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Efficacy of recombinant human epidermal growth factor plus sodium hyaluronate eye drops in diabetic dry eye post-cataract surgery

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World Journal of Diabetes 2024年第6期15卷 1234-1241页

作者： Jun-Ling Li Jin Zhao zhen-feng guo Chang Xiao Xuan Liu Department of Ophthalmology Tianjin Beichen HospitalThe Affiliated Hospital of Nankai UniversityTianjin 300400China Department of Ophthalmology Xianyang First People’s HospitalXianyang 712000Shaanxi ProvinceChina

BACKGROUND Dry eye syndrome(DES)after diabetic cataract surgery can seriously affect the patient’s quality of ***,effective alleviation of symptoms in patients with this disease has important clinical *** To explore the clinical effect of recombinant human epidermal growth factor(rhEGF)plus sodium hyaluronate(SH)eye drops on DES after cataract surgery in patients with *** We retrospectively evaluated 82 patients with diabetes who experienced DES after cataract surgery at Tianjin Beichen Hospital,Affiliated Hospital of Nankai University between April 2021 and April *** were classified into an observation group(42 cases,rhEGF+SH eye drops)and a control group(40 cases,SH eye drops alone),depending on the different treatment *** therapeutic efficacy,dry eye symptom score,tear film breakup time(TFBUT),basic tear secretion score[assessed using Schirmer I test(SIt)],corneal fluorescein staining(FL)score,tear inflammatory markers,adverse reactions during treat-ment,and treatment satisfaction were compared between the two *** Therapeutic efficacy was higher in the observation group compared with the control *** groups showed improved TFBUT and dry eye,as well as improved SIt and FL scores after treatment,with a more pronounced improvement in the observation *** no marked differences in adverse reactions were observed between the two groups,treatment satisfaction was higher in the observation *** rhEGF+SH eye drops rendered clinical benefits to patients by effectively ameliorating dry eye and visual impairment with favorable efficacy,fewer adverse reactions,and high safety ***,this treatment should be promoted in clinical practice.

关键词： Recombinant human epidermal growth factor Sodium hyaluronate eye drops Diabetic patients Dry eye syndrome after cataract surgery Therapeutic efficacy

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Hotspots and trends of risk factors in gastric cancer: A visualization and bibliometric analysis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2200-2218页

作者： Meng Li Ning Gao Shao-Li Wang Yu-feng guo zhen Liu Department of Gastroenterology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Department of Acupuncture and Moxibustion Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China

BACKGROUND The lack of specific symptoms of gastric cancer(GC)causes great challenges in its early *** it is essential to identify the risk factors for early diagnosis and treatment of GC and to improve the survival *** To assist physicians in identifying changes in the output of publications and research hotspots related to risk factors for GC,constructing a list of key risk factors,and providing a reference for early identification of patients at high risk for *** Research articles on risk factors for GC were searched in the Web of Science core collection,and relevant information was extracted after *** literature was analyzed using Microsoft Excel 2019,CiteSpace V,and VOSviewer *** A total of 2514 papers from 72 countries and 2507 research institutions were ***(n=1061),National Cancer Center(n=138),and Shoichiro Tsugane(n=36)were the most productive country,institution,or author,*** research hotspots in the study of risk factors for GC are summarized in four areas,namely:Helicobacter pylori(***)infection,single nucleotide polymorphism,bio-diagnostic markers,and GC risk prediction *** In this study,we found that *** infection is the most significant risk factor for GC;single-nucleotide polymorphism(SNP)is the most dominant genetic factor for GC;bio-diagnostic markers are the most promising diagnostic modality for *** risk prediction models are the latest current research *** conclude that the most important risk factors for the development of GC are *** infection,SNP,smoking,diet,and alcohol.

关键词： Gastric cancer Risk factor Bibliometric Research hotspots VOSviewer

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For Mega-Constellations: Edge Computing and Safety Management Based on Blockchain Technology

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China Communications 2024年第2期21卷 59-73页

作者： zhen Zhang Bing guo Chengjie Li College of Computer Science Sichuan UniversityChengdu 610064China The Key Laboratory for Computer Systems of State Ethnic Affairs Commission School of Computer Science and TechnologySouthwest Minzu UniversityChengdu 610225China National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of ChinaChengdu 611731China

