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Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

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Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu Huang Qiuyu Pang Lexin zheng Jiaxi Lin Hanxi Li Lingbo Wan Tao Wang Department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and *** plays a key role in the establishment and maintenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental ***,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system *** hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell *** cholesterol accumulation in the brain has been found after intracerebral *** this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target

Microwave irradiation-induced deterioration of rock mechanical properties and implications for mechanized hard rock excavation

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Journal of Rock Mechanics and Geotechnical Engineering 2025年第1期17卷 275-290页

作者： zheng Yang Ming Tao Muhammad Burhan Memon Dengdeng Zhuang Yan Zhao School of Resources and Safety Engineering Central South UniversityChangshaChina

In this study,a novel microwave-water cooling-assisted mechanical rock breakage method was proposed to address the issues of severe tool wear at elevated temperatures,poor rock microwave absorption,and excessive microwave energy *** investigation object was sandstone,which was irradiated at 4 kW microwave power for 60 s,180 s,300 s,and 420 s,followed by air and water ***,uniaxial compression,Brazilian tension,and fracture tests were *** evolution of damage in sandstone was measured using active and passive nondestructive acoustic detection *** roughness of the fracture surfaces of the specimens was quantified using the box-counting *** damage mechanisms of microwave heating and water cooling on sandstone were discussed from both macroscopic and microscopic *** experimental results demonstrated that as the duration of the microwave irradiation increased,the P-wave velocity,uniaxial compressive strength(UCS),elastic modulus(E),tensile strength,and fracture toughness of sandstone exhibited various degrees of weakness and were further weakened by water ***,an increase in the microwave irradiation duration enhanced the damaging effect of water *** P-wave velocity of the sandstone was proportional to the mechanical *** heating and water cooling weakened the brittleness of the sandstone to a certain *** fractal dimension of the fracture surface was correlated with the duration of microwave heating,and the water-cooling treatment resulted in a rougher fracture *** analysis of the instantaneous cutting rate revealed that water cooling can substantially enhance the efficiency of microwave-assisted rock breakage.

关键词： Hard rock breakage Microwave irradiation Water cooling Acoustic testing Fractal dimension Instantaneous cutting rate

Social function scores and influencing factors in patients with residual depressive symptoms

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World Journal of Psychiatry 2025年第1期15卷 117-127页

作者： Zong-Ling Liao Xiao-Li Pu Zhi-Yi zheng Jie Luo Department 1 of Psychiatry Gele Mountain Hospital of Chongqing Mental Health CenterChongqing 400030China Department of Psychology Chongqing Jiangjin District Psychiatric HospitalChongqing 402260China Department of Psychiatry Chongqing Third Social Welfare InstituteChongqing 400036China Women and Children’s Mental Health Center Affiliated Hospital of Chongqing Population and Family Planning Research InstituteChongqing 400020China

BACKGROUND At present,the influencing factors of social function in patients with residual depressive symptoms are still *** depressive symptoms are highly harmful,leading to low mood in patients,affecting work and interpersonal communication,increasing the risk of recurrence,and adding to the burden on *** the influencing factors of their social function is of great *** To explore the social function score and its influencing factors in patients with residual depressive *** This observational study surveyed patients with residual depressive symptoms(case group)and healthy patients undergoing physical examinations(control group).Participants were admitted between January 2022 and December *** functioning was assessed using the Sheehan Disability Scale(SDS),and scores were compared between *** influencing SDS scores in patients with residual depressive symptoms were analyzed by applying multiple linear regression while using the receiver operating characteristic curve,and these RESULTS The SDS scores of the 158 patients with depressive symptoms were 11.48±*** with the control group,the SDS scores and all items in the case group were *** scores were higher in patients with relapse,discon-tinuous medication,drug therapy alone,severe somatic symptoms,obvious residual symptoms,and anxiety scores≥*** history,medication compliance,therapy method,and residual symptoms correlated positively with SDS scores(r=0.354,0.414,0.602,and 0.456,respectively).Independent influencing factors included disease history,medication compliance,therapy method,somatic symptoms,residual symptoms,and anxiety scores(P<0.05).The areas under the curve for predicting social functional impairment using these factors were 0.713,0.559,0.684,0.729,0.668,and 0.628,respectively,with sensitivities of 79.2%,61.8%,76.8%,81.7%,63.6%,and 65.5%and specificities of 83.3%,87.5%,82.6%,83.3%,86.7%,and 92.1%,respectively.C

关键词： Depressive Residual symptoms Social function Influence factors

The golden era of scientific publishing in China

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Zoological Research 2025年第01期 1-2页

作者： Yong-Gang Yao Yong-Tang zheng Kunming Institute of Zoology Chinese Academy of Sciences

In Chinese culture,the dragon symbolizes faith,strength,courage,and an air of *** 2024,guided by this auspicious emblem and supported by authors,readers,reviewers,and editorial board members,Zoological Research(ZR) has successfully completed its annual publishing objectives,achieved significant progress,and secured continued national funding support through its selection for China's Science and Technology Journal Excellence Action Plan (phaseⅡ).As we enter the year of the snake,a symbol of wisdom,renewal,transformation,and growth,we take this opportunity to reflect on past achievements and express our sincere appreciation to all contributors.

