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Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2210-2227页

作者： Qing Zhao junjie Feng Fubin Liu Qianxin Liang Manlin Xie Jiaming Dong Yanfang Zou Jiali Ye Guilong Liu Yue Cao Zhaodi Guo Hongzhi Qiao Lei zheng Kewei Zhao Guangzhou Key Laboratory of Chinese Medicine Research on Prevention and Treatment of Osteoporosis the Third Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510378China Guangdong Engineering Research Center of Chinese Herbal-derived Vesicles Guangzhou University of Chinese MedicineGuangzhou 510006China Department of Laboratory Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangdong Engineering and Technology Research Center for Rapid Diagnostic Biosensors Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China The Fifth Affiliated Hospital Sun Yat-sen University Zhuhai 519000China Department of Blood Transfusion Guangdong Heyou International HospitalFoshan 528306China School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China

Although various anti-osteoporosis drugs are available,the limitations of these therapies,including drug resistance and collateral responses,require the development of novel anti-osteoporosis *** Drynariae displays a promising anti-osteoporosis effect,while the effective component and mechanism remain ***,we revealed the therapeutic potential of Rhizoma Drynariae-derived nanovesicles(RDNVs)for postmenopausal osteoporosis and demonstrated that RDNVs potentiated osteogenic differentiation of human bone marrow mesenchymal stem cells(hBMSCs)by targeting estrogen receptor-alpha(ERα).RDNVs,a natural product isolated from fresh Rhizoma Drynariae root juice by differential ultracentrifugation,exhibited potent bone tissue-targeting activity and anti-osteoporosis efficacy in an ovariectomized mouse ***,effectively internalized by hBMSCs,enhanced proliferation and ERαexpression levels of hBMSC,and promoted osteogenic differentiation and bone ***,via the ERαsignaling pathway,RDNVs facilitated mRNA and protein expression of bone morphogenetic protein 2 and runt-related transcription factor 2 in hBMSCs,which are involved in regulating osteogenic *** analysis revealed that naringin,existing in RDNVs,was the active component targeting ERαin the osteogenic *** together,our study identified that naringin in RDNVs displays exciting bone tissue-targeting activity to reverse osteoporosis by promoting hBMSCs proliferation and osteogenic differentiation through estrogen-like effects.

关键词： Rhizoma Drynariae-derived nanovesicles Bone marrow mesenchymal stem cells Bone targeting Osteogenic differentiation ERαsignaling Naringin Bone morphogenetic protein 2 Runt-related transcription factor 2

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Comments on‘historical imaginaries,historic urban branding,and the local state in China:rejuvenation discourse,manufactured heritage and simulacrascapes’by Andrew Malcolm law

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Built Heritage 2024年第1期8卷 84-86页

作者： junjie Su School of Ethnology and Sociology Yunnan UniversityNo 2 North Cuihu RoadKunming City 650091YunnanChina

Andrew Malcolm Law's intervention article,‘Historical imaginaries,historic urban branding,and the local state in China:rejuvenation discourse,manufactured heritage and simulacrascapes,presents an interdisciplinary discussion on the construction,in terms of imaginaries and branding,of Chinese historic cities through an investigation of the development and interpretation of the discourse of Chinese national *** article closely examines heritage in Xi'an,China,although the findings and implications may also be relevant to other historic cities/towns in China,which would invite additional studies on both the discourse and practices related to heritage cities in China and across the world.

关键词： discourse law heritage

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Transformer-Aided Deep Double Dueling Spatial-Temporal Q-Network for Spatial Crowdsourcing Analysis

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 893-909页

作者： Yu Li Mingxiao Li Dongyang Ou junjie Guo Fangyuan Pan Department of Computing Hangzhou Dianzi UniversityHangzhou310018China

With the rapid development ofmobile Internet,spatial crowdsourcing has becomemore andmore *** crowdsourcing consists of many different types of applications,such as spatial crowd-sensing *** terms of spatial crowd-sensing,it collects and analyzes traffic sensing data from clients like vehicles and traffic lights to construct intelligent traffic prediction *** collecting sensing data,spatial crowdsourcing also includes spatial delivery services like DiDi and *** task assignment and worker selection dominate the service quality for spatial crowdsourcing *** research conducted task assignments via traditional matching approaches or using simple network ***,advanced mining methods are lacking to explore the relationship between workers,task publishers,and the spatio-temporal attributes in ***,in this paper,we propose a Deep Double Dueling Spatial-temporal Q Network(D3SQN)to adaptively learn the spatialtemporal relationship between task,task publishers,and workers in a dynamic environment to achieve optimal ***,D3SQNis revised through reinforcement learning by adding a spatial-temporal transformer that can estimate the expected state values and action advantages so as to improve the accuracy of task *** experiments are conducted over real data collected fromDiDi and ELM,and the simulation results verify the effectiveness of our proposed models.

