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DAMAGE MECHANICS FINITE ELEMENT METHOD FOR PREDICTION OF TOTAL FATIGUE LIVES OF METAL STRUCTURE MEMBERS

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Chinese Journal of Aeronautics 1992年第4期 223-233页

作者： zheng xu-dong,Zhang Xing(Beijing University of Aeronautics and Astronautics,Beijing China)

Damage mechanics method is applied to studying fatigue problems of metallic *** governing equations of stress-damage field and finiteelement-additional loading method are ***,formulas of predictingfatigue crack formation and propagation lives of structural members are derived withdamage increment as step *** lives of typical notched plates with various geometricalparameters,made of 2024 and 7075 are *** results show that the agreementbetween theoretical S — N curves and experimental ones is very *** methodrequires short CPU time and can be applied to engineering practice.

关键词： TOTAL DAMAGE MECHANICS FINITE ELEMENT METHOD FOR PREDICTION OF TOTAL FATIGUE LIVES OF METAL STRUCTURE MEMBERS NACA

Standardized processes of biomass briquetting densification fuel

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Forestry Studies in China 2012年第1期14卷 80-84页

作者： ZHAO Fang ZHANG Ya-zhuo xu zheng-dong LI Li ZHANG Shuang-bao College of Materials Science and Technology Beijing Forestry University Beijing 100083 P. R. China

Forest biomass resources are available in enormous quantities in China. The development of forest biomass briquetting densification fuel, which has a high calorific value, can ease the energy shortage in China. But the molding technology is still at the primary stage with many questions unresolved, such as unequal distribution of resources, imperfect technology and an inadequate mechanism of market supply and demand. There are no consistent production and quality standards to refer to, which seriously hinder the industrialization of biomass molding technology. Hence, it is imperative to speed up the formulation of production standards of biomass briquetting densification fuel which not only conform to international standards, but are in accordance with national condi- tions in China. Drawing on the standards of biomass briquetting densification fuel in Europe, a standard system should be concerned with raw material collection, transport and storage of the end products, terminology, denomination and classification of molding equipment, as well as with technical conditions, testing methods, safety and environmental protection. The establishment of a stan- dard system is useful for the development of a healthy, orderly and sustainable biomass fuel industry.

关键词： biomass briquetting densification fuel standardized process

State of research and trends in development of wood adhesives

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Forestry Studies in China 2011年第4期13卷 321-326页

作者： ZHAO Lei-feng LIU Yu xu zheng-dong ZHANG Ya-zhuo ZHAO Fang ZHANG Shuang-bao College of Materials Science and Technology Beijing Forestry University Beijing 100083 P. R. China

We aim to present an overview of the status of adhesives in the wood industry, especially in the area of wood-based panels. The review summarizes the current state of research of two kinds of adhesives, i.e., synthetic adhesives and natural adhesives. Synthetic adhesives, consisting of urea-formaldehyde resins （UF）, phenol-formaldehyde resins （PF）, polyvinyl acetate emulsion （PVAc） and isocyanates, are widely used. For UF, most investigations are concerned with the reduction of free formaldehyde; for PF, most studies focus on finding new chemicals to replace phenol. PVAc has poor properties, but these can be improved by a blending reactions and copolymerization with other chemicals. Isocyanate is an environmentally friendly synthetic adhesive, but also suffers from inadequate properties. Natural adhesives, such as protein/starch, lignin and tannins, have poor bonding effect that limits their level of use, but their main advantages are that they are environmentally friendly and a renewable resource. Studies of modification can improve the bonding performances and gradually cause natural adhesives to become applied in industrial production. Some proposals for future development and the importance of environmentally friendly adhesives are provided, which will be helpful in future theoretical and experimental research.

关键词： synthetic adhesives natural adhesives main features development trend

Pyroptosis,ferroptosis,and autophagy in spinal cord injury:regulatory mechanisms and therapeutic targets

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Neural Regeneration Research 2025年第10期20卷 2787-2806页

作者： Qingcong zheng Du Wang Rongjie Lin Weihong xu Department of Spinal Surgery the First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Arthritis Clinical and Research Center Peking University People’s HospitalBeijingChina Department of Orthopedic Surgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Regulated cell death is a form of cell death that is actively controlled by *** studies have shown that regulated cell death plays a key role after spinal cord *** and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal ***,a complex form of cell death that is interconnected with various regulated cell death mechanisms,has garnered significant attention in the study of spinal cord *** injury triggers not only cell death but also cellular survival *** signaling pathways play pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury by regulating pyroptosis,ferroptosis,and ***,this review aims to comprehensively examine the mechanisms underlying regulated cell deaths,the signaling pathways that modulate these mechanisms,and the potential therapeutic targets for spinal cord *** analysis suggests that targeting the common regulatory signaling pathways of different regulated cell deaths could be a promising strategy to promote cell survival and enhance the repair of spinal cord ***,a holistic approach that incorporates multiple regulated cell deaths and their regulatory pathways presents a promising multi-target therapeutic strategy for the management of spinal cord injury.

