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Methionine-dependence and combination chemotherapy on human gastric cancer cells in vitro

World Journal of Gastroenterology 2002年第2期8卷 230-232页

作者： Wei-Xin Cao Jing-Min Ou Xu-Feng Fei,Department of Clinical Nutrition,Shanghai Institute of Digestive Surgery,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China zheng-Gang zhu hao-Ran Yin Min Yan Yan-Zhen Lin,Department of Surgery,Shanghai Institute of Digestive Surgery,Ruijin Hospital,Shanghai Second Medical University,Shangha 200025,China Department of Clinical Nutrition Ruijin Hospital Shanghai Second Medical University 197 Ruijiner Road Shanghai 200025 China. fische@***

AIM: To elucidate whether human primary gastric cancer and gastric mucosa epithelial cells in vitro can grow normally in a methionine (Met) depleted environment, i.e. Met-dependence, and whether Met-depleting status can enhance the killing effect of chemotherapy on gastric cancer cells. METHODS: Fresh human gastric cancer and mucosal tissues were managed to form monocellular suspensions, which were then cultured in the Met-free but homocysteine-containing (Met(-)Hcy(+)) medium, with different chemotherapeutic drugs. The proliferation of the cells was examined by cell counter, flow cytometry (FCM) and microcytotoxicity assay (MTT). RESULTS: The growth of human primary gastric cancer cells in Met(-)Hcy(+) was suppressed, manifested by the decrease of total cell counts [1.46 +/- 0.42 (x 10(9).L(-1)) in Met(-)Hcy(+) vs 1.64 +/-0.44(x 10(9).L(-1)) in Met(+)Hcy(-), P<0.01], the decline in the percentage of G(0)G(1) phase cells (0.69 +/- 0.24 in Met(-)Hcy(+) vs 0.80 +/- 0.18 in Met(+)Hcy(-), P<0.01) and the increase of S cells (0.24 +/- 0.20 in Met(-)Hcy(+) vs 0.17 +/- 0.16 in Met(+)Hcy(-), P<0.01); however, gastric mucosal cells grew normally. If Met(-)Hcy(+) medium was used in combination with chemotherapeutic drugs, the number of surviving gastric cancer cells dropped significantly. CONCLUSION: Human primary gastric cancer cells in vitro are Met-dependent; however, gastric mucosal cells have not shown the same characteristics. Met(-)Hcy(+) environment may strengthen the killing effect of chemotherapy on human primary gastric cancer cells.

关键词： Antineoplastic Combined Chemotherapy Protocols Cells, Cultured Culture Media Epithelial Cells Gastric Mucosa Humans Methionine Research Support, Non-U.S. Gov't Stomach Neoplasms

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Chiral phosphoramidite ligand-modulated palladium auto-tandem catalysis for asymmetric dehydrogenative dienylation of imines with α-alkenes

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Science China Chemistry 2025年

作者： Zhong-Sheng Nong hao-Fan Qian Ying-Chun Chen Pu-Sheng Wang Liu-zhu Gong Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of China Key Laboratory of Drug Targeting and Drug Delivery System (Sichuan University) Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University School of Materials and Chemistry Southwest University of Science and Technology

The development of efficient processes allowing rapid access to complex chiral molecules from easily available alkenes is a long-term pursuit in the synthetic chemistry community. Transition metal-catalyzed asymmetric functionalization of allylic C–H bond represents a unique alternative toward this goal. However, enantioselective dehydrogenative transformation of olefins to value-added optically enriched molecules remains yet to be discovered. Here, we report a highly enantioselective dehydrogenative dienylation of imines with unactivated α-alkenes driven by the synergistic action of palladium complex and carboxylic acid. Chiral phosphoramidite ligands turned out to be superior in modulating the performance of palladium autotandem catalysis and allowed a broad range of α-alkenes and imines to be transformed into chiral dienylamines. Mechanistic studies suggest that the dienes could be in situ generated from α-alkenes through a palladium(0)-mediated dehydrogenative process in the presence of excess benzoquinone oxidants, and then participated in the Pd-chiral phosphoramidite-catalyzed intermolecular vinylogous-type addition to the imines activated by the carboxylic acid co-catalyst. Notably, the second β-H elimination occurring in the dienylation event might be the turnover-limiting step.

