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Onward

World Journal of Pediatrics 2015年第1期11卷 5-6页

作者： Qiang Shu zheng-yan zhao Hangzhou China

Adecade's publication of the World Journal of Pediatrics(WJP)is an occasion on which to look back how the journal is growing up since it was born in July *** still remember the proposal to launch an international pediatric journal which was discussed at a meeting of hospital directors in *** over one year's preparation,the inauguration issue of WJP appeared as the first peer reviewed English-language pediatric journal in China.

关键词： journal remember director

Conformation Disturbance of CopC by α-Naphthylamine

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Chemical Research in Chinese Universities 2009年第3期25卷 269-272页

作者： LI Hui-qing zheng Xiao-yan zhao Ya-qin yanG Bin-sheng Institute of Molecular Science Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University Taiyuan 030006 P. R. China

It is known that urea and guanidine hydrochloride（GuHC1） induce conformational change of proteins in a certain range of molar ratios. In our research, a-naphthylamine（NA） above 10^-4 mol/L at pH 7.0 was discovered to perturb the conformation of CopC, a copper resistant protein with a Greek fl-barrel motif; this was reflected by the greater fluorescence quenching and red-shifted emission peak of CopC. The conformation change of CopC was also verified in acrylamide collision experiment by comparing quenching levels of CopC in the presence or the abscence of NA. Comparison of emission change of CopC-Cu^2＋ with that of apo-CopC showed a consistent result with their denaturation in GuHCl. And decreasing fluorescence polarization of CopC with increasing NA concentration is consistent with a more extend conformation of CopC. Interaction mechanism was also explored.

关键词： α-Naphthylamine(NA) CopC Conformational change

A high-fat high-energy diet influences hepatic CYP3A expression and activity in low-birth-weight developing female rats

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World Journal of Pediatrics 2016年第4期12卷 489-497页

作者： Shao-Qing Ni Yin Lou Xiu-Min Wang zheng Shen Jue Wang zheng-yan zhao Su Zeng The National Clinical Trial Institute Children's HospitalZhejiang University School of Medicine and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal DiseasesHangzhouChina Pharmacy Department Children's HospitalZhejiang University School of Medicine and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal DiseasesHangzhouChina Department of Endocrinology Children's HospitalZhejiang University School of Medicine and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal DiseasesHangzhouChina Lab Center Children's HospitalZhejiang University School of Medicine and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal DiseasesHangzhouChina Department of Children's Health and Care Children's HospitalZhejiang University School of Medicine and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal DiseasesHangzhouChina Department of Pharmaceutical Analysis and Drug Metabolism College of Pharmaceutical SciencesZhejiang UniversityHangzhouChina

Background:The objective of this study was to investigate the effects of a high-fat,high-energy(HFHE)diet on the hepatic expression of CYP3A in low-birthweight developing female ***:Pregnant rats were divided into nourished and undernourished *** offspring of the nourished rats were defined as the normal-birth-weight(NBW)group,and those of undernourished rats were defined as the low-birth-weight(LBW)*** to their birth weights and diets,the rats were subdivided into the following four groups:NBW-normal diet(NN)group;NBW-HFHE(NH)group;LBW-normal diet(LN)group;and LBW-HFHE(LH)*** samples were isolated on days 3,7,14,21,28,56 and 84 after ***:The CYP3A1 mRNA levels in the LH group on days 3,56 and 84 were significantly higher than those of the NN group(P<0.05).CYP3A1 expression was significantly higher in the LH group than that in the NH group on days 21,28 and 84(P<0.05).CYP3A1 mRNA expression was higher in the LH group than that in the LN group on days 3 and 21(P<0.05).No zonal CYP3A1 expression pattern was observed in the LH developmental *** LH group had significantly higher mean activity than the LN group on days 7,14,28 and ***:Our results indicated that an HFHE diet can result in alterations of CYP3A expression in a developmental LBW rat model.

