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How to manage the malposition of deep vein catheterization into the artery?

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Journal of Geriatric Cardiology 2024年第6期21卷 682-685页

作者： Jun-Na SUN hai dong Peng CHEN Zi-Qi LI Li-You SUI Bin QI Quan-Min JING Department of Cardiovascular Diseases the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouChina Department of Cardiology General Hospital of Northern Theater CommandShenyangChina

Central venous catheterization establishes temporary,efficient,and rapid use of deep venous access in patients,which provides high flow rate fluid perfusion,enables measurement of central venous pressure,and acts as an important reference for clinical ***,various complications such as pneumothorax,hemothorax,hematoma,and puncture failure can easily occur during the puncture and catheterization process.

关键词： process enable catheter

cNPAS2 inducedβcell dysfunction by regulating KANK1 expression in type 2 diabetes

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World Journal of Diabetes 2024年第9期15卷 1932-1941页

作者： Yan-Bin Yin Wei Ji Ying-Lan Liu Qian-Hao Gao dong-dong He Shi-Lin Xu Jing-Xin Fan Li-hai Zhang Department of General Surgery The First Affiliated Hospital of Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina Department of Anesthesiology Yantai Affiliated Hospital of Binzhou Medical UniversityYantai 264199Shandong ProvinceChina Operating Room The First Affiliated Hospital of Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina Department of Anesthesiology Huazhong University of Science and Technology Union Jiangbei HospitalWuhan 430100Hubei ProvinceChina Department of Endocrinology The First Affiliated Hospital of Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina

BACKGROUND Diabetes mellitus type 2(T2DM)is formed by defective insulin secretion with the addition of peripheral tissue resistance of insulin *** has been affecting over 400 million people all over the *** To explore the pathogenesis of T2DM and to develop and implement new prevention and treatment strategies for *** Receiver operating characteristic(ROC)curve analysis was used to conduct diagnostic *** expression level of genes was determined by reverse transcription-PCR as well as Western *** proliferation assays were performed by cell counting kit-8(CCK-8)*** last,T2DM mice underwent Roux-en-Y gastric bypass *** We found that NPAS2 was significantly up-regulated in isletβcell apoptosis of *** ROC curve revealed that NPAS2 was capable of accurately diagnosing ***2 overexpression did increase the level of *** addition,the CCK-8 test revealed knocking down NPAS2 and KANK1 increased the proliferation of MIN6 *** last,we found that gastric bypass may treat type 2 diabetes by down-regulating NPAS2 and *** This study demonstrated that NPAS2 inducedβcell dysfunction by regulating KANK1 expression in type 2 diabetes,and it may be an underlying therapy target of T2DM.

关键词： Diabetes mellitus type 2 KANK1 NPAS2 Gastric bypass

Stable operation of highly loaded pure Si-Fe anode under ambient pressure via carboxy silane-directed robust solid electrolyte interphase

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Journal of Energy Chemistry 2024年第7期94卷 568-576页

作者： Guntae Lim dong Guk Kang Hyeon Gyu Lee Yen hai Thi Tran Kihun An Junghyun Choi Kwang Chul Roh Do Youb Kim Seung-Wan Song Department of Chemical Engineering&Applied Chemistry Chungnam National University Daejeon 34134Republic of Korea Energy Storage Materials Center Korea Institute of Ceramic Engineering&TechnologyJinju 52851Republic of Korea Advanced Energy Materials Research Center Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea

Incorporation of higher content Si anode material beyond 5 wt% to Li-ion batteries(LIBs)is challenging,owing to large volume change,swelling,and solid electrolyte interphase(SEI)instability ***,a strategy of diacetoxydimethylsilane(DAMS)additive-directed SEI stabilization is proposed for a stable operation of Si-0.33FeSi_(2)(named as Si-Fe)anode without graphite,which provides siloxane inorganics and organics enrichment that compensate insufficient passivation of fluoroethylene carbonate(FEC)additive and reduce a dependence on *** stable cycling performance of highly loaded(3.5 mA h cm^(-2))pure Si-Fe anode is achieved with 2 wt%DAMS combined with 9 wt%FEC additives under ambient pressure,yielding high capacity 1270 mA h g^(-1)at 0.5 C and significantly improved capacity retention of 81% after 100 cycles,whereas short circuit and rapid capacity fade occur with FEC only ***-directed robust SEI layer dramatically suppresses swelling and particles crossover through separator,and therefore prevents short circuit,demonstrating a possible operation of pure Si or Sidominant anodes in the next-generation high-energy-density and safe LIBs.

