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Mitochondrial dysfunction:mechanisms and advances in therapy

Signal Transduction and Targeted Therapy 2024年第6期9卷 2362-2390页

作者： Yao Zong Hao Li Peng liao Long Chen Yao Pan Yongqiang zheng Changqing Zhang Delin Liu Minghao zheng Junjie Gao Centre for Orthopaedic Research Medical SchoolThe University of Western AustraliaNedlandsWA 6009Australia Department of Orthopaedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China Institute of Microsurgery on Extremities and Department of Orthopedic SurgeryShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCAS Center for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Sixth People’s Hospital Fujian No.16Luoshan SectionJinguang RoadLuoshan StreetJinjiang CityQuanzhouFujianChina

Mitochondria,with their intricate networks of functions and information processing,are pivotal in both health regulation and disease ***,mitochondrial dysfunctions are identified in many common pathologies,including cardiovascular diseases,neurodegeneration,metabolic syndrome,and ***,the multifaceted nature and elusive phenotypic threshold of mitochondrial dysfunction complicate our understanding of their contributions to ***,these complexities do not prevent mitochondria from being among the most important therapeutic *** recent years,strategies targeting mitochondrial dysfunction have continuously emerged and transitioned to clinical *** intervention such as using healthy mitochondria to replenish or replace damaged mitochondria,has shown promise in preclinical trials of various *** components,including mtDNA,mitochondria-located microRNA,and associated proteins can be potential therapeutic agents to augment mitochondrial function in immunometabolic diseases and tissue ***,we review current knowledge of mitochondrial pathophysiology in concrete examples of common *** also summarize current strategies to treat mitochondrial dysfunction from the perspective of dietary supplements and targeted therapies,as well as the clinical translational situation of related pharmacology ***,this review discusses the innovations and potential applications of mitochondrial transplantation as an advanced and promising treatment.

关键词： dysfunction injuries replace

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Soil amendment strategies determining microbial community composition and their assembly processes in a continuously cropped soil

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Soil Ecology Letters 2024年第3期6卷 85-95页

作者： Hongkai liao Chunli zheng Juan Li Jian Long Yaying Li Guizhou Provincial Key Laboratory of Mountain Environment Guizhou Normal UniversityGuiyang 550001China The Key Laboratory of Environmental Pollution Monitoring and Disease Control Ministry of EducationDepartment of ToxicologySchool of Public HealthGuizhou Medical UniversityGuiyang 550025China Key Laboratory of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key Laboratory of Urban Environmental Processes and Pollution Control Ningbo(Beilun)Zhongke Haixi Industry Technology Innovation CenterNingbo 315800China

Reductive soil disinfestation(RSD)is an important tool for sustainable agricultural ***,the differences in soil bacterial communities and their community assembly processes among RSD and other treatment strategies(e.g.,biochar and chemical fumigation)are still subject to open *** this study,soils subjected to various treatments–un-treated control(CK),chemical soil fumigation with CaCN2(CF),1%biochar(1%B),3%biochar(3%B),and reductive soil disinfestation(RSD)are *** samples were collected,incubated,and then used for growth of tomato *** Sloan neutral community model indicates that stochastic processes dominate in bacterial community assembly for both biochar and CF *** contrast,this work shows that RSD treatment can have a strong impact on soil bacterial community *** relative abundance of Firmicutes increased during unplanted soil incubation,whereas Proteobacteria and Bacteroidetes dominated in the rhizosphere after planting of *** stochasticity ratio reveals that deterministic selection played an important role in the bacterial assembly under RSD *** found that RSD amendment yielded lower biomass than that for other treatments after 28 days of tomato *** results suggest that although RSD treatment has great potential to rebuild soil bacterial ecology by shaping bacterial communities and their assembly processes,it is important to monitor and manage soil conditions(e.g.,soil nutrients or physical properties)before planting to ensure plant productivity.

