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Chinese herbal medicine Ginkgo biloba *** for ischemic stroke:An overview of systematic reviews and meta-analyses

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Journal of Integrative Medicine 2024年第2期22卷 163-179页

作者： tian-tian Meng Ya-ping You Min li jian-bo Guo Xin-bin song jing-yi Ding xiao-long Xie An-qi li Shang-jin li Xiang-jun yin Peng Wang Zhe Wang Bao-liang Wang Qing-yong He Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100032China Department of Rehabilitation Dongfang HospitalBeijing University of Chinese MedicineBeijing 100071China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Chinese Medicine the University of Hong KongHong KongChina Graduate School Henan University of Chinese MedicineZhengzhou 450008Henan ProvinceChina Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100010China Department of Cardiology Guang’anmen HospitalChina Academy of Chinese Medical SciencesZhengzhou 450008Henan ProvinceChina School of Integrated Traditional Chinese and Western Medicine Southwest Medical UniversityHangzhou 310053Zhejiang ProvinceChina School of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhu 310053Zhejang ProvinceChina Department of Neurology the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450003Henan ProvinceChina

Background:Ginkgo biloba ***(GBLPs)are a class of Chinese herbal medicine used in the adjuvant treatment of ischemic stroke(IS).Recently,several systematic reviews(SRs)and meta-analyses(MAs)of GBLPs for IS have been ***:This overview aims to assess the quality of related SRs and *** strategy:Pub Med,Embase,Cochrane library,Web of Science,Chinese Biological Medicine,China National Knowledge Infrastructure,Wanfang,and Chinese Science and Technology Journals databases were searched from their inception to December 31,*** criteria:SRs and MAs of randomized controlled trials(RCTs)that explored the efficacy of GBLPs for patients with IS were *** extraction and analysis:Two independent reviewers extracted data and assessed the methodological quality,risk of bias(ROB),reporting quality,and credibility of evidence of the included SRs and MAs using A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2),Risk of Bias in Systematic Reviews(ROBIS),the Preferred Reporting Items for Systematic Reviews and Meta-analyses(PRISMA),and the Grading of Recommendations Assessment,Development and Evaluation(GRADE),***,descriptive analysis and data synthesis were ***:Twenty-nine SRs/MAs involving 119 outcomes were included in this *** overall methodological quality of all SRs/MAs was critically low based on AMSTAR 2,and 28 had a high ROB based on the *** to the PRISMA statement,the reporting items of the included SRs/MAs are relatively *** results based on GRADE showed that of the 119 outcomes,8 were rated as moderate quality,24 as low quality,and 87 as very low *** on the data synthesis,GBLPs used in conjunction with conventional treatment were superior to conventional treatment alone for decreasing neurological function ***:GBLPs can be considered a beneficial supplemental therapy for ***,because of the low quality of the existing eviden

关键词： statement synthesis alone

Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： Hai-Sheng Zhao Dong li Shao-lin Xiong yan-Qiu Zhang yang Su Wei Chen yi Zhao xiao-Bo li Jia-Cong liu Wen-Xi Peng Rui Qiao Xin-Qiao li Xiang-yang Wen li-Ming song Shi-Jie zheng Xin-ying song xiao-Yun Zhao Yue Huang Shuang-Nan Zhang Shuo xiao Ce Cai zheng-Hua An Can Chen Gang Chen Wei Chen yan-Qi Du Min Gao Ke Gong Dong-Ya Guo Zhi-Wei Guo jian-jian He Bin li Chao li Chao-yang li Gang li jian-Hui li Lu li Qing-Xin li yan-Guo li jing liang xiao-Hua liang Jin-Yuan liao xiao-jing liu Ya-Qing liu Qi Luo Xiang Ma Bin Meng Ge Ou Dong-li Shi jing-yan Shi Gong-Xing Sun Xi-Lei Sun You-li Tuo Chen-Wei Wang Hui Wang Jin Wang Jin-Zhou Wang Ping Wang Wen-Shuai Wang Hong Wu Sheng-Lun Xie yan-Bing Xu Yu-Peng Xu Wang-Chen xue Sheng yang Min Yao jian-ying Ye Qi-Bin yi Chao-Yue Zhang Da-li Zhang fan Zhang Fei Zhang Hong-Mei Zhang Kai Zhang Peng Zhang xiao-Lu Zhang Zhen Zhang Guo-ying Zhao Shi-yi Zhao Chao zheng Xing Zhou Yue Zhu Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space Science College China West Normal UniversityNanchong 637002China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics Sciences&Technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 *** subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak *** subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive *** periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence *** paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our *** precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

