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Efficient hybrid neural network for spike sorting

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Journal of Systems Engineering and Electronics 2013年第1期24卷 157-164页

作者： Hongge Li pan yu Tongsheng Xia School of Electronics Information Engineering Beihang University

Artificial neural network has been used successfully to develope the automatic spike extraction. In order to address some of the problems before the wireless transmission of the implantable chip, the automatic spike sorting method with low complexity and high efficiency is proposed based on the hybrid neural network with the principal component analysis network （PCAN） and normal boundary response （NBR） self-organizing mapping （SOM） net- work classifier. An automatic PCAN technique is used to reduce the dimension and eliminate the correlation of the spike signal. The NBR-SOM network performs the spike sorting challenge and improves the classification performance. The experimental results show that based on the hybrid neural network, the spike sorting method achieves the accuracy above 97.91% with signals contain- ing five classes. The proposed NBR-SOM network classifier is to further improve the stability and effectiveness of the classification system.

关键词： neural network spike sorting implantable microsys-tern.

Developmental and Reproductive Toxicity of Soybean Isoflavones to Immature SD Rats

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Biomedical and Environmental Sciences 2008年第3期21卷 197-204页

作者： LEI GUAN yu HUANG zhen-yu CHEN Food and Nutritional Sciences Programme Department of Biochemistry Department of Physiology The Chinese University of Hong Kong Shatin N. T. Hong Kong China

Objective To investigate the dose-dependent toxic effect of soybean isoflavone extracts （SIE） on reproductive development in immature rats. Methods Growing male and female rats （n=50 each, 4 weeks） were divided into five groups fed with a standard cereal-based diet and gastrogavaged daily with 0, 30, 150, 300, and 600 mg SIE / kg body weight, respectively, for 12 weeks. Body weight, organ weights, and serum level of estrogen and testosterone were measured. Results Oral administration of SIE had no effect on food intake but decreased food efficiency ratio （P〈0.01）. Suppression on body weight gain by SIE was dose-dependent and the effect was greater on male than on female rats （P〈0.01）. SIE at high doses exhibited hepatotoxicity by increasing a relative liver weight, and also caused a smaller uterus but a greater relative ovary in female rats, while leading to larger relative testis and epididymis in male rats. SIE could decrease progesterone concentrations in female rats, whereas in male rats it reduced not only total testosterone level but also sperm count compared with the control group （P〈0.05）. Conclusion SIE at a range of 50-1000 times of human intake level affects not only growth but also development of reproductive system in growing rats.

关键词： Isoflavones Rat Reproduction Soybean Toxicity

Review of single-camera stereo-digital image correlation techniques for full-field 3D shape and deformation measurement

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Science China(Technological Sciences) 2018年第1期61卷 2-20页

作者： pan Bing yu LiPing ZHANG QianBing Institute of Solid Mechanics Beihang University Department of Civil Engineering The University of Hong Kong

Single-camera stereo-digital image correlation(stereo-DIC) techniques have gained increasing attentions and demonstrated excellent prospects in the experimental mechanics community owing to their prominent advantages of cost-effectiveness,compactness, and the avoidance of the complicated camera synchronization. Using additional optical devices, e.g. a diffraction grating, a bi-prism or a set of planar mirrors, pseudo stereo images of a test sample surface can be recorded with a single *** correlating these stereo images using DIC, full-field three-dimensional(3 D) shape and deformation can be retrieved. This review comprehensively summarizes the historical development, methodologies, strengths and weaknesses of the diffraction grating-based, prism-based, four-mirror-adaptor-based single-camera stereo-DIC techniques, and the recently proposed novel full-frame single color camera-based stereo-DIC technique for full-field 3 D shape and deformation measurement. The optical arrangements, principles and calibration procedures of these single-camera stereo-DIC techniques are described in detail. Since high-speed deformation measurement is efficiently achieved by combining the single-camera stereo-DIC with one high-speed camera, single-camera stereo-DIC techniques show great potential in impact engineering, vibration and other dynamic tests.

