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A novel chronic nerve compression model in the rat

Neural Regeneration Research 2018年第8期13卷 1477-1485页

作者： zhen-yu Liu zhen-Bing Chen Jiang-Hai Chen Department of Hand Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology

Current animal models of chronic peripheral nerve compression are mainly silicone tube models. However, the cross section of the rat sciatic nerve is not a perfect circle, and there are differences in the diameter of the sciatic nerve due to individual differences. The use of a silicone tube with a uniform internal diameter may not provide a reliable and consistent model. We have established a chronic sciatic nerve compression model that can induce demyelination of the sciatic nerve and lead to atrophy of skeletal muscle. In 3-week-old pups and adult rats, the sciatic nerve of the right hind limb was exposed, and a piece of surgical latex glove was gently placed under the nerve. N-butyl-cyanoacrylate was then placed over the nerve, and after it had set, another piece of glove latex was placed on top of the target area and allowed to adhere to the first piece to form a sandwich-like complex. Thus, a chronic sciatic nerve compression model was produced. Control pups with latex or N-butyl-cyanoacrylate were also prepared. Functional changes to nerves were assessed using the hot plate test and electromyography. Immunofluorescence and electron microscopy analyses of the nerves were performed to quantify the degree of neuropathological change. Masson staining was conducted to assess the degree of fibrosis in the gastrocnemius and intrinsic paw muscles. The pup group rats subjected to nerve compression displayed thermal hypoesthesia and a gradual decrease in nerve conduction velocity at 2 weeks after surgery. Neuropathological studies demonstrated that the model caused nerve demyelination and axonal irregularities and triggered collagen deposition in the epineurium and perineurium of the affected nerve at 8 weeks after surgery. The degree of fibrosis in the gastrocnemius and intrinsic paw muscles was significantly increased at 20 weeks after surgery. In conclusion, our novel model can reproduce the functional and histological changes of chronic nerve compression injury tha

关键词： nerve regeneration chronic nerve compression carpal tunnel syndrome nerve conduction velocity N-butyl-cyanoacrylate hypoesthesia demyelination remyelination intrinsic muscles collagen deposition axonal irregularity neural regeneration

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Implicit high-order discontinuous Galerkin method with HWENO type limiters for steady viscous flow simulations

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Acta Mechanica Sinica 2013年第4期29卷 526-533页

作者： zhen-Hua Jiang Chao Yan Jian yu College of Aeronautics Science and Engineering Beijing University of Aeronautics and Astronautics

Two types of implicit algorithms have been im- proved for high order discontinuous Galerkin （DG） method to solve compressible Navier-Stokes （NS） equations on tri- angular grids. A block lower-upper symmetric Gauss- Seidel （BLU-SGS） approach is implemented as a nonlin- ear iterative scheme. And a modified LU-SGS （LLU-SGS） approach is suggested to reduce the memory requirements while retain the good convergence performance of the origi- nal LU-SGS approach. Both implicit schemes have the sig- nificant advantage that only the diagonal block matrix is stored. The resulting implicit high-order DG methods are applied, in combination with Hermite weighted essentially non-oscillatory （HWENO） limiters, to solve viscous flow problems. Numerical results demonstrate that the present implicit methods are able to achieve significant efficiency improvements over explicit counterparts and for viscous flows with shocks, and the HWENO limiters can be used to achieve the desired essentially non-oscillatory shock tran- sition and the designed high-order accuracy simultaneously.

关键词： Discontinuous Galerkin (DG) scheme ~ Implicitmethod ~ HWENO ~ High order ~ Unstructured grids

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Prognostic value of computed tomography derived skeletal muscle mass index in lung cancer:A meta-analysis

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World Journal of Clinical Cases 2022年第20期10卷 6927-6935页

作者： Xue-Lin pan Hong-Jun Li zhen Li zhen-Lin Li Department of Radiology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China Hospital of Medicine Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND The prognostic role of the skeletal muscle mass index(SMI)derived from computed tomography(CT)imaging been well verified in several types of ***,whether the SMI could serve as a reliable and valuable predictor of long-term survival in lung cancer patients remains *** To identify the prognostic value of the CT-derived SMI in lung cancer *** The PubMed,Web of Science,and Embase electronic databases were searched up to November 5,2021 for relevant *** Reference Citation Analysis databases were used during the literature searching and *** ratios(HRs)and 95%confidence intervals(CIs)were calculated to assess the association of the SMI with the overall survival(OS)of lung cancer *** statistical analyses were performed with STATA 12.0 *** A total of 12 studies involving 3002 patients were *** pooled results demonstrated that a lower SMI was significantly related to poorer OS(HR=1.23,95%CI:1.11-1.37,P<0.001).In addition,the subgroup analyses stratified by treatment(nonsurgery vs surgery),tumor stage(advanced stage vs early stage),and tumor type(non-small cell lung cancer vs lung cancer)showed similar *** The CT-derived SMI is a novel and valuable prognostic indicator in lung cancer and might contribute to the clinical management and treatment of lung cancer patients.