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Construction of N-doped copper metal-organic frameworks for promoting photocatalytic carbon dioxide reduction to ethylene

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Science China Chemistry 2025年第2期68卷 601-609页

作者： Fan Guo Zong-zheng He Peng Wang Xiao-Yu Zhang Hongjian Yu Qin-Chao Wang Wei-Yin Sun School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China Coordination Chemistry Institute State Key Laboratory of Coordination ChemistrySchool of Chemistry and Chemical EngineeringNanjing National Laboratory of MicrostructuresCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China

Engineering nonmetallic atom-doped metal-organic framework(MOF)catalyst to promote C−C coupling and realize conversion of CO_(2) into C_(2 )multi-carbon hydrocarbon products is still ***,with 2-methylimidazole as a dopant of N element,an N-doped NH_(2)-CuBDC catalyst was obtained via a facile and simple stirring *** illumination,compared with catalytic CO_(2) reduction to C1 product of CO by original MOF,N-doped NH_(2)-CuBDC can motivate generation of C_(2)H_(4),which is difficult to achieve in photocatalytic system by MOF-based *** transfer rates of photo-generated charges have been expedited due to the high electron density around Cu catalytic sites after *** importantly,C–C coupling intermediate CO–CHO*was identified by in situ Fourier transform infrared spectroscopy during the catalytic CO_(2) reduction reaction process,which further indicates the presence of Cu–N sites in the NH_(2)-CuBDC can facilitate the formation of C2H_(4) *** work uncovers a new paradigm to design photocatalysts for enhancing the reduction of CO_(2) to C_(2) products.

关键词： metal-organic frameworks C-C coupling doping photocatalytic CO_(2) reduction Cu-based catalysts

Effect of graphene addition on activation and kinetic properties of La-Mg-Ni-based hydrogen storage alloys

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Journal of Iron and Steel Research International 2025年第1期32卷 227-238页

作者： Dian-chen Feng Chun-ling zheng Zhi-yuan Zhao Dong-sheng Zhou Hui-ping Ren Yang-huan Zhang School of Materials and Metallurgy Inner Mongolia University of Science and TechnologyBaotou014010Inner MongoliaChina Collaborative Innovation Center of Integrated Exploitation of Bayan Obo Multi-Metal Resources Inner Mongolia University of Science and TechnologyBaotou014010Inner MongoliaChina Department of Functional Material Research China Iron and Steel Research Institute GroupBeijing100081China

The La_(1.7)Pr_(0.3)Mg_(16)Ni hydrogen storage alloy was prepared by medium-frequency induction melting,and then the composite hydrogen storage alloy powder of La_(1.7)Pr_(0.3)Mg_(16)Ni+x wt.%(x=0,2,4,and 6)graphene was prepared by ball milling for 10 *** effect of the addition of graphene on the activation and hydrogen de/absorption properties of La_(1.7)Pr_(0.3)Mg_(16)Ni alloy was *** result demonstrated that these composite alloys were composed of La_(2)Mg_(17),La_(2)Ni_(3),and Mg_(2)Ni *** saturated hydrogen absorption,it was composed of LaH_(3),Mg_(2)NiH_(4),and MgH_(2)phases,while during the dehydrogenation process,it was composed of LaH_(3),Mg,and Mg_(2)Ni *** addition of graphene can help get a more homogeneous granule after ball milling and accelerate the first activation of dehydrogenation/hydrogen *** hydrogen release activation energy of the alloys first decreases and then increases as the graphene content increases from x=0 wt.%to x=6 wt.%.The minimum activation energy of the composite hydrogen storage alloy is 51.22 kJ mol^(-1) when x=4 wt.%.

关键词： La-Mg-Ni alloy Graphene Mechanical ball milling Activation property Dynamic performance

Isothermal reduction kinetics and reduction prediction for iron ore pellets

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Journal of Iron and Steel Research International 2025年第1期32卷 64-72页

作者： Fei Meng Hao Liu Yue-lin Qin Huang-jie Hua Yin Deng Ze-zheng Sun Long-hai Liu School of Metallurgy and Materials Engineering Chongqing University of Science and TechnologyChongqing401331China CISDI Group Co. Ltd.Chongqing401122China College of Materials Science and Engineering Chongqing UniversityChongqing400044China Sichuan Desheng Group Vanadium&Titanium Co. Ltd.Leshan614000SichuanChina

Iron ore pellets,as one of the main charges of blast furnaces,have a greater impact on the CO_(2)emission reduction and stable operation of blast *** isothermal reduction behavior of the pellets obtained from a Chinese steel plant was studied in the gas mixtures of CO and N_(2).The results showed the reduction process is divided into two *** reduction in the initial stage(time t≤40 min)is cooperatively controlled by internal diffusion and interface chemical reactions with the activation energy of 30.19 and 16.67 kJ/mol,*** controlling step of the reduction in the final stage(t>40 min)is internal diffusion with the activation energy of 34.60 kJ/*** reduction process can be described by two equations obtained from kinetic *** reduction degree can be predicted under different temperatures and time,and the predicted results showed an excellent correlation with the experimental *** reduction mechanisms were confirmed by the analysis of the scanning electron microscope equipped with an energy dispersive spectrometer and optical microscope.

