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Biomedical and Environmental Sciences 2021年第4期34卷 314-318页

作者： PANG Xiu Hong zheng xiao yong LIN Yun zheng Hao XU Jun LIU Dong JIN Chun Yan ZHANG Lu Ping ZHANG Yu Ting CHU Jiu Sheng CHAI yong Chuan YANG Tao Department of Otolaryngology-Head and Neck Surgery Taizhou People's Hospitalthe Fifth Affiliated Hospital of Nantong University&Clinical Hospital of Dalian Medical UniversityTaizhou 225300JiangsuChina Department of Dermatology Taizhou People's Hospitalthe Fifth Affiliated Hospital of Nantong UniversityTaizhou 225300JiangsuChina Department of Otolaryngology-Head and Neck Surgery the Ninth People's HospitalShanghai Jiaotong University School of MedicineShanghai 200011China Ear Institute Shanghai Jiaotong University School of MedicineShanghai 200011China Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases Shanghai 200011China Department of Clinical Medicine Medical School of Nantong UniversityNantong 226000JiangsuChina Life scientific School Neuroregenerative Key Laboratory of Jiangsu and Ministry of EducationNeuroregenerative Co-innovation CenterNantong UniversityNantong 226000JiangsuChina Department of Medical Genetics Taizhou People's Hospitalthe Fifth Affiliated Hospital of Nantong UniversityTaizhou 225300JiangsuChina Department of Otolaryngology-Head and Neck Surgery Affiliated Hospital of Nantong UniversityNantong 226000JiangsuChina

SIX1(OMIM 601205),as a member of the SIX homeobox transcription factor family,belongs to homologs of the Drosophila‘sine oculis’gene that expresses primarily in the developing visual system of the *** SIX family includes six members(SIX1–SIX6),which share a homologous DNA-binding homeodomain(HD)and a highly conserved protein–protein interacting SIX domain(SD)[1].

关键词： SIX1 homeobox belongs

知识网络中心势越高，越有产品创新能力吗？——基于商业集团成员企业间知识网络的研究

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研究与发展管理 2019年第6期31卷 104-114页

作者：郑小勇浙江师范大学经济与管理学院

基于整体网结构模型探索了商业集团成员企业间知识网络中心势与集团产品创新能力的关系。研究发现,成员企业间的市场知识网络中心势提高会对集团产品创新能力产生不利影响,产业多元化对上述关系具有正向调节作用,即对于多元化程度越高... 详细信息

基于整体网结构模型探索了商业集团成员企业间知识网络中心势与集团产品创新能力的关系。研究发现,成员企业间的市场知识网络中心势提高会对集团产品创新能力产生不利影响,产业多元化对上述关系具有正向调节作用,即对于多元化程度越高的商业集团而言,市场知识网络中心势对产品创新能力的不利影响会越明显。成员企业间的技术知识网络中心势与集团产品创新能力的关系呈倒U形,且产业多元化对上述关系有显著的负向调节作用,即对于多元化程度越低的商业集团而言,成员间技术知识网络中心势对集团产品创新能力的倒U形影响关系越明显。研究表明,只有成员间技术知识网络中心势适度的商业集团才会有较为理想的产品创新力,多元化程度低的商业集团更是如此。

关键词：商业集团知识网络中心势产业多元化产品创新能力

基于二次场的可控源电磁法三维有限元-无限元数值模拟

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地球物理学报 2017年第9期60卷 3655-3666页

作者：张林成汤井田任政勇肖晓中南大学地球科学与信息物理学院长沙410083 有色金属成矿预测与地质环境监测教育部重点实验室长沙410083

本文提出了一种新的混合有限元-无限元三维可控源电磁法(CSEM)问题快速高精度正演模拟算法.首先从电场双旋度方程出发,推导了水平电偶极子源的二次场边值问题,采用无限元代替截断边界条件和有限元离散内部计算区域的新策略,达到减小计... 详细信息

本文提出了一种新的混合有限元-无限元三维可控源电磁法(CSEM)问题快速高精度正演模拟算法.首先从电场双旋度方程出发,推导了水平电偶极子源的二次场边值问题,采用无限元代替截断边界条件和有限元离散内部计算区域的新策略,达到减小计算区域的目的,基于并行直接求解技术,实现多源CSEM问题的快速精确求解.其次,通过层状解析模型测试,一方面验证了新算法的正确性,另一方面通过与其他三种已知CSEM问题求解策略进行对比,表明了本文提出的基于二次场有限元-无限元算法具有离散区域小、求解速度快和计算精度高等优点.最后,通过3D模型计算,清晰直观地模拟了场源阴影效应,为野外数据的处理与解释提供指导.

