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Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou Gao Qin dong Dan Zou Zhijun Yang Lili Guo Ruxiang Xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

Chemical characteristics of aerosol particles (PM_(2.5)) at a site of Horqin Sand-land in northeast China

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Journal of Environmental Sciences 2006年第4期18卷 701-707页

作者： SHEN zhen-xing CAO Jun-ji LI Xu-xiang WANG Ya-qiang JIE dong-mei ZHANG Xiao-ye Department of Environmental Science and Engineering Xi＇an Jiaotong University Xi＇an 710049 China SKLLQG Institute of Earth Environment Chinese Academy of Sciences Xi＇an 710075 China Chinese Academy of Meteorological Sciences Beijing 100081 China Urban and Environment Science College Northeast Normal University Changchun 130024 China

The objective of this study was to characterize the mass concentration and chemical composition of aerosol particles（PM2.5） collected at Tongliao（Inner Mongolia Autonomous Region, China）, a site in Horqin Sand-land in northeast China. During spring 2005, the mass concentration for PM2.5 was （126±71）μg/m^3 in average. Five dust storm events were monitored with higher concentration of （255 ± 77）μg/m^3 in average than the non dusty days of （106 ± 44）μg/m^3. Concentrations for 20 elements were obtained by the PIXE method. Mass concentrations of ALl, Mg, Si, K, Ca, Ti, Mn, and V, which increased with the PM2.5 concentration, were higher than the pollution elements （S, Cl, Zn, Ar, Se, Br, and Pb）. Enrichment factor relative to crust material was also calculated, which showed dust trace elements were mainly from earth upper crust and pollution elements were dominated the anthropogenic aerosols. The Si/Al, Ca/Al, and Fe/Al ratios in PM2.5 samples at Tongliao were 4.07, 0.94, and 0.82, respectively, which were remarkably different with those on other source regions, such as ＂Western desert source region＂, ＂North desert source region＂ and central Asia source. Air mass back-trajectory analysis identified three kinds of general pathways were associated with the aerosol particle transport to Tongliao, but have the similar elemental ratios, implying that elemental signatures for dust aerosol from Horqin Sand-land were different with other regions.

关键词： dust aerosol mass concentration elemental composition transport pathway

Neutrophils inhibit CD8^(+)T cells immune response by arginase-1 signaling in patients with sepsis

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World Journal of Emergency Medicine 2022年第4期13卷 266-273页

作者： Xiao-kang Dai zhen-xing Ding Yuan-yuan Tan Hua-rui Bao dong-yao Wang Hong Zhang Department of Emergency the First Affiliated Hospital of Anhui Medical UniversityHefei 230027China Department of Hematology the First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineHefei 230001China Division of Molecular Medicine Hefei National Laboratory for Physical Sciences at Microscalethe Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Life SciencesUniversity of Science and Technology of ChinaHefei 230001China Anhui Province Key Laboratory of Immunology in Chronic Diseases Bengbu Medical CollegeBengbu 233030China

BACKGROUND:Patients with sepsis often exhibit an acute inflammatory response,followed by an immunosuppressive phase with a poor immune ***,the underlying mechanisms have not been fully ***:We sought to comprehensively characterize the transcriptional changes in neutrophils of patients with sepsis by transcriptome ***,we conducted a series of experiments,including real-time quantitative polymerase chain reaction(RT-qPCR)and flow cytometry to investigate the role of arginase-1 signaling in ***:Through the analysis of gene expression profiles,we identified that the negative regulation of T cell activation signaling was enriched,and the expression of arginase-1 was high in neutrophils from patients with ***,we conducted flow cytometry and found that the function of CD8^(+)T cells in septic patients was ***,neutrophils from septic patients inhibited the percentage of polyfunctional effector CD8^(+)T cells through ***,the proportions of granzyme B^(+)IFN^(-)γ^(+)CD8^(+)T and TNF^(-)α^(+)IFN^(-)γ^(+)CD8^(+)T cells increased after inhibition of arginase-1 ***:The impaired effector function of CD8^(+)T cells could be restored by blocking arginase-1 signaling in patients with sepsis.

关键词： Sepsis Effector CD8+T cells Neutrophils Arginase-1 Interferon-γ

非对称型假体设计及全膝关节置换后的力学分析

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中国组织工程研究 2025年第3期29卷 510-516页

作者：苏德君董万鹏董跃福张吉超张震上海工程技术大学材料科学与工程学院上海市201620 徐州医科大学附属连云港医院江苏省连云港市222061

背景:全膝关节置换是治疗膝关节晚期病症的有效手段,但假体衬垫容易因内部应力变化而产生磨损失效,寿命有限且术后患者的活动能力降低。如何对假体进行改进设计来满足患者更多的需求是假体研究的重要方向。目的:基于半月板的形态设计一... 详细信息

背景:全膝关节置换是治疗膝关节晚期病症的有效手段,但假体衬垫容易因内部应力变化而产生磨损失效,寿命有限且术后患者的活动能力降低。如何对假体进行改进设计来满足患者更多的需求是假体研究的重要方向。目的:基于半月板的形态设计一种非对称型假体,并与对称设计的后稳定型假体进行比较,分析2种假体的应力分布情况和衬垫的接触面积变化,以探究非对称型假体设计是否存在优势。方法:通过有限元方法对1例膝骨关节炎患者进行模拟截骨和假体装配,建立基于非对称型假体及对称设计的后稳定型假体的全膝关节置换术后膝关节模型。在0°,10°,20°,30°的屈膝条件下,探究股骨假体、胫骨假体以及衬垫上的Mises应力,并通过对比衬垫内外侧的接触面积,分析全膝关节置换后膝关节生物力学变化和运动行为的改变。结果与结论:(1)在0°-30°的屈膝过程中,2种假体衬垫上的Mises应力峰值均表现出先减小后增大的趋势,且内侧始终大于外侧。(2)非对称型设计的假体与后稳定型假体相比,应力峰值更低;在屈膝30°时,非对称型假体衬垫内外侧的Mises应力峰值分别为15.81 MPa和11.95 MPa,后稳定型衬垫为16.70 MPa和13.76 MPa,两者内侧差值约为5.33%,而外侧则相差13.15%;对比股骨假体和胫骨假体上的Mises应力峰值,非对称型假体在屈膝过程中始终低于后稳定型假体。(3)在0°站立位时,后稳定型假体衬垫的内侧接触面积为17.96 mm^(2)、外侧为34.10 mm^(2);而非对称型假体衬垫的内外侧接触面积分别为105.47 mm^(2)和107.80 mm^(2),具有更大的接触面积且两侧差距更小。(4)结果表明,非对称型假体的生物力学表现更好,且能够对维持膝关节稳定性、提升关节活动度有所帮助。这种设计能够在一定程度上还原膝关节以内侧髁为轴进行外旋的运动机制,是一种更为有效的膝关节假体选择方案。

关键词：膝关节全膝关节置换非对称型假体设计生物力学有限元分析

Asymmetric transfer hydrogenation of ketones catalyzed by nickel complex with new PNO-type ligands

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Chinese Chemical Letters 2012年第5期23卷 533-536页

作者： zhen Rong dong Yan Yun Li Shen Luan Yu Guo Song Sun Jing xing Gao State Key Laboratory for Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Guangxi Research Institute of Chemical Industry Nanning 530001China

The new polydentate mixed-N,P,O chiral ligands have been synthesized by the condensation of bis（o-formylphenyl）- phenylphosphane and R-phenylglycinol in CHCl_3,and fully characterized by IR,NMR and EIMS *** ligands were employed with a simple Ni complex Ni（PPh_s）_2Cl_2 in situ as catalytic systems for asymmetric transfer hydrogenation of ketones,and the corresponding optical alcohols were obtained with up to 84%ee under mild conditions.