关键词： amendment strategy reductive soil disinfestation bacterial community assembly processes

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Improved ferroelectric properties of CMOS back-end-of-line compatible Hf_(0.5)Zr_(0.5)O_(2)thin films by introducing dielectric layers

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Journal of Materiomics 2024年第2期10卷 277-284页

作者： Changfan Ju Binjian Zeng Ziqi Luo Zhibin Yang Puqi Hao Luocheng liao Qijun Yang Qiangxiang Peng Shuaizhi zheng Yichun Zhou Min liao Key Laboratory of Low Dimensional Materials and Application Technology of Ministry of Education School of Materials Science and EngineeringXiangtan UniversityXiangtan411105China School of Advanced Materials and Nanotechnology Xidian UniversityXi'an710126China

Hf_(0.5)Zr_(0.5)O_(2)(HZO)ferroelectric thin films have gained significant attention for the development of next-generation ferroelectric memories by complementary-metal-oxide semiconductor(CMOS)back-end-of-line(BEOL)processing,due to their relatively low crystallization ***,it remains challenging to achieve excellent ferroelectric properties with post deposition annealing(PDA)process at a BEOL compatible *** these lines,in this work,it is demonstrated that the ferroelec-tricity of 15 nm thick HZO thin film prepared by PDA process at 400℃can be improved to varying degrees,via depositing 2 nm thick dielectric layers of Al_(2)O_(3),HfO_(2),or ZrO_(2)at either the bottom or the top of the ***,the HZO thin film with the top-Al_(2)O_(3)layer exhibits remarkable ferroelectric prop-erties,which are independent of the thickness of *** 6 nm thick HZO thin film shows a total remanent polarization(2Pr)of 31 mC/cm^(2)under an operating voltage of 2.5 *** results represent a significant advancement in the fabrication of high-performance,BEOL compatible ferroelectric mem-ories,as compared to previously reported state-of-the-art works.

关键词： Al_(2)O_(3) BEOL processing Ferroelectricity Hf_(0.5)Zr_(0.5)O_(2)(HZO)

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Copper-catalyzed asymmetric dearomatizing amination of 2-naphthols:Csp^(2)–N coupling via 1,3-reductive elimination

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Science China Chemistry 2024年第8期67卷 2694-2700页

作者： Aying Yihuo Maoping Pu zheng Tan Jibang liao Jiuqi Tan Qi-Lin Zhou Xiaohua Liu Xiaoming Feng Key Laboratory of Green Chemistry&Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengdu 610064China Key Laboratory and Institute of Elemento-Organic Chemistry College of Chemistry Frontiers Science Centerfor New Organic MatterNankai UniversityTianjin300071China

An efficient catalytic asymmetric dearomatizing amination of 2-naphthols and phenols catalyzed by N,N′-dioxide-copper(I)complex as a chiral catalyst was presented.A variety of optically activeβ-naphthalenone compounds with a nitrogen-containing quaternary carbon stereocenter were obtained with high yield and enantioselectivity under mild reaction *** studies indicated that this Csp^(2)–N dearomatizing coupling proceeds via 1,3-reductive elimination of phenolate-Cu~Ⅲ-amino intermediate in five-membered ring transition *** origin of enantioselectivity has also been elucidated based on density functional theory calculations.

关键词： asymmetric catalysis amination dearomatization copper catalysis coupling reaction

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Stable Cycling of All-Solid-State Lithium Batteries Enabled by Cyano-Molecular Diamond Improved Polymer Electrolytes

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Nano-Micro Letters 2024年第10期16卷 561-575页

作者： Yang Dai Mengbing Zhuang Yi-Xiao Deng Yuan liao Jian Gu Tinglu Song Hao Yan Jin-Cheng zheng Department of Chemical Engineering Shanghai UniversityShangda Road 99Shanghai 200444People's Republic of China Department of Physics Xiamen UniversityXiamen 361005People's Republic of China Experimental Center of Advanced Materials School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People's Republic of China Department of Physics and Department of New Energy Science and Engineering Xiamen University Malaysia43900 SepangMalaysia

The interfacial instability of the poly(ethylene oxide)(PEO)-based electrolytes impedes the long-term cycling and further application of all-solid-state lithium metal *** this work,we have shown an effective additive 1-adaman-tanecarbonitrile,which con-tributes to the excellent per-formance of the poly(ethylene oxide)-based *** to the strong interaction of the 1-Adamantanecarboni-trile to the polymer matrix and anions,the coordination of the Li^(+)-EO is weakened,and the binding effect of anions is strengthened,thereby improving the Li^(+)conductivity and the electrochemical *** diamond building block on the surface of the lithium anode can sup-press the growth of lithium ***,the 1-Adamantanecarbonitrile also regulates the formation of LiF in the solid electrolyte interface and cathode electrolyte interface,which contributes to the interfacial stability(especially at high voltages)and protects the electrodes,enabling all-solid-state batteries to cycle at high voltages for long periods of ***,the Li/Li symmetric cell undergoes long-term lithium plating/stripping for more than 2000 h.1-Adamantanecarbonitrile-poly(ethylene oxide)-based LFP/Li and 4.3 V Ni_(0.8)Mn_(0.1)Co_(0.1)O_(2)/Li all-solid-state batteries achieved stable cycles for 1000 times,with capacity retention rates reaching 85%and 80%,respectively.