关键词：边界条件有限元-无限元并行求解器场源阴影效应

商业集团从属企业双重合法性与成长绩效的关联机制

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管理工程学报 2016年第2期30卷 9-19页

作者：郑小勇魏江浙江师范大学浙江金华321004 浙江大学管理学院浙江杭州310058

商业集团从属企业具有成员企业和独立法人双重身份,其合法性也具有双重属性。由此,本文提出并界定了从属企业的双重合法性概念,并探讨了双重合法性对从属企业成长绩效的影响及其作用机制。研究发现从属企业的成员合法性和社会合法性对... 详细信息

商业集团从属企业具有成员企业和独立法人双重身份,其合法性也具有双重属性。由此,本文提出并界定了从属企业的双重合法性概念,并探讨了双重合法性对从属企业成长绩效的影响及其作用机制。研究发现从属企业的成员合法性和社会合法性对其成长绩效有显著影响,并且两者交互会对成长绩效形成协同影响。从作用机制上看:(1)成员合法性主要通过影响从属企业内部资源获取进而影响成长绩效;(2)成员合法性还对从属企业外部资源获取水平有显著影响,并经由外部资源获取的中介影响其成长绩效;(3)社会合法性则主要通过影响从属企业外部资源获取进而影响其成长绩效。

关键词：商业集团从属企业双重合法性资源获取成长绩效

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商业集团从属企业合法性双元与成长绩效关系

管理科学学报 2015年第6期18卷 1-14页

作者：郑小勇魏江浙江师范大学金华321004 浙江大学杭州310058

根据商业集团从属企业双重身份的特点,分析了其合法性的双元属性,并提出了合法性双元的概念.在此基础上,文章将合法性双元解构为平衡和联合两个维度,分别分析了两者与从属企业成长绩效之间的关系,以及他们对从属企业成长产生作用的内在... 详细信息

根据商业集团从属企业双重身份的特点,分析了其合法性的双元属性,并提出了合法性双元的概念.在此基础上,文章将合法性双元解构为平衡和联合两个维度,分别分析了两者与从属企业成长绩效之间的关系,以及他们对从属企业成长产生作用的内在机理.实证结果表明资源获取对联合维度与从属企业成长绩效的关系具有显著的中介作用,而平衡维度与成长绩效的关系未得到实证支持.文章还进一步探讨了对合法性双元与从属企业资源获取关系的调节性因素,实证结果表明环境不确定性正向调节联合维度与资源获取的关系,而对平衡维度与资源获取的关系具有反向调节作用;环境包容性反向调节联合维度与资源获取的关系,而对平衡维度与资源获取的关系具有正向调节作用.

关键词：商业集团从属企业合法性双元资源获取成长绩效

A novel flexible endoscope-based transumbilical fenestration of liver cyst

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Chinese Medical Journal 2008年第23期121卷 2461-2462页

作者： CAI Xiu-jun DAI Yi WANG Jian-guo YU Hong LIANG xiao zheng Xue-yong WANG Yi-fan Department of General Surgery Sir Run Run Shaw Hospital Affiliated with School of Medicine Zhejiang University Hangzhou Zhejiang 310016 China

Laparoscopic procedure as a minimally invasive surgery had been introduced into many abdominal surgery. Smaller incisions of the abdominal wall reduce postoperative pain and the risk of wound complications, and provide an excellent cosmetic result compared with open surgery. Flexible endoscope-based transgastric, transcolonic, or transvaginal surgery for abdominal exploration, cholecystectomy, appendectomy, and tubal ligation may further reduce the surgical invasion.

关键词： liver cyst fenestration flexible endoscope, transumbilical

Identification of Heat Tolerance Linked Molecular Markers of Chinese Cabbage(Brassica campestris ***)

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Agricultural Sciences in China 2002年第7期1卷 786-791页

作者： zheng xiao-ying, WANG yong-jian, SONG Shun-hua, LI Li and YU Shuan-cang(Beijing Vegetable Research Center, Beijing 100089 , P.R. China) Beijing Vegetable Research Center Beijing 100089 P.R. China

Genetically stable population of recombination inbred line (RIL) was derived from a cross between a heat tolerant line 177 and a heat sensitive line 276 of Chinese cabbage (Brassica campestris L. ssp. pekinensis) by single seed descent. The RILs were analyzed using isozyme, RAPD and AFLP techniques in order to find molecular markers that are linked to heat tolerance quantitative trait loci (QTL). The results of variance analysis of single factor indicated that there were 9 molecular markers closely linked with heat tolerance QTL, including 5 AFLP markers, 3 RAPD markers and 1 PGM isozyme marker. Total genetic contribution of these makers to heat tolerance was 46.7%. Five of the nine markers distributed in one linkage group, the remaining 4 markers were located in separate groups. Thus the 9 heat tolerance linked markers distributed in 5 independent locations in the genome of Chinese cabbage.

