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Expression and predictive value of miR-489 and miR-21 in melanoma metastasis

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World Journal of Clinical Cases 2019年第19期7卷 2930-2941页

作者： Hao Mo Jian Guan zhen-Chao Yuan Xiang Lin zhen-jie wu Bin Liu Ju-Liang He Department of Bone and Soft Tissue Surgery Guangxi Medical University Cancer Hospital

BACKGROUND Melanoma is a highly malignant skin tumour, and is one of the most rapidly growing malignant tumors in recent years. According to statistics, the morbidity of cancer increases with age, accounting for 1.6% of new cancer cases and 0.6% of deaths worldwide. Melanoma has a serious impact on society and families, thus it is of great significance to find biological markers related to the diagnosis and treatment of *** To explore the expression and predictive value of mir-489 and mir-21 in melanoma *** A total of 60 patients with malignant melanoma treated at our hospital from June2017 to December 2018 were selected as a research group, while 40 healthy subjects were selected as a control group. qRT-PCR technique was used to detect miR-489 and miR-21 in serum of the two groups. ROC curve was drawn to evaluate the predictive value and diagnostic efficiency. Spearman test was used for correlation analysis. Logistic single-and multiple-factor analyses were performed to identify the risk factors related to melanoma *** The expression of miR-489 in the research group was significantly lower than that in the control group(P < 0.001). However, the expression of miR-21 in the research group was significantly higher than that in the control group(P < 0.001).The expression of miR-489 and miR-21 was related to TNM stage and metastasis(P < 0.001). In the diagnosis of melanoma patients, the sensitivity, specificity, and AUC of miR-489 alone were 75.56%, 80.00%, and 0.852, respectively. The sensitivity, specificity, and AUC of miR-21 alone were 77.78%, 82.22%, and 0.844,respectively. MiR-489 was negatively correlated with TNM stage of melanoma(r=-0.612, P < 0.001), while miR-21 was positively correlated with TNM stage(r =0.609, P < 0.001). Logistic single-and multiple-factor regression analyses showed that TNM stage, miR-489, and mir-21 were independent risk factors for malignant melanoma *** MiR-489 and miR-21 may par

关键词： MiR-489 MiR-21 Melanoma metastasis Predictive value

A comparison of perioperative outcomes between extraperitoneal robotic single-port and multiport radical prostatectomy with the da Vinci Si Surgical System

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Asian Journal of Andrology 2021年第6期23卷 640-647页

作者： Guan-Qun Ju Zhi-Jun Wang Jia-Zi Shi Zong-Qin Zhang zhen-jie wu Lei Yin Bing Liu Lin-Hui Wang Dong-Liang Xu Department of Urology Changzheng HospitalNaval Medical UniversityShanghai 200003China Urology Centre Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200021China

To evaluate outcomes between extraperitoneal robotic single-port radical prostatectomy(epR-spRP)and extraperitoneal robotic multiport radical prostatectomy(epR-mpRP)performed with the da Vinci Si Surgical System,comparison was performed between 30 single-port(SP group)and 26 multiport(MP group)*** included operative time,estimated blood loss(EBL),hospital stay,peritoneal violation,pain scores,scar satisfaction,continence,and erectile *** median operation time and EBL were not different between the two *** the SP group,the median operation time of the first 10 patients was obviously longer than that of the latter 20 patients(P<0.001).The median postoperative hospital stay in the SP group was shorter than that in the MP group(P<0.001).The rate of peritoneal damage in the SP group was less than that in the MP group(P=0.017).The pain score and overall need for pain medications in the SP group were lower than those in the MP group(P<0.001 and P=0.015,respectively).Patients in the SP group were more satisfied with their scars than those in the MP group 3 months postoperatively(P=0.007).At 3 months,the cancer control,recovery of erectile function,and urinary continence rates were similar between the two *** is safe and feasible to perform epR-spRP using the da Vinci Si surgical ***,epR-spRP can be a treatment option for localized prostate *** epR-spRP still has a learning curve,it has advantages for postoperative pain and self-assessed *** the absence of the single-port robotic surgery platform,we can still provide minimally invasive surgery for patients.

