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Cloud-Verhulst hybrid prediction model for dam deformation under uncertain conditions

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Water Science and Engineering 2018年第1期11卷 61-67页

作者： Jin-ping He zhen-xiang jiang Cheng Zhao zheng-quan Peng Yu-qun Shi School of Water Resources and Hydropower Engineering Wuhan UniversityWuhan 430072China State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan 430072China Large Dam Safety Supervision Center National Energy AdministrationHangzhou 311122China

Uncertainties existing in the process of dam deformation negatively influence deformation prediction. However, existing deformation pre- diction models seldom consider uncertainties. In this study, a cloud-Verhulst hybrid prediction model was established by combing a cloud model with the Verhulst model. The expectation, one of the cloud characteristic parameters, was obtained using the Verhulst model, and the other two cloud characteristic parameters, entropy and hyper-entropy, were calculated by introducing inertia weight. The hybrid prediction model was used to predict the dam deformation in a hydroelectric project. Comparison of the prediction results of the hybrid prediction model with those of a traditional statistical model and the monitoring values shows that the proposed model has higher prediction accuracy than the traditional sta- tistical model. It provides a new approach to predicting dam deformation under uncertain conditions.

关键词： Dam deformation prediction Cloud model Verhulst model Uncertainty Inertia weight

Predefined-Time Constrained Optimization of Multi-Agent Systems Under Impulsive Effects

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IEEE/CAA Journal of Automatica Sinica 2025年第1期12卷 255-257页

作者： Zhuyan jiang Xiaoyang Liu xiang jiang Jinde Cao the School of Computer Science and Technology Jiangsu Normal University IEEE the School of Mathematics Southeast University

Dear Editor,This letter investigates predefined-time optimization problems(OPs) of multi-agent systems(MASs), where the agent of MASs is subject to inequality constraints, and the team objective function accounts for impulse effects. Firstly, to address the inequality constraints,the penalty method is introduced. Then, a novel optimization strategy is developed, which only requires that the team objective function be strongly convex.

关键词： Constrained optimization

Human iPSC-derived mesenchymal stem cells relieve high blood pressure in spontaneously hypertensive rats via splenic nerve activated choline acetyltransferase-positive cells

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Science China(Life Sciences) 2025年第2期68卷 502-514页

作者： zhen Zhang Weijun Huang Xiaoran Zhang Zhecun Wang Manting Xie Bingbing Xie Yiling Wang Xiaoyong Chen Andy Peng xiang Qiuling xiang Center for Stem Cell Biology and Tissue Engineering Key Laboratory for Stem Cells and Tissue EngineeringMinistry of EducationSun Yat-sen UniversityGuangzhou 510080China Department of Physiology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Department of Vascular Surgery the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510062China

Despite substantial advancements in modern medicine,the management of hypertension remains a major *** cell-based therapies have recently demonstrated remarkable efficacy in treating cardiovascular diseases,including ***,the antihypertensive mechanism of mesenchymal stem cells(MSCs)has not been extensively *** study aimed to investigate the role of injected MSCs in regulating blood pressure *** previous study demonstrated that human induced pluripotent stem cellderived mesenchymal stem cells(hiPSC-MSCs)are functional and homogeneous sources for MSC-based *** the injection of hiPSCMSCs,a significant reduction in blood pressure and end target organ inflammation were observed in spontaneously hypertensive rats(SHRs).Cell tracking assays demonstrated that the injected hiPSC-MSCs accumulated in the spleens of the *** injected hiPSC-MSCs accumulated adjacent to the splenic nerve,potentially contributing to the antihypertensive ***,the hiPSC-MSCs released abundant glutamate,which acts as a neuromodulator to activate the splenic sympathetic *** inhibition of glutamate synthesis by siRNA,the ability of hiPSC-MSCs to activate sympathetic nerves was significantly *** addition,the antihypertensive effects of hiPSC-MSCs were eliminated after splenic nerve denervation(SND),underscoring the critical role of the splenic ***,activation of the splenic nerve resulted in increased release of norepinephrine(NE),which increased the number of choline acetyltransferase-positive(ChAT^(+))cells in the spleen and peripheral ***,the acetylcholine(ACh)produced by elevated ChAT+cells could act as a vasodilator,lowering blood pressure and mitigating inflammation in end target *** summary,our findings indicate that hiPSC-MSCs effectively lower blood pressure in hypertension by influencing the splenic nerves and regulating ChAT+*** connection between blood pressur

