the future breeding of high-quality rice varieties.

关键词： Rice Grain quality Chalkiness QTL identification Gene

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Multicomponent remote C(sp^(2))–H bond addition by Ru catalysis:An efficient access to the alkylarylation of 2H-imidazoles

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Chinese Chemical Letters 2024年第10期35卷 257-261页

作者： Yi luo Lin dong Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

Sequential C–H bond addition with two different coupling partners is a powerful method for the rapid and modular construction of complex molecules based on simple starting ***,an efficient ruthenium-catalysed multicomponent long-range C–H functionalization of 2H-imidazoles was *** protocol showed good substrate suitability and yielded alkyl arylation products with potential biological activity.

关键词： Remote C-H functionalization Multi-component reaction Ruthenium catalysis 2H-Imidazoles

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Impurity formation mechanism of silicon carbide crystals smelted by Acheson process

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Journal of Iron and Steel Research International 2024年第6期31卷 1367-1375页

作者： dong Feng Hong-qiang Ru Xu-dong luo Jie-gang You Ling Zhang School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 114051LiaoningChina Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) Institute of Advanced CeramicsSchool of Materials Science and EngineeringNortheastern UniversityShenyang 110819LiaoningChina Liaoning Institute of Science and Technology Benxi 117004LiaoningChina

In order to further promote the application of SiC refractories in modern steel metallurgy,the occurrence forms and formation mechanism of impurities in SiC crystals smelted by Acheson process were *** techniques of inductively coupled plasma-atomic emission spectrometry,X-ray diffraction,and scanning electron microscopy were combined to examine the types and occurrence forms of impurities in smelted SiC *** results showed that the main impurities in the SiC are free Si,free C,oxides(CaO·Al_(2)O_(3)·2SiO_(2),3Al_(2)O_(3)·2SiO_(2),CaO·SiO_(2) and SiO_(2))and alloy phases(Fe_(x)Si_(y),Fe_(x)Si_(y)Ti_(z) and Fe_(x)Al_(y)Si_(z)).The formation process of impurities during the smelting of SiC can be described as follows:At high temperature,the SiO_(2) and Fe,Ti related oxide impurities present in the raw materials are reduced to Si,Fe,and Ti metal *** the reduction process,the free Si,Fe_(x)Si_(y) and Fe_(x)Si_(y)Ti_(z) are precipitated from the melt during *** Si primarily exists in aggregated form within the SiC crystal,while the alloy phase is predominantly found at the interface between SiC and free Si,with Fe_(x)Si_(y)Ti_(z) embedded within *** the end of the cooling process,other impurity oxides such as Al_(2)O_(3),CaO,and some unreduced SiO_(2) solidify to form calcium-aluminum-silicate glass phases,predominantly located between SiC *** remaining C from the reaction is mainly dispersed as free C within the SiC crystal and at the interface between SiC and free Si.

关键词： Impurity element Formation mechanism Smelted SiC crystal SiC refractory Occurrence form

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Emerging roles of non-coding RNAs in colorectal cancer oxaliplatin resistance and liquid biopsy potential

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World Journal of Gastroenterology 2023年第1期29卷 1-18页

作者： zheng-dong luo Yi-Feng Wang Yu-Xiao Zhao Long-Chen Yu Tian Li Ying-Jing Fan Shun-Jie Zeng Yan-Li Zhang Yi Zhang Xin Zhang Department of Clinical Laboratory Qilu Hospital of Shandong UniversityShandong Engineering Research Center of Biomarker and Artificial Intelligence ApplicationJinan 250012Shandong ProvinceChina Department of Clinical Laboratory Shandong Provincial Third HospitalJinan 250012Shandong ProvinceChina

Colorectal cancer(CRC)is one of the most common malignancies of the digestive tract,with the annual incidence and mortality increasing *** chemotherapy is a preferred therapeutic regimen for patients with advanced ***,most patients will inevitably develop resistance to *** studies have reported that non-coding RNAs(ncRNAs),such as microRNAs,long non-coding RNAs,and circular RNAs,are extensively involved in cancer ***,emerging evidence has revealed that ncRNAs mediate chemoresistance to oxaliplatin by transcriptional and post-transcriptional regulation,and by epigenetic *** this review,we summarize the mechanisms by which ncRNAs regulate the initiation and development of CRC chemoresistance to ***,we investigate the clinical application of ncRNAs as promising biomarkers for liquid CRC *** review provides new insights into overcoming oxaliplatin resistance in CRC by targeting ncRNAs.

关键词： Colorectal cancer Non-coding RNAs Oxaliplatin Resistance Liquid biopsy biomarkers

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Optimal Stochastic Scheduling Strategy of Multi-vector Energy Complex Integrated with Full-blown Power-to-biomethane Model

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 863-873页

作者： Guanwei Zeng Chengxi Liu Minfang Liao Yongjian luo Xuzhu dong Hubei Engineering and Technology Research Center for AC/DC Intelligent Distribution Network WuhanChina the School of Electrical Engineering and Automation Wuhan UniversityWuhanChina

We propose an optimal stochastic scheduling strategy for a multi-vector energy complex(MEC),considering a fullblown model of the power-to-biomethane(Pt M)*** conventional optimization that uses a simple efficiency coefficient to coarsely model energy conversion between electricity and biomethane,a detailed Pt M model is introduced to emphasize the reactor kinetics and chemical equilibria of *** model crystallizes the interactions between the Pt M process and MEC flexibility,allowing to adjust the operating condition of the methanation reactor for optimal MEC operation in stochastic *** optimization and flowsheet design of the Pt M process increase the average selectivity of methane(i.e.,ratio between net biomethane production and hydrogen consumption)up to 83.7%in the proposed synthesis *** results can provide information and predictions to operators about the optimal operating conditions of a Pt M unit while improving the MEC flexibility.