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Research on the deformation mechanism of flexural toppling deep-seated landslides based on large centrifuge physical model testing: A case study of the Genie landslide in the Tibetan Plateau

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Journal of Earth Science 2025年

作者： Shichao Cao Xiujun Dong Changbao Guo Ruian Wu Zhihua Yang Guang zheng Xiaoqiang zhu State Key Laboratory of Geohazard Prevention and Geoenvironment Protection， Chengdu University of Technology Institute of Geomechanics， Chinese Academy of Geological Sciences Key Laboratory of Active Tectonics and Geological Safety， Ministry of Natural Resources

Flexural toppling is a widespread failure mode in natural and excavated anti-inclined rock slopes of the eastern Tibetan Plateau， which can further evolve into large deep-seated landslides， posing significant threats to the construction and operation of important infrastructure. In this study， we took the large deep-seated Genie landslide as a case study and established a centrifuge physical model to analyze the deformation mechanism and evolutionary process of flexural toppling deep-seated landslides under the effect of gravity. The results indicate that the geomechanical mode of landslide instability is characterized by flexural toppling-shearing-sliding， with the deformation process could be divided into three stages: initial slow deformation stage marked by crack generation， rapid deformation stage characterized by the expansion and fracturing of cracks， and a low-speed deformation stage characterized by creep. Notably， the sliding surfaces do not adhere strictly to predefined bending zones but develop cracks along the bending parts， which gradually expand and penetrate deeper， eventually forming multiple potential sliding surfaces. The analysis of the entire process deformation evolution of flexural toppling deep-seated landslides suggests that the rapid deformation stage is the optimal time to take action for landslide prevention and control. The study demonstrates that the shear strength also plays a key factor in the evolution of flexural toppling. The research reveals the deformation mechanism and evolutionary process of large deep-seated landslides in deep-cut canyon areas， providing valuable reference for the prediction， assessment， and prevention of such slopes and landslides.

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High-temperature self-powered X-ray detection in a bilayered hybrid ferroelectric halide perovskite

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Science China Chemistry 2025年

作者： Yingying zheng Panpan Yu Yunpeng Yao Shihai You Zeng-Kui zhu Junhua Luo School of Chemistry and Chemical Engineering Jiangxi Normal University Key Laboratory of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal University School of Environmental and Material Engineering Yantai University Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China

X-ray detectors which convert X-ray irradiation into electrical signals play an important role in diverse applications including medical diagnosis, security examination, nondestructive inspection, personal X-ray dosimeters and fundamental research[1–5]. Recently, metal halide perovskites（MHP） have been developed as a promising family for X-ray detection contributing to their intrinsic advantages, e.g.,simple synthesis, efficient X-ray absorption and excellent semiconducting properties[5–10].

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu zheng Ruizhi Li Yin Wang Peifeng Li Hai zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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基于语料库的朝鲜语命名实体结构特征研究

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外语学刊 2025年第1期 9-18页

作者：黄政豪金光洙延边大学工学院延吉133002 延边大学外国语学院延吉133002

本文统计Klue⁃ner和Kochet⁃ner两个命名实体语料库中的新闻、评论和文化遗产文本数据包含的不同类别朝鲜语命名实体。根据统计结果分析朝鲜语命名实体的音节长度特征分布和格词尾结合率。分析结果表明,音节长度和格词尾的使用在命名实... 详细信息

本文统计Klue⁃ner和Kochet⁃ner两个命名实体语料库中的新闻、评论和文化遗产文本数据包含的不同类别朝鲜语命名实体。根据统计结果分析朝鲜语命名实体的音节长度特征分布和格词尾结合率。分析结果表明,音节长度和格词尾的使用在命名实体分类中具有一定的规律可循。本文的研究成果可用于命名实体分类工作,同时也可以为朝鲜语命名实体语料库构建提供分布结构建议。

关键词：朝鲜语格词尾命名实体识别特征提取名词分类

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The low-latitude sodium layer:comparative data from lidar observations at Hainan,China and São Paulo,Brazil

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Earth and Planetary Physics 2025年第1期9卷 39-53页

作者： Fang Wu Jing Jiao GuoTao Yang LiFang Du zhengKuan Liu haoRan zheng JiXin Guo ShaoHua Gong YaJun zhu State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Hainan National Field Science Observation and Research Observatory for Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China China-Brazil Joint Laboratory for Space Weather NSSC/INPESão Josédos Campos 12227-010Brazil School of Physics and Electronics Engineering Hainan Normal UniversityHaikou 571158China

Physical and chemical processes observed in the mesosphere and thermosphere above the Earth’s low latitudes are complex and highly interrelated to activity in the low-latitude *** sodium detected by lidar can yield clues to dynamic and chemical processes in these spatial layers above the Earth’s *** paper is based on sodium layer data collected at two low-latitude stations,one in the northern hemisphere and one in the *** low-latitude sodium layer exhibits conspicuous seasonal variations in shape,density,and altitude;these variations are similar between Earth’s hemispheres:sodium layer density at both stations reaches its seasonal maximum in autumn and minimum in ***,maximal Na density over Brazil is greater than that over *** variations of Na density above the two low-latitude stations are also similar;at both,maxima are observed before *** variations of the Na layer over Brazil that differ from those observed in the northern hemisphere may be related to the South Atlantic Magnetic Anomaly(SAMA)or fountain *** suggest that low-latitude Na layer data may provide useful additional evidence that could significantly improve the low-latitude part of the WACCM-Na model.