In mega-constellation Communication Systems, efficient routing algorithms and data transmission technologies are employed to ensure fast and reliable data transfer. However, the limited computational resources of satellites necessitate the use of edge computing to enhance secure *** edge computing reduces the burden on cloud computing, it introduces security and reliability challenges in open satellite communication channels. To address these challenges, we propose a blockchain architecture specifically designed for edge computing in mega-constellation communication systems. This architecture narrows down the consensus scope of the blockchain to meet the requirements of edge computing while ensuring comprehensive log storage across the network. Additionally, we introduce a reputation management mechanism for nodes within the blockchain, evaluating their trustworthiness, workload, and efficiency. Nodes with higher reputation scores are selected to participate in tasks and are appropriately incentivized. Simulation results demonstrate that our approach achieves a task result reliability of 95% while improving computational speed.

关键词： blockchain consensus mechanism edge computing mega-constellation reputation management

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High-Performance Recyclable Furan-based Epoxy Resin and Its Carbon Fiber Composites with Dense Hydrogen Bonding

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Chinese Journal of Polymer Science 2024年第1期42卷 73-86,I0008页

作者： Chang-Bo Zhao Lu-Kun feng Hui Xie Ming-Liang Wang Bing guo Zhi-Yong Xue Cai-zhen Zhu Jian Xu Advanced Materials Research Institute North China Electric Power UniversityBejing 102206China Institute of Low-Dimensional Materials Genome Initiative College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060China Chengdu Institute of Organic Chemistry Chinese Academy of SciencesChengdu 610041China School of Science and Shenzhen Key Laboratory of Flexible Printed Electronics Technology and Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive ApplicationHarbin Institute of TechnologyShenzhen 518055China

The emerging biomass-based epoxy vitrimers hold great potential to fulfill the requirements for sustainable development of *** the existence of dynamic chemical bonds in vitrimers often reduces both the thermal and mechanical properties of epoxy resins, it is challenging to produce recyclable epoxy vitrimers with both excellent mechanical properties and good thermal stability. Herein, a monomer 4-(((5-(hydroxymethyl)furan-2-yl)methylene)amino)phenol(FCN) containing furan ring with potential to form high density of hydrogen bonding among repeating units is designed and copolymerized with glycerol triglycidyl ether to yield epoxy resin(FCN-GTE), which intrinsically has dual hydrogen bond networks, dynamic imine structure and resultant high performance. Importantly, as compared to the BPA-GTE, the FCN-GTE exhibits significantly improved mechanical properties owing to the increased density of hydrogen bond network and physical crosslinking interaction. Furthermore, density functional theory(DFT) calculation and in situ FTIR analysis is conducted to decipher the formation mechanism of hydrogen bond network. In addition, the FCN-GTE possesses superior UV shielding, chemical degradation, and recyclability because of the existence of abundant imine bonds. Notably, the FCN-GTE-based carbon fiber composites could be completely recycled in an amine *** study provides a facile strategy for synthesizing recyclable biomass-based high-performance epoxy vitrimers and carbon fiber composites.

关键词： Furan Hydrogen bond network Dynamic Schiff base Carbon fiber composites Recycling

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Recent progress of Pt-based oxygen reduction reaction catalysts for proton exchange membrane fuel cells

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Rare Metals 2024年第6期43卷 2444-2468页

作者： feng Zhan Kun-Song Hu Jin-Hua Mai Li-Sheng Zhang zhen-guo Zhang Huan He Xin-Hua Liu School of Resources Environment and MaterialsGuangxi UniversityNanning530004China School of Transportation Science and Engineering Beihang UniversityBeijing 102206China IDTECH(Suzhou)Co.Ltd Suzhou 215217China Dyson School of Design Engineering Imperial College LondonLondon SW72AZUK

With the increasing consumption of fossil fuels,proton exchange membrane fuel cells(PEMFCs)have attracted considerable attention as green and sustainable energy conversion *** slow kinetics of the cathodic oxygen reduction reaction(ORR)has a major impact on the performance of PEMFCs,and although platinum(Pt)can accelerate the reaction rate of the ORR,the scarcity and high cost of Pt resources still limit the development of ***,the development of low-cost high-performance ORR catalysts is essential for the commercial application and development of *** paper reviews the research progress of researchers on Pt-based ORR catalysts in recent years,including Pt/C catalysts,Pt-based alloy catalysts,Pt-based intermetallic compounds,and Pt-based single-atom catalysts(SACs),with a focus on Pt-based alloy catalysts with different *** described in detail the difficulties and solutions in the research process of various ORR catalysts and explained the principle of their activity enhancement with density functional theory(DFT).In addition,an outlook on the development of Pt-based catalysts is given,and reducing the amount of Pt used and improving the performance of catalysts are the directions to work on in the coming period.