关键词： Nickel complex NPO-type ligand Asymmetric transfer hydrogenation Ketones

Numerical design optimization of compressor blade based on ADOP

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航空动力学报 2007年第11期22卷 1903-1908页

作者： JIN dong-hai GUI xing-min School of Jet Propulsion Beijing University of Aeronautics and Astronautics Beijing 100083 China

An aerodynamic design optimization platform(ADOP) has been *** numerical optimization method is based on genetic algorithm(GA),Pareto ranking and fitness sharing *** platform was used for design optimization of the stator of an advanced transonic stage to seek high adiabatic *** compressor stage efficiency is increased by 0.502% at optimal point and the stall margin is enlarged by nearly 1.0% at design rotating *** flow fields of the transonic stage were simulated with FINE/Turbo software *** optimization result indicates that the optimization platform is effective in 3D numerical design optimization problems.

关键词：最优化设计压缩机桨片空气动力学 ADOP 遗传算法

Experiment of heat transfer in oscillating turbulent flow in a pipe with constant heat flux

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航空动力学报 2013年第9期28卷 1949-1955页

作者： LI Ming-zhen dong Jin-zhong School of Energy and Power Engineering Beijing University of Aeronautics and Astronautics

Heat transfer characteristics of oscillating turbulent air flow in a pipe heated with constant heat flux were experimentally *** experiments were performed over a range of 245.7 to 902 of the kinetic Reynolds number and 25 to 175 of the dimensionless oscillation *** effects of these two dimensionless parameters were *** results show that the cycle-averaged local Nusselt number increases with both the kinetic Reynolds number and the dimensionless oscillation *** space-cycle averaged Nusselt number also effectively increases with the kinetic Reynolds number and the dimensionless oscillation *** on the experimental data,a correlation equation of the space-cycle averaged Nusselt number for air in terms of these two dimensionless parameters has been obtained.

关键词： oscillating turbulent flow heat transfer kinetic Reynolds number Nusselt number constant heat flux

Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： Mei Zhang Wenhao Li Yangfei Chen Yang Jiang Xiaofei Guo Han dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

Testing of Seedborne Fungi in Wheat Germplasm Conserved in the National Crop Genebank of China

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Agricultural Sciences in China 2007年第6期6卷 682-687页

作者： DUAN Can-xing WANG Xiao-ming ZHU zhen-dong WU Xiao-fei Institute of Crop Sciences Chinese Academy of Agricultural Sciences~The National Key Facilities for Crop Gene Resources and GeneticImprovement （NFCRI） Beijing 100081 P.R.China

There is a primary understanding of the dominant fungi in wheat seeds conserved in the National Crop Genebank of China （NCGB） and an evaluation of the healthy status of wheat germplasm propagated in different regions. A total of 1 465 wheat accessions were detected for seedbone fungi by blotter, agar plate, and wash tests. By blotter test, 17 genera of fungi, including more than 30 species, were detected in 712 wheat accessions from Shaanxi, Hebei, and Qinghai provinces, China. Alternaria was the most frequently detected in wheat seeds from Shaanxi Province, followed by Rhizopus, Penicillium, Aspergillus, Bipolaris, Cladosporium, Gonatobotrys, Chaetomium, and others. Seedborne fungi in wheat seeds from Hebei Province, with relatively high incidence were Alternaria, Rhizopus, Penicillium, Aspergillus, Bipolaris, Cladosporium, and Fusarium. In the seeds from Qinghai Province, Alternaria, Rhizopus, Bipolaris, Cladosporium, and Trichothecium are important seed-borne fungi. The seed germination was reduced substantially when seeds were infected by Fusarium verticillioides （syn. F. moniliforme）, Bipolaris nodulosa, and Cladosporium herbarum. Eighteen genera and 25 species of fungi were identified in 353 accessions from Shaanxi Province using the agar plate test. The dominant fungi were Alternaria, Aspergillus, Bipolaris, Gonatobotrys, Penicillium, and Fusarium. The smut fungi, Ustilago tritici, was detected by the wash test in 400 accessions, but it was low in incidence in 300 seed samples from Shaanxi Province （1.3%）, and in 100 samples from Hebei Province （2.0%）. Totally 19 genera of fungi were detected in wheat seed samples, and some seedborne fungi were saprophytic and others were biotrophic which could cause seedborne diseases in the field.

关键词： wheat gerrnplasm seedborne fungi seed health detection