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Lithofacies palaeogeography of the Carboniferous and Permian in the Qinshui Basin, Shanxi Province, China

Journal of Palaeogeography 2015年第4期4卷 387-413页

作者： Long-Yi Shao Zhi-Yu Yang xiao-Xu Shang zheng-hui xiao Shuai Wang Wen-Long Zhang Ming-Quan zheng Jing Lu State Key Laboratory of Coal Resources and Safe Mining School of Geosciences and Surveying Engineering China University of Mining and Technology (Beijing) Hunan Provincial Key Laboratory of Shale Gas Resource Utilization Hunan University of Science and Technology No.105 Geological Brigade of Qinghai Administration of Coal Geology Fujian Institute of Geological Survey

The Qinshui Basin in the southeastern Shanxi Province is an important area for coalbed methane（CBM） exploration and production in China, and recent exploration has revealed the presence of other unconventional types of gas such as shale gas and tight sandstone gas. The reservoirs for these unconventional types of gas in this basin are mainly the coals, mudstones, and sandstones of the Carboniferous and Permian; the reservoir thicknesses are controlled by the depositional environments and palaeogeography. This paper presents the results of sedimentological investigations based on data from outcrop and borehole sections, and basin-wide palaeogeographical maps of each formation were reconstructed on the basis of the contours of a variety of lithological parameters. The palaeogeographic units include the depositional environments of the fluvial channel, flood basin（lake）, upper delta plain, lower delta plain, delta front, lagoon, tidal flat, barrier bar, and carbonate *** Benxi and Taiyuan Formations are composed mainly of limestones, bauxitic mudstones,siltstones, silty mudstones, sandstones, and economically exploitable coal seams, which were formed in delta, tidal flat, lagoon, and carbonate platform environments. The Shanxi Formation consists of sandstones, siltstones, mudstones, and coals; during the deposition of the formation, the northern part of the Qinshui Basin was occupied mainly by an upper delta plain environment, while the central and southern parts were mainly occupied by a lower delta plain environment and the southeastern part by a delta front environment. Thick coal zones occur in the central and southern parts, where the main depositional environment was a lower delta plain. The thick coal zones of the Taiyuan Formation evidently occur in the sandstone-rich belts, located mainly in the lower delta plain environment in the northern part of the basin and the barrier bar environments in the southeastern part of the basin. In contrast, the thick

关键词： palaeogeography Shanxi Province Qinshui Basin Shanxi Formation Taiyuan Formation coal measure coalbed methane Permian Carboniferous

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Investigation of the status of interhospital transport of critically ill pediatric patients

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World Journal of Pediatrics 2015年第1期11卷 67-73页

作者： Jun Qiu xiao-Li Wu zheng-hui xiao Xian Hu Xue-Li Quan Yi-Min Zhu Department of Children's Intensive Research Center Hunan Children's HospitalChangsha 410007China Department of Obstetrics and Gynecology Maternal And Child Health Hospital Of Hunan ProvinceChangsha 410007China

Background:With the unequal distribution of medical resources in developing countries,critially ill children need to be transferred to tertiary hospitals from primary hospitals with limited *** a large number of critically ill children are transferred each day in China,the standard process of inter-hospital transport is not ***:We retrospectively analyzed the data collected during transport.A total number of 9231 patients(≤14 years)who had been transferred to the Hunan Children's Hospital by a specialized team from primary hospitals from January 1,2009 to June 30,2012 were included in the ***:Nearly half of the critically ill children were neonates(48.72%)and two thirds of the children were suffering from respiratory,neurological and cardiac *** adjusted odds ratios(OR)and 95%confidence intervals(CI)were calculated using unconditional logistic *** time in non-working hours was longer than the working hours(OR=1.186,95%CI=1.059-1.329).Our study showed that mobilization time for neonates was shorter than that for older children(OR=0.801,95%CI=0.692-0.928).The mobilization time of referral cases was shorter in areas within a radius of 50 km than in those within a radius of over 250 km(OR=0.427,95%CI=0.350-0.521).Referred patients in summer needed a significantly shorter mobilization time than in winter(OR=0.705,95%CI=0.616-0.806).Conclusion:Standardized processes and guidelines for inter-hospital transport would be essential to ensure effective transport of patients and reduce the mobilization activation time.