关键词： CYP3A development high-energy diet low birth weight

Pediatrics in China: challenges and prospects

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World Journal of Pediatrics 2018年第1期14卷 1-3页

作者： yang Liu Li-Li yang Si-Yun Xu zheng-yan zhao Editorial Office of World Journal of Pediatrics Children’sHospitalZhejiang University School of MedicineHangzhouChina Department of Children’s Health Care Children’s HospitalZhejiang University School of Medicine3333BinshengRoadHangzhou310052China

China has the largest number of children in the world. The population of children between 0 and 14 years of age was about 227 million in 2015. It is a great and arduous task to ensure the healthy growth of all children in China. Mater-nal and child health care in China has achieved significant improvements. China has achieved the Millennium Develop-ment Goal 4 [ 1 ], the mortality rate of children under 5 years of age showed an overall downward trend from 61.0 per 1000 in 1991 to 10.7 per 1000 in 2015 (2)However, China still faces many challenges, such as the serious shortage of pediatricians, shortage and uneven distribution of medical resources, imbalances among different population groups and different regions.

关键词： Pediatrics in China challenges prospects

Journal’s responsibility in maintaining scientifc integrity

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World Journal of Pediatrics 2022年第1期18卷 1-3页

作者： Li-Li yang Si-Yun Xu Zhi-Yi yang zheng-yan zhao Qiang Shu National Clinical Research Center for Child Health National Children’s Regional Medical CenterChildren’s HospitalZhejiang University School of MedicineHangzhou 310052China

Scientifc integrity has been regarded as a priority in scientifc development in China[1].The Chinese governmental agencies have paid unprecedented attentions on promoting scientifc integrity in recent *** May 2018,the Communist Party of China Central Committee and the State Council issued guidelines on promoting scientifc integrity[2].Ever-harsher punishments for researchers who committing scientifc misconduct were introduced by the Chinese government[3].In November,2018,43 penalties for major academic misconduct were endorsed by 41 national government ***,the Ministry of Science and Technology of China(MOST)were established a notifcation system for reporting cases involving in scientifc misconduct and the related penalties publicly.

关键词： integrity scient Communist

Effect of maternal lipid profile,C-peptide,insulin,and HBA1c levels during late pregnancy on large-for-gestational age newborns

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World Journal of Pediatrics 2014年第2期10卷 175-181页

作者： Ruo-Lin Hou Huan-Huan Zhou Xiao-yang Chen Xiu-Min Wang Jie Shao zheng-yan zhao Department of Children's Health Care Children's HospitalZhejiang University School of MedicineHangzhou 310003China Department of Endocrinology Children's HospitalZhejiang University School of MedicineHangzhou 310003China

Background:Large-for-gestational age(LGA)newborns can increase the risk of metabolic *** studies have shown that the levels of maternal blood lipids,connecting peptide(C-peptide),insulin and glycosylated hemoglobin(HbA_(1c))were significantly different between LGA and appropriate-for-gestational age(AGA)*** study aimed to determine the effect of the levels of maternal lipids,C-peptide,insulin,and HbA_(1c) during late pregnancy on LGA ***:This study comprised 2790 non-diabetic women in late *** their newborns,2236(80.1%)newborns were AGA,and 554(19.9%)newborns were *** and neonatal characteristics were obtained from questionnaires and their case *** levels of maternal fasting serum apolipoprotein A1(ApoA1),triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),C-peptide,insulin and blood HbA_(1c) were *** chi-square and Mann-Whitney U test were used to analyze categorical variables and continuous variables between the AGA and LGA groups,*** logistic regression analysis was made to determine the independent risk factors for LGA ***:Maternal TG,C-peptide,insulin and HbA_(1c) levels were signifi cantly higher in the LGA group than in the AGA group(P<0.05).The LGA group had signifi cantly lower levels of maternal TC,HDL-C and LDL-C than the AGA group(P<0.05).After adjustment for confounding variables,including maternal age,pre-pregnancy body mass index,education,smoking,annual household income,amniotic fluid volume,gestational hypertension,newborn gender and gestational age at blood collection,high maternal TG levels remained signifi cantly associated with LGA newborns(P<0.05).Conclusion:High maternal TG level during late pregnancy is signifi cantly associated with LGA newborns.

