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Multidisciplinary management of ulcerative colitis complicated by immune checkpoint inhibitor-associated colitis with life-threatening gastrointestinal hemorrhage:A case report

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2329-2336页

作者： Na Hong Bo Wang Hang-Cheng Zhou zheng-Xiang wu Hua-Ying Fang Geng-Qing Song Yue Yu Department of Gastroenterology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Pathology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036Anhui ProvinceChina Intelligent Pathology Institute Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036Anhui ProvinceChina Department of Gastroenterology and Hepatology Metro Health Medical CenterCase Western Reserve UniversityClevelandOH 44109United States

BACKGROUND Programmed cell death 1(PD-1)inhibitors are immune checkpoint inhibitors(ICI)that have demonstrated significant efficacy in treating various advanced malignant *** most patients tolerate treatment well,several adverse drug reactions,such as fatigue,myelosuppression,and ICI-associated colitis,have been *** SUMMARY This case involved a 57-year-old male patient with ulcerative colitis complicated by hepatocarcinoma who underwent treatment with tirelizumab(a PD-1 inhibitor)for six *** treatment led to repeated life-threatening lower gastrointestinal *** patient received infliximab,vedolizumab,and other salvage procedures but ultimately required subtotal colectomy due to uncontrollable massive lower gastrointestinal ***,postoperative gastrointestinal bleeding has stopped,the patient’s stool has turned yellow,and his full blood cell count has returned to *** This case highlights the necessity of early identification,timely and adequate treatment of ICI-related colitis,and rapid escalation to achieve the goal of improving prognosis.

关键词： Ulcerative colitis Hepatocarcinoma Immune checkpoint inhibitor-associated colitis Colectomy Case report

申威26010众核处理器上Winograd卷积算法的研究与优化

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计算机研究与发展 2024年第4期61卷 955-972页

作者：武铮金旭安虹中国科学技术大学计算机科学与技术学院合肥230026

卷积作为深度学习中被频繁使用的关键部分,其并行算法的研究已成为高性能计算领域中的热门话题.随着我国自主研发的申威26010众核处理器在人工智能领域的快速发展,对面向该处理器的高性能并行卷积算法提出了迫切的需求.针对申威26010处... 详细信息

卷积作为深度学习中被频繁使用的关键部分,其并行算法的研究已成为高性能计算领域中的热门话题.随着我国自主研发的申威26010众核处理器在人工智能领域的快速发展,对面向该处理器的高性能并行卷积算法提出了迫切的需求.针对申威26010处理器的架构特征以及Winograd卷积算法的计算特性,提出了一种高性能并行卷积算法——融合Winograd卷积算法.该算法不同于依赖官方GEMM(general matrix multiplication)库接口的传统Winograd卷积算法,定制的矩阵乘实现使得该算法的执行过程变得可见,且能够更好地适应现实中常见卷积运算.整个算法由输入的Winograd变换、卷积核的Winograd变换、核心运算和输出的Winograd逆变换4部分构成,这4个部分并不是单独执行而是融合到一起执行.通过实时地为核心运算提供需要的变换后数据,并将计算结果及时地逆变换得到最终的输出数据,提高了算法执行过程中的数据局部性,极大地降低了整体的访存开销.同时,为该算法设计了合并的Winograd变换模式、DMA(direct memory access)双缓冲、片上存储的强化使用、输出数据块的弹性处理以及指令重排等优化方案.最终的实验结果表明,在VGG网络模型的总体卷积测试中,该算法性能是传统Winograd卷积算法的7.8倍.同时,抽取典型卷积神经网络模型中的卷积进行测试,融合Winograd卷积算法能够在所有的卷积场景中发挥明显高于传统Winograd卷积算法的性能.其中,最大能够发挥申威26010处理器峰值性能的116.21%,平均能够发挥峰值性能的93.14%.

关键词：深度学习 Winograd卷积高性能计算并行算法申威处理器

不同相移角度绕组对双三相永磁同步电机电磁性能的影响分析

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东南大学学报（自然科学版） 2024年第4期54卷 972-980页

作者：花为吴铎杜晋文吴政东南大学电气工程学院南京210096 东南大学软件学院苏州215000 东南大学集成电路学院南京210096

由于双三相永磁同步电机两套三相绕组之间可采用不同相移角度,以一台24槽22极双三相永磁同步电机为例,分析了相移角度对电机性能的影响规律.首先,基于各槽绕组磁动势间的相位关系,推导了在采用单层绕组和双层绕组时,两套三相绕组之间可... 详细信息

由于双三相永磁同步电机两套三相绕组之间可采用不同相移角度,以一台24槽22极双三相永磁同步电机为例,分析了相移角度对电机性能的影响规律.首先,基于各槽绕组磁动势间的相位关系,推导了在采用单层绕组和双层绕组时,两套三相绕组之间可行的空间相移角度,即0°、15°和30°,并对比分析了不同空间相移角度绕组产生的电枢磁动势频谱;然后,结合电枢磁动势谐波和电机电磁性能之间的关系,通过有限元仿真,验证了0°、15°和30°相移角度的绕组拓扑对不平衡磁拉力、反电势、平均转矩和转矩脉动等电磁性能的影响规律;最后,制作了2台单层和双层空间相移30°绕组的样机,并通过实验验证了理论和有限元仿真分析的正确性.结果表明:空间相移0°存在明显的不平衡磁拉力;空间相移30°电机平均转矩最大,转矩脉动最小.