关键词： autophagy cell death ferroptosis inflammation pathological mechanisms pyroptosis regulated cell death regulatory pathways spinal cord injury therapeutic targets

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新兴煤矿较软围岩中大断面硐室施工技术

煤炭科学技术 2007年第7期35卷 41-43页

作者：许正东龙煤矿业集团有限责任公司鹤岗分公司新兴煤矿黑龙江鹤岗154105

软岩、煤岩互层、断层带以及硐室群中施工特大断面硐室,采用锚索、锚杆、钢筋梯、钢筋网,联合支护方式,成功取代了以往采用的被动支护的砌碹支护,架棚支护工艺,为在破碎、煤岩断层中施工大断面硐室,总结摸索出一条成功的经验。

关键词：特大断面硐室锚杆锚索钢筋梯钢筋网联合支护

重拾能倾处理交互,超越媒体比较研究——能倾处理交互对教育技术研究之意义与价值的新解读

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现代教育技术 2014年第5期24卷 12-18页

作者：郑旭东华中师范大学教育信息技术学院湖北武汉430079

对技术与教育相互作用之机制的破解是利用技术促进教育的基础和前提。该文认为,能倾处理交互正是一个致力于揭示技术与教育相互作用机制的研究框架。在对历史的追索中发现,能倾处理交互源于实验心理学和相关性心理学这两种不同研究路向... 详细信息

对技术与教育相互作用之机制的破解是利用技术促进教育的基础和前提。该文认为,能倾处理交互正是一个致力于揭示技术与教育相互作用机制的研究框架。在对历史的追索中发现,能倾处理交互源于实验心理学和相关性心理学这两种不同研究路向的聚合,突破了对教育的一维性概念化理解。该文从教育技术学的视角出发,在对能倾处理交互的基本假设及其研究进展的历史与逻辑进行考察的基础上,认为能倾处理交互这一理论框架在科学层面上极大推进了对个别化教学的探索,并帮助教育技术超越了媒体比较的研究框架,走出了寻求"超级媒体"的理论迷局,开辟了学习、媒体与认知交互机制研究的新天地,对今天我们面对层出不穷之新媒体如何避免重蹈媒体比较研究的覆辙,把焦点集中于媒体如何促进学习的研究具有重要价值。

关键词：能倾处理交互媒体比较研究程序教学个体差异个别化教学

培育反思性实践者:博物馆教育工作者专业发展的现实与未来

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现代教育技术 2015年第7期25卷 5-11页

作者：郑旭东华中师范大学教育信息技术学院湖北武汉430079

由各种社会历史因素推动的教育的制度变迁与重塑以及博物馆作为一种社会机构的变革与发展,推动着博物馆教育工作者的身份认知、角色定位与实践探索的转变。从博物馆本位的"解说员"到教育本位的"博物馆教育工作者",见证了博物馆教育作为... 详细信息

由各种社会历史因素推动的教育的制度变迁与重塑以及博物馆作为一种社会机构的变革与发展,推动着博物馆教育工作者的身份认知、角色定位与实践探索的转变。从博物馆本位的"解说员"到教育本位的"博物馆教育工作者",见证了博物馆教育作为一种专门职业的持续进步。然而,信息化与全球化合流推动的新一轮社会历史变革又对博物馆教育工作者提出了新的要求与挑战,职业准备不足严重制约着博物馆教育工作者的专业化水平。面对新挑战,博物馆教育工作者的专业发展必须把反思性实践作为新的认识论框架,把实践社团作为促进专业发展的基本途径。只有这样,博物馆教育工作者才能成为在实践中认识、在实践中反思、在认识与反思中实践的反思性实践者,有效应对狂飙突进之社会变革中持续变化的博物馆教育。

关键词：解说员博物馆教育工作者反思性实践者

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从博物馆教育到场馆学习的演进:历史与逻辑

现代教育技术 2015年第2期25卷 5-11页

作者：郑旭东华中师范大学教育信息技术学院湖北武汉430079

该文对博物馆教育功能之发挥的历史演进及其背后的内在逻辑进行了探索,认为现代意义上的公共博物馆及公立学校系统的创建构成了博物馆教育的历史发端,其背后隐藏的是文艺复兴以来的启蒙精神,而响应的则是近代以来教育民主化的呼声。进... 详细信息

该文对博物馆教育功能之发挥的历史演进及其背后的内在逻辑进行了探索,认为现代意义上的公共博物馆及公立学校系统的创建构成了博物馆教育的历史发端,其背后隐藏的是文艺复兴以来的启蒙精神,而响应的则是近代以来教育民主化的呼声。进步教育运动的两大派别——管理进步教育和教学进步教育——在20世纪上半叶极大地推动了博物馆教育的研究与实践,一方面为博物馆教育提供了科学的研究方法,另一方面为博物馆教育确立了价值取向,即提供经验而不是知识。20世纪下半叶,以布鲁纳领导的课程与教学改革运动为代表的教育改革运动推动了博物馆教育向场馆学习的历史转型,而在这场转型背后的逻辑实际上是从"以博物馆为本位"向"以学习为本位"的演进与发展,是对基于赫尔巴特之教育传统的突破,关注与彰显的是学习者所处的主体与中心地位。

关键词：博物馆教育场馆学习进步教育博物馆本位学习本位

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan xu Jie Mu Yu Leng Lei Ma Yu zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions