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Understanding tissue-specificity with human tissue-specific regulatory networks

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Science China(Information Sciences) 2016年第7期59卷 51-60页

作者： Weili GUO Lin ZHU Suping DENG xingming ZHAO Deshuang HUANG College of Electromics and Information Engineering Tongji University

Tissue-specificity is important for the function of human body. However, it is still not clear how the functional diversity of different tissues is achieved. Here we construct gene regulatory networks in 13 human tissues by integrating large-scale transcription factor(TF)-gene regulations with gene and protein expression data. By comparing these regulatory networks, we find many tissue-specific regulations that are important for tissue identity. In particular, the tissue-specific TFs are found to regulate more genes than those expressed in multiple tissues, and the processes regulated by these tissue-specific TFs are closely related to tissue ***, the regulations that are present in certain tissue are found to be enriched in the tissue associated disease genes, and these networks provide the molecular context of disease genes. Therefore, recognizing tissuespecific regulatory networks can help better understand the molecular mechanisms underlying diseases and identify new disease genes.

关键词： tissue-specificity gene regulatory network transcription factor tissue-specific regulation disease gene

Quantum network coding for multi-unicast problem based on 2D and 3D cluster states

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Science China(Information Sciences) 2016年第4期59卷 5-19页

作者： Jing LI Xiubo CHEN xingming SUN Zongpeng LI Yixian YANG Information Security Center State Key Laboratory of Networking and Switching TechnologyBeijing University of Posts and Telecommunications Department of Computer Science University of Calgary School of Computer and Software Nanjing University of Information Science & Technology

We mainly consider quantum multi-unicast problem over directed acyclic network, where each source wishes to transmit an independent message to its target via bottleneck channel. Taking the advantage of global entanglement state 2D and 3D cluster states, these problems can be solved efficiently. At first, a universal scheme for the generation of resource states among distant communication nodes is provided. The corresponding between cluster and bigraph leads to a constant temporal resource cost. Furthermore, a new approach based on stabilizer formalism to analyze the solvability of several underlying quantum multi-unicast networks is presented. It is found that the solvability closely depends on the choice of stabilizer generators for a given cluster state. And then, with the designed measurement basis and parallel measurement on intermediate nodes, we propose optimal protocols for these multi-unicast sessions. Also, the analysis reveals that the resource consumption involving spatial resources, operational resources and temporal resources mostly reach the lower bounds.

关键词： quantum information network coding multi-unicast cluster state stabilizer formalism

Experimental studies on effects of surface morphologies on corona characteristics of conductors subjected to positive DC voltages

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High Voltage 2020年第4期5卷 489-497页

作者： Zhu Jie He Zichen Wu Jiale Bian xingming State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206People's Republic of China

As the surface conditions play a significant role on corona discharge and its related effects of the conductors,the influence of fine particulate matter on positive-polarity,direct-current conductors was studied experimentally in this *** surface morphologies of the conductor could be discovered from the *** typical morphologies are the parallel chains of *** evaluate the surface condition quantitively,the surface roughness of the conductors is *** is found that the applied voltage and testing time have a great influence on the surface *** that,the corona characteristics of conductors are *** reveals that the total ground level electric field and ion flow density increases with the surface roughness growing.

关键词： surface particles roughness

A nonlocal strain gradient shell model incorporating surface effects for vibration analysis of functionally graded cylindrical nanoshells

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Applied Mathematics and Mechanics(English Edition) 2019年第12期40卷 1695-1722页

作者： Lu LU Li ZHU xingming GUO Jianzhong ZHAO Guanzhong LIU Shanghai Institute of Applied Mathematics and Mechanics Shanghai Key Laboratory of Mechanics in Energy Engineering School of Mechanics and Engineering ScienceShanghai UniversityShanghai 200072 China Department of Mechanical Engineering University of Alberta School of Mathematics and Computational Sciences Xiangtan UniversityXiangtan 411105 Hunan Province China

In this pap er, a novel size-dep endent functionally graded (FG) cylindrical shell model is develop ed based on the nonlocal strain gradient theory in conjunction with the Gurtin-Murdoch surface elasticity theory . The new model containing a nonlocal parameter, a material length scale parameter, and several surface elastic constants can capture three typical typ es of size e ects simultaneously , which are the nonlocal stress ef- fect, the strain gradient e ect, and the surface energy e ects. With the help of Hamilton’s principle and rst-order shear deformation theory , the non-classical governing equations and related b oundary conditions are derived. By using the prop osed model, the free vibra- tion problem of FG cylindrical nanoshells with material prop erties varying continuously through the thickness according to a p ower-law distribution is analytically solved, and the closed-form solutions for natural frequencies under various b oundary conditions are obtained. After verifying the reliability of the prop osed model and analytical method by comparing the degenerated results with those available in the literature, the in uences of nonlocal parameter, material length scale parameter, p ower-law index, radius-to-thickness ratio, length-to-radius ratio, and surface e ects on the vibration characteristic of func- tionally graded cylindrical nanoshells are examined in detail.