关键词： Historical behavior analysis spatial crowdsourcing deep double dueling Q-networks

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Thiol-mediated transportation pathway:an approach for improving tumor penetration of nanomedicines in vivo

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Science China Chemistry 2024年第1期67卷 383-389页

作者： junjie Zhang Weican Sun Xing Wang Senyan Chen Jingying Li Huanghao Yang New Cornerstone Science Laboratory Key Laboratory for Analytical Science of Food Safety and Biology(Ministry of Education)College of ChemistryFuzhou UniversityFuzhou 350116China Department of Chemistry and College of Biological Science and Engineering Fuzhou UniversityFuzhou 350116China

Abnormal tumor microenvironment imposes barriers to tumor penetration of nanomedicine,which remains a major challenge for effective ***,we present disulfide-based nanoparticles that actively penetrate deep tumors in vivo through a thiol-mediated transportation *** achieve active tumor accumulation in vivo,disulfide-based nanoparticles are modified with folic acid units(FA-DBNPs).It is gratifying that FA-DBNPs still enter cells via the thiol-mediated pathway,which facilitates transcellular transportation and tumor penetration both in vitro and in ***,FA-DBNPs exhibit GSH concentration-dependent depolymerization characterization,indicating that the GSH level in tumor tissues regulates the penetration depth of *** from these advantages,FA-DBNPs showed potent anti-tumor activity in mouse models,leading to the significant regression of *** current study lays a foundation that thiol-mediated transportation is a promising approach in nanomedicine design for solid tumor therapy.

关键词： deep penetration thiol-mediated pathway transcellular transportation solid tumor

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Algorithmic approach to discrete fracture network flow modeling in consideration of realistic connections in large-scale fracture networks

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3798-3811页

作者： Qihua Zhang Shan Dong Yaoqi Liu junjie Huang Feng Xiong Badong National Observation and Research Station of Geohazards China University of GeosciencesWuhan430074China SINOPEC Shanghai Engineering Co. Ltd.Shanghai200120China Faculty of Engineering China University of GeosciencesWuhan430074China

Analyzing rock mass seepage using the discrete fracture network(DFN)flow model poses challenges when dealing with complex fracture *** paper presents a novel DFN flow model that incorporates the actual connections of large-scale ***,this model efficiently manages over 20,000 fractures without necessitating adjustments to the DFN *** geometric analyses,such as identifying connected fractures,dividing the two-dimensional domain into closed loops,triangulating arbitrary loops,and refining triangular elements,are fully *** analysis processes are comprehensively introduced,and core algorithms,along with their pseudo-codes,are outlined and explained to assist readers in their programming *** accuracy of geometric analyses is validated through topological graphs representing the connection relationships between *** practical application,the proposed model is employed to assess the water-sealing effectiveness of an underground storage cavern *** analysis results indicate that the existing design scheme can effectively prevent the stored oil from leaking in the presence of both dense and sparse ***,following extensive modification and optimization,the scale and precision of model computation suggest that the proposed model and developed codes can meet the requirements of engineering applications.

关键词： Discrete fracture network(DFN)flow model Geometric algorithm Fracture flow Water-sealing effect

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Permeable carbon fiber based thermoelectric film with exceptional EMI shielding performance and sensor capabilities

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Journal of Advanced Ceramics 2024年第8期13卷 1119-1131页

作者： junjie Zhu Chuan Sun Wanlin Feng Mengran Chen Peng-An Zong Chunlei Wan College of Materials Science and Engineering Nanjing Tech UniversityNanjing 211800China Nationai Innovation Institute of Defense Technology Academy of Military Sciences of the People's Liberation Army of ChinaBeijing 100089China Institute of Nuclear Physics and Chemistry Innovation Research Team for Advanced CeramicsChina Academy of Engineering PhysicsMianyang 621900China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

Thermoelectric(TE)technologies offer a promising approach for directly converting skin heat into electricity for wearable *** p-type Sb2Tes and n-type BizTes as top-performing materials at room temperature,their rigid inorganic structure,with ultralow moisture permeability,poses challenges in warm and humid conditions,fostering bacterial growth and potential skin *** address this issue,we developed a cross-linked core-shell structure by electrodepositing Sb_(2)Te_(3)(Bi_(2)Te_(3))onto carbon fiber(CF).This architecture significantly improved the electrical conductivity and the Seebeck coefficient,resulting in a remarkable 300-fold increase in the power factor compared to that of pure *** CF/Sb_(2)Te_(3) and CF/Bi2Te films demonstrated optimal power factors of 450 and 121μW·m^(-1)·K^(-2),***,the fabricated films exhibited outstanding moisture permeability,over 3000 g·m^(-2)·d^(-1),exceptional electromagnetic interference shielding efficiency approaching 93 dB,and versatility as sensors for language assistance and respiratory *** attributes underline their broad applicability,emphasizing their suitability for human health protection in diverse scenarios.

