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基于肠道菌群及其代谢产物SCFA探讨左归降糖通脉方对2型糖尿病大鼠糖脂代谢的影响

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湖南中医药大学学报 2024年第3期44卷 365-373页

作者：彭岚玉李定祥姚敬心罗政邓奕辉湖南中医药大学湖南长沙410208

目的基于肠道菌群及代谢产物短链脂肪酸(short-chain fatty acid,SCFA)探讨左归降糖通脉方(Zuogui Jiangtang Tongmai formula,ZJTF)干预2型糖尿病(type 2 diabetes mellitus,T2DM)的可能机制。方法取12只SD大鼠为空白(Control)组,喂食普通饲料;48只大鼠为造模组,以高脂饲料联合链脲佐菌素(streptozocin,STZ)制备T2DM模型。造模成功后随机分为模型(DM)组、ZJTF低剂量(ZJTF.L,12 g·kg^(-1))组、ZJTF高剂量(ZJTF.H,24 g·kg^(-1))组、二甲双胍150 mg·kg^(-1)+阿托伐他汀10 mg·kg^(-1)(M.A)组,药物干预4周。监测大鼠精神状态、体质量与随机血糖;ELISA检测血清胰岛素(insulin,INS)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、炎症因子的水平;生化分析法检测血脂常规含量;HE染色观察结肠病理改变;16SrRNA观察肠道菌群结构;GC-MS检测血清SCFA水平。结果与Control组比较,DM组出现多饮、多食、多尿、体质量减轻等症状;血糖、INS、HbA1c明显上升(P<0.01);总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)水平升高,高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)明显降低(P<0.01);白细胞介素-1β(interleukin-1β,IL-1β)、白细胞介素-6(interleukin-6,IL-6)及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平均明显升高(P<0.01);结肠固有层出现部分中断和消失,细胞肿胀、绒毛紊乱。DM组厚壁菌门和变形菌门、肠杆菌科、埃希菌-志贺菌属的相对丰度增加;血清乙酸、丁酸含量下降(P<0.05,P<0.01)。与DM组比较,ZJTF组血糖、INS、HbAlc均明显降低(P<0.05,P<0.01);TC、TG、LDL-C明显降低,HDL-C明显升高(P<0.01);IL-1β、IL-6及TNF-α水平明显降低(P<0.01);结肠细胞肿胀及炎性浸润缓解;拟杆菌门和疣微菌门、乳酸菌科、阿克曼菌属丰度增加;血清丁酸、乙酸含量升高(P<0.05,P<0.01)。结论左归降糖通脉方可能通过调节肠道菌群和SCFAs水平起到降血糖、稳血脂、减轻炎症反应的作用。

关键词：左归降糖通脉方 2型糖尿病肠道菌群短链脂肪酸糖脂代谢

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经皮吸收促进剂用量对压敏胶黏附性的影响

北华大学学报（自然科学版） 2024年第3期25卷 359-364页

作者：罗正李茂键陈桂雪刘亚男赵南晰北华大学药学院吉林吉林132013

目的探讨经皮吸收促进剂(简称促透剂)用量对透皮贴剂中压敏胶黏附性的影响。方法选择Plurol■Oleique CC497为模型促透剂,两种不同内聚力聚丙烯酸酯压敏胶为模型压敏胶,制备不同促透剂用量的贴剂,测定初黏力、持黏力、180°剥离强度和... 详细信息

目的探讨经皮吸收促进剂(简称促透剂)用量对透皮贴剂中压敏胶黏附性的影响。方法选择Plurol■Oleique CC497为模型促透剂,两种不同内聚力聚丙烯酸酯压敏胶为模型压敏胶,制备不同促透剂用量的贴剂,测定初黏力、持黏力、180°剥离强度和流变学参数。利用调制差示扫描量热法测定压敏胶玻璃化转变温度;利用红外光谱分析促透剂与压敏胶的相互作用机制。结果随着促透剂用量的增加,两种压敏胶初黏力提高,持黏力下降,高内聚力压敏胶在高促透剂用量下黏附性能仍较好。促透剂的加入会降低压敏胶的玻璃化转变温度,增加压敏胶分子流动性。红外光谱结果显示,Plurol■Oleique CC497与压敏胶间可能发生氢键作用,破坏了压敏胶聚合物分子间的相互作用,使黏附力发生变化。结论促透剂的加入会增加压敏胶的黏附性失效风险,在高促透剂用量下,应选择高内聚力压敏胶制备透皮贴剂。