关键词： nonlocal strain gradient theory surface elasticity theory rst-order shear deformation theory vibration functionally graded (FG) cylindrical nanoshell

Roles of UV light strength and auxiliary electric field in the photocatalytic degradation effect of organic contaminant

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High Voltage 2019年第2期4卷 113-121页

作者： Lin YaoYu Ma YanXiang Bian xingming Sun PengCheng State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206People's Republic of China Department of Materials Science and Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA

The accumulation of contaminants on the electrical devices could adversely affect the *** present work used photocatalytic functional material to coat on the surface of the electrical devices to prevent the influence of organic *** kind of material was mainly composed of TiO_(2)that can remove the contamination by the effect of *** photocatalysis was affected by the strength of UV light and electric *** the experiment,methyl orange(MO)was used as the organic *** effect of UV light and auxiliary electric field were analysed based on the theoretical *** the stronger UV light,more electron-hole pairs were generated,photocatalytic effect became more *** the auxiliary electric field,the recombination of electron and hole could be restrained that would increase the productive rate of hole;therefore,more hydroxyl radical will be produced to degrade MO.

关键词： field auxiliary photocatalytic

Coupling Characteristics and Control of Dual Mechanical Port Machine with Spoke Type Permanent Magnet Arrangement

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Chinese Journal of Mechanical Engineering 2014年第6期27卷 1186-1202页

作者： ZHUANG xingming SONG Qiang WEN Xuhui ZHAO Feng FAN Tao National Engineering Laboratory for Electric Vehicles Beijing Institute of Technology Institute of Electrical Engineering Chinese Academy of Sciences

Dual mechanical port machine（DMPM）, as a novel electromechanical energy conversion device, has attracted widespread attention. DMPM with spoke type permanent magnet arrangements（STPM-DMPM）, which is one of several types of DMPM, has been of interest recently. The unique coupling characteristics of STPM-DMPM are beneficial to improving system performance, but these same characteristics increase the difficulties of control. Now there has been little research about the control of STPM-DMPM, and this has hindered its practical application. Based on a mathematical model of STPM-DMPM, the coupling characteristics and the merits and demerits of such devices are analyzed as applied to a hybrid system. The control strategies for improving the disadvantages and for utilizing the advantage of coupling are researched. In order to weaken the interaction effect of torque outputs in the inner motor and the outer motor that results from coupling in STPM-DMPM, a decoupling control method based on equivalent current control is proposed, and independent torque control for the inner motor and outer motor is achieved. In order to solve address the problem of adequately utilization of coupling, minimizing the overall copper loss of the inner motor and the outer motor of STPM-DMPM is taken as the optimization objective for optimal control, and the purpose of utilizing the coupling adequately and reasonably is achieved. The verification tests of the proposed decoupling control and optimal control strategies are carried out on a prototype STPM-DMPM, and the experimental results show that the interaction effect of torque outputs in the inner motor and the outer motor can be markedly weakened through use of the control method. The overall copper loss of the inner motor and the outer motor can be markedly reduced through use of the optimal control method, while the power output remains unchanged. A breakthrough in the control problem of STPM-DMPM is accomplished by combining the control method

关键词： dual mechanical port machine spoke type permanent magnet arrangement coupling characteristics decoupling control optimal control

The Little Stonemason

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China Book International 2024年第3期 20-21页

作者： zheng Yan Li xingming Peking University School of Arts

This book tells the story of a little stonemason who followed his master to Datong,Shanxi,to carve the Yungang Grottoes,showing readers how the Yungang Grottoes came into being,the integration of ethnic groups during the Northern Wei Dynasty,and the changes in artistic style of Buddhist *** details of the illustrations have been strictly verified by historical researchers and through the illustrator's fieldwork,and are supported by the latest research results of Yungang studies and archaeological findings.

关键词： details illustration verified

Accuracy enhancement of the spherical actuator with a two-level geometric calibration method

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Chinese Journal of Aeronautics 2014年第2期27卷 328-337页

作者： Zhang Liang Chen Weihai Liu Jingmeng Wu xingming Chen I-Ming School of Automation Science and Electrical Engineering Beihang University School of Mechanical and Aerospace Engineering Nanyang Technological University

This paper presents a two-level geometric calibration method for the permanent magnet （PM） spherical actuator to improve its motion control accuracy. The proposed actuator is com- posed of a stator with circumferential coils and a rotor with multiple PM poles. Due to the assembly and fabrication errors, the real geometric parameters of the actuator will deviate from their design values. Hence, the identification of such errors is critical for the motion control tasks. A two-level geometric calibration approach is proposed to identify such errors. In the first level, the calibration model is formulated based on the differential form of the kinematic equation, which is to identify the geometric errors in the spherical joint. In the second level, the calibration model is formulated based on the differential form of torque formula, which is to calibrate the geometric parameters of the magnetization axes of PM poles and coils axes. To demonstrate the robustness and availability of the calibration algorithm, simulations are conducted. The results have shown that the proposed two-level calibration method can effectively compensate the geometric parameter errors and improve the positioning accuracy of the spherical actuator.

关键词： ACtuators Geometric calibration Parameter identification PositiOning accuracy Spherical actuator

Is one-line hybrid rice coming?

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Journal of Integrative Plant Biology 2019年第8期61卷 908-910页

作者： xingming Hu Fanmiao Wang Makoto Matsuoka Bioscience and Biotechnology Center Nagoya UniversityNagoya 464-8601Japan State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhou 310006China

Asian cultivated rice is one of the most important cereal crops and feeds half of the world’s population,especially in eastern and southeastern Asian countries(Virmani 2012).It is estimated that about 20%or more increase in rice production would be likely needed in the next 20 years due to the growing population and environmental changes(Virmani 2012).

关键词： cereal crops rice southeastern