关键词： large-for-gestational-age newborns late pregnancy maternal lipid profile triglyceride

Factors associated with fasting plasma ghrelin levels in children and adolescents

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World Journal of Gastroenterology 2008年第5期14卷 790-794页

作者： Chao-Chun Zou Li Liang zheng-yan zhao Department of Endocrinology the Children's Hospital of Zhejiang University School of Medicine Hangzhou 310003 Zhejiang Province China

AIM:To measure plasma ghrelin levels in children and adolescents, analyze the associated factors, and investigate the role of ghrelin in obesity, insulin resistance and reproductive physiology. METHODS:A total of 283 subjects aged 4.8-15.8 year were enrolled. Fasting blood samples were collected and plasma ghrelin levels were measured by radioimmunoassay. Fasting glucose (FG), fasting insulin (FI), baseline testosterone (T), estradiol (E2), prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), serum total cholesterol (TC), triglyceride (TG), alanine aminotransferase (ALT) and uric acid (UA) were measured. Body mass index (BMI), insulin resistance by homeostasis model (HOMA-IR) and beta cell function by homeostasis model (HOMA-β) were calculated. RESULTS:The median ghrelin level was 290 ng/L (15.0-1325.0 ng/L). Bivariate correlation analysis showed that ghrelin levels were inversely correlated with BMI, ALT, TG, UA, LH, FI and HOMA-IR (all P < 0.05). No other significant correlation was found between ghrelin levels and age, gender, TC, E2, FSH, PRL, FG and HOMA-β. Stepwise multiple regression analysis showed that only BMI and FI were independent determinants of plasma ghrelin levels in these children and adolescents (P = 0.018 and P = 0.046, respectively), which explained 25.4% of the variance. CONCLUSION:These data suggest that the lower ghrelin levels in obese subjects may be the result of obesity and hyperinsulinemia, which is very common in obese subjects. Moreover, ghrelin may regulate human reproductive physiology indirectly.

关键词： Ghrelin Obesity Body mass index Insulin

Social responsibilities of a pediatric journal:considerations and future directions

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World Journal of Pediatrics 2021年第1期17卷 1-2页

作者： Li-Li yang Xian-Jun Wang Qi Qi Si-Yun Xu Yi-Cheng Xie zheng-yan zhao Qiang Shu National Clinical Research Center for Child Health National Children's Regional Medical CenterChildren's HospitalZhejiang University School of MedicineHangzhou 310052China

***,the former editor of JAMA,elucidated many social responsibilities for medical journal editing as early as 1987[1].During the pandemic,a medical journal should highlight its social responsibilities in publishing high-qual-ity contents,promoting education to the health care pro-viders and providing readers with the timely and accurate information[1].At the time of this editorial published,the global cases of coronavirus disease 2019(COVID-19)had surpassed 85 *** pandemic and its resulting eco-nomic,health,and educational disruptions have affected all aspects of the youth's lives[2].Quarantine and social isola-tion,increased risks of child abuse and neglect,financially and psychologically stressed family members have led to negative mental outcomes in children and adolescents.

关键词： journal editor publishing

Management of children with COVID-19: experiences from China

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World Journal of Pediatrics 2020年第3期16卷 217-218页

作者： Si-Yun Xu Li-Li yang Qi Qi Xian-Jun Wang Yi-Cheng Xie zheng-yan zhao Qiang Shu Children's Hospital Zhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children's Regional Medical CenterHangzhou 310052China

The coronavirus disease 2019 (COVID-19) global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major public health *** a special population,children have special respiratory tract structure characteristics,immature immune system,and susceptibility to respiratory virus ***,it is highly important for clinicians to treat the infected children cautiously despite most pediatric patients have milder symptoms and better prognosis compared with the adult patients.

关键词： respiratory acute patients