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Apigenin ameliorates imiquimod-induced psoriasis in C57BL/6J mice by inactivating STAT3 and NF-κB

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Food Science and Human Wellness 2024年第1期13卷 211-224页

作者： Xianshe Meng Shihong zheng Zequn Yin Xuerui Wang Daigang Yang Tingfeng Zou Huaxin Li Yuanli Chen Chenzhong liao Zhouling Xie Xiaodong fan Jihong Han Yajun Duan Xiaoxiao Yang Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes College of Food and Biological EngineeringHefei University of TechnologyHefei 230601China Tianjin Key Laboratory of human Development and Reproductive Regulation Department of General GynecologyTianjin Central Hospital of Gynecology and ObstetricsTianjin 300100China Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials of Ministry of EducationCollege of Life SciencesNankai UniversityTianjin 300071China

Psoriasis is a chronic autoimmune disease featured by patches on the *** is caused by malfunction of immune cells and keratinocytes with inflammation as one of its key ***(API)is a natural flavonoid with anti-inflammatory and immunoregulatory ***,we speculated that API can ameliorate psoriasis,and determined its effect on the development of psoriasis by using imiquimod(IMQ)-induced psoriasis mouse *** results showed that API attenuated IMQ-induced phenotypic changes,such as erythema,scaling and epidermal thickening,and improved splenic *** differentiation of immune cells was restored in API-treated ***,we revealed that API is a key regulator of signal transducer activator of transcription 3(STAT3).API regulated immune responses by reducing interleukin-23(IL-23)/STAT3/IL-17A ***,it suppressed IMQ-caused cell hyperproliferation by inactivating STAT3 through regulation of extracellular signal-regulated kinase 1/2 and nuclear factor-κB(NF-κB)***,API reduced expression of inflammatory cytokines through inactivation of NF-κ*** together,our study demonstrates that API can ameliorate psoriasis and may be considered as a strategy for psoriasis treatment.

关键词： Psoriasis Apigenin Imiquimod Inflammation Signal transducer activator of transcription 3 (STAT3) Nuclear factor-κB(NF-κB)

Copper(I)Cluster of Aggregation-Induced Emission and X-Ray Scintillator Characteristic

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Chemical Research in Chinese Universities 2024年第5期40卷 887-893页

作者： XIONG Jiayu WU Minjian YAO liao-Yuan MOE Key Laboratory of Cluster Sciences Beijing Key Laboratory of Photoelectroic/Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing102488P.R.China Tangshan Research Institute Beijing Institute of TechnologyTangshan063000P.R.China

Due to their precise atomic structures,photoluminescent copper nanoclusters(Cu NCs)have promising applications in basic research and technical applications,such as bioimaging,cell labeling,phototherapy,and photoactivation *** this work,we report a simple strategy for synthesizing novel CuNCs co-protected by alkynyl and phosphine ligands with the molecular formula[Cu_(7)(PPh_(3))_(10)(PE)_(3)(CH_(3)O)](Cu_(4)@Cu_(3)).Single-crystal X-ray crystallography reveals that the NC core exhibits an open square structure and an overall pyramid *** Cu_(4)@Cu_(3) units are connected through weak interactions to form dimers in crystals,creating a molecular cage that looks like two tightly closed ***_(4)@Cu_(3)exhibits dual emission in the visible *** is also an aggregation-induced emission(AIE)-active luminescent substance,which exhibits strong emission in the visible light region when ***,it has the properties of radioluminescent(RL)and could be a potential scintillator *** study not only enriches the types of atomically accurate AIE clusters,but also holds significant importance for the development of a new generation of high-performance and environmentally friendly X-ray scintillators.

关键词： Copper nanocluster Aggregation-induced emission X-Ray scintillator

KeyEE:Enhancing Low-Resource Generative Event Extraction with Auxiliary Keyword Sub-Prompt

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Big Data Mining and Analytics 2024年第2期7卷 547-560页

作者： Junwen Duan Xincheng liao Ying An Jianxin Wang Hunan Key Laboratory of Bioinformatics School of Computer Science and EngineeringCentral South UniversityChangsha 410083China Big Data Institute Central South UniversityChangsha 410083China

Event Extraction(EE)is a key task in information extraction,which requires high-quality annotated data that are often costly to *** classification-based methods suffer from low-resource scenarios due to the lack of label semantics and fine-grained *** recent approaches have endeavored to address EE through a more data-efficient generative process,they often overlook event keywords,which are vital for *** tackle these challenges,we introduce KeyEE,a multi-prompt learning strategy that improves low-resource event extraction by Event Keywords Extraction(EKE).We suggest employing an auxiliary EKE sub-prompt and concurrently training both EE and EKE with a shared pre-trained language *** the auxiliary sub-prompt,KeyEE learns event keywords knowledge implicitly,thereby reducing the dependence on annotated ***,we investigate and analyze various EKE sub-prompt strategies to encourage further research in this *** experiments on benchmark datasets ACE2005 and ERE show that KeyEE achieves significant improvement in low-resource settings and sets new state-of-the-art results.

