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Prevalence of late-onset hypogonadism among middle-aged and elderly males in China:results from a national survey

Asian Journal of Andrology 2021年第2期23卷 170-177页

作者： Yi-Jun Liu Xu-Bo Shen Na Yu Xue-Jun Shang Yi-Qun Gu Lian-Dong Zuo Cheng-Liang Xiong zhen Ye yuan-Zhong Zhou School of Public Health Zunyi Medical UniversityZunyi 563000China Scientific Research Center The Third Affiliated Hospital of Guang Dong Medical University(Long Jiang Hospital of Shunde District Foshan City)Foshan 528318China Department of Andrology Eastern Theater General HospitalNanjing 210002China Institute of Science and Technology National Research Institute for Family PlanningBeijing 100081China Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhou 510632China Family Planning Research Institute Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Urology and Andrology Wuhan Tongji Reproductive Medicine HospitalWuhan 430013China

This study aimed to propose an operational definition of late-onset hypogonadism(LOH)that incorporates both clinical symptoms and serum testosterone measurements to evaluate the prevalence of LOH in aging males in China.A population-based sample of 6296 men aged 40 years-79 years old was enrolled from six representative provinces in *** total testosterone(TT),sex hormone-binding globulin(SHBG),and luteinizing hormone(LH)were measured and free testosterone(cFT)was *** Aging Males’Symptoms(AMS)scale was used to evaluate the LOH ***,5078 men were included in this *** TT levels did not decrease with age(P=0.59),and had no relationship with AMS symptoms(P=0.87 for AMS total score,P=0.74 for≥3 sexual symptoms).The cFT levels decreased significantly with age(P<0.01)and showed a negative association with the presence of≥3 sexual symptoms(P=0.03).The overall estimated prevalence of LOH was 7.8%(395/5078)if a cFT level<210 pmol l−1 combined with the presence of≥3 sexual symptoms was used as the criterion of *** them,26.1%(103/395)and 73.9%(292/395)had primary and secondary hypogonadism,*** adjustment for confounding factors,primary and secondary hypogonadism was positively related to age and *** mass index was an independent risk factor for secondary *** results suggest that the AMS total score is not an appropriate indicator for decreased testosterone,and that the cFT level is more reliable than TT for LOH *** hypogonadism is the most common form of LOH.

关键词： Aging Males'Symptoms calculated free testosterone late-onset hypogonadism middle-aged and elderly male total testosterone

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等径角挤压后Ti5553钛合金的冲蚀磨损机理演变

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摩擦学学报 2015年第1期35卷 45-52页

作者：李振华华晨程先华浙江海洋学院船舶与海洋工程学院浙江舟山316022 上海交通大学机械与动力工程学院上海200240 清华大学摩擦学国家重点实验室北京100084

本文中系统研究了经等径角挤压(ECAE)处理后的Ti5553钛合金在海砂环境中的冲蚀磨损机理演变历程和失效原因.发现Ti5553钛合金在高角度冲蚀工况下,其冲蚀磨损机理从初期的微切削转变为冲击挤压变形,并保持稳定;合金显微组织中弥散的α相... 详细信息

本文中系统研究了经等径角挤压(ECAE)处理后的Ti5553钛合金在海砂环境中的冲蚀磨损机理演变历程和失效原因.发现Ti5553钛合金在高角度冲蚀工况下,其冲蚀磨损机理从初期的微切削转变为冲击挤压变形,并保持稳定;合金显微组织中弥散的α相以及ECAE工艺影响了冲蚀机理演变过程及冲蚀磨损程度;提高合金的强度、韧塑性对于抵抗冲蚀磨损起到了促进作用.

