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Precise gradient separation of nanoparticles using reduced graphene oxide-polyoxomolybdate membranes

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Science China Chemistry 2025年第1期68卷 209-216页

作者： Yixin Yang Wanlei Zhao Ruoxuan zheng Hongqiang Li Wei Chen Yu-Fei song State Key Laboratory of Chemical Resource engineering Beijing University of Chemical TechnologyBeijing 100029China Quzhou Institute for Innovation in Resource Chemical engineering Quzhou 324000China

The purification and size sieving of nanoparticles(NPs)represents a significant scientific ***,the rGO-polyoxometalates(POMs=PMo_(12),Mo_(132)and Mo_(368))membranes were fabricated successfully via a simple and scalable POMsassisted in-situ photoreduction *** the mass ratio of rGO to PMo_(12)was 1:30,the resultant rGO-PMo_(12)membranes with highly ordered and uniform nanochannels of 1.0 nm can be obtained,which showed an accurate carbon quantum dots(CQDs)separation with a cut-off size approximately 1.0 *** increase of the size of the interlayered POMs from PMo_(12)(1.0 nm),{Mo132}(2.9 nm)to{Mo_(368)}(3.8 nm),the resultant rGO-PMo_(12),rGO-Mo_(132)and rGO-Mo_(368)exhibited precise gradient separation of CQDs and Au nanoparticles by size exclusion *** results pave a promising way to construct new twodimensional(2D)membranes for highly efficient size-selective separation.

关键词： reduced graphene oxide polyoxometalates membranes gradient separation nanoparticles

Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui Yueru Shen zheng song Dinggang Fan Bing Hu Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

Internal transcribed spacer sequencing to explore the intrinsic composition of fungal communities in fungal esophagitis

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World Journal of Gastroenterology 2025年第7期31卷 26-38页

作者： Yi-Kang song Lin zheng Ai-Xin Liu Jun-Ji Ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesShijiazhuang050000Hebei ProvinceChina

BACKGROUND Fungal esophagitis(FE)is caused by fungal invasion of the esophageal *** endoscopy,the esophageal mucosa shows edema,congestion,erosion,and ulceration,and bleeds easily when touched,and the surface of the mucosa is covered with small white spots like"bean curd residue".Clinical cases showing typical FE under endoscopic imaging but negative esophageal mucosal brush(referred to as suspected FE)have increased the difficulty and challenge of clinical diagnosis and *** present,the esophageal fungal flora of suspected case has not been thoroughly *** To characterize the fungal flora in FE,suspected FE,and the esophageal normal controls(NCs),and to identify marker species to improve detection of *** This was a case-control study.A total of 19 patients with FE,16 with suspected FE,and 10 NCs were selected by *** esophageal cell brush samples of each group were sequenced by internal transcribed spacer(ITS)1 and analyzed by *** In FE and suspected FE patients,species richness,species diversity and species evenness,as measured by the Chao1 index,Shannon index and Pielou index,were lower than in the NCs,and the comparison between the FE and NCs was the most significant(Pents was significantly increased(Pents was 99.5%(Pents,the relative abundance of Ascomycota and Candida in the esophageal flora of suspected FE patients was decreased,while the relative abundance of Yarrowia,Thermomyces and Pichia was *** ITS showed that composition of the fungal community was similar in the F

关键词： Fungal microbiota Esophagitis Candida Yarrowia Biomarker

A High-Order Numerical Method Based on Legendre Polynomial Approximation for Fourth-Order Eigenvalue Problem in Cylinder Domain

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Journal of Mathematical Research with Applications 2025年第2期 195-219页

作者： Jun ZHANG Jihui zheng Fangying song Computational Mathematics Research Center Guizhou University of Finance and Economics School of Mathematical Sciences Guizhou Normal University School of Mathematics and Stastistics Fuzhou University

In this work, an efficient spectral method is proposed to solve the fourth-order eigenvalue problem in cylinder domain. Firstly, the key point of this method is to decompose the original model into a kind of decoupled two-dimensional eigenvalue problem by cylindrical coordinate transformation and Fourier series expansion, and deduce the crucial essential pole conditions. Secondly, we define a kind of weighted Sobolev spaces, and establish a suitable variational formula and its discrete form for each two-dimensional eigenvalue problem. Furthermore, we derive the equivalent operator formulas and obtain some prior error estimates of spectral theory of compact operators. More importantly, we further obtained error estimates for approximating eigenvalues and eigenfunctions by using two newly constructed projection operators. Finally,some numerical experiments are performed to validate our theoretical results and algorithm.