关键词： Skeletal muscle mass index Computed tomography Lung cancer Prognosis Meta-analysis

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An experimental study on the effects of friction modifiers on wheel-rail dynamic interactions with various angles of attack

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Railway Engineering Science 2022年第3期30卷 360-382页

作者： zhen Yang pan Zhang Jan Moraal Zili Li Section of Railway Engineering Delft University of TechnologyStevinweg 12628 CN DelftThe Netherlands

By modifying friction to the desired level,the application of friction modifiers(FMs)has been considered as a promising emerging tool in the railway engineering for increasing braking/traction force in poor adhesion conditions and mitigating wheel/rail interface deterioration,energy consumption,vibration and *** the effectiveness of FMs in wheel–rail dynamic interactions is crucial to their proper applications in practice,which has,however,not been well *** study experimentally investigates the effects of two types of top-of-rail FM,***-A and FM-B,and their application dosages on wheel–rail dynamic interactions with a range of angles of attack(AoAs)using an innovative well-controlled V-track test *** tested FMs have been used to provide intermediate friction for wear and noise *** effectiveness of the FMs is assessed in terms of the wheel–rail adhesion characteristics and friction rolling induced axle box acceleration(ABA).This study provides the following new insights into the study of FM:the applications of the tested FMs can both reduce the wheel–rail adhesion level and change the negative friction characteristic to positive;stick–slip can be generated in the V-Track and eliminated by FM-A but intensified by FM-B,depending on the dosage of the FMs applied;the negative friction characteristic is not a must for stick–slip;the increase in ABA with AoA is insignificant until stick–slip occurs and the ABA can thus be influenced by the applications of FM.

关键词： Friction modifier V-track test rig Adhesion Wheel–rail dynamic interaction Angle of attack Axle box acceleration

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Quantum connectivity optimization algorithms for entanglement source deployment in a quantum multi-hop network

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Frontiers of physics 2018年第2期13卷 1-12页

作者： zhen-zhen Zou Xu-Tao yu Zai-Chen Zhang State Key Laboratory of Millimeter Waves Southeast University Nanjing 210096 China National Mobile Communications Research Lab Southeast University Nanjing 210096 China

At first, the entanglement source deployment problem is studied in a quantum multi-hop network, which has a significant influence on quantum connectivity. Two optimization algorithms are introduced with limited entanglement sources in this paper. A deployment algorithm based on node position （DNP） improves connectivity by guaranteeing that all overlapping areas of the distribution ranges of the entanglement sources contain nodes. In addition, a deployment algorithm based on an improved genetic algorithm （DIGA） is implemented by dividing the region into grids. From the simulation results, DNP and DIGA improve quantum connectivity by 213.73% and 248.83% compared to random deployment, respectively, and the latter performs better in terms of connectivity. However, DNP is more flexible and adaptive to change, as it stops running when all nodes are covered.

关键词： entanglement source deployment quantum connectivity deployment algorithm

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Manufacture and Performance of Ionic Polymer-Metal Composites

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Journal of Bionic Engineering 2007年第3期4卷 143-149页

作者： Min yu Hui Shen zhen-dong Dai Institute of Bio-inspired Structure and Surface Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 P. R. China

Ion-exchange Polymer Metal Composites （IPMC） are a new class of intelligent material that can be used effectively as actuators and artificial muscles. IPMC was fabricated and its displacement and force characteristics were investigated with respect to voltage, frequency and waveform of the controlling signal. A square waveform input generated slightly larger displacement and force than sinusoidal or triangular waveform. When the voltage was increased and the frequency was decreased, displacement and force were both increased. However, although the bending deformation of IPMC was large, the output force was much lower than we expected. Improvement of the force output is key and is the main obstacle to be overcome in order to make IPMC of practical use.

关键词： IPMC artificial muscle

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A new fluorescent quinoline derivative toward the acid-responsivity in both solution and solid states

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Chinese Chemical Letters 2020年第11期31卷 2909-2912页

作者： Pu Wang Dan Liu Yongshuai Wang pan Zhang panpan yu Mincan Wang Yonggang zhen Huanli Dong Wenping Hu College of Chemistry and Institute of Green Catalysis Zhengzhou UniversityZhengzhou 450052China Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Beijing Key Laboratory for Optical Materials and Photonic Devices Department of ChemistryCapital Normal UniversityBeijing 100048China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)&Department of Chemistry School of ScienceTianjin UniversityTianjin 300072China

In this article,an acid-responsive luminescent material,1,4-di(quinoline-6-yl)buta-1,3-diyne(DQBD)is designed and *** different pH values,gradual changes of fluorescence colors for DQBD in both solution and solid phases are demonstrated due to the protonation ***,such responsive characteristics can also be reversible,suggesting DQBD as a promising fluorescent material with great potential for reusable-and accurate-p H sensors in the future.