关键词： Pt-based catalysts PEMFCs Pt-based intermetallic compounds Single-atom catalysts

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Left ventricular thrombosis caused cerebral embolism during venoarterial extracorporeal membrane oxygenation support: A case report

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World Journal of Clinical Cases 2024年第5期12卷 973-979页

作者： Yao-Bang Bai feng Zhao zhen-Hua Wu guo-Ning Shi Nan Jiang Intensive Care Unit Department of Cardiac SurgeryTianjin Chest HospitalTianjin 300222China Department of Cardiac Surgery Tianjin Chest HospitalTianjin 300222China

BACKGROUND Venoarterial(VA)extracorporeal membrane oxygenation(ECMO),an effective short-term circulatory support method for refractory cardiogenic shock,is widely ***,retrospective analyses have shown that VA-ECMO-assisted cases were associated with a relatively high mortality rate of approximately 60%.Embolization in important organs caused by complications of left ventricular thrombosis(LVT)during VA-ECMO is also an important *** the incidence of LVT during VA-ECMO is not high,the consequences of embolization are *** SUMMARY A 37-year-old female patient was admitted to hospital because of fever for 4 d and palpitations for 3 *** excluding the diagnosis of coronary heart disease,we established a diagnosis of“clinically explosive myocarditis”.The patient still had unstable hemodynamics after drug treatment supported by VA-ECMO,with heparin for *** day 4 of ECMO support,a left ventricular thro-mbus attached to the papillary muscle root of the mitral valve was found by transthoracic *** ventricular decompression was performed and ECMO was successfully removed,but the patient eventually died of multiple cerebral *** LVT with high mobility during VA-ECMO may cause embolism in important ***,a"wait and see"strategy should be avoided.

关键词： Venoarterial extracorporeal membrane oxygenation Left ventricular thrombosis Cerebral embolism Magnetic Resonance Imaging Therapy Case report

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Epileptic brain network mechanisms and neuroimaging techniques for the brain network

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Neural Regeneration Research 2024年第12期19卷 2637-2648页

作者： Yi guo Zhonghua Lin zhen Fan Xin Tian Department of Neurology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Sichuan Provincial Center for Mental Health Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Geriatrics Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurology Chongqing Key Laboratory of NeurologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Epilepsy can be defined as a dysfunction of the brain network,and each type of epilepsy involves different brain-network changes that are implicated diffe rently in the control and propagation of interictal or ictal *** more detailed information on brain network alterations can help us to further understand the mechanisms of epilepsy and pave the way for brain network-based precise therapeutic approaches in clinical *** increasing number of advanced neuroimaging techniques and electrophysiological techniques such as diffusion tensor imaging-based fiber tra ctography,diffusion kurtosis imaging-based fiber tractography,fiber ball imagingbased tra ctography,electroencephalography,functional magnetic resonance imaging,magnetoencephalography,positron emission tomography,molecular imaging,and functional ultrasound imaging have been extensively used to delineate epileptic *** this review,we summarize the relevant neuroimaging and neuroelectrophysiological techniques for assessing structural and functional brain networks in patients with epilepsy,and extensively analyze the imaging mechanisms,advantages,limitations,and clinical application ranges of each technique.A greater focus on emerging advanced technologies,new data analysis software,a combination of multiple techniques,and the construction of personalized virtual epilepsy models can provide a theoretical basis to better understand the brain network mechanisms of epilepsy and make surgical decisions.

关键词： electrophysiological techniques epilepsy functional brain network functional magnetic resonance imaging functional near-infrared spectroscopy machine leaning molecular imaging neuroimaging techniques structural brain network virtual epileptic models

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Deformation and stability of the seawall,considering the strength uncertainty of cement mixing piles

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第6期25卷 483-501页

作者： Yuansheng YU Lingling LI Xiangmiao KONG Chengyuan LI zhen guo Key Laboratory of Offshore Geotechnics and Material of Zhejiang Province College of Civil Engineering and ArchitectureZhejiang UniversityHangzhou310058China Hainan Institute Zhejiang UniversitySanya572000China Ninghai Highway and Transportation Management Center Ningbo315600China Ninghai Traffic Engineering Construction Management Institute Ningbo315600China