关键词： Pellet Reduction behavior Kinetics Mechanism Reduction prediction

Development and application of an intelligent thermal state monitoring system for sintering machine tails based on CNN-LSTM hybrid neural networks

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Journal of Iron and Steel Research International 2025年第1期32卷 52-63页

作者： Da-lin Xiong Xin-yu Zhang zheng-wei Yu Xue-feng Zhang Hong-ming Long Liang-jun Chen Anhui Province Key Laboratory of Metallurgical Engineering&Resources Recycling Anhui University of TechnologyMa’anshan243002AnhuiChina School of Metallurgical Engineering Anhui University of TechnologyMa’anshan243032AnhuiChina School of Computer Science Anhui University of TechnologyMa’anshan243032AnhuiChina

Real-time prediction and precise control of sinter quality are pivotal for energy saving,cost reduction,quality improvement and efficiency enhancement in the ironmaking *** advance,the accuracy and comprehensiveness of sinter quality prediction,an intelligent flare monitoring system for sintering machine tails that combines hybrid neural networks integrating convolutional neural network with long short-term memory(CNN-LSTM)networks was *** system utilized a high-temperature thermal imager for image acquisition at the sintering machine tail and employed a zone-triggered method to accurately capture dynamic feature images under challenging conditions of high-temperature,high dust,and *** feature images were then segmented through a triple-iteration multi-thresholding approach based on the maximum between-class variance method to minimize detail loss during the segmentation *** the advantages of CNN and LSTM networks in capturing temporal and spatial information,a comprehensive model for sinter quality prediction was constructed,with inputs including the proportion of combustion layer,porosity rate,temperature distribution,and image features obtained from the convolutional neural network,and outputs comprising quality indicators such as underburning index,uniformity index,and FeO content of the *** accuracy is notably increased,achieving a 95.8%hit rate within an error margin of±*** the system is applied,the average qualified rate of FeO content increases from 87.24%to 89.99%,representing an improvement of 2.75%.The average monthly solid fuel consumption is reduced from 49.75 to 46.44 kg/t,leading to a 6.65%reduction and underscoring significant energy saving and cost reduction effects.

关键词： Sinter quality Convolutional neural network Long short-term memory Image segmentation FeO prediction

Synergistic promotion strategy of “dual-site” and “dual-path” to enhance the C–C coupling between CO_(2) and HCHO driven by photoelectrocatalysis

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Journal of Energy Chemistry 2025年第1期100卷 39-49页

作者： Hongqiang Yang Jianfeng zheng Guoyu Wang Yifei Gao Yatao Yang Jia Li Xiaojin Han Yan Cui Zhanggen Huang National Key Laboratory of High Efficiency and Low Carbon Utilization of Coal Institute of Coal ChemistryChinese Academy of ScienceTaiyuan 030001ShanxiChina University of Chinese Academy of Science Beijing 100049China Shenyang University of Chemical Technology Shenyang 110142LiaoningChina

Photoelectrocatalytic coupling CO_(2)and volatile organic compounds (VOCs) is a promising green strategy for the synergistic conversion of the two carbon-containing resources to *** catalytic efficiency is always at the mercy of chemical inertness of CO_(2)and the competitive hydrogen evolution of ***,a modified g-C_(3)N_(4)/ZnAl-LDH Z-scheme heterojunction catalyst with dual reaction site was rationally designed and precisely *** Faraday efficiency of ethanol reached 68.67%with a corresponding formation rate of 227.3μmol g^(-1)h^(-1).As revealed by in-situ characterizations and density functional theory calculations,CO_(2)and HCHO were absorbed at Zn site and N site,***,*CO generated from CO_(2)and HCHO was converted to*CH_(3)O and*CHO on the dual-active-site *** detailed reaction mechanism experiments indicated that C–C coupling only occurred between*CO and*CH_(3)O in electrocatalysis *** from the“*CO+*CH_(3)O”path,another“*CO+*CHO”coupling path was also detected in photoelectrocatalytic *** selectivity of ethanol was significantly enhanced due to the synthesis of dual-site catalyst and the dual-path coupling path between CO_(2)and HCHO simultaneously driven by light and electricity.

关键词： g-C_(3)N_(4)/ZnAl-LDH heterojunction Z-scheme C-C coupling Ethanol