关键词：经皮吸收促进剂压敏胶黏附性贴剂

Recent advances of composite electrolytes for solid-state Li batteries

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Journal of Energy Chemistry 2022年第4期31卷 524-548页

作者： Laiqiang Xu Jiayang Li Honglei Shuai zheng luo Baowei Wang Susu Fang Guoqiang Zou Hongshuai Hou Hongjian Peng Xiaobo Ji College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083HunanChina

All-solid-state lithium batteries(ASSLBs)are recognized as high energy density batteries system without safety issues within the next generation of *** development of solid electrolytes is the crucial step of *** composite electrolyte has stable physical and electrochemical characteristics,and its comprehensive performance surpasses the individual solid electrolyte,bringing unique vitality to the solid ***,their intrinsic weakness limits the development of composite *** this review,we provide a comprehensive and in-depth understanding of the challenges and opportunities of composite electrolytes,with special focus on mechanisms of ion transport,nanostructure design towards high ionic conductivity,interfacial issues within electrolytes and ***,future development is prospected,which can shed light on researchers in this field and accelerate the industrial production of composite electrolytes.

关键词： High energy density Composite electrolytes Ion transport High ionic conductivity Interfacial issues

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千金藤素抗病毒作用的免疫学机制研究

药物评价研究 2024年第6期47卷 1232-1239页

作者：王靳勇何昱廷谢芳成翠芹张美琦初英杰罗政李俊良徐安龙王遥北京中医药大学中药学院北京102488 北京中医药大学生命科学学院北京102488

目的探索千金藤素体内外的抗病毒作用,并基于抗病毒天然免疫通路探究其抗病毒作用的分子机制。方法CCK-8法检测千金藤素(0.0625~64.0000μmol·L^(-1))对A549细胞活力的影响;利用表达绿色荧光蛋白的水疱性口炎病毒(VSV-GFP)感染A549细... 详细信息

目的探索千金藤素体内外的抗病毒作用,并基于抗病毒天然免疫通路探究其抗病毒作用的分子机制。方法CCK-8法检测千金藤素(0.0625~64.0000μmol·L^(-1))对A549细胞活力的影响;利用表达绿色荧光蛋白的水疱性口炎病毒(VSV-GFP)感染A549细胞模型,结合流式细胞术检测千金藤素对病毒复制的影响并探究预处理、吸附过程及吸附后加药对VSV-GFP病毒复制的影响;实时荧光定量PCR(qRT-PCR)检测千金藤素对甲型流感病毒(H1N1)、脑心肌炎病毒(EMCV)和单纯疱疹病毒I型(HSV-1)复制的影响;构建VSV感染小鼠模型探究千金藤素的体内抗病毒作用;A549细胞中利用生物信息学方法探究其抗病毒机制;qRT-PCR检测药物处理A549和原代胚胎成纤维细胞(MEF)后IFNB1及干扰素刺激基因(ISGs)表达变化;免疫印迹法(Immunoblotting)检测人源单核细胞白血病细胞(THP-1)中TBK1和STAT1的磷酸化水平。结果与模型组相比,千金藤素在A549细胞中显著抑制VSV、H1N1、EMCV和HSV-1复制;千金藤素不影响VSV的吸附过程,而预处理或吸附后给药可以显著抑制病毒复制;千金藤素提高VSV感染小鼠的存活率;千金藤素激活基于IFN-I通路的抗病毒天然免疫应答。结论千金藤素通过激活基于IFN-I通路的抗病毒天然免疫发挥体内外抗病毒作用。

关键词：千金藤素抗病毒天然免疫 I型干扰素通路干扰素刺激基因抗病毒

Nanomedicine Disrupts Stromal Barriers to Augment Drug Penetration for Improved Cancer Therapy

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Chinese Journal of Chemistry 2024年第10期42卷 1175-1189页