关键词： hiPSC-MSCs hypertension splenic nerve ChAT+cells

Unraveling the role of long non‑coding RNAs in chronic heat stress‑induced muscle injury in broilers

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Journal of Animal Science and Biotechnology 2025年第1期16卷 206-217页

作者： zhen Liu Yingsen Liu Tong Xing Jiaolong Li Lin Zhang Liang Zhao Yun jiang Feng Gao College of Animal Science and Technology Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu ProvinceJiangsu Collaborative Innovation Center of Meat Production and ProcessingQuality and Safety ControlNanjing Agricultural UniversityNanjing 210095People’s Republic of China Anhui Key Laboratory of Livestock and Poultry Product Safety Engineering Institute of Animal Husbandry and Veterinary MedicineAnhui Academy of Agricultural SciencesHefei 230031China Institute of Agro‑Products Processing Jiangsu Academy of Agricultural SciencesNanjing 210014People’s Republic of China School of Food Science and Pharmaceutical Engineering Nanjing Normal UniversityNanjing 210023People’s Republic of China

Background Chronic heat stress(CHS)is a detrimental environmental stressor with a negative impact on the meat quality of ***,the underlying mechanisms are not fully *** study investigates the effects of CHS on long non-coding RNA(lncRNA)expression and muscle injury in broilers,with a focus on its implications for meat *** The results showed that CHS diminished breast muscle yield,elevated abdominal fat deposition,induced cellular apoptosis(P<0.05),and caused *** analysis revealed 151 differentially expressed(DE)lncRNAs when comparing the normal control(NC)and HS groups,214 DE lncRNAs when comparing the HS and PF groups,and 79 DE lncRNAs when comparing the NC and pair-fed(PF)*** eliminating the confounding effect of feed intake,68 lncRNAs were identified,primarily associated with cellular growth and death,signal transduc-tion,and metabolic ***,the apoptosis-related pathway P53,lysosomes,and the fibrosis-related gene TGF-β2 were significantly upregulated by *** These findings indicate that chronic heat stress induces cellular apoptosis and muscle injury through lncRNA,leading to connective tissue accumulation,which likely contributes to reduced breast muscle yield and meat quality in broilers.

关键词： Apoptosis Broiler Chronic heat stress LncRNA Muscle

Impacts of near-M_(s)austempering treatment on microstructure evolution and bainitic transformation kinetics of a medium Mn steel

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Journal of Iron and Steel Research International 2025年第1期32卷 249-259页

作者： Yong-gang Yang Xin-yue Liu Rui-zhi Li Yu-lai Chen Hong-xiang Wu Guo-min Sun zhen-li Mi National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing 100083China Technology Center Ningbo Iron&Steel Co.Ltd.Ningbo 315800ZhejiangChina

The microstructure evolution and bainitic transformation of an Fe-0.19C-4.03Mn-1.48Si steel subjected to near-M_(s)austempering treatment were systematically investigated by combining dilatometer,X-ray diffraction,and electron *** additional austempering treatments with isothermal temperatures above M_(s)were used as *** show that the incubation period for the bainitic transformation occurs when the medium Mn steel is treated with the austempering temperature above M_(s).However,when subjected to near-M_(s)isothermal treatment,the medium Mn steel does not show an incubation period and has the fastest bainitic transformation ***,the largest volume fraction of bainite with a value of 74.7%is obtained on the condition of near-M_(s)austempering treatment after cooling to room *** and microstructure evolution analysis indicates that the elimination of the incubation period and the fastest rate of bainitic transformation are related to the preformed *** advent of preformed martensite allows the specimen to generate more bainite in a limited *** bainitic ferrite nucleation at austenite grain boundaries and through autocatalysis at ferrite/austenite interfaces,a model is established to understand the kinetics of bainite formation and it can describe the nucleation rate of bainitic transformation well when compared to the experimental results.

关键词： Medium manganese steel Bainitic transformation Microstructure Near-M_(s)austempering Transformation modeling

As-cast Ti_(x)(AlVCr)_(100−x)light-weight medium entropy alloys with high strength and uniform compressive plasticity

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Transactions of Nonferrous Metals Society of China 2025年第1期35卷 194-206页

作者： Ming-jie KAI Yu-jie MA Xiao-tian WANG Liang CHENG Jian-bo HU Yao-yao HU Tai-ran XU Gui-jiang LI xiang-kang MENG zhen-hua CAO College of Materials Science and Engineering Nanjing Tech UniversityNanjing 210009China School of Intelligent Manufacturing and Information Jiangsu Shipping CollegeNantong 226010China Laboratory for Shock Wave and Detonation Physics Institute of Fluid PhysicsChina Academy of Engineering PhysicsMianyang 621900China National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesNanjing UniversityNanjing 210093China