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Passive activity enhances residual control ability in patients with complete spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming Gao Zejia He Jia zheng Hongming Bai Jia-Sheng Rao Guiyun song Wei song Xiaoguang Li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina Department of Rehabilitation engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期68卷 369-376页

作者： song-Meng Wang Hao Nian Yan-Fang Wang Li-Shuo zheng Yu-Tao zheng Yi-Wei Dong Liping Huang Xiaoping Wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China School of Pharmaceutical Science Hengyang Medical SchoolUniversity of South ChinaHengyang 421001China School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal UniversityGuilin 541004China

Studying molecular recognition in aqueous environments is crucial for understanding biological ***,we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine *** subtle modifications can significantly affect the binding properties of these receptors,which is similar to the mutations in biological *** theoretical calculations and molecular recognition experiments demonstrated that these“mutations”have an impact on the hydrophobicity and charge distribution of the hosts,consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

关键词： host-guest interaction hydrophobic effect endo-functionalized cavity mutation pyridine

Impact of triglyceride-glucose index on the long-term prognosis of advanced gastric cancer patients receiving immunotherapy combined with chemotherapy

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World Journal of Gastroenterology 2025年第5期31卷 68-83页

作者： Zhi-Yuan Yao Xiao Ma Yong-zheng Cui Jie Liu zheng-Xiang Han Jun song Department of Oncology The Affiliated Hospital of Xuzhou Medical CollegeXuzhou 221000Jiangsu ProvinceChina Department of Oncology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210008Jiangsu ProvinceChina Department of Radiotherapy The Affiliated Hospital of Xuzhou Medical CollegeXuzhou 221000Jiangsu ProvinceChina Department of Gastrointestinal Surgery The Affiliated Hospital of Xuzhou Medical CollegeXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is the fifth most common malignancy and the third leading cause of death *** advancements in immunotherapies,patient prognosis remains poor,necessitating the identification of key prognostic factors to optimize the treatment *** resistance,as indicated by the triglyceride glucose(TyG)index,is increasingly recognized for its impact on cancer progression and immune modulation,and its potential role in GC prognosis is of particular *** To investigate whether the TyG index,a surrogate marker of insulin resistance,can predict the prognosis of patients with advanced GC receiving immunotherapy combined with *** This retrospective study included 300 patients with advanced GC who received sintilimab combined with *** patients were categorized into two groups according to high or low TyG index,and independent prognostic factors for overall survival(OS)were determined using Cox proportional hazards regression analysis,which led to the development of a nomogram *** Of the included patients,136 had a high TyG index and 164 had a low TyG *** median progression-free survival of the high TyG index group was significantly longer than that of the low TyG index ***,the median OS of the high TyG index group was significantly longer than that of the low TyG index *** ob-jective response and disease control rates in the two groups were 18.38%vs 9.15%and 58.82%vs 46.95%,*** significant difference was noted in the incidence of adverse reactions at any level between the two groups(P>0.05).In multivariate analysis,the Eastern Cooperative Oncology Group score,programmed cell death ligand 1 expression,and TyG index acted as independent prognostic factors for *** these factors,the hazard ratio of the TyG index was 0.36(95%confidence interval:0.36-0.55,Pent prognos

关键词： Triglyceride glucose index Gastric cancer Sintilimab Prognostic model Efficacy Safety

Global hotspots and trends on environmental exposure and cardiovascular disease from 1999 to 2022

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World Journal of Cardiology 2025年第1期17卷 92-109页