作者： Guo-Feng luo Wei-Hai Chen Xian-zheng Zhang state Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei KeyLaboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanHubei 430079China Key Laboratoryof Biomedical Polymers of Ministry of Education&Departmentof Chemistry Wuhan UniversityWuhanHubei 430072China

Tumor stroma composing diverse extracellular matrixes(ECM)and stromal cells shapes a condensed physical barrier,which severely hampers the efficient accessibility of nanomedicine to tumor cells,especially these deep-seated in the core of *** barrier significantly compromises the antitumor effects of drug-loaded nanomedicine,revealing the remarkable importance of disrupting stromal barrier for improved tumor therapy with deep penetration *** achieve this goal,various nanoparticle-based strategies have been developed,including direct depleting ECM components via delivering anti-fibrotic agents or targeting stromal cells to suppress ECM expression,dynamic regulation of nanoparticles’physicochemical properties(i.e.,size,surface charge,and morphology),mechanical force-driven deep penetration,natural/biomimetic self-driven nanomedicine,and transcytosis-inducing *** these nanostrategies were systemically summarized in this review,and the design principles for obtaining admirable nanomedicine were *** the rapid development of nanotechnology,elaborate design of multifunctional nanomedicine provides new opportunities for overcoming the critical stromal barriers to maximize the therapeutic index of various therapies,such as chemotherapy,photodynamic therapy,and immunotherapy.

关键词： Nanomedicine Tumor stroma Deep penetration Enhanced drug perfusion Cancer therapy Drug carriers Biomaterials Nanotechnology

基于GIS信息量法的地质灾害易发性评价——以榆林市吴堡县为例

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价值工程 2024年第19期43卷 101-103页

作者：孙瑞梁苏舒阳雒铮张二锋西安科技大学高新学院西安710109 陕西省矿产地质调查中心西安710068 中煤科工集团重庆研究院有限公司重庆400039

在吴堡县地质灾害野外调查的基础上,针对吴堡县地质灾害,选取坡度、坡高、坡型、坡向和斜坡地质结构类型作为评价指标,基于ArcGIS平台进行易发性评价。根据评价结果,可将吴堡县划分为极高易发区、高易发区、中易发区、低易发区和不易发... 详细信息

在吴堡县地质灾害野外调查的基础上,针对吴堡县地质灾害,选取坡度、坡高、坡型、坡向和斜坡地质结构类型作为评价指标,基于ArcGIS平台进行易发性评价。根据评价结果,可将吴堡县划分为极高易发区、高易发区、中易发区、低易发区和不易发区5个等级,分布面积分别为35.78km2、65.58km2、198.88km2、104.72km2、15.89km2,并结合野外调查数据对评级结果进行验证,准确度较好。其评价结果可以为吴堡县乡村建设提供科学的地质依据,减少地质灾害造成的人员和经济财产的损失。

关键词：地质灾害易发区评价 GIS 信息量法

Pannexins in the musculoskeletal system:new targets for development and disease progression

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Bone Research 2024年第2期12卷 255-269页

作者： Yan luo Shengyuan zheng Wenfeng Xiao Hang Zhang Yusheng Li Department of Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Clinical Medicine Xiangya Medicine SchoolCentral South UniversityChangshaHunan 410008China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China

During cell differentiation,growth,and development,cells can respond to extracellular stimuli through communication ***(Panx)family and connexin(Cx)family are two important types of channel-forming *** family contains three members(Panx1-3)and is expressed widely in bone,cartilage and *** there is no sequence homology between Panx family and Cx family,they exhibit similar configurations and *** to Cxs,the key roles of Panxs in the maintenance of physiological functions of the musculoskeletal system and disease progression were gradually revealed ***,we seek to elucidate the structure of Panxs and their roles in regulating processes such as osteogenesis,chondrogenesis,and muscle *** also focus on the comparison between Cx and *** a new key target,Panxs expression imbalance and dysfunction in muscle and the therapeutic potentials of Panxs in joint diseases are also discussed.