关键词： natural language processing Event Extraction(EE) Multi-Prompt Learning(MPL) low-resource

Demonstration of normally-off p-channel GaN transistor with high threshold voltage and low subthreshold swing based on single p-GaN

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Science China(Information Sciences) 2024年第9期67卷 348-349页

作者： Yangfeng LI Zian DONG Shuai CHEN Qin WANG Tong LI Shulin CHEN Kun zheng Jie ZHANG Guojian DING Yang WANG Haiqiang JIA Rong YANG Lei liao Changsha Semiconductor Technology and Application Innovation Research Institute College of Semiconductors (College of Integrated Circuits) Hunan University Hunan San'an Semiconductor Co. Ltd. Songshan Lake Materials Laboratory

GaN outperforms silicon in applications with high power and high frequency owing to the high critical electric field and high electron mobility. However, the hole-based GaN transistors which are pivotal to the GaN-based CMOS circuits and high-side switching are still under investigation. Two-dimensional hole gas(2DHG) has been used to demonstrate the p-channel GaN field-effect-transistors(FETs) [1–5].

关键词： MOSFETS

Positive definiteness of real quadratic forms resulting from the variable-step L1-type approximations of convolution operators

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Science China Mathematics 2024年第2期67卷 237-252页

作者： Hong-Lin liao Tao Tang Tao Zhou School of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 211106China Division of Science and Technology BNU-HKBU United International CollegeZhuhai 519087China SUSTech International Center for Mathematics Shenzhen 518055China NCMIS&LSEC Institute of Computational Mathematics and Scientific/Engineering ComputingAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China

The positive definiteness of real quadratic forms with convolution structures plays an important rolein stability analysis for time-stepping schemes for nonlocal operators. In this work, we present a novel analysistool to handle discrete convolution kernels resulting from variable-step approximations for convolution *** precisely, for a class of discrete convolution kernels relevant to variable-step L1-type time discretizations, weshow that the associated quadratic form is positive definite under some easy-to-check algebraic conditions. Ourproof is based on an elementary constructing strategy by using the properties of discrete orthogonal convolutionkernels and discrete complementary convolution kernels. To our knowledge, this is the first general result onsimple algebraic conditions for the positive definiteness of variable-step discrete convolution kernels. Using theunified theory, we obtain the stability for some simple nonuniform time-stepping schemes straightforwardly.

关键词： discrete convolution kernels positive definiteness variable time-stepping orthogonal convolution kernels complementary convolution kernels

A bounding surface visco-plasticity model considering generalized spacing ratio of soils

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1832-1846页

作者： Xiaosen Kang Hongjian liao Qiangbing Huang Jianbing Peng Department of Geological Engineering Chang’an UniversityXi’an710054China Department of Civil Engineering Xi’an Jiaotong UniversityXi’an710049China

The non-unique critical state of soils with time-dependent behaviors is a significant issue in geotechnical engineering ***,previous bounding surface plasticity models cannot predict accurately the non-unique critical state of soils,because the distance between the compression line and critical state line charged by strain-rate effect is basically *** fill this gap,a generalized spacing ratio of soils is defined in the elasto-viscoplastic framework,and a bounding surface visco-plasticity model is formulated and verified,which can consider the generalized spacing ***,the generalized spacing ratio of soils reflects the distance between the compression line and the critical state line of soils with time-dependent ***,the generalized spacing ratio is introduced into an improved anisotropic bounding surface.A new expression of the visco-plastic multiplier is derived by solving the consistency equation of an anisotropic bounding *** the expression,a strain rate index is proposed to account for the strain-rate effect on visco-plastic strain increment,and a visco-plastic hardening modulus is derived to predict the visco-plastic response of soils in overconsolidation *** model is then verified through constant strain rate tests and creep ***,it can capture the non-unique critical states of soils with time-dependent behaviors due to the generalized spacing ratio and the creep rupture of soils due to the visco-plastic multiplier that considers the stress ratio and visco-plastic strain rate.