关键词： High-energy Li-ion battery Pure Si-Fe anode without graphite Silane additive SEI layer Suppressed swelling

Transient diabetes mellitus with ABCC8 variant successfully treated with sulfonylurea:Two case reports and review of literature

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World Journal of Diabetes 2024年第8期15卷 1811-1819页

作者： Ling-Hua Shen Yan Cui dong-Xia Fu Wei Yang Sheng-Nan Wu Hui-Zhen Wang hai-Hua Yang Yong-Xing Chen hai-Yan Wei Department of Endocrinology and Metabolism Henan Key Laboratory of Children's Genetics and Metabolic DiseasesChildren's Hospital Affiliated to Zhengzhou UniversityHenan Children's Hospital Zhengzhou Children's HospitalZhengzhou 450018Henan ProvinceChina

BACKGROUND Transient neonatal diabetes mellitus(TNDM)is a rare form of diabetes mellitus that usually presents within the first 6 mo of *** often enter remission within several months,although relapse can occur later in *** in the ABCC8 gene,which encodes the sulfonylurea receptor 1 of the ATP-sensitive potassium channel in pancreatic beta cells,are associated with TNDM and permanent neonatal *** study describes a novel de novo c.3880C>T heterozygous ABCC8 variant that causes TNDM and can be treated with sulfonylurea *** SUMMARY We retrospectively analyzed 2 Chinese patients with TNDM who were diagnosed,treated,or referred for follow-up between September 2017 and September *** patients were tested for mutations using targeted next-generation *** with neonatal diabetes mellitus caused by a c.3880C>T heterozygous missense variant in the ABCC8 gene have not been reported *** children had an onset of post-infectious diabetic ketoacidosis,which is worth *** a follow-up visit after discontinuing insulin injection,oral glyburide was found to be effective with no adverse *** Early genetic testing of neonatal diabetes mellitus aids in accurate diagnosis and treatment and helps avoid daily insulin injections that may cause pain.

关键词： Neonatal diabetes mellitus ABCC8 Sulfonylurea receptors 1 KATP channels Sulfonylurea Glyburide Insulinulin Case report

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社会责任纳入企业战略的识别要素研究

软科学 2015年第7期29卷 30-34页

作者：郑海东孙宽莉张音中国石油大学(华东)经济管理学院青岛266580

基于案例研究方法对识别企业是否将CSR纳入企业战略的问题进行了探讨。研究发现:可以从3个维度13个要素来判断CSR纳入企业战略的情况:期望契合度,即企业承担CSR是否满足了客户、员工、政府、社区及竞争伙伴等关键利益相关者的期望;战略... 详细信息

基于案例研究方法对识别企业是否将CSR纳入企业战略的问题进行了探讨。研究发现:可以从3个维度13个要素来判断CSR纳入企业战略的情况:期望契合度,即企业承担CSR是否满足了客户、员工、政府、社区及竞争伙伴等关键利益相关者的期望;战略写入度,即企业是否通过相应的机制将CSR纳入企业战略;业务关联度,即在业务执行上企业是否将CSR与业务紧密结合。

关键词：企业社会责任企业战略识别要素案例研究

Novel magnetic compression technique for the treatment of postoperative anastomotic stenosis in rectal cancer:A case report

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1926-1932页

作者： Miao-Miao Zhang Huan-Chen Sha hai-Rong Xue Yuan-Fa Qin Xiao-Gang Song Yun Li Yu Li zheng-Wu Deng Yu-Lin Gao Fang-Fang dong Yi Lyu Xiao-Peng Yan Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Shaanxi Provincial Key Laboratory of Magnetic Medicine The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of National Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina

BACKGROUND The treatment of postoperative anastomotic stenosis after excision of rectal cancer is *** balloon dilation and radial incision are not effective in all *** present a new endoscopy-assisted magnetic compression technique(MCT)for the treatment of rectal anastomotic *** successfully applied this MCT to a patient who developed an anastomotic stricture after radical resection of rectal cancer.A 50-year-old man had undergone laparoscopic radical rectal cancer surgery at a local hospital 5 months ago.A colonoscopy performed 2 months ago indicated that the rectal anastomosis was narrow due to which ileostomy closure could not be *** patient came to the Magnetic Surgery Clinic of the First Affiliated Hospital of Xi'an Jiaotong University after learning that we had successfully treated patients with colorectal stenosis using *** performed endoscopy-assisted magnetic compression surgery for rectal *** magnets were removed 16 d later.A follow-up colonoscopy performed after 4 months showed good anastomotic patency,following which,ileostomy closure surgery was *** MCT is a simple,non-invasive technique for the treatment of anastomotic stricture after radical resection of rectal *** technique can be widely used in clinical settings.