关键词：等径角挤压细晶强化冲蚀磨损机理机理演变 Ti5553钛合金三维轮廓

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Photoluminescence Properties of Two-dimensional Planar Layer and Three-dimensional Island Layer for ZnO Films Grown Using MOCVD

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Chemical Research in Chinese Universities 2006年第6期22卷 692-695页

作者： huaNG Ke-ke HOU Chang-min GAO Zhong-min LI Xiang-shan FENG Shou-hua ZHANG yuan-tao ZHU Hui-chao DU Guo-tong State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Department of Electronic Science and Engineering Jilin University Changchun 130012 P. R. China

ZnO（002） films with different thicknesses ranging from 7 to 300 nm were grown on sapphire（006） substrates via metal-organic chemical vapor deposition （MOCVD）. The two-dimensional（2D） planar layer and the three-dimensional（3D） island layer were studied by using of X-ray diffraction（XRD） rocking curves and atomic force microscopy （AFM）. The room temperature photoluminescence （PL） spectra show a blue shift of the peak positions of the uhraviolet（UV） emission with increasing film thickness. The blue shift is remarkably high（393-380 nm） when an increase in film thickness（7-15 nm） is accompanied by the change of structure from a 2D planar layer to a 3D island layer. The PL spectra at 77 K also indicate that there are different transition mechanisms in the film thickness from a 2D planar layer to a 3D island layer near the 2D layer region.

关键词： ZnO films Metal-organic chemical vapor deposition(MOCVD) Photoluminescence Planar layer Island layer

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Robust Object Tracking under Appearance Change Conditions

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International Journal of Automation and computing 2010年第1期7卷 31-38页

作者： Qi-Cong Wang yuan-Hao Gong Chen-Hui Yang Cui-hua Li Department of Computer Science, Xiamen University, Xiamen 361005, PRC Department of Computer Science Xiamen University Xiamen PRC

We propose a robust visual tracking framework based on particle filter to deal with the object appearance changes due to varying illumination, pose variantions, and occlusions. We mainly improve the observation model and re-sampling process in a particle filter. We use on-line updating appearance model, affine transformation, and M-estimation to construct an adaptive observation model. On-line updating appearance model can adapt to the changes of illumination partially. Affine transformation-based similarity measurement is introduced to tackle pose variantions, and M-estimation is used to handle the occluded object in computing observation likelihood. To take advantage of the most recent observation and produce a suboptimal Gaussian proposal distribution, we incorporate Kalman filter into a particle filter to enhance the performance of the resampling process. To estimate the posterior probability density properly with lower computational complexity, we only employ a single Kalman filter to propagate Gaussian distribution. Experimental results have demonstrated the effectiveness and robustness of the proposed algorithm by tracking visual objects in the recorded video sequences.

关键词： Visual tracking particle filter observation model Kalman filter expectation-maximization (EM) algorithm

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U系列新型合成阿片类物质的质谱特征

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质谱学报 2021年第1期42卷 84-92,I0004页

作者：钱振华贾薇花镇东刘翠梅公安部物证鉴定中心北京100038 公安部禁毒情报技术中心北京100193

采用气相色谱-质谱联用法(GC-MS)和超高效液相色谱-串联四极杆飞行时间质谱法(UPLC-QTOF MS)分析国际药物滥用市场最新流行的U系列新型合成阿片类物质,分别在电子轰击源(EI)和电喷雾正离子(ESI^+)-碰撞诱导解离(CID)模式下采集数据。EI... 详细信息

采用气相色谱-质谱联用法(GC-MS)和超高效液相色谱-串联四极杆飞行时间质谱法(UPLC-QTOF MS)分析国际药物滥用市场最新流行的U系列新型合成阿片类物质,分别在电子轰击源(EI)和电喷雾正离子(ESI^+)-碰撞诱导解离(CID)模式下采集数据。EI模式下,U系列新型合成阿片类物质的分子离子峰丰度较低,几乎都出现了m/z 84、125(或者m/z 112、153)的峰;ESI^+模式下,U系列新型合成阿片类物质的碎裂主要发生在酰胺基的两端及内部,二级质谱图中除准分子离子峰([M+H]^+)外,至少还会出现5个峰,分别为离子碎片A~E,其中A为基峰,A比B的质量数多80,C比D的质量数多28,E的精确质量数为81.069 9。通过总结该类物质在两种模式下获得的碎片离子与分子结构的关系,推测其可能的碎裂途径,并归纳了通过谱图推导未知U系列新型合成阿片类物质结构的方法,可为该类物质的鉴定提供参考。