Single-cell immune profiling reveals distinct immune response in asymptomatic COVID-19 patients

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3108-3118页

作者： Xiang-Na Zhao Yue You xiao-Ming Cui Hui-Xia Gao Guo-lin Wang Sheng-Bo Zhang lin Yao li-Jun Duan Ka-li Zhu Yu-ling Wang li li jian-Hua Lu Hai-Bin Wang jing-fang fan Huan-Wei zheng Er-Hei Dai Lu-yi tian Mai-Juan Ma Center for Disease Control and Prevention of Chinese People's liberation Army BeijingChina The Walter and Eliza Hall Institute of Medical Research ParkvilleVicAustralia Department of Medical Biology The University of MelbourneParkvilleVicAustralia State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijingChina The Fifth Hospital of Shijiazhuang Hebei Medical UniversityShijiazhuangChina

While some individuals infected by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)present mild-to-severe disease,many SARS-CoV-2-infected individuals are *** sought to identify the distinction of immune response between asymptomatic and moderate *** performed single-cell transcriptome and T-cell/B-cell receptor(TCR/BCR)sequencing in 37 longitudinal collected peripheral blood mononuclear cell samples from asymptomatic,moderate,and severe patients with healthy *** patients displayed increased CD56^(bri)CD16^(-) natural killer(NK)cells and upregulation of interferon-gamma in effector CD4^(+) and CD8^(+) T cells and NK *** showed more robust TCR clonal expansion,especially in effector CD4^(+) T cells,but lack strong BCR clonal expansion compared to moderate ***,asymptomatic patients have lower interferon-stimulated genes(ISGs)expression in general but large interpatient variability,whereas moderate patients showed various magnitude and temporal dynamics of the ISGs expression across multiple cell populations but lower than a patient with severe *** data provide evidenee of different immune signatures to SARS-CoV-2 in asymptomatic infections.

关键词： patients asymptomatic interferon

Long-term analysis of clear nights using satellite data considering astronomical sites in western China

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Research in Astronomy and Astrophysics 2020年第6期20卷 96-108页

作者： Zi-Huang Cao li-Yong liu Yong-Heng Zhao Lu Feng Hugh RAJones Huang Shen Jin-Xin Hao yan-Jie xue Yong-Qiang Yao jing Xu Ali Esamdin Zhao-Xiang Qi jian-Rong Shi jian li Yuan tian zheng Wang Tai-Sheng yan Xia Wang jian-Ping Xiong Si-Cheng Yu Jun-Bo Zhang Zhi-Xia Shen Yun-ying jiang Jia yin Guang-Xin Pu Peng Wei Chun-Hai Bai Guo-Jie Feng Lu Ma Teng-Fei song jian-Feng Wang jian-Feng tian Xian-Qun Zeng Zhi-Gang Hou Shi-Long liao Zhi-song Cao Dong-Wei fan Yun-Fei Xu Chang-Hua li yi-Han Tao National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Centre for Astrophysics University of HertfordshireHatfieldUK School of Journalism.Communication University of China Beijing 100024China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Yunnan Observatories Chinese Academy of SciencesKunming 650216China

