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T6SS阳性CRKP临床感染特征及毒力基因分析

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中国感染控制杂志 2024年第4期23卷 488-493页

作者：刘莉娟储雯雯王梦闫涛龚真周强刘周安徽医科大学第二附属医院检验科安徽合肥230601

目的分析T6SS阳性耐碳青霉烯类肺炎克雷伯菌(CRKP)临床感染特征,以及其耐药、毒力基因检出率和生物膜形成能力,为临床防控CRKP感染提供参考数据。方法收集2019年1月—2022年12月安徽某三甲医院临床分离的CRKP菌株及患者资料,PCR法检测T... 详细信息

目的分析T6SS阳性耐碳青霉烯类肺炎克雷伯菌(CRKP)临床感染特征,以及其耐药、毒力基因检出率和生物膜形成能力,为临床防控CRKP感染提供参考数据。方法收集2019年1月—2022年12月安徽某三甲医院临床分离的CRKP菌株及患者资料,PCR法检测T6SS基因、毒力基因、耐药基因和分子分型,96孔板结晶紫染色法检测生物膜形成能力。结果共纳入160株CRKP。标本来源以痰(46.9%)和血(26.3%)为主。CRKP菌株呈现多重耐药表型,以携带bla KPC(80.6%)为主,其次为bla NDM(17.5%)。根据是否携带T6SS将CRKP分为T6SS阳性组(129株,80.6%)和T6SS阴性组(31株,19.4%)。T6SS阳性组患者患慢性肺部疾病和心脏疾病比例高于T6SS阴性组(P<0.05),且预后较阴性组差(P<0.05)。T6SS阳性组中,iuc A、mrk D、rmp A2、peg 344、wab G、fim H检出率均高于T6SS阴性组(均P<0.05)。CRKP中以ST11型(68.8%)为主,其中K64-ST11型占比70.9%,K47-ST11型占比25.5%。T6SS阳性组ST11型和K64-ST11型CRKP占比均高于T6SS阴性组(均P<0.05)。T6SS阳性组CRKP生物膜形成能力强于T6SS阴性组(P<0.001)。两组除bla OXA-48基因外,在携带其他碳青霉烯类耐药基因和抗菌药物耐药率方面差异无统计学意义。结论该地区CRKP呈现多重耐药,CRKP菌株T6SS检出率高,T6SS阳性CRKP毒力基因检出率更高,且生物膜形成能力更强。

关键词：肺炎克雷伯菌 T6SS 毒力基因耐碳青霉烯类碳青霉烯酶

Transformation power or development pressure:economic growth targets and urban carbon productivity

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Chinese Journal of Population,Resources and Environment 2024年第2期22卷 176-184页

作者： Longtao Chen Yi zheng Xianfeng Han Juan liu School of Management and Economics Kunming University of Science and TechnologyKunming 650500China School of Foreign Languages and Literatures Chongqing Normal UniversityChongqing 401331China

Maintaining moderate economic growth targets(EGTs)is the key for local governments to effectively implement the“carbon peak and carbon neutrality”goals under the refreshed development *** panel data of 276 prefecture-level cities in China's Mainland from 2010 to 2020,and employing methods such as intermediary and threshold models,this study empirically analyzes the internal mechanism of EGT’s impact on urban carbon productivity(UCP).Our findings demonstrate that:①The overall EGT during the analyzed period is not conducive to improving *** conclusion remains valid after a series of robustness *** effect is more pronounced in the central region and resource-based cities than in the east-west region and non resource-based cities.②EGT not only directly suppresses UCP but also exerts indirect negative impacts on UCP from three aspects:delaying the digital economy(DE),constraining financial expansion(FE),and hindering green technology innovation(GTI).This negative indirect effect is similar to or even surpasses the direct effect,suggesting that the internal relationship between EGT and“dual-carbon”goals should be re-evaluated from a new compound perspective.③EGT not only has a simple linear impact on UCP but also significantly exhibits a dynamic evolution pattern in inverted“U”*** is,as EGT continuously upgrades,a nonlinear impact on UCP emerges in the form of“promoting first,suppressing later”.This indicates that surpassing the“degree”limit for EGT will be detrimental to the improvement of *** study broadens the scope of carbon productivity analysis by introducing a new perspective centered on *** insights gleaned from this research offer valuable guidance for local governments to effectively manage economic growth expectations and promote the synchronized achievement of dual-carbon objectives.