关键词： 1-Adamantanecarbonitrile(ADCN) Poly(ethylene oxide) All-solid-state batteries Interfacial stability High voltage

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Theoretical probe into universal tetrad effect for complexation discrepancy between lanthanide elements and organophosphoric extractant diethyl phosphoric acid

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Journal of Rare Earths 2024年第6期42卷 1142-1148,I0006页

作者： Haifeng zheng Yanling Li Xuyi Zhang Jinglu Han Songsong Li Guolong Wu Qingshi Liu Xiaojuan Liu Wuping liao State Key Laboratory of Rare Earth Resources Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China University of Science and Technology of China Hefei230026China School of Chemistry and Chemical Engineering Nanchang UniversityNanchang330031China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341000China

The deep understanding of 4f-correlated electron motion behavior is experimentally limited due to similar physicochemical properties of rare earth elements(REEs).While the solvent extraction behavior originating from the continuous occupation of 4f electrons along the lanthanide family provides a particular platform to probe the 4f electrons motion behavior and its correlations to their versatile ***,the complexation between REEs and the prototypical extractant of diethyl phosphoric acid(DEP)was substantially studied based on quantum mechanical *** results firstly show that the average bond lengths between Ln and six coordinated oxygen atoms are consistent with lanthanide contraction phenomenon,and gadolinium break effect is also obviously ***,the"tetrad effect"is figured out based on the subtle discrepancy of 4f electrons occupation,namely La-Nd,Sm-Eu,Gd-Dy and ***,the main composition is 4f5d6p for La-Nd,while the discrepancy is due to the increasing electrons in the 5d shell,while it is 4f5d for *** Gd-Dy,their 4f orbitals accept little electrons and the donating electrons flow into 6s5d subshells due to the half-filled stability and the enhancement of shielding *** electrons donate into 5d6p subshells due to multiply electrons occupation of 4f orbitals for *** detailed analyses obviously clarify the"tetrad effect"along the lanthanide family due to the different variation of 4f orbital *** is expected that these microscopic understandings provide important guidance for the separation of REEs and the design of new extractants.

关键词： Theoretical calculation Rare earths 4f electron Tetrad effect Gadolinium break

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Antibacterial properties of cerium oxide nanoparticles:Recent progresses and future challenges

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Particuology 2024年第10期93卷 264-283页

作者： Heishu zheng Jiajing Tang Yanhua Wei Xi Deng Yingjuan Zhang Xiangyu Ma Xudong Jiang Zhi Ping Xu Hongbing liao College&Hospital of Stomatology Guangxi Medical UniversityNanning530021China Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction Guangxi Medical UniversityNanning530021China The First Affiliated Hospital of Guangxi Medical University Nanning530021China School of Medicine Guangxi University of Science and TechnologyLiuzhou545005China Institute of Biomedical Health Technology and Engineering and Institute of Systems and Physical Biology Shenzhen Bay LaboratoryShenzhen518107China Australian Institute for Bioengineering and Nanotechnology(Bld 75) The University of QueenslandSt LuciaQueensland 4074Australia

Use of cerium oxide nanoparticles(CeO_(2) NPs)to optimize management of resistant microorganisms has received increasing attention due to non-specific activity of inorganic antibacterial *** the mechanism of action is essential to elucidating the antibacterial activity of CeO_(2) NPs against ***,this review aims to summarize the antibacterial mechanisms of CeO_(2) NPs and correlate the structural and physicochemical properties of CeO_(2) NPs to their antibacterial *** further summarize the strategies for the improvement of the antibacterial performance of CeO_(2) NPs and provide our opinions for future challenges as a conclusion.

关键词： Nanoparticles Cerium oxide Antibacterial activity Nanozyme Fenton reaction

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Genome wide investigation of Hsf gene family in Phoebe bournei:identification,evolution,and expression after abiotic stresses

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Journal of Forestry Research 2024年第5期35卷 201-215页

作者： Wenhai liao Xinghao Tang Jingshu Li Qiumian zheng Ting Wang Shengze Cheng Shiping Chen Shijiang Cao Guangqiu Cao College of Forestry Fujian Agriculture and Forestry UniversityFuzhou 350002People’s Republic of China University Key Laboratory of Forest Stress Physiology Ecology and Molecular Biology of Fujian ProvinceFuzhou 350002People’s Republic of China Fujian Academy of Forestry Sciences Fuzhou 350002People’s Republic of China College of Plant Protection Fujian Agriculture and Forestry UniversityFuzhou 350002People’s Republic of China