关键词： Quinoline derivative Stimuli-responsive Protonation effect Fluorescence switch pH sensor

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First-principles Study of Electron Transport Through Oligoacenes

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Chinese Journal of Chemical Physics 2009年第1期22卷 7-12页

作者： zhen pan Qun-xiang Li Qin-wei Shi Xiao-ping Wang Hefei National Laboratory for Physical Sciences at Microscale University of Science and Technology of China Hefei 230026 China

The electronic transport properties of oligoacenes sandwiched between two Au（111） surfaces with serial and parrallel configurations were investigeted by using a fully self-consistent nonequilibrium Green＇s function method combined with density functional calculations. This theoretical results show that the conductivity of oligoacenes with both sandwiched configurations at low bias voltage is mainly determined by the tail of the transmission peak from the perturbed highest occupied molecular orbital. When the molecular length increases, the zero-bias voltage conductance G（0） of oligoacenes with serial configuration neither follows Magoga＇s exponential law nor displays the even-odd oscillation effect, while the G（O） of the oligoacenes sandwiched with parallel configuration monotonically increases. The reduction of energy gaps, the alignment of the Fermi level, and the spatial distribution of the perturbed molecular orbitals are used to self-consistently explore the transport mechanism through oligoacenes.

关键词： Transport property Oligoacene Zero-bias voltage conductance First-principles calculation

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Online Detection of Broken Rotor Bar Fault in Induction Motors by Combining Estimation of Signal Parameters via Min-norm Algorithm and Least Square Method

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Chinese Journal of Mechanical Engineering 2017年第6期30卷 1285-1295页

作者： pan-pan Wang Qiang yu Yong-Jun Hu Chang-Xin Miao School of Electrical and Power Engineering ChinaUniversity of Mining and Technology Xuzhou 221116China

Current research in broken rotor bar （BRB） fault detection in induction motors is primarily focused on a high-frequency resolution analysis of the stator current. Compared with a discrete Fourier transformation, the parametric spectrum estimation technique has a higher frequency accuracy and resolution. However, the existing detection methods based on parametric spectrum estima- tion cannot realize online detection, owing to the large computational cost. To improve the efficiency of BRB fault detection, a new detection method based on the min-norm algorithm and least square estimation is proposed in this paper. First, the stator current is filtered using a band-pass filter and divided into short overlapped data windows. The min-norm algorithm is then applied to determine the fre- quencies of the fundamental and fault characteristic com- ponents with each overlapped data window. Next, based on the frequency values obtained, a model of the fault current signal is constructed. Subsequently, a linear least squares problem solved through singular value decomposition is designed to estimate the amplitudes and phases of the related components. Finally, the proposed method is applied to a simulated current and an actual motor, the results of which indicate that, not only parametric spectrum estimation technique.

关键词： Fault detection Broken rotor bars Min-norm Least squares method Induction motors

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A Blockchain-Based Flexible Data Auditing Scheme for the Cloud Service

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Chinese Journal of Electronics 2021年第6期30卷 1159-1166页

作者： FAN Kefeng LI Fei yu Haiyang YANG zhen China Electronics Standardization Institute Guangzhou Sequoia DB Co. College of Computer Science Beijing University of Technology

Nowdays, cloud storage technology has become a hot topic, and an increasing number of users are concerned with the security of their data in the *** auditing schemes on the cloud are proposed and the introduction of a third-party auditor to assist users in verifying the integrity of cloud data. As a centralized node, the third-party auditor has to communicate with all cloud users and cloud service providers, which becomes the bottleneck of the whole scheme. To solve this problem,we design a blockchain-based flexible cloud data auditing scheme. In our scheme, a decentralized auditing framework is proposed to eliminate the dependency on the thirdparty auditor, which increases the stability, security and performance of the whole scheme. Since the cloud service provider can automatically generates auditing proofs, our scheme can relieve the communication burdens of the cloud service provider. The proposed scheme also adapts the Merkle Hash tree to improve the verification *** analysis and experiments show that the proposed scheme is secure and has better stability and verification efficiency.

关键词： auditing schemes blockchain-based flexible data auditing scheme cloud users third-party auditor cloud service provider auditing decentralized auditing framework cloud storage technology security of data cloud computing data integrity storage management blockchain-based flexible cloud data

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