关键词： Economic growth target Urban carbon productivity Mediating effects Dynamic evolution

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污水泵内颗粒通过性能及流动损失特性研究

流体机械 2024年第4期52卷 28-35页

作者：刘梁成倪子建刘栋范佳宁尤保健江苏大学能源与动力工程学院江苏镇江212013 上海凯泉泵业(集团)有限公司上海201804

为了研究柱状颗粒参数对污水泵内固液两相流动特性以及通过性能的影响规律,采用CFD-DEM耦合方法计算了离心泵内固液两相流动,基于熵产理论分析了不同颗粒物性条件下泵内的流动损失特性,并通过试验对其进行了验证。结果表明:柱状颗粒长... 详细信息

为了研究柱状颗粒参数对污水泵内固液两相流动特性以及通过性能的影响规律,采用CFD-DEM耦合方法计算了离心泵内固液两相流动,基于熵产理论分析了不同颗粒物性条件下泵内的流动损失特性,并通过试验对其进行了验证。结果表明:柱状颗粒长径比、体积分数和密度影响了污水泵内颗粒的通过性能以及流动损失;固相浓度从1%增大至5%,泵的扬程降低1.97 m,效率降低2.2%,颗粒通过能力逐渐降低;颗粒密度从1000 kg/m^(3)增大至2500 kg/m^(3),泵的扬程降低1.63 m,效率降低3.76%,颗粒通过能力略有增强;在各工况下,总熵产变化规律与泵性能变化规律一致,高熵产区域主要集中在叶片进口边附近,说明熵产分析能够有效反映泵内的流动损失特性。研究结果可为污水泵的优化设计提供理论依据。

关键词：污水泵柱状颗粒 CFD-DEM 通过性能熵产

极地半潜式海洋平台在不同环境载荷下的动态响应分析

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船舶力学 2024年第3期28卷 422-434页

作者：张奥博闯振菊刘社文李春郑季顺迎屈衍大连海事大学船舶与海洋工程学院辽宁大连116026 上海勘探设计研究院有限公司上海200335 大连理工大学工业装备结构分析国家重点实验室辽宁大连116024 华南理工大学海洋科学与工程学院广州511442

北极地区拥有丰富的油气资源,在该海域进行油气资源的开发和利用具有巨大的发展前景,但也极具挑战性。当前海洋平台的设计规范并未充分考虑海冰的影响。北极海域存在无冰期和有冰期,为了实现平台全年在海上进行作业,需要联合考虑波浪载... 详细信息

北极地区拥有丰富的油气资源,在该海域进行油气资源的开发和利用具有巨大的发展前景,但也极具挑战性。当前海洋平台的设计规范并未充分考虑海冰的影响。北极海域存在无冰期和有冰期,为了实现平台全年在海上进行作业,需要联合考虑波浪载荷和冰载荷的作用。本文研究某半潜式海洋平台在波浪、平整冰以及碎冰不同工况下的动态响应,采用势流理论和莫里森方程计算波浪载荷,利用离散元方法求解冰载荷,使用细长体有限元的方法分析锚泊系统,通过非线性时域计算求解得出平台的运动以及锚泊系统受力。结果显示:相较于其他环境载荷,平整冰作用下锚链的张力最大;在较小的海冰厚度、海冰密集度和冰块平均面积下的碎冰区,平台的运动符合现行安全规范。本文的研究可为北极地区油气资源的安全开发提供参考价值。

关键词：北极油气资源半潜式海洋平台波浪载荷冰载荷冰与结构相互作用

6G New Multiple Access Technology

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China Communications 2024年第1期21卷 I0002-I0005页

作者： Yifei Yuan Yongpeng Wu Lei Wang Zhifeng Yuan Wei Bai Yuanwei liu Tsinghua University in China Carnegie Mellon University USA Wuhan University WuhanChina Southeast University NanjingChina Carleton University OttawaONCanada Nanjing University of Post and Telecommunications Shanghai Jiaotong University ShanghaiChina the School of Electronic Engineering and Computer Science Queen Mary University of London

As a basic technology at physical layer of mobile communications,non-orthogonal multiple access has been attracting wide attention across the academia and the *** the standardization of the fifth-generation(5G)of mobile communications,3GPP conducted preliminary study on non-orthogonal multiple access without reaching the consensus to standardize the technology.

关键词： technology Access attracting

A novel fluorescent probe for volatile amine vapor detection

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Chinese Chemical Letters 2024年第3期35卷 3-4页

作者： Lulu Bu Daofu liu Longde Wang Mei Sun Chao Gao Yongshu Xie School of Chemistry and Materials Engineering Anhui Province Key Laboratory of Low Temperature Co-Fired MaterialsHuainan Normal UniversityHuainan 232038China College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material Technology of Ministry of EducationHangzhou Normal UniversityHangzhou 311121China Shanghai Key Laboratory of Functional Materials Chemistry Key Laboratory for Advanced Materials and Institute of Fine ChemicalsSchool of Chemistry&Molecular EngineeringEast China University of Science&TechnologyShanghai 200237China

In recent years,fluorescent probes have gained significant prominence in the field of substance analysis and detection[1–4].The development of high-performance volatile amine gas sensors is crucial for applications i... 详细信息

关键词： volatile gained probe

Communication-efficient distributed estimation and computation using skew-normal distribution

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Acta Mathematica Sinica,English Series 2024年

作者： Danlu WANG Yanyan liu Chao MA School of Mathematics and Statistics Wuhan University Department of Engineering Science Faculty of Innovation Engineering Macau University of Science and Technology

In this paper, we introduce a communication-efficient distributed estimation method tailored for massive datasets exhibiting skewness. The data are stored across multiple machines. We construct a surrogate likelihood which only need to transfer subgradient from local machines to approximate higher-order derivatives of the global likelihood. An enhanced EM algorithm is developed for computations. The proposed method not only addresses the non-normality of data by utilizing first-order gradient information in each transmission, ensuring low communication overhead, but also ensures privacy protection. Simulation studies illustrate the superior performance of the proposed methods.