A large ground-based optical/infrared telescope is being planned for a world-class astronomical site in *** cloud-free night percentage is the primary meteorological consideration for evaluating candidate *** data from GMS and NOAA satellites and the MODIS instrument were utilized in this research,covering the period from 1996 to *** data analysis benefits from overlapping results from different independent teams as well as a uniform analysis of selected sites using GMS+NOAA *** significant ground-based monitoring is needed to validate these findings,we identify three different geographical regions with a high percentage of cloud-free conditions(~83%on average),which is slightly lower than at Mauna Kea and Cerro Armazones(~85%on average)and were chosen for the large international projects TMT and ELT *** study finds evidence that cloud distributions and the seasonal changes affected by the prevailing westerly winds and summer monsoons reduce the cloud cover in areas influenced by the *** is consistent with the expectations from climate change models and is suggestive that most of the identified sites will have reduced cloud cover in the future.

关键词： methods statistical-site testing-atmospheric effects-MODIS

Waveguide distribution system of the HEPS linac

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Radiation Detection Technology and Methods 2023年第4期7卷 502-513页

作者： Xiang He jing-Ru Zhang Hua Shi Ou-zheng xiao jing-Dong liu Nan Gan Hao Zeng xiao-Ping li Guan Shu Feng-li Zhao Sheng-Chang Wang Xin-Peng Ma Cai Meng Da-Yong He Fei li Dong Dong Zu-Sheng Zhou jing-yi li jian-li Wang Bing-lin Deng Pi-Long tian Xu-jian Wang Hong song Qi yang Xiang-Cheng Kong National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei230029China Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China Zhang jiang Laboratory Shanghai200120China

Purpose The High-Energy Photon Source(HEPS)is a 6 GeV storage ring-based light source under construction in Beijing,*** accelerator consists of a 6 GeV storage ring,a full-energy booster,an S-band normal-conducting 500 MeV linac,and three transport *** the beginning of HEPS,a stable linac is quite important,which needs a qualified waveguide distribution system to transmit microwave power from klystrons to accelerating *** Installation and high-power conditioning of the HEPS linac were performed from February to September *** assembly and conditioning of the waveguide distribution system were completed in April and July,*** design of the waveguide distribution system began in 2018 and was finalized at the end of 2020 after multiple *** Owing to careful design,fabrication,and assembly preparation,the assembly and conditioning of the system proceeded smoothly and considerable time was *** The entire process from the design to the ultimate realization of the system is introduced in detail in this *** measurement results were obtained for some waveguide components.

关键词： HEPS linac Waveguide distribution system System design Assembly and commissioning High-power conditioning

Insight-HXMT on-orbit thermal control status and thermal deformation impact analysis

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Radiation Detection Technology and Methods 2023年第3期7卷 337-349页

作者： Ai-Mei Zhang yi-fan Zhang Jin-Yuan liao Yu-Peng Xu Yu-Sa Wang Wen-Bo Luo Yu-Peng Zhou Zhi-ying Qian xiao-Bo li fang-Jun Lu Shuang-Nan Zhang li-Ming song Cong-Zhan liu fan Zhang jian-yin Nie Juan Wang Sheng yang Tong Zhang xiao-jing liu Rui-Jie Wang Xu-fang li yi-Fei Zhang zheng-Wei li xue-Feng Lu He Xu Di Wu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Beijing Institute of Spacecraft System Engineering CASTBeijing 100094China

Purpose The Hard X-ray Modulation Telescope is China’s first X-ray astronomy satellite launched on June 15,2017,dubbed *** and passive thermal control measures are employed to keep devices at suitable *** this paper,we analyzed the on-orbit thermal monitoring data of the first 5 years and investigated the effect of thermal deformation on the point spread function(PSF)of the *** We examined the data of the on-orbit temperatures measured using 157 thermistors placed on the collimators,detectors and their support structures and compared the results with the thermal control *** thermal deformation was evaluated by the relative orientation of the two star sensors installed on the main support *** effect was estimated with evolution of the PSF obtained with calibration scanning observations of the Crab *** The on-orbit temperatures met the thermal control requirements thus far,and the effect of thermal deformation on the PSF was negligible after the on-orbit pointing calibration.