关键词：双三相永磁同步电机绕组结构不平衡磁拉力反电势转矩转矩脉动

Differentiation and immunosuppressive function of CD19^(+)CD24^(hi)CD27^(+) regulatory B cells are regulated through the miR-29a-3p/NFAT5 pathway

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 472-480页

作者： Jin-Yang Li Tian-Shuo Feng Ji Gao Xin-Xiang Yang Xiang-Cheng Li Zhen-Hua Deng Yong-Xiang Xia zheng-Shan wu Hepatobiliary Center the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Key Laboratory of Liver Transplantation Chinese Academy of Medical SciencesNanjing 210029China NHC Key Laboratory of Living Donor Liver Transplantation Nanjing Medical UniversityNanjing 210029China

Background: Regulatory B cells(Bregs) is an indispensable element in inducing immune tolerance after liver transplantation. As one of the microRNAs(miRNAs), mi R-29a-3p also inhibits translation by degrading the target mRNA, and yet the relationship between Bregs and mi R-29a-3p has not yet been fully explored. This study aimed to investigate the impact of miR-29a-3p on the regulation of differentiation and immunosuppressive functions of memory Bregs(m Bregs) and ultimately provide potentially effective therapies in inducing immune tolerance after liver transplantation. Methods: Flow cytometry was employed to determine the levels of Bregs in peripheral blood mononuclear cells. TaqMan low-density array miRNA assays were used to identify the expression of different miRNAs, electroporation transfection was used to induce mi R-29a-3p overexpression and knockdown, and dual luciferase reporter assay was used to verify the target gene of miR-29a-3p. Results: In patients experiencing acute rejection after liver transplantation, the proportions and immunosuppressive function of m Bregs in the circulating blood were significantly impaired. mi R-29a-3p was found to be a regulator of m Bregs differentiation. Inhibition of miR-29a-3p, which targeted nuclear factor of activated T cells 5(NFAT5), resulted in a conspicuous boost in the differentiation and immunosuppressive function of m Bregs. The inhibition of mi R-29a-3p in CD19~+ B cells was capable of raising the expression levels of NFAT5, thereby promoting B cells to differentiate into m Bregs. In addition, the observed enhancement of differentiation and immunosuppressive function of m Bregs upon mi R-29a-3p inhibition was abolished by the knockdown of NFAT5 in B cells. Conclusions: mi R-29a-3p was found to be a crucial regulator for m Bregs differentiation and immunosuppressive function. Silencing mi R-29a-3p could be a potentially effective therapeutic strategy for inducing immune tolerance after liver transplantation.

关键词： Regulatory B cells miR-29a-3p NFAT5 Liver transplantation

Inflammatory response in gastrointestinal cancers:Overview of six transmembrane epithelial antigens of the prostate in pathophysiology and clinical implications

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World Journal of Clinical Oncology 2024年第1期15卷 9-22页

作者： Ze-Xuan Fang Wen-Jia Chen zheng wu Yan-Yu Hou Yang-zheng Lan Hua-Tao wu Jing Liu The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

Chronic inflammation is known to increase the risk of gastrointestinal cancers(GICs),the common solid tumors *** lesions,such as chronic atrophic inflammation and ulcers,are related to inflammatory responses in vivo and likely to occur in hyperplasia and ***,due to the lack of effective therapeutic targets,the prognosis of patients with GICs is still ***,it is found that six transmembrane epithelial antigens of the prostate(STEAPs),a group of metal reductases,are significantly associated with the progression of malignancies,playing a crucial role in systemic metabolic homeostasis and inflammatory *** structure and functions of STEAPs suggest that they are closely related to intracellular oxidative stress,responding to inflammatory *** the imbalance status of abnormal oxidative stress,STEAP members are involved in cell transformation and the development of GICs by inhibiting or activating inflammatory *** review focuses on STEAPs in GICs along with exploring their potential molecular regulatory mechanisms,with an aim to provide a theoretical basis for diagnosis and treatment strategies for patients suffering from these types of cancers.