关键词： Multi-vector energy complex optimal stochastic scheduling power-to-biomethane unit process synthesis natural gas

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Effect of bipolar-plates design on corrosion,mass and heat transfer in proton-exchange membrane fuel cells and water electrolyzers:A review

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1599-1616页

作者： Jiuhong Zhang Xiejing luo Yingyu Ding Luqi Chang Chaofang dong Key Laboratory for Corrosion and Protection(MOE) Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Beijing Advanced Innovation Center for Materials Genome Engineering Beijing 100083China

Attaining a decarbonized and sustainable energy system,which is the core solution to global energy issues,is accessible through the development of hydrogen ***-exchange membrane water electrolyzers(PEMWEs)are promising devices for hydrogen production,given their high efficiency,rapid responsiveness,and *** plates account for a relatively high percentage of the total cost and weight compared with other components of ***,optimization of their design may accelerate the promotion of *** paper reviews the advances in materials and flow-field design for bipolar ***,the working conditions of proton-exchange membrane fuel cells(PEMFCs)and PEMWEs are compared,including reaction direction,operating temperature,pressure,input/output,and ***,the current research status of bipolar-plate substrates and surface coatings is summarized,and some typical channel-rib flow fields and porous flow fields are ***,the effects of materials on mass and heat transfer and the possibility of reducing corrosion by improving the flow field structure are ***,this review discusses the potential directions of the development of bipolar-plate design,including material fabrication,flow-field geometry optimization using threedimensional printing,and surface-coating composition optimization based on computational materials science.

关键词： bipolar-plates flow design mass and heat transfer corrosion water electrolyzers fuel cells

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Heat Shock Factor A1s are required for phytochrome-interacting factor 4-mediated thermomorphogenesis in Arabidopsis

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Journal of Integrative Plant Biology 2024年第1期66卷 20-35页

作者： Bingjie Li Shimeng Jiang Liang Gao Wenhui Wang Haozheng luo Yining dong Zhihua Gao Shuzhi zheng Xinye Liu Wenqiang Tang Key Laboratory of Molecular and Cellular Biology of Ministry of Education Hebei Research Center of the Basic Discipline of Cell BiologyHebei Collaboration Innovation Center for Cell SignalingHebei Key Laboratory of Molecular and Cellular BiologyCollege of Life SciencesHebei Normal UniversityShijiazhuang 050024China School of Information Technology Hebei University of Economics and BusinessShijiazhuang 050061China

Thermomorphogenesis and the heat shock(HS)response are distinct thermal responses in plants that are regulated by PHYTOCHROME-INTERACTING FACTOR 4(PIF4)and HEAT SHOCK FACTOR A1s(HSFA1s),*** is known about whether these responses are interconnected and whether they are activated by similar *** analysis of transcriptome dynamics in response to warm temperature(28℃)treatment revealed that 30 min of exposure activated the expression of a subset of HSFA1 target genes in Arabidopsis ***,a loss-of-function HSFA1 quadruple mutant(hsfa1-cq)was insensitive to warm temperature-induced hypocotyl *** hsfa1-cq plants grown at 28℃,the protein and transcript levels of PIF4 were greatly reduced,and the circadian rhythm of many thermomorphogenesis-related genes(including PIF4)was ***,the nuclear localization of HSFA1s and the binding of HSFA1d to the PIF4 promoter increased following warm temperature exposure,whereas PIF4 overexpression in hsfa1-cq partially rescued the altered warm temperature-induced hypocotyl growth of the *** together,these results suggest that HSFA1s are required for PIF4 accumulation at a warm temperature,and they establish a central role for HSFA1s in regulating both thermomorphogenesis and HS responses in Arabidopsis.

关键词： HSFA1 PIF4 thermomorphogenesis

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Effect of solvent on the initiation mechanism of living anionic polymerization of styrene:A computational study

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Chinese Journal of Chemical Engineering 2024年第5期69卷 135-142页

作者： Shen Li Yin-Ning Zhou Zhong-Xin Liu zheng-Hong luo School of Chemical Engineering and Technology Hainan UniversityHaikou 570228China Department of Chemical Engineering School of Chemistry and Chemical EngineeringState Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China

For living anionic polymerization(LAP),solvent has a great influence on both reaction mechanism and *** this work,by using the classical butyl lithium-styrene polymerization as a model system,the effect of solvent on the mechanism and kinetics of LAP was revealed through a strategy combining density functional theory(DFT)calculations and kinetic *** terms of mechanism,it is found that the stronger the solvent polarity,the more electrons transfer from initiator to solvent through detailed energy decomposition analysis of electrostatic interactions between initiator and solvent ***,we also found that the stronger the solvent polarity,the higher the monomer initiation energy barrier and the smaller the initiation rate ***,initiation is more favorable at lower temperatures based on the calculated results ofΔG_(TS).Finally,the kinetic characteristics in different solvents were further examined by kinetic *** is found that in benzene and n-pentane,the polymerization rate exhibits first-order ***,slow initiation and fast propagation were observed in tetrahydrofuran(THF)due to the slow free ion formation rate,leading to a deviation from first-order kinetics.

关键词： Living anionic polymerization Solvent effect Reaction kinetics Computational chemistry Mathematical modeling Kinetic modeling

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