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Resatorvid protects against hypoxic-ischemic brain damage in neonatal rats

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Neural Regeneration Research 2020年第7期15卷 1316-1325页

作者： Li-Jun Jiang zhen-xing Xu Ming-Fu Wu Gai-Qin dong Li-Li Zhang Jun-Yan Gao Chen-Xi Feng xing Feng Department of Neonatology Children's Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neonatology Affiliated Hospital of Yangzhou UniversityYangzhouJiangsu ProvinceChina

Secondary brain damage caused by hyperactivation of autophagy and inflammatory responses in neurons plays an important role in hypoxic-ischemic brain damage(HIBD).Although previous studies have implicated Toll-like receptor 4(TLR4)and nuclear factor kappa-B(NF-κB)in the neuroinflammatory response elicited by brain injury,the role and mechanisms of the TLR4-mediated autophagy signaling pathway in neonatal HIBD are still *** hypothesized that this pathway can regulate brain damage by modulating neuron autophagy and neuroinflammation in neonatal rats with ***,we established a neonatal HIBD rat model using the Rice-Vannucci method,and injected 0.75,1.5,or 3 mg/kg of the TLR4 inhibitor resatorvid(TAK-242)30 minutes after hypoxic *** results indicate that administering TAK-242 to neonatal rats after HIBD could significantly reduce the infarct volume and the extent of cerebral edema,alleviate neuronal damage and neurobehavioral impairment,and decrease the expression levels of TLR4,phospho-NF-κB p65,Beclin-1,microtubule-associated protein l light chain 3,tumor necrosis factor-α,and interleukin-1βin the ***,TAK-242 appears to exert a neuroprotective effect after HIBD by inhibiting activation of autophagy and the release of inflammatory cytokines via inhibition of the TLR4/NF-κB signaling *** study was approved by the Laboratory Animal Ethics Committee of Affiliated Hospital of Yangzhou University,China(approval No.20180114-15)on January 14,2018.

关键词： autophagy hypoxic-ischemic brain damage neonatal hypoxic-ischemic brain damage neuroinflammation nuclear factor kappa-B resatorvid TAK-242 Toll-like receptor 4

Trichlorozirconium η~2-Hydrazonides： Synthesis, Characterization and Their Catalytic Behavior toward Ethylene Polymerization

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Chinese Journal of Polymer Science 2016年第3期34卷 390-398页

作者： Xin-e Duan Qi-feng xing zhen-ming dong Jian-bin Chao Sheng-di Bai 刘滇生孙文华 Institute of Applied Chemistry Shanxi Untverstty Taiyuan 030006 China School of Chemistry and Chemical Engineering Shanxi University Taiyuan 030006 China Key Laboratory of Engineering Plastics and Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

The trichlorozirconium η~2-hydrazonides（R=H, A; R=CH_3, B） were synthesized through the finely controlled stoichiometrical reactions of anhydrous zirconium tetrachloride with the lithium salt of either 1-（furan-2-ylmethylene）-2-phenylhydrazonide or 1-（furan-2-ylethylidene）-2-phenyl hydrazonide in the solvent tetrahydrofuran（THF）, respectively. These complexes were highly sensitive to air and moisture due to solely using less bulky ligand of hydrazonides. The molecular structures of the title complexes, determined by means of single crystal X-ray diffraction, were found to be the distorted pentagonal bipyramid geometry around zirconium atom, with three chlorides and the hydrazonato ligand acting as the η~2-coordination mode as well as two incorporated THF molecules. Upon activation with either methylaluminoxane（MAO） or modified methylaluminoxane（MMAO）, both complexes A and B exhibited catalytic activities toward ethylene polymerization, producing polyethylenes with ultra-high molecular weights.

关键词： Titanium complexes Phenylhydrazonide Ethylene polymerization Ultra-high molecular weight polyethylene

Mechanical performance of 22SiMn2TiB steel welded with lowtransformation- temperature filler wire and stainless steel filler wire

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Journal of Iron and Steel Research International 2024年第4期31卷 967-981页

作者： Zi-dong Lin Kai-jie Song zhen Sun Zi-qian Zhu Xue-feng Zhao Constantinos Goulas Wei Ya xing-hua Yu School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China Department of Design Production and Management Faculty of Engineering Technology.University of TwenteEnschede 7500 AETheNetherlands Rotterdam Additive Manufacture Fieldlab(RAMLAB) Rotterdam 3089 JWTheNetherlands