作者： Xin-Jie Zhang Qing Tan zheng-Yu Xu song Wen Shu-Bo Chen Department of Graduate Chengde Medical UniversityShijiazhuang 067000Hebei ProvinceChina Department of Surgical Urology Hebei Province Xingtai People’s HospitalXingtai 054031Hebei ProvinceChina Department of Rheumatology The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260Guangdong ProvinceChina Department of Orthopedics Tianjin Medical University General HospitalTianjin 300052China Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080Guangdong ProvinceChina

BACKGROUND The increasing risk of cardiovascular disease(CVD)associated with worsening environmental exposure is a critical health concern garnering global research *** To systematically assess the scope and characteristics of research on the relationship between environmental exposure and *** A thorough examination of publications on the relationship between environmental exposure and CVD from 1999 to 2022 was carried out by extensively screening the literature using the Web of Science Core *** language of the selected publications was standardized to ***,different academic tools such as CiteSpace,VOSviewer,HistCite,Python,Matplotlib,and Bibliometrix were utilized to examine the research trends in this *** The study’s findings indicated a steady increase in scientific publications among the 1640 analyzed documents,peaking in 2022 with 197 *** United States emerged as the leading nation regarding high-quality publications and international *** University was identified as the most prolific institution.“environmental research”was the most frequently contributing journal,and Muenzel T was recognized as the top *** research hotspots are primarily concentrated on themes such as“cardiovascular disease”,“exposure”,“risk”,“mortality”,and“air pollution”.CONCLUSION This study highlights increasing research on the link between environmental exposure and CVD,identifying key exposures and diseases while emphasizing the need for further investigation into underlying mechanisms.

关键词： Bibliometrics environmental exposure Cardiovascular disease CiteSpace VOSviewer Web of Science

A seaweed-inspired separator for high performance Zn metal batteries:Boosting kinetics and confining side-reactions

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Journal of energy Chemistry 2025年第2期101卷 191-200页

作者： Qianzhi Gou Horan Luo Long Qu Feilin Yu Kaixin Wang Sida Zhang Ziga Luogu Ben Zhang Yujie zheng Bingye song John Wang Meng Li National Innovation Center for Industry-Education Integration of energy Storage MOE Key Laboratory of Low-grade Energy Utilization Technologies and SystemsCQU-NUS Renewable Energy Materials & Devices Joint Laboratory College of Energy & Power Engineering Chongqing University School of Building Services Science and engineering Xi'an University of Architecture and Technology School of Chemistry and Chemical engineering Chongqing University of Science and Technology Southwest Technology and engineering Research Institute National University of Singapore (Chongqing) Research Institute

Uncontrolled dendrite growth,sluggish reaction kinetics,and drastic side reactions on the anodeelectrolyte interface are the main obstacles that restrict the application prospect of aqueous zinc-ion *** glass fiber（GF） separator with chemical inertness is almost ineffective in restricting these ***,inspired by the ionic enrichment behavior of seaweed plants,a facile biomass species,anionic sodium alginate（SA）,is purposely decorated on the commercial GF separator to tackle these issues towards Zn *** from the abundant zincophilic functional groups and superior mechanical strength properties,the as-obtained SA@GF separator could act as ion pump to boost the Zn2+transference number（0.68）,reduce the de-solvation energy barrier of hydrated Zn2+,and eliminate the undesired concentration polarization effect,which are verified by experimental tests,theoretical calculations,and finite element simulation,*** on these efficient modulation mechanisms,the SA@GF separator can synchronously achieve well-aligned Zn deposition and the suppression of parasitic ***,the Zn‖Zn coin cell integrated with SA@GF separator could yield a prolonged calendar lifespan over 1230 h(1 mA cm-2and 1 mAh cm-2),exhibiting favorable competitiveness with previously reported separator modification ***,the Zn-MnO2full and pouch cell assembled with the SA@GF separator also delivered superior cycling stability and rate performance,further verifying its practical application *** work provides a new design philosophy to stabilize the Zn anode from the aspect of separator.

关键词： Aqueous zinc-ion batteries Dendrite-free Interfacial reaction kinetics Separator modification Sodium alginate