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High Hydrostatic Pressure Exacerbates Bladder Fibrosis through Activating Piezo1

Current Medical Science 2024年第4期44卷 718-725页

作者： Bo-lang DENG Dong-xu LIN Zhi-peng LI Kang LI Peng-yu WEI Chang-cheng LUO Meng-yang ZHANG Quan ZHOU zheng-long yang Zhong CHEN Department and Institute of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Rehabilitation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China

Objective Bladder outlet obstruction(BOO)results in significant fibrosis in the chronic stage and elevated bladder ***1 is a type of mechanosensitive(MS)channel that directly responds to mechanical *** identify new targets for intervention in the treatment of BOO-induced fibrosis,this study investigated the impact of high hydrostatic pressure(HHP)on Piezo1 activity and the progression of bladder *** Immunofluorescence staining was conducted to assess the protein abundance of Piezo1 in fibroblasts from obstructed rat *** fibroblasts were cultured under normal atmospheric conditions(0 cmH_(2)O)or exposed to HHP(50 cmH_(2)O or 100 cmH_(2)O).Agonists or inhibitors of Piezo1,YAP1,and ROCK1 were used to determine the underlying *** The Piezo1 protein levels in fibroblasts from the obstructed bladder exhibited an elevation compared to the control *** significantly promoted the expression of various pro-fibrotic factors and induced proliferation of ***,the protein expression levels of Piezo1,YAP1,ROCK1 were elevated,and calcium influx was increased as the pressure *** effects were attenuated by the Piezo1 inhibitor *** Piezo1 activator Yoda1 induced the expression of pro-fibrotic factors and the proliferation of fibroblasts,and elevated the protein levels of YAP1 and ROCK1 under normal atmospheric conditions in ***,these effects could be partially inhibited by YAP1 or ROCK inhibitors.

关键词： high hydrostatic pressure bladder outlet obstruction fibrosis Piezo1

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Facile O-alkylation of highly hydrophilic hyperbranched polyglycerol

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Chinese Chemical Letters 2007年第2期18卷 192-194页

作者： De Cheng Wan Jun Jie Yuan zheng long yang Hong Ting Pu [a]Institute of Functional Polymer School of Materials Science and Engineering Tongji University Shanghai 200092 China

A facile and selective route for O-alkylation of highly hydrophilic, multifunctional hyperbranched polyglycerol (PG) under non-aqueous phase transfer catalyzed conditions in dimethyl sulfoxide was developed, through w... 详细信息

关键词： Hyperbranched polyglycerol O-Alkylation Phase transfer Selectivity

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Two-dimensional mesoporous materials:From fragile coatings to flexible membranes

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Chinese Chemical Letters 2013年第2期24卷 89-92页

作者： zheng-long yang Jiao-Li Li Cheng-Liang Zhang Yun-Feng Lu Zhen-Zhong yang School of Chemistry and Materials Science Ludong University lnstitute of Chemistry Chinese Academy of Sciences Institute of Chemistry Chinese Academy of Sciences Department of Chemical and Biomolecular Engineering.University of California at Los Angeles Los AngelesCA 90095USA

Received 30 November 2012 Received in revised form 24 December 2012 Accepted 26 December 2012 Available online 29 January 2013

关键词： Mesoporous materialsTwo-dimensional materialsCoatingsMembranes

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Disparity estimation for multi-scale multi-sensor fusion

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Journal of Systems Engineering and Electronics 2024年第2期35卷 259-274页

作者： SUN Guoliang PEI Shanshan long Qian zheng Sifa yang Rui Suzhou Automotive Research Institute Tsinghua UniversitySuzhou 215000China Beijing Smarter Eye Technology Co. Ltd.Beijing 100023China College of Artifical Intelligence Tianjin University of Science and TechnologyTianjin 300457China State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China Department of Precision Instrument Tsinghua UniversityBeijing 100084China

The perception module of advanced driver assistance systems plays a vital *** schemes often use a single sensor for data processing and environmental perception or adopt the information processing results of various sensors for the fusion of the detection *** paper proposes a multi-scale and multi-sensor data fusion strategy in the front end of perception and accomplishes a multi-sensor function disparity map generation scheme.A binocular stereo vision sensor composed of two cameras and a light deterction and ranging(LiDAR)sensor is used to jointly perceive the environment,and a multi-scale fusion scheme is employed to improve the accuracy of the disparity *** solution not only has the advantages of dense perception of binocular stereo vision sensors but also considers the perception accuracy of LiDAR *** demonstrate that the multi-scale multi-sensor scheme proposed in this paper significantly improves disparity map estimation.