Heat shock transcription factors(Hsfs)have important roles during plant growth and development and responses to abiotic *** identification and func-tion of Hsf genes have been thoroughly studied in various herbaceous plant species,but not woody species,especially Phoebe bournei,an endangered,unique species in *** this study,17 members of the Hsf gene family were identi-fied from *** using bioinformatic ***-netic analysis indicated that PbHsf genes were grouped into three subfamilies:A,B,and *** motifs,three-dimensional structure,and physicochemical properties of the PbHsf proteins were also *** structure of the PbHsf genes varied in the number of exons and ***-diction of cis-acting elements in the promoter region indi-cated that PbHsf genes are likely involved in responses to plant hormones and stresses.A collinearity analysis dem-onstrated that expansions of the PbHsf gene family mainly take place via segmental *** expression levels of PbHsf genes varied across different plant *** the basis of the expression profiles of five representative PbHsf genes during heat,cold,salt,and drought stress,PbHsf pro-teins seem to have multiple functions depending on the type of abiotic *** systematic,genome-wide investigation of PbHsf genes in *** and their expression patterns provides valuable insights and information for further func-tional dissection of Hsf proteins in this endangered,unique species.

关键词： Phoebe bournei Hsf gene family Evolutionary analysis Expression mechanism Abiotic stresses

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Friction between Strongly Compressed Polymer Brushes

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Chinese Journal of Polymer Science 2024年第9期42卷 1368-1374,I0008页

作者： Qi liao Institute of Chemistry Chinese Academy of SciencesBejing 100190China

We present the results of molecular dynamics simulations of steady shear between a pair of neutral polymer brushes,as well as a pair of charged polymer brushes in the strongly compressed *** results of the molecular dynamic simulations of neutral and polyelectrolyte brushes in implicit solvent including normal forces,shear forces,viscosities and friction coefficients as a function of separation between brushes,are presented in the *** comparison of the simulation results of neutral and charged brushes shows that the charged brushes is in the quasi-neutral regime,and the dependence of viscosity on the separation distance show the similar power law of neutral *** simulation results confirm that the implicit solvent simulations of polyelectrolyte brushes that ignore hydrodynamics interaction are in agreement with the scaling predictions qualitatively because of screening of hydrodynamic interaction and long-range electrostatic interactions on the correlation length *** of neutral and charged brushes show the lubrication properties that the friction coefficient decreases with the separation decreases at enough large ***,a maximum of friction coefficients is observed for polyelectrolyte brushes,which is in contrast to the neutral brushes with monotonical dependence.

关键词： Polymer brush Frictions coefficient Polyelectrolyte Lubrication

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A novel nano-grade organosilicon polymer:Improving airtightness of compressed air energy storage in hard rock formations

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International Journal of Mining Science and Technology 2024年第3期34卷 305-321页

作者： Zhuyan zheng Guibin Wang Chunhe Yang Hongling Ma Liming Yin Youqiang liao Kai Zhao Zhen Zeng Hang Li Yue Han Institute of Rock and Soil Mechanics Chinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Geomechanics and Geotechnical Engineering Wuhan 430071China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044China PowerChina Huadong Engineering Corporation Limited Hangzhou 310014China

Enhancing cavern sealing is crucial for improving the efficiency of compressed air energy storage(CAES)in hard rock *** study introduced a novel approach using a nano-grade organosilicon polymer(NOSP)as a sealant,coupled with an air seepage evaluation model that incorporates Knudsen ***,the initial coating application methods were outlined,and the advantages of using NOSP compared to other sealing materials,particularly regarding cost and construction techniques,were also examined and *** results indicated a significant reduction in permeability of rock specimens coated with a 7–10μm thick NOSP ***,under a 0.5 MPa pulse pressure,the permeability decreased to less than 1 n D,and under a 4 MPa pulse pressure,it ranged between4.5×10^(-6)–5.5×10^(-6)m D,marking a 75%–80%decrease in granite *** sealing efficacy of NOSP surpasses concrete and is comparable to rubber *** optimal viscosity for application lies between 95 and 105 KU,and the coating thickness should ideally range from 7 to 10μm,applied to substrates with less than 3%*** study provides new insights into air transport and sealing mechanisms at the pore level,proposing NOSP as a cost-effective and simplified solution for CAES applications.

关键词： Compressed air energy storage Lining Permeability Transient pulse method Hard rock cavern Nano-grade organosilicon polymer coating

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