关键词： thermoelectric(TE) carbon fiber(CF) Bi_(2)Te_(3) electrodeposition moisture permeability electromagnetic interference shielding

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Model moisture transport in oil-paper insulation of transformer:Theory and experiment

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High Voltage 2024年第4期9卷 879-887页

作者： junjie Zhou Zhicheng Wu Yiran Guo Rui Zhang Wenbing Zhu Qiaogen Zhang State Key Laboratory of Electric Insulation and Power Equipment Xi'an Jiaotong UniversityXi'anChina State Grid Shandong Electric Power Research Institute JinanChina

The insulation performance of oil paper insulation is significantly affected by moisture such that monitoring moisture content is ***,it is difficult to obtain the moisture content accurately due to its dynamic change under multi physical *** the moisture transportation in oil paper insulation under multi physical fields becomes a vital method in solving the problem.A multi physical model describing moisture migration was proposed,which considered the effects of temperature on moisture in different existing states in oil-immersed paper(OIP).The temperature distribution formed a vapour pressure gradient to drive moisture migration and affected migration ***,experiments and simulations of moisture migration were performed,which showed that the experiments were in good agreement with *** results revealed that the temperature gradient caused uneven moisture distribution and the increased temperature reduced OIP moisture *** established model could fully characterise moisture migration under temperature gradient,which provided a theoretical reference for predicting the risk of partial dampness and evaluating insulation performance.

关键词： moisture insulation distribution

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High spectral efficiency 4-mode 400-km transmission using hybrid probabilistically and geometrically shaped 128QAM

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Science China(Technological Sciences) 2024年第5期67卷 1628-1630页

作者： DING junjie YU JianJun WANG Chen LONG JianYu ZHU Min ZHANG Jiao Pervasive Communication Research Center Purple Mountain LaboratoriesNanjing 211111China Key Laboratory for Information Science of Electromagnetic Waves(MoE) Fudan UniversityShanghai 200433China

Wavelength division multiplexing(WDM)and space division multiplexing(SDM)based on few-mode fiber(FMF)and multi-core fiber(MCF)have been vigorously developed to increase the transmission capacity of optical communication networks[1–5].However,the mode crosstalk generated in the mode division multiplexing(MDM)system causes the correlation between different mode signals,which seriously damages the transmission ***,an effective multiple-input-multiple-output(MIMO)time domain or frequency domain equalizer should be used to eliminate the crosstalk between different mode signals.

关键词： crosstalk fiber multiplexing

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多元复合地基沉降计算方法探讨

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华中科技大学学报（自然科学版） 2007年第12期35卷 87-90页

作者：郑俊杰高学伸王仙芝华中科技大学土木工程与力学学院控制结构湖北省重点实验室湖北武汉430074 华华中科技大学土木工程与力学学院控制结构湖北省重点实验室湖北武汉430074

以Winkler分布弹簧模拟垫层的作用,考虑垫层、桩和土之间的相互作用;并以Geddes解和Boussinesq解为依据,求出了在单位荷载下网格单元顶部的沉降,即单元的柔度系数;运用弹性理论叠加原理,建立了包括桩顶沉降、土顶沉降及其对应荷载的线... 详细信息

以Winkler分布弹簧模拟垫层的作用,考虑垫层、桩和土之间的相互作用;并以Geddes解和Boussinesq解为依据,求出了在单位荷载下网格单元顶部的沉降,即单元的柔度系数;运用弹性理论叠加原理,建立了包括桩顶沉降、土顶沉降及其对应荷载的线性方程组.求解该方程可以进一步求出多元复合地基中主桩、次桩对土的桩土应力比和主桩、次桩及土的荷载分担比.通过工程实例进行分析,表明本文方法的计算结果和现场实测结果符合很好.

关键词：多元复合地基相互作用地基沉降桩土应力比分层地基模型

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Demagnetization Analysis and Velocity Tracking Control of In-wheel Motor

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Journal of Harbin Institute of Technology(New Series) 2024年第2期31卷 1-11页

作者： Haihong Li junjie Chen Zhiqi Liu School of Mechanical Engineering Taiyuan University of Science and TechnologyTaiyuan Shanxi 030024China

The error caused by irreversible demagnetization damages the accurate velocity tracking of an in-wheel motor in a mobile robot.A current feedforward vector control system based on ESO is proposed to compensate it for the demagnetization motor.A demagnetization mathematical model is established to describe a permanent magnet synchronous motor,which took the change of permanent magnet flux linkage parameters as a factor to count the demagnetization error in velocity *** uncertain disturbance estimation model of the control system is built based on ESO,which eliminates the system error by the feedforward current *** is compared with the vector control method in terms of control *** simulation results show that the current feedforward vector control method based on ESO reduces the velocity tracking error greatly in conditions of motor demagnetization less than 30%.It is effective to improve the operation accuracy of the mobile robot.

关键词： mobile robot velocity tracking disturbance estimation vector control

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