关键词： extraperitoneal approach minimally invasive surgery prostate cancer robotic radical prostatectomy single-port

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑Yuan Yu Jing wu Guang Yin Fan‑zhen Jiao Zhong‑zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong wu Yushan Chen zhen Wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei wu Yuqing Liu Hongli Li Lemei Zhu Lingfeng Zeng zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

Photoinduced radical sulfur dioxide insertion with asymmetric cyclization of alkenes: accessing β-chiral sulfones bearing S-stereocentric cyclic sulfinamides

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Science China Chemistry 2025年第01期 257-263页

作者： Jiapian Huang Chenxin Wang Xu Wang Xiaoyu Zhou Wei Xiao jie wu School of Pharmaceutical and Chemical Engineering & Institute for Advanced Studies Taizhou University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences School of Chemistry and Chemical Engineering Henan Normal University

The generation of various β-chiral sulfones bearing chiral cyclic sulfinamides through photoredox-catalyzed sulfur dioxide insertion with asymmetric radical cyclization is described. This method features a broad substrate scope and excellent stereospecificity. Computational studies reveal that the dispersion interaction between sulfinyl group and CH2SO2Ph group plays a crucial role in the stereoselectivity control.

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“心寄窍于耳”研究进展

中华中医药学刊 2007年第4期25卷 769-771页

作者：陈晓杰甄杰武广州中医药大学广东广州510405

通过对近10年来有关“心寄窍于耳”的临床报道、实验研究及生理病理等方面进行了归纳、整理、分析,综述“心寄窍于耳”的研究进展,对“心寄窍于耳”的理论进行了较为科学的探讨,旨在论证“心寄窍于耳”理论的科学性,深入探求心与耳的关系。

关键词：心寄窍于耳心主神明心主血脉

六磨汤加减联合超声离子导入治疗便秘型肠易激综合征的临床研究

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中国中西医结合消化杂志 2019年第5期27卷 338-342页

作者：文慧华甄杰武广州市番禺区中心医院中医科广东广州511400 广州市番禺区中医院内一科广东广州511400

[目的]观察六磨汤加减联合超声离子导入治疗便秘型肠易激综合征(IBS-C)的临床疗效,探讨新的治疗便秘型IBS的中医疗法。[方法]选取2017年1月～2018年12月就诊的IBS-C病患,共100例。随机分为治疗组和对照组,治疗组给予六磨汤加减联合超声... 详细信息

[目的]观察六磨汤加减联合超声离子导入治疗便秘型肠易激综合征(IBS-C)的临床疗效,探讨新的治疗便秘型IBS的中医疗法。[方法]选取2017年1月～2018年12月就诊的IBS-C病患,共100例。随机分为治疗组和对照组,治疗组给予六磨汤加减联合超声离子导入治疗,对照组给予乳果糖口服溶液治疗,治疗2周后,比较2组的临床疗效。[结果]治疗组的疗效显著优于对照组(P<0.01)。[结论]六磨汤加减联合超声离子导入治疗IBS-C较乳果糖有一定优势,尤其在改善患者腹痛、腹胀、排便频率等方面,疗效更好。本研究中,治疗组所取得的良好的临床疗效,为中医治疗IBS-C提供一定的临床依据。

关键词：六磨汤超声离子导入便秘型肠易激综合征中医药疗法

清热健脾法联合四联疗法治疗幽门螺杆菌相关性慢性胃炎的临床观察

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中国中西医结合消化杂志 2015年第6期23卷 401-403,407页

作者：甄杰武何志良广州市番禺区中医院内一科广东广州511400

[目的]观察清热健脾法联合四联疗法治疗幽门螺杆菌(Hp)相关性慢性胃炎的疗效。[方法]Hp阳性慢性胃炎患者,共100例。随机分为治疗组和对照组各50例。对照组给予西药四联疗法;治疗组在对照组基础上,给予中药汤剂;疗程均为10d。对比2组治... 详细信息

[目的]观察清热健脾法联合四联疗法治疗幽门螺杆菌(Hp)相关性慢性胃炎的疗效。[方法]Hp阳性慢性胃炎患者,共100例。随机分为治疗组和对照组各50例。对照组给予西药四联疗法;治疗组在对照组基础上,给予中药汤剂;疗程均为10d。对比2组治疗前后疗效。[结果]治疗组的疗效优于对照组(P<0.05)。[结论]中西医结合治疗幽门螺杆菌相关性慢性胃炎疗效优于单用西药。本研究中,治疗组运用清热健脾为法,所取得的良好的临床疗效,进一步证明了湿热脾虚是幽门螺杆菌相关性慢性胃炎的基本中医病机。

关键词：慢性胃炎幽门螺杆菌中西医疗法