关键词： Rectal cancer Magnetic compression technique Magnetosurgery Anastomotic stricture Magnetic surgery clinic Case report

New First-line Immunotherapy-based Therapies for Unresectable Hepatocellular Carcinoma: A Living Network Meta-analysis

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 15-24页

作者： Jian-Jian Chen Zhi-Cheng Jin Biao Luo Yu-Qing Wang Rui Li hai-dong Zhu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjingJiangsuChina

Background and Aims:Several first-line immune checkpoint inhibitor(ICI)-based combination therapies have been identified for unresectable hepatocellular carcinoma(uHCC).This network meta-analysis(NMA)aimed to provide the most updated evidence about the preferred first-line ICI-based regimens for ***:A comprehensive literature search was performed in various databases from database inception to May *** phase 3 trials evaluating first-line single-agent ICIs,molecular-target agents(MTAs),or their combinations in uHCC were *** main endpoints were overall survival(OS)and progression-free survival(PFS).Pooled effect estimates were calculated using a random effects model within the frequentist *** analyses based on etiology were also ***:Twelve trials at low risk of bias with 8,275 patients comparing 13 treatments were *** with atezolizumab plus bevacizumab was comparable to sintilimab plus IBI305[hazard ratio(HR):1.16;95%confidence interval(CI):0.80–1.68]and camrelizumab plus apatinib(HR:1.06;95%CI:0.75–1.51).The combination therapies,apart from atezolizumab plus cabozantinib in OS and durvalumab plus tremelimumab in PFS,had higher P-score than single-agent MTAs or *** survival benefits were associated with a high risk of adverse events leading to treatment *** proportion of patients with hepatitis B virus-related HCC receiving ICIs combinations might positively correlate with survival advantages(R2=0.8039,p=0.0155).Conclusion:This NMA demonstrated that atezolizumab plus bevacizumab remains the stand of care and confers comparable survival benefits to sintilimab plus IBI305 and camrelizumab plus apatinib in first-line therapy for *** optimal treatment algorithms should consider efficacy,safety,and etiology.

关键词： Hepatocellular carcinoma Systemic therapy Immunotherapy Molecular targeted therapy Tyrosine protein kinase inhibitors Overall survival

政府干预与地方国有企业市场竞争力--基于现金持有竞争效应视角

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经济与管理研究 2013年第8期34卷 28-38页

作者：王勇刘志远郑海东中国石油大学(华东)经济管理学院南开大学商学院

本文基于现金持有竞争效应的视角,理论剖析和实证考察地方国有企业是否具有市场竞争实力及其政府干预的影响。研究结果发现,地方国有企业现金持有具有显著的竞争效应,且仅存在于受到政府干预较弱的地方国有企业中,表明了政府过度干预会... 详细信息

本文基于现金持有竞争效应的视角,理论剖析和实证考察地方国有企业是否具有市场竞争实力及其政府干预的影响。研究结果发现,地方国有企业现金持有具有显著的竞争效应,且仅存在于受到政府干预较弱的地方国有企业中,表明了政府过度干预会弱化企业市场竞争力。进一步研究表明,政府过度干预异化了企业现金资源的用途,使企业的税费负担和非生产性支出增加,进而弱化了其现金持有竞争效应。

关键词：地方国有企业市场竞争力现金持有竞争效应政府干预

战略视角下石油公司社会责任评价框架构造与验证

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中国人口·资源与环境 2013年第5期23卷 71-76页

作者：王芳何松彪郑海东中国石油大学(华东)经济管理学院山东青岛266555 中央财经大学会计学院北京100081 中央财经大学商学院北京100081

企业社会责任是持续的热点议题。当前企业对社会责任的披露多基于形象宣传的目的,评价指标选取存在目的性与片面性,降低了企业社会责任的执行力。石油企业是关乎国民经济和国家安全的特大型国有企业,其社会责任履行的效果直接影响到国... 详细信息

企业社会责任是持续的热点议题。当前企业对社会责任的披露多基于形象宣传的目的,评价指标选取存在目的性与片面性,降低了企业社会责任的执行力。石油企业是关乎国民经济和国家安全的特大型国有企业,其社会责任履行的效果直接影响到国家的利益和社会的和谐发展。本文论证了公司战略视角构建石油公司社会责任框架的理论依据,提出了石油公司社会责任框架设计的基本原则,并从政府责任(股东责任)、社区责任、员工责任、消费者责任和生态环境责任五个维度优选了38项测评指标构建石油企业社会责任框架。在此框架下,文章收集了我国石油公司的相关数据,利用熵权和TOPSIS方法对石油公司的社会责任履行状况进行了评价。评价结果显示,基于战略视角构建的社会责任评价框架体系能够将石油公司战略使命和企业社会责任有效关联,能够突出企业经营中必须肩负的社会责任,且能够反映石油公司社会责任绩效在行业中的位次。

关键词：石油公司社会责任公司战略可持续发展 TOPSIS