关键词： X-ray Insight-HXMT Thermal control Temperature Star sensor data Pointing PSF

Transcriptomic Landscape Analysis Reveals a Persistent DNA Damage Response in Metabolic Dysfunction-associated Steatohepatitis Post-dietary Intervention

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 765-779页

作者： Zi-Yuan Zou tian-yi Ren Jia-Qi li Ting-ying Jiao Meng-Yu Wang Lei-Jie Huang Shuang-Zhe lin Yuan-yang Wang xiao-Zhen Guo Ye-Yu song Rui-Xu yang Cen Xie jian-Gao fan Center for Fatty liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina University of Chinese Academy of Sciences BeijingChina Human Phenome Institute School of Life SciencesFudan UniversityShanghaiChina Department of Gastroenterology Ningbo No.2 HospitalNingboZhejiangChina Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition ShanghaiChina

Background and Aims:Metabolic dysfunction-associated steatotic liver disease(MASLD)and its more advanced form,metabolic dysfunction-associated steatohepatitis,have emerged as the most prevalent liver diseases ***,lifestyle modification is the foremost guidelinerecommended management strategy for ***,it remains unclear which detrimental signals persist in MASLD even after disease ***,we aimed to examine the persistent changes in liver transcriptomic profiles following this ***:Male C57BL/6J mice were divided into three groups:Western diet(WD)feeding,chow diet(CD)feeding,or diet reversal from WD to *** 16 weeks of feeding,RNA sequencing was performed on the mice’s livers to identify persistent alterations characteristic of ***,RNA sequencing databases containing high-fat diet-fed P53-knockout mice and human MASLD samples were ***:WD-induced MASLD triggered persistent activation of the DNA damage response(DDR)and its primary transcription factor,P53,long after the resolution of the hepatic phenotype through dietary *** levels of P53 might promote apoptosis,thereby exacerbating metabolic dysfunction-associated steatohepatitis,as they strongly correlated with hepatocyte ballooning,an indicator of apoptosis ***,P53 knockout in mice led to downregulated expression of apoptosis signaling in the ***,P53 may regulate apoptosis by transcriptionally activating the expression of apoptosis-enhancing nuclease(AEN).Consistently,P53,AEN,and the apoptosis process all exhibited persistently elevated expression and showed a strong inter-correlation in the liver following dietary ***:The liver demonstrated upregulation of DDR signaling and the P53-AEN-apoptosis axis both during and after exposure to *** findings provide new insights into the mechanisms of MASLD relapse,highlighting DDR signaling as a promising target to prevent MASLD recu

关键词： Apoptosis DNA Damage Metabolic dysfunction-associated steatotic liver disease RNA-Seq Tumor suppressor protein P53 Western Diets

Stepped-up development of accelerator mass spectrometry method for the detection of ^(60)Fe with the HI-13 tandem accelerator

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Nuclear Science and Techniques 2024年第4期35卷 136-143页

作者： yang Zhang Sheng-Quan yan Ming He Qing-Zhang Zhao Wen-Hui Zhang Chao-Xin Kan jian-Ming Zhou Kang-Ning li xiao-Fei Wang jian-Cheng liu Zhao-Hua Peng Zhuo liang Ai-ling li jian zheng Qi-Wen fan Yun-Ju li You-Bao Wang Zhi-Hong li yang-Ping Shen Ding Nan Wei Nan Yu-Qiang Zhang Jia-ying-Hao li Jun-Wen tian jiang-lin Hou Chang-Xin Guo Zhi-Cheng Zhang Ming-Hao Zhu Yu-Wen Chen Yu-Chen jiang Tao tian Jin-Long Ma yi-Hui liu jing-Yu Dong Run-Long liu Mei-Yue-Nan Ma Yong-Shou Chen Wei-Ping liu Bing Guo China Institute of Atomic Energy P.O.Box 275(10)Beijing 102413China College of Science Southern University of Science and TechnologyShenzhen 518055China School of Physics Xi’an Jiaotong UniversityXi’an 710049China