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Lumbar and neck injuries of occupants in different reclining postures

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Chinese Journal of Traumatology 2024年第4期27卷 211-217页

作者： Di-Yi liu Sen Xiao Fei-Fei Han Bo-Tao Hu School of Mechanical Engineering Hebei University of TechnologyTianjin300131China CATARC(Tianjin) Automotive Engineering Research Institute Co.Ltd.Tianjin300399China

Purpose:With the increasing level of automation in automobiles,the advent of autonomous vehicles hasreduced the tendency of drivers and passengers to focus on the task of *** increasing automation in automobiles reduced the drivers'and passengers'focus on driving,which allowed occupants tochoose a more relaxed and comfortable sitting ***,the occupant's sitting position wentfrom a frontal,upright position to a more relaxed and reclined one,which resulted in the existing restraint systems cannot to keep occupants safe and *** study aimed to determine the effects ofdifferent reclining states on occupants'lumbar and neck ***:This is an original research on the field of automotive safety *** indifferent initial sitting positions(25°,35°,45°,and 55°)were adapted to changes in seat back angle andrestraint systems and placed in the same frontal impact *** injury indexes,lumbar axialcompression force and acceleration,as well as occupant dynamic response during the impact,werecompared in different sitting *** injury response and kinematic characteristics of occupants indifferent reclining positions were analyzed by the control variable ***:As the sitting angle increased,the occupant's head acceleration decreased,and the forward-leanangle *** in the standard sitting position had the greatest neck injury,with an Nij of0.95,and were susceptible to abbreviated injury scale 2+cervical medullary *** the seatbackangle increased,the geometric position of the lumbar spine tended to be horizontal,and the impact loadtransmitted greater forces to the lumbar *** occupant's lumbar injury was greatest in the lyingposition,with a peak axial compression force on the lumbar region of 5.5 KN,which was 2.3 KN greaterthan in the standard sitting ***:The study of occupant lumbar and neck injuries based on different recline states can providea theoretical bas

关键词： Frontal impact Recline position Lumbar injury Neck injury Kinematics Road traffic injury Road safety

瓜蒌皮注射液治疗高同型半胱氨酸颈动脉粥样硬化的效果及机制研究

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中国中西医结合外科杂志 2024年第1期30卷 112-118页

作者：甄庆强朱冬霞刘永昌孙岩济南市人民医院肝胆血管外科山东济南271100 济南市人民医院中医科山东济南271100 山东第一医科大学附属省立医院血管外科山东济南250021

目的:探讨瓜蒌皮注射液治疗高同型半胱氨酸颈动脉粥样硬化的效果和潜在机制。方法:选取2019年1月—2021年1月济南市人民医院收治的高同型半胱氨酸颈动脉粥样硬化患者120例,采用随机数字表法分为观察组(60例)和对照组(60例)。观察组采用... 详细信息

目的:探讨瓜蒌皮注射液治疗高同型半胱氨酸颈动脉粥样硬化的效果和潜在机制。方法:选取2019年1月—2021年1月济南市人民医院收治的高同型半胱氨酸颈动脉粥样硬化患者120例,采用随机数字表法分为观察组(60例)和对照组(60例)。观察组采用他汀类药物联合瓜蒌皮注射液治疗,对照组采用他汀类药物治疗,比较两组患者治疗前后血脂水平、同型半胱氨酸水平和颈动脉内膜中层厚度。利用网络药理学和生物信息学思路挖掘瓜蒌皮干预颈动脉粥样硬化的潜在机制,设计动物实验加以验证。结果:瓜蒌皮注射液可显著降低患者总胆固醇、甘油三酯、低密度脂蛋白胆固醇和血清同型半胱氨酸水平,减小颈动脉内中膜厚度,效果优于单独使用他汀类药物。网络药理学和实验研究证实,瓜蒌皮注射液可抑制高同型半胱氨酸动脉粥样硬化模型大鼠腹主动脉肿瘤坏死因子-α(TNF-α)、核转录因子-κB p65、基质金属蛋白酶-9(MMP-9)和血管细胞黏附因子-1(VCAM-1)水平。结论:瓜蒌皮注射液可降低高同型半胱氨酸颈动脉粥样硬化患者血脂水平,延缓病情的进展。瓜蒌皮注射液可调控TNF/NF-κB信号通路,发挥抗高同型半胱氨酸颈动脉粥样硬化的作用。

关键词：颈动脉粥样硬化高同型半胱氨酸瓜蒌皮注射液网络药理学生物信息学