The cement mixing (CM) pile is a common method of improving soft offshore ground. The strength growth of CM piles under complex conditions is affected by many factors, especially the cement and moisture contents, and shows significant uncertainty. To investigate the stochasticity of the early strength of CM piles and its impact on the displacement and stability of a seawall, a series of laboratory tests and numerical analyses were carried out in this study. Vane shear tests were conducted on the cement-solidified soil to determine the relationships between the undrained shear strength s_(u) of the cement soil curing in the seawater and the cement content a_(c), as well as the in situ soil moisture content w. It can be inferred that the 24 h undrained shear strength follows a normal distribution. A numerical model considering the random CM pile strength was established to investigate the deformation of the seawall. Due to the uncertainty of CM pile strength, the displacement of the seawall demonstrates a certain discreteness. The decrease of the mean undrained shear strength of CM piles causes a corresponding increase in the average displacement of the seawall. When the mean strength of CM piles is lower than a certain threshold, there is a risk of instability. Furthermore, the heterogeneity of the strength within an individual CM pile also has an impact on seawall displacement. Attention should be paid to the uncertainty of CM pile strength to control displacement and stability.

关键词： Construction uncertainty Cement mixing(CM)pile Strength of cement soil Seawall stability Random finite element method(RFEM) Monte Carlo simulation(MCS)

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Impacts of pancreatic exocrine insufficiency on gut microbiota

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 271-279页

作者： Yulin guo feng CAO Fei LI Department of General Surgery Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Acute Pancreatitis Clinical Center of Capital Medical University Beijing 100053China

Pancreatic exocrine insufficiency(PEI)can be induced by various kinds of diseases,including chronic pancreatitis,acute pancreatitis,and *** main pathogenetic mechanism of PEI involves the decline of trypsin synthesis,disorder of pancreatic fluid flow,and imbalance of secretion *** studies have shown that PEI could induce gut bacterial overgrowth and dysbiosis,with the abundance of Lactobacillus and Bifidobacterium increasing the most,which could be partially reversed by pancreatic enzyme replacement *** studies have also confirmed the association between PEI and the dysbiosis of gut *** exocrine secretions and changes in duodenal p H as well as bile salt malabsorption brought about by PEI may affect and shape the abundance and composition of gut *** turn,the gut microbiota may impact the pancreatic exocrine acinus through potential bidirectional *** forward,more and higher-quality studies are needed that focus on the mechanism underlying the impact of PEI on the gut microbiota.

关键词： Pancreatic exocrine insufficiency Gut microbiota Gut microbiome Pancreatic enzyme replacement therapy

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Regulation of solvation structure and the cooperation environment of potassium bonds for wider-temperature adaptive potassium storage

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Rare Metals 2024年第4期43卷 1610-1621页

作者： Bing-Bing Liu Yi-Hui Liu You-Bin Zhang zhen-guo Qi guo-Hui Qin State Key Laboratory Base for Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao266042China Shandong Synergetic Innovation Center of Ecological and Chemical Engineering Qingdao266042China

Antimony selenide(Sb_(2)Se_(3))is one of the perspective candidates for potassium-ion batteries due to its advanced virtues stem including featured high capacity,fertile reserves and the relative narrow band *** the unique advantages,it is still plagued by the unstable interface compatibility and poor wider-temperature *** optimization of microstructure and the construction of inorganic-organic hybrids with a low desolvation barrier and rapid kinetics behaviors are efficient to address these *** Sb_(2)Se_(3)nanorods enclosed by the S-doped carbon layer(SC),further crosslinked by the poly(N-isopropylacrylamide)(PM)film(PM@Sb_(2)Se_(3)@SC),were artificially fabricated,and it displays the enrichment ion aggregated model as well as contacted ion pair state,the well-tailored cooperation environment of potassium bonds,assuring a homogeneous potassium deposition and an excellent widertemperature *** complicated experimental studies and theoretical calculations authenticate the synergistic effects of geometric conformation and compositional design for the tremendously enhanced potassium ***,the full device over PM@Sb_(2)Se_(3)@SC anode and the potassium Prussian blue cathode manifests impressively durable cycling life and wider-temperature adaptability,verifying the glorious contribution from the finely manipulation in solvation structure and potassium bonds to enhancing the potassium storage behaviors.

关键词： Anode Sb_(2)Se_(3) rods Interface compatibility Inorganic-organic electrode Potassium ion battery

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