The Moon provides a unique environment for investigating nearby astrophysical events such as *** samples retain valuable information from these events,via detectable long-lived“fingerprint”radionuclides such as^(60)*** this work,we stepped up the development of an accelerator mass spectrometry(AMS)method for detecting^(60)Fe using the HI-13tandem accelerator at the China Institute of Atomic Energy(CIAE).Since interferences could not be sufficiently removed solely with the existing magnetic systems of the tandem accelerator and the following Q3D magnetic spectrograph,a Wien filter with a maximum voltage of±60 kV and a maximum magnetic field of 0.3 T was installed after the accelerator magnetic systems to lower the detection background for the low abundance nuclide^(60)Fe.A 1μm thick Si_(3)N_(4) foil was installed in front of the Q3D as an energy *** particle detection,a multi-anode gas ionization chamber was mounted at the center of the focal plane of the ***,an^(60)Fe sample with an abundance of 1.125×10^(-10)was used to test the new AMS *** results indicate that^(60)Fe can be clearly distinguished from the isobar^(60)*** sensitivity was assessed to be better than 4.3×10^(-14)based on blank sample measurements lasting 5.8 h,and the sensitivity could,in principle,be expected to be approximately 2.5×10^(-15)when the data were accumulated for 100 h,which is feasible for future lunar sample measurements because the main contaminants were sufficiently separated.

关键词： Accelerator mass spectrometry Wien filter Isobar separation Supernovae Chang'e-5 lunar samples

Data processing and data products from 2017 to 2019 campaign of astronomical site testing at Ali,Daocheng and Muztagh-ata

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Research in Astronomy and Astrophysics 2020年第6期20卷 109-130页

作者： Zi-Huang Cao Jin-Xin Hao Lu Feng Hugh RAJones jian li jing Xu li-Yong liu Teng-Fei song jian-Feng Wang Hua-lin Chen yan-Jie xue Huang Shen Yong-Heng Zhao Zhao-Xiang Qi jian-Rong Shi Yuan tian zheng Wang Xia Wang Jin-liang Hou Jin-Ming Bai Ji yang Xu Zhou Yong-Qiang Yao Jia yin Ali Esamdin Guang-Xin Pu Peng Wei Chun-Hai Bai Guo-Jie Feng Lu Ma Xuan Zhang Yu liu Chong Pei Zhi-Xia Shen Yun-ying jiang jian-Feng tian Xian-Qun Zeng Zhi-Gang Hou Xu yang Jun-Bo Zhang Shi-Long liao Dong-Wei fan Yun-Fei Xu jian-Ping Xiong Tai-Sheng yan Xi Zhang Chang-Hua li yi-Han Tao Si-Cheng Yu Zhi-song Cao Hong-Shuai Wang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Centre for Astrophysics University of HertfordshireHatfieldUK School of Journalism Communication University of ChinaBeijing 100024China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Yunnan Observatories Chinese Academy of SciencesKunming 650216China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210033China Beijing Kaiyang Space Technology Co. LtdBeijing 100085China

Based on previous site testing and satellite cloud data,Ali,Daocheng and Muztagh-ata have been selected as candidate sites for the Large Optical/Infrared Telescope(LOT) in *** present the data collection,processing,management and quality analysis for our site testing based on using similar *** analyze meteorological data,seeing,background light,cloud and precipitable water vapor data from 2017 March 10 to 2019 March *** also investigated the relative usefulness of our all-sky camera data in comparison to that from the meteorological TERRA satellite data based on a night-by-night comparison of the correlation and consistency between *** find a 6% discrepancy arising from a wide range of factors.

关键词： LOT Site-selection-data processing