TX-80 low-transformation-temperature(LTT)welding wire was used to replace the traditional ER 307Si welding wire to realize the connection of 22SiMn2TiB armor steel in manual overlay *** previously existing issues,such as welding cracks,large welding deformation,and severe welding residual stress,were solved to ensure good strength and ductility *** particular,with the same welding conditions,TX-80 LTT wire eliminates welding *** reduces the welding deformation no matter the base pretreatment of pre-setting angle or no pre-setting *** comparison,it was found that the microstructure at the TX-80 weld is mainly composed of martensite and a small amount of retained *** contrast,the microstructure of the ER 307Si weld consists of a large amount of austenite and a small amount of skeleton-like *** variation trend of residual stress and microhardness from the weld to the base were investigated and compared with the mechanical properties of base *** TX-80 and the ER 307Si tensile samples elongation is 6.76%and 6.01%,while the ultimate tensile strengths are 877 and 667 MPa,*** average impact toughness at room temperature of the ER 307Si weld is 143.9 J/cm^(2),much higher than that of the TX-80 weld,which is only 36.7 J/cm^(2).The relationship between impact and tensile properties with microstructure species and distribution was *** addition,the fracture surface of the tensile and the impact samples was observed and *** dimples,fewer pores,larger radiation zone,and shear lips of TX-80 samples indicate better tensile ductility and worse impact toughness than those of ER 307Si weld.

关键词： Low-transformation-temperature material 22SiMn2TiB steel Welding deformation Residual stress Martensitic transformation Mechanical property

Damage of a large-scale reinforced concrete wall caused by an explosively formed projectile(EFP)

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Defence Technology（防务技术） 2023年第10期28卷 280-297页

作者： Li-kai Hao Wen-bin Gu Ya-dong Zhang Qi Yuan xing-bo Xie Shao-xin Zou zhen Wang Ming Lu College of Field Engineering Army Engineering University of PLANanjing210000China Unit 31539 of PLA Beijing100000China Engineering Research Center of Safety and Protection of Explosion and Impact of Ministry of Education Southeast UniversityNanjing210000China Southwest University of Science and Technology Mianyang621000China

To quickly break through a reinforced concrete wall and meet the damage range requirements of rescuers entering the building,the combined damage characteristics of the reinforced concrete wall caused by EFP penetration and explosion shock wave were *** on LS-DYNA finite element software and RHT model with modified parameters,a 3D large-scale numerical model was established for simulation analysis,and the rationality of the material model parameters and numerical simulation algorithm were *** this basis,the combined damage effect of EFP penetration and explosion shock wave on reinforced concrete wall was studied,the effect of steel bars on the penetration of EFP was highlighted,and the effect of impact positions on the damage of the reinforced concrete wall was also *** results reveal that the designed shaped charge can form a crater with a large diameter and high depth on the reinforced concrete *** average crater diameter is greater than 67 cm(5.58 times of charge diameter),and crater depth is greater than 22 cm(1.83 times of charge diameter).The failure of the reinforced concrete wall is mainly caused by EFP *** only EFP penetration is considered,the average diameter and depth of the crater are 54.0 cm(4.50 times of charge diameter)and 23.7 cm(1.98 times of charge diameter),*** effect of explosion shock wave on crater depth is not significant,resulting in a slight increase in crater *** average crater depth is 24.5 cm(2.04 times of charge diameter)when the explosion shock wave is *** effect of explosion shock wave on the crater diameter is obvious,which can aggravate the damage range of the crater,and the effect gradually decreases with the increase of standoff *** with the results for a plain concrete wall,the crater diameter and crater depth of the reinforced concrete wall are reduced by 5.94%and 9.96%,*** to the case in which the steel bar is not hit,when

关键词： Reinforced concrete Explosively formed projectile(EFP) Penetration Explosion shock wave Numerical simulation

Statistical Properties of 6.7 GHz Methanol Maser Sources

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Chinese Journal of Astronomy and Astrophysics 2003年第1期3卷 49-68页

作者： YeXu xing-Wuzheng dong-RongJiang NationalAstronomicalObservatories ChineseAcademyofSciencesUrumqi830011／／ShanghaiAstronomicalObservatoryChineseAcademyofSciencesShanghai200030 DepartmentofAstronomy NanjingUniversityNanjing210093 ShanghaiAstronomicalObservatory ChineseAcademyofSciencesShanghai200030

We present a statistical analysis of 482 6.7 GHz methanol maser sources from the available literature, on their maser emission and the characteristics of their associated infrared sources. On the color-color diagram, more than 70% of the objects fall within a very small region (0.57 ≤ [25-12] ≤ 1.30 and 1.30 ≤ [60-12] ≤ 2.50). This suggests that 6.7 GHz methanol maser emission occurs only within a very short evolutionary phase during the earliest stage of star formation. The velocity ranges of the masers belong to two main groups: one from 1 to 10 km s?1, and one from about 11 to 20 km s?1. These velocity ranges indicate that the masers are probably associated with both disks and outflows. The correlations between the maser and infrared flux densities, and between the maser and infrared luminosities, suggest that far-infrared radiation is a possible pumping mechanism for the masers which most probably originate from some outer molecular envelopes or disks.