关键词：气相色谱-质谱(GC-MS) 超高效液相色谱-串联四极杆飞行时间质谱(UPLC-QTOF MS) U系列新型合成阿片类物质新精神活性物质碎裂途径

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Effects of gibberellin A_(4/7), 6-benzylaminopurine and chlormequat chloride on the number of male and female strobili and immature cones in Chinese Pine (Pinus tabuliformis) with foliar sprays

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Journal of Forestry Research 2011年第3期22卷 353-359页

作者： ZHAO Peng Keith E. Woeste ZHANG Shuo-xin YANG Peihua FAN Jun-feng huaNG Zhong-lian MA zhen-hua College of Forestry Northwest A＆F University Yangling Shaanxi 712100 P. R. China USDA Forest Service Hardwood Tree Improvement and Re-generation Center Department of Forestry and Natural Resources PurdueUniversity 715 West State Street West Lafayette IN 47907 USA. QinlingNational Forest Ecosystem Research Station Ningshan Shaanxi 711600 P. R. China Donald Danforth Plant Science Center St. Louis MO 63132 USA Northwest Forestry Exploring Institute of China State Forestry Administra-tion Xi＇an Shaanxi 710048 P. R. China

Three kinds of plant growth regulators, gibberellinA 4/7 （GA 4/7 ）, 6-benzylaminopurine （BA）, and chlormequat chloride （CCC）, were evaluated for their ability to promote strobilus and cone production in a Chinese pine （Pinus tabuliformis Carr.） clonal seed orchard. Treatments （0, 250, 500, or 1000 mg L -1 ） were applied during three periods （June- July, July-August and August-September） in 2005. Of the three plant growth regulators, GA 4/7 was the best for promoting flower and cone production. Trees sprayed with GA 4/7 （500 mg L -1 ） from June to September had significantly more female strobili and immature cones than controls and other treatments （p≤0.0001）. The best time to apply GA 4/7 was in June. BA at 500 mg L -1 significantly increased female flower and immature cone production, compared to other treatments and controls （p≤0.0001）, while promotion of male strobili was unchanged. Chlormequat chloride at 1000 mg L -1 significantly increased the number of male strobili, compared to the other treatments （p≤0.0001）. Spraying CCC at500 mg L -1 significantly increased the number of female strobili, compared to controls （p0.05）, but it had no effect on immature cone production （p0.05）. These results are important for improving seed production and seed orchard management of Chinese pine.

关键词： flower promotion conifer seed production breeding Pinus tabuliformis Carr.

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Experimental Study Enhancing the Chemosensitivityof Multiple Myeloma to Melphalan by Using a Tissue-Specific APE1-Silencing RNA Expression Vector

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中国实用内科杂志 2007年第S1期27卷 72-73页

作者： CHEN Xing- hua ZHANG Xi YANG zhen- Zhou LI Zhong- Jun WANG Ji-Gang WANG Qing-Yu

Introduction:Multiple myeloma (MM) is a geriatric disease with onset at an average age of approximately 61 *** the aging of the population,the incidence rate of MM is *** the United States,the annual incidence rate of MM is 2-5/100,*** myeloma accounts for approximately 1% of all tumor eases and slightly >10% of cases with hematologic *** an

关键词： APE RNA Experimental Study Enhancing the Chemosensitivityof Multiple Myeloma to Melphalan by Using a Tissue-Specific APE1-Silencing RNA Expression Vector

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基于输入扩张的闭环系统子空间辨识及其强一致性分析

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自动化学报 2007年第7期33卷 703-708页

作者：杨华李少远上海交通大学自动化系上海200240

针对闭环条件下的子空间辨识问题,结合线性代数和几何学的基本概念,将输入输出误差序列包含至输入子空间中,基于输入扩张的状态空间构造方法,提出一种新的闭环辨识算法;解决开环算法应用于闭环系统辨识时产生有偏估计,甚至不能正确辨识... 详细信息