关键词： skeletal diseases system

Impact of Local Climate Zones on the Urban Heat and Dry Islands in Beijing:Spatial Heterogeneity and Relative Contributions

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Journal of Meteorological Research 2024年第1期38卷 126-137页

作者： Zuofang zheng Fu luo Nana LI Hua GAO Yuanjian YANG Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089 School of Atmospheric Physics Nanjing University of Information Science&TechnologyNanjing 210044 Key Laboratory of Urban Meteorology China Meteorological AdministrationBeijing 100089

Based on the building height and density data on a 100-m resolution,hourly 2-m temperature and humidity data at83 automatic weather stations,and gridded local climate zone(LCZ)data on a 120-m resolution in urban Beijing in2020,this study first employs the semivariogram combined with building parameters to calculate spatial correlations and has identified an LCZ grid resolution of 500 m suitable for best usage of the available observation ***,how the spatially heterogeneous LCZs affect and contribute to the canopy urban heat island intensity(UHII)and urban dry island intensity(UDII)are quantitatively *** is found that UHII is high in winter and low in summer with a unimodal diurnal variation while UDI is low in winter but high in summer with a bimodal diurnal *** LCZ with compact mid-rise(open high-rise)buildings exhibits the highest UHII(UDII),followed by the compact high-rise(compact low-rise),while the LCZ of scattered trees presents both the lowest UHII and the lowest *** most significant difference in the UHII(UDII)among the nine LCZ types in the urban area of Beijing is2.62℃(1.1 g kg^(-1)).Area-weighted averaging analysis reveals that the open mid-rise LCZ is the most significant contributor to the UHII(UDII),immediately followed by compact mid-rise(open low-rise),with the least contribution from bare rock or paved(scattered trees).The results also indicate that beyond the intrinsic physical properties of the LCZs of a city,their area proportions cannot be overlooked in evaluating their impact on the UHI and *** quantitatively findings could help urban planners to create a livable urban climate and environment by adjusting the relevant land use.

关键词： local climate zone(LCZ) urban heat island(UHI) urban dry island(UDI) distribution pattern contribution rate Beijing

三子养亲汤对营养性肥胖Wistar大鼠肥胖因子的影响

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基层中医药 2024年第6期3卷 78-83页

作者：侯建婷罗政谢熠丹尹富锦苏春丽李军昆明市中医医院云南昆明650000 云南中医药大学云南昆明650000

目的探究三子养亲汤对营养性肥胖Wistar大鼠肥胖因子的影响。方法将50只大鼠随机分为空白组10只与造模组40只,造模组随机分为模型组及三子养亲汤高、中、低组,每组各10只。浓缩制得药液浓度为1.875 g/mL的水煎剂,给药剂量为高剂量组每只... 详细信息

目的探究三子养亲汤对营养性肥胖Wistar大鼠肥胖因子的影响。方法将50只大鼠随机分为空白组10只与造模组40只,造模组随机分为模型组及三子养亲汤高、中、低组,每组各10只。浓缩制得药液浓度为1.875 g/mL的水煎剂,给药剂量为高剂量组每只10.8 g/(kg·d),中剂量组每只5.4 g/(kg·d),低剂量组每只2.7 g/(kg·d),模型组及空白组按每只0.1 mL/(10 g·d)灌胃给予纯净水。给药时间为6周。实验结束后根据各ELISA试剂盒说明书方法步骤检测肥胖因子指标:肾素活性(PRA),血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)、瘦素(LP)、游离脂肪酸(FFA)、空腹血糖(FBG)及血清胰岛素(INS)。结果血糖各组均无显著差异。胰岛素、瘦素、肾素、醛固酮、血管紧张素Ⅱ、游离脂肪酸浓度,高脂饲料饲养各组均高于空白组(P<0.05),高中低剂量组均低于模型组(P<0.05),且高剂量组最低(P<0.05)。脂联素浓度高脂饲料饲养各组均低于空白组(P<0.05),高中低剂量组明显高于模型组(P<0.05),高剂量组最高(P<0.05)。结论三子养亲汤可改善肥胖大鼠的胰岛素抵抗,降低RAS系统中肾素、醛固酮、血管紧张素Ⅱ的浓度,同时降低游离脂肪酸及瘦素的浓度,增加脂联素的浓度,调节肥胖因子,达到治疗肥胖的效果。

关键词：三子养亲汤肥胖瘦素脂联素醛固酮肾素