关键词： critically ill pediatric patients inter-hospital transport specialist retrieval teams

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Impact of mTOR gene polymorphisms and gene-tea interaction on susceptibility to tuberculosis

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World Journal of Clinical Cases 2020年第19期8卷 4320-4330页

作者： Mian Wang Shu-Juan Ma Xin-Yin Wu Xian Zhang Julius Abesig zheng-hui xiao Xin Huang Hai-Peng Yan Jing Wang Meng-Shi Chen Hong-Zhuan Tan Hunan Provincial Key Laboratory of Clinical Epidemiology Xiangya School of Public HealthCentral South UniversityChangsha 410078Hunan ProvinceChina Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangsha 410078Hunan ProvinceChina Department of Occupational and Environmental Hygiene Xiangya School of Public HealthCentral South UniversityChangsha 410078Hunan ProvinceChina Hunan Provincial Key Laboratory of Pediatric Emergency Hunan Children's HospitalChangsha 410007Hunan ProvinceChina Department of Epidemiology and Health Statistics Hunan Normal UniversityChangsha 410008Hunan ProvinceChina

BACKGROUND mTOR gene is a key component of the PI3K/Akt/mTOR signaling pathway,and its dysregulation is associated with various *** studies have demonstrated that tea drinking is a protective factor against tuberculosis(TB).This study was designed to explore five single nucleotide polymorphisms(SNPs)of mTOR in the Han population of China to determine how their interactions with tea drinking affect susceptibility to *** To investigate if the polymorphisms of mTOR gene and the gene-tea interaction are associated with susceptibility to *** In this case-control study,503 patients with TB and 494 healthy controls were enrolled by a stratified sampling *** cases were newly registered TB patients from the county-level centers for disease control and prevention,and the healthy controls were permanent residents from Xin'ansi Community,Changsha *** data and environmental exposure information including tea drinking were obtained from the study *** genotyped five potentially functional SNP sites(rs2295080,rs2024627,rs1057079,rs12137958,and rs7525957)of mTOR gene and assessed their associations with the risk of TB using logistic regression analysis,and marginal structural linear odds models were used to estimate the gene-environment *** The frequencies of four SNPs(rs2295080,rs2024627,rs1057079,and rs7525957)were found to be associated with susceptibility to TB(P<0.05).Genotypes GT(OR 1.334),GG(OR 2.224),and GT+GG(OR 1.403)at rs2295080;genotypes CT(OR 1.562)and CT+TT(OR 1.578)at rs2024627,genotypes CT(OR 1.597),CC(OR 2.858),and CT+CC(OR 1.682)at rs1057079;and genotypes CT(OR 1.559)and CT+CC(OR 1.568)at rs7525957 of mTOR gene were significantly more prevalent in TB patients than in healthy *** relative excess risk of interaction between the four SNPs(rs2295080,rs2024627,rs1057079,and rs7525957)of mTOR genes and tea drinking were found to be-1.5187(95%CI:-1.9826,-1.0547,P<0.05),-1.8270(95%CI:-2.3587,-

关键词： Tuberculosis mTOR Tea drinking Gene-environment interaction The relative excess risk of interaction Single nucleotide polymorphism

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A metabolite of Danshen formulae (IDHP) induces angiogenesis and protects rat brains against focal ischemia via CaMKKβ/AMPK(Thr172)/eNOS(Ser1177) signaling

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中国药理学与毒理学杂志 2021年第10期35卷 734-735页

作者： LIAO Sha LIU Rui-min XU Dan-ni ZHU Ming-hui ZHAO Qi LUO Xian-lin LI Zhu LUO Quan-li FAN Tai-ping zheng xiao-hui College of Life Sciences Northwest UniversityXi′an 710069China Angiogenesis and Chinese Medicine Laboratory Department of PharmacologyUniversity of CambridgeCambridgeUK

OBJECTIVE Only limited number of drugs are currently available for treating ischemic *** angiogenesis has recently emerged as one of the most promising therapies for cerebral ischemic ***-β-(3,4-dihydroxyphenyl)-α-hydroxypropanoate(IDHP)is a metabolite derived from the botanical formulation for Dantonic®.Here,we investigated the angiogenic efficacy of IDHP in cerebral *** The in vivo effects of IDHP were evaluated in the C57BL/6 mouse Matrigel plug and rat transient middle cerebral artery occlusion(tMCAO)*** human umbilical vein endothelial cells(HUVEC)and human brain microvascular endothelial cells(HBMEC)were used to explore the effects of IDHP on stimulating proliferation,migration and tube formation in *** and Western blotting were used to quantitate the release and expression of relevant target molecules and signaling *** IDHP reduced infarct volume and improved sensorimotor function in rats subjected to tMCAO by promoting angiogenesis,and promoted Matrigel neovascularization in ***,IDHP produced a biphasic modulation on proliferation and migration both in HUVEC and *** also induced tube formation in a 12-day HUVEC-HDF co-culture model and in Matrigel ***-induced angiogenesis was accompanied by increased levels of p-AMPKα(Thr172)and p-eNOS(Ser1177)both in vitro and in vivo,and the decreased level of VEGF in rat brains on day 1 whereas enhanced level of VEGF on day 3 and 7 after ***,AMPK knockdown or pharmacologically inhibiting AMPK and its upstream kinases(CaMKKβ)inhibited the eNOS phosphorylation induced by IDHP in ***,selective eNOS inhibitor(L-NIO),selective CaMKKβinhibitor(STO)and AMPKa inhibitor(Compound C)blocked the capillary-like tube formation in the co-culture model induced by IDHP(10 nmol·L^(-1)).CONCLUSION Collectively,these findings showed that IDHP protected rats from cerebral ischemia-reperfusion injury by promoting angi