关键词： stereo vision light deterction and ranging(LiDAR) multi-sensor fusion multi-scale fusion disparity map

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Solvothermal synthesis of PbTe/SnTe hybrid nanocrystals

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Chinese Chemical Letters 2014年第6期25卷 849-853页

作者： Wei Jiang zheng-long yang Ding Weng Jun-Wei Wang Yun-Feng Lu Min-Juan Zhang Zhen-Zhong yang School of Chemistry and Materials Science Ludong University Department of Chemical and Biomolecular Engineering University of California at Los Angeles Materials Research Department Toyota Motor Engineering and Manufacturing North AmericaInc.1555 Woodridge AvenueAnn ArborMI 48105USA Institute of Chemistry Chinese Academy of Sciences

PbTe/SnTe hybrid nanocrystals with designed shape, chemical composition and narrow size distribution were synthesized by an efficient solvothermal approach. This approach enables mass and economical synthesis of PbTe-based nanocrystals. The organic ligands were completely removed by pretreatment with a super-hydride solution, making it possible to fabricate fully dense and robust thermoelectric devices with increased electrical conductivity.

关键词： Lead telluride Tin telluride Hybrid nanocrystal Solvothermal synthesis

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Mechanism study of Cu(Ⅱ) adsorption from acidic wastewater by ultrasonic-modified municipal solid waste incineration fly ash

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Chinese Journal of Chemical Engineering 2024年第3期67卷 157-165页

作者： Shunda lin yang Lu Lin zheng Ling long Xuguang Jiang Jianhua Yan State Key Laboratory of Clean Energy Utilization Institute for Thermal Power EngineeringZhejiang UniversityHangzhou 310027China Zhejiang University Qingshanhu Energy Research Center Hangzhou 310027China Hangzhou Xiaoshan Jinjiang Green Energy Co. Ltd.XiaoshanHangzhou 310000China

High concentrations of copper ions(Cu(Ⅱ)) in water will pose health risks to humans and the ecological environment. Therefore, this study aims to utilize ultrasonic-cured modified municipal solid waste incineration(MSWI) fly ash for Cu(Ⅱ) adsorption to achieve the purpose of “treating waste by waste.” The effects of p H, adsorption time, initial concentration, and temperature on the modified MSWI fly ash’s adsorption efficiency were systematically studied in this article. The adsorption performance of the modified MSWI fly ash can be enhanced by the ultrasonic modification. At pH = 2, 3 and 4, the adsorption capacity of the modified MSWI fly ash for Cu(Ⅱ) increased by 2.7, 1.9 and 1.2 times, respectively. Furthermore, it was suggested that the adsorption process of the modified MSWI fly ash can be better simulated by the pseudo-second-order kinetic model, with a maximum adsorption capacity calculated by the Langmuir model of 24.196 mg.g-1. Additionally, the adsorption process is spontaneous,endothermic, and chemisorption-dominated from the thermodynamic studies(ΔH and ΔS > 0, ΔG < 0).Finally, the enhanced adsorption performance of the modified MSWI fly ash for Cu(Ⅱ) may be attributed to electrostatic interaction and chelation effects.

关键词： Ultrasound MSWI fly ash Cu(Ⅱ) Wastewater Adsorption

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Zincophilic Ti_(3)C_(2)Cl_(2)MXene and anti-corrosive Cu NPs for synergistically regulated deposition of dendrite-free Zn metal anode

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Journal of Materials Science & Technology 2024年第2期169卷 137-147页

作者： Yunfei Shen Yi Liu Kaisheng Sun Tiantian Gu Gang Wang Yue yang Jianxiang Pang yang zheng Xiaodong yang long Chen Key Laboratory for Green Process of Chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical EngineeringShihezi UniversityShihezi 832003China Institute for Chemistry Chemnitz University of TechnologyChemnitz 09107Germany CAS Key Laboratory of Functional Materials and Devices for Special Environments Xinjiang Key Laboratory of Electronic Information Materials and DevicesCenter of Materials Science and Optoelectronics EngineeringXinjiang Technical Institute of Physics and Chemistry of CASUrumqi 830011China Key Laboratory of Ecophysics and Department of Physics College of ScienceShihezi UniversityShihezi 832003China

Dendrites growth,chemical corrosion,and hydrogen evolution reaction(HER)on zinc anodes are the main barriers for the development of aqueous zinc-ion batteries(AZIBs).Constructing interfacial protec-tive layer is an effective way to alleviate the side reactions on the ***,Cu/Ti_(3)C_(2)Cl_(2)MXene(CMX)with high zincophilic and hydrophobic property is prepared by the lewis molten salts etching method,and the CMX interface protection layer is constructed by a simple spin *** CMX coat-ing layer can provide abundant nucleation sites and uniformize the charge distribution through the zin-cophilic Ti_(3)C_(2)Cl_(2)MXene matrix,leading to homogenous Zn *** addition,the hydrophobic coat-ing contained anti-corrosive Cu nanoparticles can prevent the Zn anode from the electrolyte,beneficial for suppressing the chemical corrosion and ***,the stable and reversible Zn plating/stripping is achieved for the Zn anode coated by the CMX,which exhibits the lifespan of over 1400 h at 0.5 mA cm^(−2),and even can steadily run for 700 h with 65 mV at 10 mA cm^(−2).Furthermore,CMX@Zn shows a high coulombic efficiency of over 100%for 3800 cycles,which indicates that the CMX@Zn electrode has excellent stability and reversibility of Zn stripping/*** full batteries assembled with ZnCoMnO/C(ZCM)cathodes also exhibits higher capacity(450.6 mAh g^(−1)at 0.1 A g^(−1))and cycle stability(capacity retention of 70%after 1500 cycles).This work enhanced the lifespan of AZIBs and broaden the research of multifunctional coating layer to other secondary batteries based on metal anodes.