关键词： single-camera stereo-DIC diffraction grating bi-prism four-mirror adapter

Novel mutations in CRYBB1/CRYBB2 identified by targeted exome sequencing in Chinese families with congenital cataract

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International Journal of Ophthalmology(English edition) 2018年第10期11卷 1577-1582页

作者： Peng Chen Hao Chen Xiao-Jing pan Su-zhen Tang yu-Jun Xia Hui Zhang Qingdao University Qingdao 266071 Shandong ProvinceChina Shandong Eye Institute Qingdao 266071 Shandong ProvinceChina Jinan Second People's Hospital Jinan 250022 ShandongProvince China

AIM：To summarize the phenotypes and identify the underlying genetic cause of the CRYBB1 and CRYBB2 gene responsible for congenital cataract in two Chinese ***：Detailed family histories and clinical data were collected from patients during an ophthalmologic examination. Of 523 inheritable genetic vision systemrelated genes were captured and sequenced by targeted next-generation sequencing,and the results were confirmed by Sanger sequencing. The possible functional impacts of an amino acid substitution were performed with Poly Phen-2 and SIFT ***：The patients in the two families were affected with congenital cataract. Sixty-five （FAMILY-1） and sixty two （FAMILY-2） single-nucleotide polymorphisms and indels were selected by recommended filtering *** was then analyzed by applying Sanger sequencing with the family members. A heterozygous CRYBB1 mutation in exon 4 （c.347T〉C, p.L116P） was identified in sixteen patients in FAMILY-1. A heterozygous CRYBB2 mutation in exon 5 （c.355G〉A, p.G119R） was identified in three patients in FAMILY-2. Each mutation cosegregated with the affected individuals and did not exist in unaffected family members and 200 unrelated normal *** mutation was predicted to be highly conservative and to be deleterious by both PolyPhen-2 and ***：TheCRYBB1 mutation（c.347T〉C）and CRYBB2 mutation （c.355G〉A） are novel in patients with congenital cataract. We summarize the variable phenotypes among the patients, which expanded the phenotypic spectrum of congenital cataract in a different ethnic background.

关键词： CRYBB1 CRYBB2 next-generation sequencing congenital cataract

Design of small-scale gradient coils in magnetic resonance imaging by using the topology optimization method

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Chinese Physics B 2018年第5期27卷 91-100页

作者： Hui pan Feng Jia zhen-yu Liu Maxim Zaitsev Juergen Hennig Jan G Korvink Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China University of Chinese Academy of Sciences Beijing 100049China Deptartment of Radiology Medical PhysicsMedical Center University of FreihurgFaculty of MedicineUniversity of FreiburgFreiburg 79106Germany Institute of Microstructure Technology Karlsruhe Institute of Technology(KIT)Karlsruhe 76344Germany

A topology optimization method based on the solid isotropic material with penalization interpolation scheme is utilized for designing gradient coils for use in magnetic resonance *** the popular stream function method,the proposed method has design variables that are the distribution of conductive material.A voltage-driven transverse gradient coil is proposed to be used as micro-scale magnetic resonance imaging(MRI)gradient coils,thus avoiding introducing a coil-winding pattern and simplifying the coil *** proposed method avoids post-processing errors that occur when the continuous current density is approximated by discrete wires in the stream function *** feasibility and accuracy of the method are verified through designing the z-gradient and y-gradient coils on a cylindrical *** design results show that the proposed method can provide a new coil layout in a compact design space.

关键词： topology optimization method gradient coils solid isotropic material with penalization magnetic resonance imaging

Regional Stability of Positive Switched Linear Systems with Multi-equilibrium Points

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International Journal of Automation and computing 2017年第2期14卷 213-220页

作者： Zhi Liu yu-zhen Wang School of Control Science and Engineering Shandong University Ji'nan 250061 China

This paper studies the regional stability for positive switched linear systems with multi-equilibrium points （PSLS-MEP）. First, a sufficient condition is presented for the regional stability of PSLS-MEP via a common linear Lyapunov function. Second, by establishing multiple Lyapunov functions, a dwell time based condition is proposed for the regional stability analysis. Third, a suprasphere which contains all equilibrium points is constructed as a stability region of the considered PSLS-MEP, which is less conservative than existing results. Finally, the study of an illustrative example shows that the obtained results are effective in the regional stability analysis of PSLS-MEP.