The effect of Ti content on the microstructure and mechanical properties of as-cast light-weight Ti_(x)(AlVCr)_(100−x)medium entropy alloys was studied by compressive tests,X-ray diffraction,scanning electron microscopy and transmission electron *** results suggest that yield strength increases and then decreases with the increment of Ti *** Ti_(60)(AlVCr)_(40)alloy has the best combination of high strength of 1204 MPa and uniform plastic strain of 70%,possessing a high specific yield strength of 255 MPa·cm^(3)/*** enhancement of strength is mainly attributed to the synergic effects of solid-solution and coherent nano-precipitation strengthening,while dislocation motion such as dislocation pinning,entanglement and dislocation cells significantly increases the strain-hardening capacity.

关键词： TiAlVCr medium entropy alloy solid solution strengthening b2 precipitate strain hardening behavior

Endoscopic ultrasound-guided liver biopsy in liver transplant recipients: A preliminary experience

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Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 108-110页

作者： Wei Rao Yue-Ping jiang Jin-zhen Cai Man Xie Division of Hepatology Liver Disease Centerthe Affiliated Hospital of Qingdao UniversityQingdao 266000China Department of Organ Transplantation the Affiliated Hospital of Qingdao UniversityQingdao 266000China Department of Gastroenterology the Affiliated Hospital of Qingdao UniversityQingdao 266000China

To the Editor:With the popularity of liver transplantation(LT)and the inspiration for long-time survival,issues related to evaluating the liver allograft have increased in recent years[1-3].Although there has been renewed interest in non-invasive methods to evaluate diffuse liver disease,liver biopsy is still the golden standard in clinical practice,particularly for liver transplant recipients(LTRs).The liver biopsy has always been performed in LTRs as a part of standard procedure in cases whose liver function was normal,named as protocol liver biopsy,or to identify histological abnormalities for abnormal liver function and provide guidance for the adjustment of immunosuppressive regimen[4,5].Percutaneous liver biopsy(PLB)has been frequently conducted in LTRs;however,the clinical implementation of protocol liver biopsy by PLB in LTRs is challenging due to their suboptimal compliance,particularly in China[6].Besides,the PLB procedure has been associated with discomfort and potentially life-threatening complications in the general population,as reported in the literature[7,8].

关键词： biopsy preliminary comfort

Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige jiang Dexiang Liu Tingting Li Chengcheng Gai Danqing Xin Yijing Zhao Yan Song Yahong Cheng Tong Li zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

Optimization of lithium extraction solar pond in Zabuye Salt Lake: Theoretical calculation combined with field experiments

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China Geology 2025年第1期8卷 26-38页

作者： Tao Ding zhen Nie Qian Wu jiang-jiang Yu Ling-zhong Bu Yun-sheng Wang En-yuan Xing Mian-ping zheng Yu-bin Li MNR Key Laboratory of Saline Lake Resources and Environments Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100037China College of Engineering Tibet UniversityLhasa 850000China

This research optimized the structure of lithium extraction solar ponds to enhance the crystallization rate and yield of Li_(2)CO_(3).Using the response surface methodology in Design-Expert 10.0.3,the authors conducted experiments to investigate the influence of four factors related to solar pond structure on the crystallization of Li_(2)CO_(3) and their pairwise *** Fluid Dynamics(CFD)simulations of the flow field within the solar pond were performed using COMSOL Multiphysics software to compare temperature distributions before and after *** results indicate that the optimal structure for lithium extraction from the Zabuye Salt Lake solar ponds includes UCZ(Upper Convective Zone)thickness of 53.63 cm,an LCZ(Lower Convective Zone)direct heating temperature of 57.39℃,a CO32−concentration of 32.21 g/L,and an added soda ash concentration of 6.52 g/*** this optimized pathway,the Li_(2)CO_(3) precipitation increased by 7.34% compared to the initial solar pond process,with a 33.33% improvement in lithium carbonate crystallization *** study demonstrates the feasibility of optimizing lithium extraction solar pond structures,offering a new approach for constructing such ponds in salt *** provides valuable guidance for the efficient extraction of lithium resources from carbonate-type salt lake brines.

关键词： Salt lake Solar pond Lithium extraction Crystallization rate Box-Behnken Computational fluid dynamics Response surface Zabuye salt lake Mineral exploration engineering