关键词： ischemic stroke angiogenesis endothelial cells functional recovery

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岩溶区桩基力学特性分析及桩型优化设计研究

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地质与勘探 2018年第4期54卷 824-832页

作者：郑晓慧中铁上海设计院集团有限公司上海200070

设计人员在岩溶区进行市政、铁路等重荷载建筑作业时,往往采用桩基础以满足上部结构对地基土的承载力需求。桩基设计亦按照岩溶区桩基技术规范,在完整基岩满足限值的前提下,验算基础承载力并选定基础设计参数,进而指导施工。分析我国各... 详细信息

设计人员在岩溶区进行市政、铁路等重荷载建筑作业时,往往采用桩基础以满足上部结构对地基土的承载力需求。桩基设计亦按照岩溶区桩基技术规范,在完整基岩满足限值的前提下,验算基础承载力并选定基础设计参数,进而指导施工。分析我国各地区岩溶勘探现状,基岩裂隙的不均匀性造成岩溶发育的不规律性,导致基岩岩溶分布与埋深无特定关系。故按照既有经验,机械执行设计规范,以完整基岩作为桩长控制的唯一因素,不可避免地造成经济浪费。通过采用土工布等限定成桩边界,建立桩基受力模型,得出岩溶段桩体可提供的最大摩阻力,并将其作为桩体力学平衡组成因素。最终通过岩溶率统计,估算潜在摩阻力值,从而在满足承载力需求的情况下,调整设计桩长及勘探深度,进而制定特定地区设计原则,优化成桩工艺、节约工程造价。

关键词：公铁两用桥梁桩型优化理论分析岩溶桩基岩溶率侧摩阻勘探深度桩长

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Experimental Study on Geometry Characteristics of Turbulent Premixed Flames for Natural Gas/Air Mixtures

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Journal of Thermal Science 2025年第1期34卷 268-282页

作者： zheng Weilin WANG Qijiao xiao Huahua CHEN xiaoxiao XIE Fan ZENG Wen Liaoning Key Lab of Advanced Test Technology for Aerospace Propulsion System Shenyang Aerospace University State Key Laboratory of Fire Science University of science and Technology of China AVIC Shenyang Aircraft Design and Research Institute

In this study,focusing on the geometry characteristics of spherical expanding flame,the turbulent premixed flames of natural gas/air mixtures were investigated in a fan-stirred turbulent *** effects of initial temperature（T=300-400 K）,initial pressure（P=0.1-0.3 MPa）,turbulence intensity（u'=1.0-2.7 m/s）,oxygen volumetric percentage(φ（O2）=15%-21%) and carbon dioxide volumetric percentage(φ（CO2）=0-20%)were delved *** flame profile under the Cartesian coordinate system was derived from the schlieren images taken by the high-speed ***,from both macroscopic and microscopic perspectives,the influence of experimental conditions on the flame geometry characteristics was explored through flame front extraction,wavelet decomposition and network *** results demonstrate that for significant flame wrinkling,changes in species concentrations and turbulence intensity have more pronounced effects on the flame wrinkling *** wrinkling of the flame front maintains a certain degree of similarity,as evidenced by the locally concentrated distribution of the angles of the maximum fluctuation *** disturbance energy under large-scale（D6-D8） disturbances exhibits relatively high values with a similar trend,exerting a significant impact on the geometry characteristics of the flame *** peaks of correlation degree are scattered either with the decomposition scale or the development of flame radius,indicating no linear correlation between different detail ***,the probability distribution of node degrees in key wrinkled regions exhibits different trends with that of large-scale wrinkling and disturbance energy,especially with changes in initial *** occurs because the number of key wrinkles varies based on the perturbation's strength or the region's ***,an increase in the fluctuation frequency of the flame's local radius may not necessarily lead to an increase in the number of key folded regions.