关键词： Six transmembrane epithelial antigens of the prostate Gastrointestinal cancer Inflammation

新质生产力赋能中国式现代化:理论逻辑、动力机制与未来路径

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新疆社会科学 2024年第2期 20-28,148页

作者：武峥安徽省中国特色社会主义理论体系研究中心安徽大学基地安徽大学马克思主义学院安徽合肥230601

新质生产力对中国式现代化有何影响?从动力机制及其未来路径等方面深度解析新质生产力赋能中国式现代化的经济、社会和环境三大价值维度。在经济方面,新质生产力通过提升产业效率和增强市场竞争力,助推经济结构升级和高质量发展;社会层... 详细信息

新质生产力对中国式现代化有何影响?从动力机制及其未来路径等方面深度解析新质生产力赋能中国式现代化的经济、社会和环境三大价值维度。在经济方面,新质生产力通过提升产业效率和增强市场竞争力,助推经济结构升级和高质量发展;社会层面,通过优化人民生活质量和公共服务,促进社会公平和全面进步;环境方面,新质生产力推广绿色发展模式,努力实现资源节约和环境友好。在新质生产力赋能中国式现代化的动力机制上,分别通过技术创新效应、组织创新效应和制度创新效应促进中国式现代化,技术创新为现代化提供科技支撑;组织创新优化管理,释放创新活力;制度创新构建高效公正的治理体系,保障现代化进程顺畅进行。未来,需要构建双支柱举国体制促进技术创新,建立良好的创新环境和创新文化完善组织创新,构建长效的制度创新机制,提高政策的稳定性和持续性等。

关键词：新质生产力中国式现代化动力机制未来路径

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基于融合发展的延安革命文物保护利用研究

西北大学学报（哲学社会科学版） 2024年第3期54卷 62-74页

作者：吴铮争潘敏西北大学文化遗产学院陕西西安710127

融合发展是新时代革命文物保护利用的创新举措。革命文物由于数量多、分布广,存在保护不平衡、展陈同质化、辐射带动效果不佳等普遍性问题。本文以延安革命文物为例,构建以革命文物为核心价值的要素体系,从全域资源视角出发,运用GIS空... 详细信息

融合发展是新时代革命文物保护利用的创新举措。革命文物由于数量多、分布广,存在保护不平衡、展陈同质化、辐射带动效果不佳等普遍性问题。本文以延安革命文物为例,构建以革命文物为核心价值的要素体系,从全域资源视角出发,运用GIS空间分析方法,综合分析革命文物空间集聚性、城市关联性、道路通达性、资源组合性等空间特性,提出“分类保护、轴线带动、组团开发”的保护利用空间策略,探索革命文物整体保护和融合发展的路径,切实推进革命文物内涵价值和空间特质融入现代生活,改善民生福祉,赋能老区发展,促进延安精神传承弘扬。

关键词：延安精神革命文物地理信息系统 GIS空间分析

Investigation and Mitigation of Carbon Deposition over Copper Catalyst during Electrochemical CO_(2)Reduction

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Precision Chemistry 2024年第4期2卷 151-160页

作者： Jing-Wen DuanMu Zhi-zheng wu Fei-Yue Gao Peng-Peng Yang Zhuang-Zhuang Niu Yu-Cai Zhang Li-Ping Chi Min-Rui Gao Division of Nanomaterials and Chemistry Hefei National Laboratory for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China

Copper(Cu)is considered to be the most effective catalyst for electrochemical conversion of carbon dioxide(CO_(2))into value-added hydrocarbons,but its stability still faces considerable ***,we report the poisoning effect of carbon deposition during CO_(2)reduction on the active sites of Cu electrodea critical deactivation factor that is often *** find that,*C,an intermediate toward methane formation,could desorb on the electrode surface to form carbon *** reveal a strong correlation between the formation of methane and the carbon deposition,and the reaction conditions favoring methane production result in more carbon *** deposited carbon blocks the active sites and consequently causes rapid deterioration of the catalytic *** further demonstrate that the carbon deposition can be mitigated by increasing the roughness of the electrode and increasing the pH of the *** work offers a new guidance for designing more stable catalysts for CO_(2)reduction.

关键词： carbon deposition roughness in situ spectrum CO_(2)electroreduction copper catalyst

Receptor tyrosine kinase-like orphan receptor 1:A novel antitumor target in gastrointestinal cancers

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World Journal of Clinical Oncology 2024年第5期15卷 603-613页

作者： zheng-Long wu Ying Wang Xiao-Yuan Jia Yi-Gang Wang Hui Wang Xinyuan Institute of Medicine and Biotechnology College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhou 310018Zhejiang ProvinceChina Department of Oncology Zhejiang Xiaoshan HospitalHangzhou 311201Zhejiang ProvinceChina

Receptor tyrosine kinase-like orphan receptor 1(ROR1)is a member of the type I receptor tyrosine kinase ***1 is pivotal in embryonic development and cancer,and serves as a biomarker and therapeutic *** has soluble and membrane-bound subtypes,with the latter highly expressed in ***1 is conserved throughout evolution and may play a role in the development of gastrointestinal cancer through multiple signaling pathways and molecular *** suggest that overexpression of ROR1 may increase tumor invasiveness and ***,ROR1 may regulate the cell cycle,stem cell characteristics,and interact with other signaling pathways to affect cancer *** review explores the structure,expression and role of ROR1 in the development of gastrointestinal *** discusses current antitumor strategies,outlining challenges and prospects for treatment.

关键词： Receptor tyrosine kinase-like orphan receptor 1 Gastrointestinal cancers Therapeutic target Molecular mechanisms Antitumor strategies