针对闭环条件下的子空间辨识问题,结合线性代数和几何学的基本概念,将输入输出误差序列包含至输入子空间中,基于输入扩张的状态空间构造方法,提出一种新的闭环辨识算法;解决开环算法应用于闭环系统辨识时产生有偏估计,甚至不能正确辨识的问题;实现闭环条件下对系统状态空间矩阵的强一致估计,并理论证明该辨识算法的强一致性:最后通过仿真实例验证本算法的有效性．

关键词：闭环辨识子空间方法强一致性

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Nano-Metal Film Thermal Conductivity Measurement by using the Femtosecond Laser Pump and Probe Method

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Chinese Physics Letters 2012年第6期29卷 231-234页

作者： ZHU Li-Dan SUN Fang-yuan ZHU Jie TANG Da-Wei LI Yu-hua GUO Chao-Hong Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190 Graduate University of Chinese Academy of Sciences Beijing 100039

Heat management at nanoscaleis a criticalissue across many areas of science and engineering,where the size effect of thermal properties plays an important *** measure the transient thermoreflectance signals of thin metal films with thicknesses from 50 to 200nm by using the femtosecond laser pump and probe method,and the experimental data are combined with the parabolic two-step model to enable us to measure thermal conductivity of the thin metal *** measurement results of Ni and Al films show that,in the thickness range from tens to hundreds of nanometer,the thermal conductivity increases with the increasing thicknesses of the films,which agrees well with the previous conclusions.

关键词： pump Femto conductivity

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Neuroprotective mechanism of L-cysteine after subarachnoid hemorrhage

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Neural Regeneration Research 2020年第10期15卷 1920-1930页

作者： Ye Xiong Dan-Qing Xin Quan Hu Ling-Xiao Wang Jie Qiu Hong-Tao yuan Xi-Li Chu De-Xiang Liu Gang Li zhen Wang Department of Physiology School of Basic Medical SciencesShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Qilu Hospital of Shandong University and Brain Science Research InstituteShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Taian Central HospitalTaianShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesShandong UniversityJinanShandong ProvinceChina

Hydrogen sulfide,which can be generated in the central nervous system from the sulfhydryl-containing amino acid,L-cysteine,by cystathionine-β-synthase,may exert protective effects in experimental subarachnoid hemorrhage;however,the mechanism underlying this effect is *** study explored the mechanism using a subarachnoid hemorrhage rat model induced by an endovascular perforation *** were treated with an intraperitoneal injection of 100 mM L-cysteine(30μL)30 minutes after subarachnoid *** 48 hours after subarachnoid hemorrhage,hematoxylin-eosin staining was used to detect changes in prefrontal cortex cells.L-cysteine significantly reduced cell *** function was assessed using a modified Garcia *** water content was measured by the wet-dry method.L-cysteine significantly reduced neurological deficits and cerebral edema after subarachnoid *** was used to detect the number of activated *** transcription-polymerase chain reaction(RT-PCR)was used to detect the levels of interleukin 1β and CD86 mRNA in the prefrontal cortex.L-cysteine inhibited microglial activation in the prefrontal cortex and reduced the mRNA levels of interleukin 1βand ***-PCR and western blot analysis of the complement system showed that L-cysteine reduced expression of the complement factors,C1q,C3αand its receptor C3aR1,and the deposition of C1q in the prefrontal *** staining was applied to detect changes in reactive oxygen species,and immunohistochemistry was used to detect the number of NRF2-and HO-1-positive cells.L-cysteine reduced the level of reactive oxygen species in the prefrontal cortex and the number of NRF2-and HO-1-positive *** blot assays and immunohistochemistry were used to detect the protein levels of CHOP and GRP78 in the prefrontal cortex and the number of CHOP-and GRP78-positive cells.L-cysteine reduced CHOP and GRP78 levels and the number of CHOP-and GRP78-

关键词： aminooxyacetic acid central nervous system complement deposition cystathionine-β-synthase early brain injury endoplasmic reticulum stress hydrogen sulfide neuroinflammation oxidative stress subarachnoid hemorrhage

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