关键词： Zinc anode Spin coating Zincophilic MXene Anti-corrosive Cu NPs Multifunctional coating

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Non-adiabatic holonomic quantum operations in continuous variable systems

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 12-19页

作者： Hao-long Zhang Yi-Hao Kang Fan Wu Zhen-Biao yang Shi-Biao zheng Fujian Key Laboratory of Quantum Information and Quantum Optics College of Physics and Information EngineeringFuzhou UniversityFuzhou 350116China

Quantum operations by utilizing the underlying geometric phases produced in physical systems are favoured due to their potential *** a system in a non-degenerate eigenstate undergoes an adiabatically cyclic evolution dominated by its Hamiltonian,it will get a geometric phase,referred to as the Berry *** a non-adiabatically cyclic evolution produces an Aharonov-Anandan geometric *** two types of Abelian geometric phases are extended to the non-Abelian cases,where the phase factors become matrix-valued and the transformations associated with different loops are *** and non-Abelian(holonomic)operations are prevalent in discrete variable systems,whose limited(say,two)energy levels,form the *** their developments in continuous systems have also been investigated,mainly due to that,bosonic modes(in,such as,cat states)with large Hilbert spaces,provide potential advantages in fault-tolerant quantum *** we propose a feasible scheme to realize non-adiabatic holonomic quantum logic operations in continuous variable systems with cat *** construct arbitrary single-qubit(two-qubit)gates with the combination of single-and two-photon drivings applied to a Kerr Parametric Oscillator(KPO)(the coupled KPOs).Our scheme relaxes the requirements of the previously proposed quantum geometric operation strategies in continuous variable systems,providing an effective way for quantum control.

关键词： cat qubit continuous variable systems non-Abelian

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Comprehensive Evaluation of Distributed PV Grid-Connected Based on Combined Weighting Weights and TOPSIS-RSR Method

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Energy Engineering 2024年第3期121卷 703-728页

作者： Yue yang Jiarui zheng long Cheng Yongnan Zhu Hao Wu Key Laboratory of Modern Power System Simulation and Control&Renewable Energy Technology Ministry of Education(Northeast Electric Power University)Jilin132012China Siping Suburban Power Supply Company State Grid Jilin Electric Power Co.Ltd.Siping136000China

To effectively quantify the impact of distributed photovoltaic(PV)access on the distribution network,this paper proposes a comprehensive evaluation method of distributed PV grid connection combining subjective and objective combination of assignment and technique for order preference by similarity to an ideal solution(TOPSIS)—rank sum ratio(RSR)(TOPSIS-RSR)*** on the traditional distribution network evaluation system,a comprehensive evaluation system has been *** fully considers the new development requirements of distributed PV access on the environmental friendliness and absorptive capacity of the distribution grid and comprehensively reflects the impact of distributed PV grid *** analytic hierarchy process(AHP)was used to determine the subjective weights of the primary indicators,and the Spearman consistency test was combined to determine the weights of the secondary indicators based on three objective assignment *** subjective and objective combination weights of each assessment indicator were calculated through the principle of minimum *** the distance between the indicators to be evaluated and the positive and negative ideal solutions,the relative closeness ranking,and qualitative binning by TOPSIS-RSR method to obtain the comprehensive evaluation results of different *** setting up different PV grid-connected scenarios and utilizing the IEEE33 node simulation algorithm,the correctness and effectiveness of the proposed subject-object combination assignment and integrated assessment method are verified.

关键词： Distributed PV grid-connected comprehensive evaluation evaluation indicator system combined subjective and objective empowerment TOPSIS-RSR method

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Black hole evaporation and its remnants with the generalized uncertainty principle including a linear term

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Communications in Theoretical Physics 2024年第2期76卷 125-136页

作者： Bo Yu zheng-wen long College of Physics Guizhou UniversityGuiyang550025China

In recent years,researchers have investigated the evaporation of Schwarzschild black holes using various forms of the generalized uncertainty principle(GUP),metric quantum correction,and noncommutative geometry,***,there are differences between the GUP correction and the other two methods in terms of describing the later stages of black hole ***,some studies argue that the GUP with a negative parameter cannot effectively correct black hole evaporation,while others contend that the positivity or negativity of the GUP parameters should not affect the correction *** the above into consideration,we reconsider black hole evaporation with the generalized uncertainty principle including a linear term(LGUP),and examine the case of negative *** results indicate that the evaporation behavior of both Schwarzschild black holes and Reissner–Nordstr?m black holes,under LGUP correction,is consistent with the results of metric quantum correction and non-commutative ***,the negative parameter LGUP can also effectively correct for black hole evaporation.

关键词： black hole evaporation generalized uncertainty principle negative parameter

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