关键词： Chinese cabbage Heat tolerance AFLP RAPD Isozyme molecular marker

Two tyrosines in CD3ε-ITAM are required to induce T lymphocyte apoptosis

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Chinese Science Bulletin 1998年第17期43卷 1480-1485页

作者： zheng Dexian 1,2, HE Yiping+1, LIU Yanxin+1, zheng yong,xiao Sheng+1, LIU Yin+1 and LIU Shilian+1 1. State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Beijing China State Key Laboratory of Experimental Hematology Institute of Hematology Chinese Academy of Medical Sciences and Peking Union Medical College Tinjin China

CD3ε of T cell antigen receptor complex (TCR/CD3) plays an important role in the resembling of the complex and activation signaling through its conservative immunoreceptor tyrosine-based activation motif (ITAM) in the cytoplasmic tail. Previous study showed that a chimera molecule, consisting of the extracellular-transmembrane domain of human CD8α fused to the cytoplasmic domain of CD3ε, induced apoptosis of T lymphocytes, indicating that apoptotic signals were transduced through the CD3ε- ITAM. To elineate involvement of the two tyrosines in apoptotic signaling pathway, cDNAs with mutations at Y170F, Y181F and Y170F/Y181F in CD8-ε-ITAM were made by point mutation and PCR, and then cloned into pcDNA3 eukaryotic expression vectors. Stable expression cell lines were established after transfection of the expression vectors into CD8+- Jurkat T lymphocytes. Stimulation of these cell lines with anti-CD8 monoclonal antibody showed that only the cells with expression of wild type chimera CD8-ε died by apoptosis, but not those cells with expressions of mutated CD8-ε chimera, indicating that the two tyrosines in CD3ε-ITAM were required for the apoptotic signal transduction in T lymphocytes.

关键词： apoptosis CD3ε-ITAM tyrosine.

科研团队创新绩效的影响因素及其作用机理研究

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科学学研究 2009年第9期27卷 1428-1438页

作者：郑小勇楼鞅浙江大学管理学院浙江杭州310058 第一创业证券有限责任公司上海518028

在团队绩效相关研究的基础上开展团队创新绩效的研究,从创新有效性和创新效率两个维度来架构团队创新绩效,探索了团队个人因素、团队结构因素和团队环境因素对团队创新绩效的影响。并在团队理论已有的概念模型基础上,提出科研团队创新... 详细信息

在团队绩效相关研究的基础上开展团队创新绩效的研究,从创新有效性和创新效率两个维度来架构团队创新绩效,探索了团队个人因素、团队结构因素和团队环境因素对团队创新绩效的影响。并在团队理论已有的概念模型基础上,提出科研团队创新绩效影响因素对创新绩效的作用机理模型,以院校科研团队为例的探索结果表明团队互动在团队结构因素及团队环境因素两者与团队创新有效性之间,以及团队个人因素与团队结构因素两者与创新效率之间有中介作用,而科研任务类型对团队互动与团队创新有效性和创新效率两者之间有一定的调节作用。

关键词：科研团队创新绩效团队理论

Protective Effects and Mechanisms of Shenhua Tablet(肾华片)on Toll-Like Receptors in Rat Model of Renal Ischemia-Reperfusion Injury

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Chinese Journal of Integrative Medicine 2019年第1期25卷 37-44页

作者： LI Qing-ping WEI Ri-bao YANG Xi zheng xiao-yong SU Ting-yu HUANG Meng-jie YIN Zhong CHEN Xiang-mei Department of Nephrology Chinese PLA General Hospital Chinese PLA Institute of Nephrology State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Disease Research

Objective: To investigate the protective effects and potential mechanisms of Shenhua Tablet(肾华片, SHT) on the toll-like receptors(TLRs)-mediated signaling pathways in a rat model of kidney ischemia-reperfusion injury(IRI). Methods: Sixty male Wistar rats were randomly divided into 5 groups: sham surgery, model control, astragaloside(150 mg·kg^(-1)·d^(-1)), low-and high-dose SHT(1.5 and 3.0 g·kg^(-1)·d^(-1), repectively) groups. One week after drug treatment, rats underwent surgery to establish the IRI models. At 24 h and 72 h after the modeling, serum creatinine(Scr) and blood urea nitrogen(BUN) were analyzed; pathological damage were scored after periodic acid-Schiff staining. TLR2, TLR4 and myeloid differentiation factor 88(My D88) protein and m RNA expressions were detected by inmmunohistochemistry, Western blot and qPCR. Tumor necrosis factor α(TNF-α) and interleukin-6(IL-6) protein expressions were detected by enzyme linked immunosorbent assay. Results: Compared with the sham group, the model group exhibited severe change in renal function(Scr: 189.42±21.50, P<0.05), pathological damage(damage score: 4.50±0.55, P<0.05), and the expression levels of TLR2, TLR4, MyD88, TNF-α, IL-6 were significantly higher than other groups. Meanwhile, the levels of TLRs in model group showed upward tendency from 24 to 72 h, unparalleled with pathological and functional changes. The aforementioned parameters were alleviated to a certain extent, and, in addition to TLRs, presented the obvious downward trending from the 24 to 72 h after the intervention in the SHT and astragaloside groups relative to the model(P<0.05); in particular, the most significant mitigation of these changes was observed in the SHT-H group(P<0.05). Conclusions: TLRs may be an important spot to treat and research in acute kidney injury. SHT could effectively mitigate renal injuries and promote recovery of IRI injuries through suppression of degeneration induced by up-regulation of TLR2 and TLR4 expression leve

关键词： Shenhua Tablet Chinese medicine kidney injury toll-like receptors myeloid differentiation factor 88 ischemia-reperfusion injury