关键词： masers ISM: molecules stars: circumstellar matter stars: formation ISM: HII regions

Adverse Effects of Opioid Analgesics in Osteoarthritis Treatment:A Global Meta-Analysis,2000-2022

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China CDC weekly 2024年第25期6卷 589-596,I0001-I0012页

作者： Heng Jiang xing xing He Zhu Tuo dong School of Public Health Harbin Medical UniversityHarbin CityHeilongjiang ProvinceChina School of Public Health Peking UniversityBeijingChina

Osteoarthritis(OA)treatment commonly depends on nonsteroidal anti-inflammatory drugs and opioid ***,the clinical use of opioids is controversial due to their adverse effects and addiction *** study,drawing on 24 randomized controlled trials(RCTs)with a total of 9,586 patients,thoroughly explored the various side effects associated with opioid use in OA *** results provide additional insight into the non-addictive risks of opioids and may assist clinicians in their judicious use,potentially fostering the advancement of safer treatment *** reducing the risks of misuse and addiction,public health and safety can be enhanced.

关键词： potential thoroughly insight

Wake-promoting effects of vagus nerve stimulation after traumatic brain injury: upregulation of orexin-A and orexin receptor type 1 expression in the prefrontal cortex

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Neural Regeneration Research 2018年第2期13卷 244-251页

作者： Xiao-yang dong zhen Feng Department of Rehabilitation Medicine the First Affiliated Hospital of Nanchang University

Orexins, produced in the lateral hypothalamus, are important neuropeptides that participate in the sleep/wake cycle, and their expres- sion coincides with the projection area of the vagus nerve in the brain. Vagus nerve stimulation has been shown to decrease the amounts of daytime sleep and rapid eye movement in epilepsy patients with traumatic brain injury. In the present study, we investigated whether vagus nerve stimulation promotes wakefulness and affects orexin expression. A rat model of traumatic brain injury was established using the free fall drop method. In the stimulated group, rats with traumatic brain injury received vagus nerve stimulation （frequency, 30 Hz, current, 1.0 mA; pulse width, 0.5 ms; total stimulation time, 15 minutes）. In the antagonist group, rats with traumatic brain injury were intracerebroventricularly injected with the orexin receptor type 1 （OXIR） antagonist SB334867 and received vagus nerve stimulation. Changes in consciousness were observed after stimulation in each group. Enzyme-linked immunosorbent assay, western blot assay and immunohistochemistry were used to assess the levels of orexin-A and OX1R expression in the prefrontal cortex. In the stimulated group, consciousness was substantially improved, orexin-A protein expression gradually increased within 24 hours after injury and OX1R expres- sion reached a peak at 12 hours, compared with rats subjected to traumatic brain injury only. In the antagonist group, the wake-promoting effect of vagus nerve stimulation was diminished, and orexin-A and OX1R expression were decreased, compared with that of the stim- ulated group. Taken together, our findings suggest that vagus nerve stimulation promotes the recovery of consciousness in comatose rats after traumatic brain injury. The upregulation of orexin-A and OXIR expression in the prefrontal cortex might be involved in the wake-promoting effects of vagus nerve stimulation.

关键词： nerve regeneration brain injury orexin-A orexin receptor type 1 vagus nerve stimulation traumatic brain injury wake-promoting coma wakefulness prefrontal cortex neurotransmitter neural regeneration

Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-Qing Qiao Guo Hui Bojing Sun dongfang Hou Meidi Wang Xueqian Wu Tao Wu dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

Energy Scattering of a Generalized Davey–Stewartson System in Three Dimension

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Acta Mathematica Sinica,English Series 2017年第9期33卷 1206-1224页

作者： Jing LU xing dong TANG School of Mathematical Sciences Beijing Normal UniversityBeijing 100875P.R.China Institute of Applied Physics and Computational Mathematics Beijing 100088P.R.China

In this paper, we study the global scattering result of the solution for the generalized Davey-Stewartson system The main difficulties are the failure of the interaction Morawetz estimate and the asymmetrical structure of nonlinearity （in particular, the nonlinearity is non-local）. To compensate, we utilize the strategy derived from concentration-compactness idea, which was first introduced by Kenig and Merle .

关键词： Davey-Stewartson system scatter global well-posedness