关键词： fan-stirred turbulent combustor geometry characteristics large-scale wrinkling network topology wavelet decomposition

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Heat strain in chemical protective clothing in hot-humid environment:Effects of clothing thermal properties

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Journal of Central South University 2021年第12期28卷 3654-3665页

作者： ZHANG Chuan-kun CHEN Ying LIANG Guo-jie WANG Xin-bo zheng xiao-hui DING Song-tao State Key Laboratory of NBC Protection for Civilian Beijing 100191China Beijing Institute of Fashion Technology Beijing 100029China

Heat strain experienced by individuals wearing chemical protective clothing(CPC)is severe and dangerous especially in hot-humid *** development of material science and interdisciplinary studies including ergonomics,physiology and heat transfer is urgently required for the reduction of heat *** aim of this paper was to study the relationship among clothing thermal properties,physiological responses and environmental *** kinds of CPC were *** participants wore CPC and walked(4 km/h,two slopes with 5%and 10%)on a treadmill in an environment with(35±0.5)℃ and RH of(60±5)%.Core temperature,mean skin temperature,heart rate,heat storage and tolerance time were recorded and *** responses were significantly affected by the clothing thermal properties and activity intensity in hot-humid *** obtained results can help further development of heat strain *** materials with lower evaporative resistance and less weight are necessary to release the heat strain in hot-humid environments.

关键词： heat strain chemical protective clothing thermal insulation evaporative resistance hot-humid environment

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近程反导舰炮武器系统射击效率评估

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系统仿真学报 2008年第23期20卷 6538-6541页

作者：郑晓晖吴晓锋冷画屏海军兵种指挥学院

近程舰炮武器系统担负着舰艇末端防空反导任务。提出了一种评估反导射击效率的方法,该方法选取了单目标毁伤概率、毁伤目标数学期望、服务概率作为射击效率指标。在确定舰炮武器系统有效射击区域的基础上,分析了反导可射击条件,研究了... 详细信息

近程舰炮武器系统担负着舰艇末端防空反导任务。提出了一种评估反导射击效率的方法,该方法选取了单目标毁伤概率、毁伤目标数学期望、服务概率作为射击效率指标。在确定舰炮武器系统有效射击区域的基础上,分析了反导可射击条件,研究了对单目标沿其航路射击的可射击时间、点射次数、受到各次点射的概率,利用经验公式得到单目标毁伤概率。然后,研究了多座舰炮对群目标射击时毁伤目标数学期望、服务概率两项评估指标的计算方法。实例计算分析表明该方法有效可行。

关键词：舰炮反导毁伤概率毁伤目标数学期望服务概率

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纳米药物状态对药物吸收影响的灰色关联度分析

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药学学报 2015年第9期50卷 1096-1100页

作者：于洁郑茂盛肖超妮郑晓晖西北大学生命科学学院陕西西安710069 西北大学化学工程学院陕西西安710069

采用灰色关联度分析方法研究了药物的表面zeta电位、形状因子和尺度等因素对药物和吞噬细胞相互作用的过程影响的关联度,并进行了机制分析。结果表明:在药物和细胞作用过程中,药物的表面zeta电位对内化过程的影响最大,形状影响次之,颗... 详细信息

采用灰色关联度分析方法研究了药物的表面zeta电位、形状因子和尺度等因素对药物和吞噬细胞相互作用的过程影响的关联度,并进行了机制分析。结果表明:在药物和细胞作用过程中,药物的表面zeta电位对内化过程的影响最大,形状影响次之,颗粒尺度影响相对较小。

关键词：灰色关联度表面zeta电位药物形状因子尺度

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基于MCSP的舰艇训练模拟系统可靠性分配研究

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系统仿真学报 2008年第24期20卷 6821-6824,6829页

作者：郑晓晖吴晓锋冷画屏海军兵种指挥学院广州510430

可靠性分配是舰艇训练模拟系统可靠性工程的重要环节。针对系统的使命任务,规划了系统的寿命剖面和任务剖面,建立了系统的任务可靠性模型。按照规定的任务可靠性指标,采用多因子系数专家评分方法将全系统的任务可靠性指标分配到各分系... 详细信息

可靠性分配是舰艇训练模拟系统可靠性工程的重要环节。针对系统的使命任务,规划了系统的寿命剖面和任务剖面,建立了系统的任务可靠性模型。按照规定的任务可靠性指标,采用多因子系数专家评分方法将全系统的任务可靠性指标分配到各分系统或设备层面,得到初步分配结果。然后,依据任务可靠性模型预计系统的任务成功概率(MCSP),比照系统规定的任务可靠性指标,进行迭代修正计算,最终得到了满足规定要求的可靠性分配优化结果。

关键词：舰艇训练模拟系统可靠性分配任务剖面可靠性模型任务成功概率(MCSP)

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