关键词： Regional stability positive switched linear system multi-equilibrium points common linear Lyapunov function multipleLyapunov function.

MODELLING STRAIN-RATE-DEPENDENCY OF NATURAL SOFT CLAYS COMBINED WITH ANISOTROPY AND DESTRUCTURATION

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Acta Mechanica Solida Sinica 2011年第3期24卷 216-230页

作者： zhen-yu Yin Minna Karstunen Department of Civil Engineering Shanghai Jiao Tong University Shanghai 200240 China Department of Civil Engineering University of Strathclyde John Anderson Building 107 Rottenrow Glasgow G40NG UK

The paper aims to investigate modelling the strain-rate-dependency of natural soft clays combined with anisotropy and destructuration using an elasto-viscoplastic model. The model is based on Perzyna＇s overstress theory and the elastoplastic model S-CLAYIS. Tests at constant strain^rate and creep tests under both one-dimensional and triaxial conditions on several clays are simulated. Simulations highlight the loading scenarios in which it is necessary to account for anisotropy and/or destructuration in order to get accurate predictions. Comparisons between the predicted and measured results demonstrate that the proposed model can successfully reproduce the time-dependent behaviour of natural soft clays under different loading conditions.

关键词： anisotropic materials creep debonding time-dependent

Spin-Polarized Currents in Double Quantum Dots with Rashba Spin-Orbit Interactions

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Chinese Physics Letters 2013年第8期30卷 132-135页

作者： LI zhen-Shan pan Hui LÜRong Department of Physics and State Key Laboratory of Software Development Environment Beihang UniversityBeijing 100191 Department of Physics Tsinghua UniversityBeijing 100084

We propose a new scheme of realizing spin-polarized currents in a double quantum dot *** the presence of Rashba spin-orbit coupling interactions and different Zeeman splittings of each quantum dot,the currents are *** polarization can be controlled by tuning the strength of Rashba spin-orbit coupling and external magnetic fields,which can produce nearly 100%spin-polarized ***,we explain and analyze the mechanism of the strongly spin-polarized *** we give two phase diagrams to display our results.

关键词： polarized quantum Rashba

Split nitrogen fertilizer application improved grain yield in winter wheat (Triticum aestivum L.) via modulating antioxidant capacity and ^(13)C photosynthate mobilization under water-saving irrigation conditions

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Ecological Processes 2021年第1期10卷 290-302页

作者： zhen Zhang zhenwen yu Yongli Zhang yu Shi Key Laboratory of Crop Ecophysiology and Farming System Ministry of AgricultureShandong Agricultural UniversityTai-an 271017ShandongChina

A water-saving cultivation technique of supplementary irrigation based on soil moisture levels has been adopted for winter wheat production in the Huang-Huai-Hai Plain of China,due to the enhanced water-use ***,appropriate split nitrogen management may further improve crop growth and grain ***,we conducted a 2-year field experiment to determine if split nitrogen management might improve wheat productivity by enhancing ^(13)C photosynthate mobilization and the antioxidant defense system under water-saving *** nitrogen management involved a constant total nitrogen rate(240 kg ha^(−1))split in four different proportions between sowing and jointing stage,i.e.,10:0(N1),7:3(N2),5:5(N3),and 3:7(N4).The N3 treatment significantly enhanced“soil-plant analysis development”values,superoxide dismutase antioxidant activity,soluble protein content,sucrose content,and sucrose phosphate synthetase activity,although it reduced the accumulation of malondialdehyde(MDA).The N3 treatment ultimately increased the amount of dry matter assimilation after anthesis *** addition,the ^(13)C isotope tracer experiment revealed that the N3 treatment promoted the assimilation of carbohydrates after anthesis and their partitioning to the developing *** to the unequal ratio treatments(N1,N2,and N4),the equal ratio treatment(N3)increased grain yield by 5.70–16.72%via increasing 1000-grain weight and number of grains per spike in both growing ***,we recommend the use of a 5:5 basal-topdressing split nitrogen fertilizer application under water-saving irrigation conditions to promote antioxidant enzyme activity and the remobilization of photosynthate after anthesis for improving wheat grain yield.

关键词： Split nitrogen fertilization Modulating antioxidant capacity ^(13)C photosynthate mobilization Water-saving irrigation