关键词： Soil Constitutive model Visco-plastic behavior Strain rate Creep Anisotropic

Effects of fracture evolution and non-Darcy flow on the thermal performance of enhanced geothermal system in 3D complex fractured rock

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International Journal of Mining Science and Technology 2024年第4期34卷 443-459页

作者： Yachen Xie Jianxing liao Pengfei Zhao Kaiwen Xia Cunbao Li Department of Civil and Mineral Engineering University of TorontoToronto M5S1A4Canada College of Water Resources and Hydropower Sichuan UniversityChengdu 610225China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsWuhan 430071China College of Civil Engineering Guizhou UniversityGuiyang 550025China Institute of Geosafety School of Engineering and TechnologyChina University of GeosciencesBeijing 100083China State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering Shenzhen UniversityShenzhen 518060China

In fractured geothermal reservoirs,the fracture networks and internal fluid flow behaviors can significantly impact the thermal *** this study,we proposed a non-Darcy rough discrete fracture network(NR-DFN)model that can simultaneously consider the fracture evolution and non-Darcy flow dynamics in studying the thermo-hydro-mechanical(THM)coupling processes for heat extraction in geothermal *** further employed the model on the Habanero enhanced geothermal systems(EGS)project located in ***,our findings illustrate a clear spatial-temporal variation in the thermal stress and pressure perturbations,as well as uneven spatial distribution of shear failure in 3D fracture *** shear failure is mainly concentrated in the first fracture ***,channeling flow have also been observed in DFNs during heat extraction and are further intensified by the expansion of fractures driven by thermal ***,the combined effect of non-Darcy flow and fracture evolution triggers a rapid decline in the resulting heat rate and *** NR-DFN model framework and the Habanero EGS's results illustrate the importance of both fracture evolution and non-Darcy flow on the efficiency of EGS production and have the potential to promote the development of more sustainable and efficient EGS operations for stakeholders.

关键词： Coupled THM model Non-Darcy flow Deformable DFN Enhanced geothermal systems

Field Study of HPTRM Combined with Vegetation and Anchor to Protect Newly Excavated Expansive Soil Slope

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Journal of Earth Science 2024年第4期35卷 1277-1288页

作者： Yingzi Xu Xuhang liao Linqiang Tang Lin Li College of Civil&Architectural Engineering Guangxi UniversityNanning530004China Guangxi Key Laboratory of Disaster Prevention and Engineering Safety Nanning530004China Guangxi Transport Vocational and Technical College Nanning530004China Department of Civil&Architectural Engineering Tennessee State UniversityTennessee37209NashvilleUSA

Anchor reinforced vegetation system(ARVS)comprises high performance turf reinforcement mats(HPTRM),vegetation and *** is a new attempt to apply the system in expansive soil slope *** goal of this paper was to evaluate the effectiveness of ARVS in protecting newly excavated expansive soil *** field tests on the bare slope,grassed slope and ARVS protective slope were carried out,including natural and artificial *** the test,the soil water content,soil deformation,and anchor axial force were monitored,and then the slope protection mechanism of ARVS was *** was found that ARVS can effectively protect expansive soil slopes compared with bare slopes and grassed *** vegetation and HPTRM form a reinforced turf,and the anchors fix it to the slope surface,thus restraining the expansion *** axial force on the anchor of ARVS includes frictional resistance and tensile force transmitted by HPTRM,which is maximum at the early stage of *** neutral point of the anchor of ARVS moves deeper under atmospheric action,but the vegetation and HPTRM on the slope surface can limit this movement.

关键词： expansive soil slope anchor reinforced vegetation system high performance turf reinforcement mats field test slope protection

A hybrid memory architecture supporting fine-grained data migration

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Frontiers of Computer Science 2024年第2期18卷 31-41页

作者： Ye CHI Jianhui YUE Xiaofei liao Haikun LIU Hai JIN National Engineering Research Center for Big Data Technology and System Services Computing Technology and System LabCluster and Grid Computing LabSchool of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Department of Computer Science Michigan Technological UniversityMichigan 49931USA

Hybrid memory systems composed of dynamic random access memory(DRAM)and Non-volatile memory(NVM)often exploit page migration technologies to fully take the advantages of different memory *** previous proposals usually migrate data at a granularity of 4 KB pages,and thus waste memory bandwidth and DRAM *** this paper,we propose Mocha,a non-hierarchical architecture that organizes DRAM and NVM in a flat address space physically,but manages them in a cache/memory *** the commercial NVM device-Intel Optane DC Persistent Memory Modules(DCPMM)actually access the physical media at a granularity of 256 bytes(an Optane block),we manage the DRAM cache at the 256-byte size to adapt to this feature of *** design not only enables fine-grained data migration and management for the DRAM cache,but also avoids write amplification for Intel Optane *** also create an Indirect Address Cache(IAC)in Hybrid Memory Controller(HMC)and propose a reverse address mapping table in the DRAM to speed up address translation and cache ***,we exploit a utility-based caching mechanism to filter cold blocks in the NVM,and further improve the efficiency of the DRAM *** implement Mocha in an architectural *** results show that Mocha can improve application performance by 8.2%on average(up to 24.6%),reduce 6.9%energy consumption and 25.9%data migration traffic on average,compared with a typical hybrid memory architecture-HSCC.

关键词： non-volatile memory hybrid memory system data migration fine-grained caching