关键词： metallic sodium layer seasonal variation nocturnal variation lidar

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Design and testing research of LiDAR for detecting atmospheric turbulence

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Optoelectronics Letters 2025年第3期21卷 172-176页

作者： QIU Duoyang LI Xianyang YANG hao zhu Xiaomeng FANG Zhiyuan XU Xiang School of Advanced Manufacturing Engineering Hefei University Anhui Provincial Engineering Technology Research Center of Intelligent Vehicle Control and Integrated Design Technology Hefei University Science Island Branch of Graduate School University of Science and Technology of China School of Mechanical and Energy Engineering Ningbo Tech University Key Laboratory of Atmospheric Optics Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences

Atmospheric turbulence is an important parameter affecting laser atmospheric transmission. This paper reports on a self-developed atmospheric turbulence detection Li DAR system (scanning differential image motion Li DAR(DIM-Li DAR) system). By designing and simulating the optical system of atmospheric turbulence detection Li DAR,the basic optical imaging accuracy has been determined.

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Research on Two-stage Voltage and Reactive Power Optimization Coordinated Control Method Considering Flexible On-load Tap Changer

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Dianwang Jishu/Power System Technology 2025年第1期49卷 272-283页

作者： Li, Jiaming Huo, Qunhai Yin, Jingyuan Lu, hao Zhou, Jing zhu, Meisheng He, Wei Dong, Hongwei Institute of Electrical Engineering Chinese Academy of Sciences Haidian District Beijing 100192 China School of Electronic Electrical and Communication Engineering University of Chinese Academy of Sciences Shijingshan District Beijing 100049 China Shanghai Jiguang Polytechnic College Baoshan District Shanghai 201901 China Three Gorges Electric Power Co. Ltd. Hubei Province Wuhan 430000 China

With the large-scale integration of distributed photovoltaic (DPV) in the distribution network, voltage exceeding limits and fluctuations are becoming increasingly severe. The voltage and reactive power optimization and coordination control method considering new power quality management devices needs to be further improved to adapt to the new changes in the power grid. This article considers the power quality regulation effect of the new flexible on-load tap changer (OLTC) and proposes a two-stage voltage and reactive power optimization coordinated control method. The first stage is the day before hour level scheduling stage. Based on distributed photovoltaic and load prediction data, the active output results of DPV and the switching results of flexible OLTC taps and capacitor banks are obtained through power flow calculation and iterative optimization. The second stage is the minute-level reactive power optimization stage. Based on the first stage, considering the reactive power output characteristics of flexible OLTC and DPV, adjusting the reactive power output of the equipment while correcting the capacitor bank switching combination in the first stage, further reducing the maximum voltage deviation of each node and making the distribution network voltage distribution more reasonable. An IEEE33 node distribution system simulation model is built in the paper. The proposed two-stage voltage and reactive power optimization coordination control method considering flexible OLTC can improve the DPV absorption level by 9.29% based on the conventional economic optimal goal of 88.07%, while meeting the requirement that the voltage deviation of the entire node is less than 0.1pu During the entire period, the overall economic efficiency improved by 7.8%. The results demonstrate the rationality and effectiveness of the proposed method. © 2025 Power System Technology Press. All rights reserved.

关键词： Quality management

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超高交联树脂吸附酚类的热力学研究与机理探讨

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水处理技术 2004年第2期30卷 82-84,87页

作者：邱宇平陈金龙李爱民费正皓朱兆连南京大学环境学院污染控制与资源化国家重点实验室江苏南京210093

合成和表征了超高交联树脂AM-1,以大孔吸附树脂AmberliteXAD-4为参照,比较研究了其在水溶液中吸附邻硝基苯酚,对硝基苯酚的吸附行为和热力学性质,测定了不同温度下的平衡吸附量,Langmuir模型和Freundlich模型均能很好拟合。利用Freundl... 详细信息

合成和表征了超高交联树脂AM-1,以大孔吸附树脂AmberliteXAD-4为参照,比较研究了其在水溶液中吸附邻硝基苯酚,对硝基苯酚的吸附行为和热力学性质,测定了不同温度下的平衡吸附量,Langmuir模型和Freundlich模型均能很好拟合。利用Freundlich模型求得△H、△G、△S。研究发现,AM-1型树脂比表面小于XAD-4型树脂的比表面,而吸附能力却更强。这得益于其更多的微孔体积及表面活性基团。

关键词：交联树脂酚类吸附作用热力学 COD 温度吸附量含酚废水废水处理

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