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Bioceramic scaffolds with two-step internal/external modification of copper-containing polydopamine enhance antibacterial and alveolar bone regeneration capability

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第1期25卷 65-82页

作者： Xiaojian JIANG Lihong LEI weilian SUN Yingming wei Jiayin han Shuaiqi ZHONG Xianyan YANG Zhongru GOU Lili CHEN Department of Oral Medicine the Second Affiliated HospitalZhejiang University School of MedicineHangzhou310009China Bio-nanomaterials and Regenerative Medicine Research Division Zhejiang–California International Nanosystem InstituteZhejiang UniversityHangzhou310058China

Magnesium-doped calcium silicate(CS)bioceramic scaffolds have unique advantages in mandibular defect repair;however,they lack antibacterial properties to cope with the complex oral ***,for the first time,the CS scaffold was functionally modified with a novel copper-containing polydopamine(PDA(Cu^(2+)))rapid deposition method,to construct internally modified(*P),externally modified(@PDA),and dually modified(*P@PDA)*** morphology,degradation behavior,and mechanical properties of the obtained scaffolds were evaluated in *** results showed that the CS*P@PDA had a unique micro-/nano-structural surface and appreciable mechanical *** the prolonged immersion stage,the release of copper ions from the CS*P@PDA scaffolds was rapid in the early stage and exhibited long-term sustained *** in vitro evaluation revealed that the release behavior of copper ions ascribed an excellent antibacterial effect to the CS*P@PDA,while the scaffolds retained good cytocompatibility with improved osteogenesis and angiogenesis ***,the PDA(Cu^(2+))-modified scaffolds showed effective early bone regeneration in a critical-size rabbit mandibular defect ***,it was indicated that considerable antibacterial property along with the enhancement of alveolar bone regeneration can be imparted to the scaffold by the two-step PDA(Cu^(2+))modification,and the convenience and wide applicability of this technique make it a promising strategy to avoid bacterial infections on implants.

关键词： Copper-containing polydopamine Modification Antibacterial property Bone regeneration Angiogenesis Bioceramic scaffold

Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen Jing-Yu Tang Rui-Rui Fan Qiang Li Gong Li Dong Liu zheng-Yao Jin Xing-Zhu Cui Tian-Xiang Chen Yi-wei Yang Rong Liu han Yi Yang Li zhen Yang Qi An Hao-Fan Bai Jiang-Bo Bai Jie Bao Ping Cao Qi-Ping Chen zhen Chen Zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai han Zi-Jie han Guo-Zhu He Yong-Cheng He Yang Hong Yi-wei Hu han-Xiong Huang wei-Hua Jia Hao-yu Jiang wei Jiang Zhi-jie Jiang Ling Kang Bo Li Chao Li Jia-Wen Li Xiao Li Jie Liu Shu-Bin Liu Guang-Yuan Luan Chang-Jun Ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Xin Tan Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Mo-han Zhang Qi-wei Zhang Xian-Peng Zhang Yu-Liang Zhang Yue Zhang Zhi-Yong Zhang Mao-Yuan Zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

Bi@C nanosphere anode with Na^(+)-ether-solvent cointercalation behavior to achieve fast sodium storage under extreme low temperatures

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Carbon Energy 2024年第9期6卷 325-337页

作者： Lingli Liu Siqi Li Lei Hu Xin Liang wei Yang Xulai Yang Kunhong Hu Chaofeng Hou Yongsheng han Shulei Chou School of Energy Materials and Chemical EngineeringHefei UniversityHefeiChina LIB Technology Center of Anhui Province Hefei UniversityHefeiChina School of Advanced Manufacturing Engineering Hefei UniversityHefeiChina State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijingChina Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhouChina

The low ion transport is a major obstacle for low-temperature(LT)sodium-ion batteries(SIBs).Herein,a core-shell structure of bismuth(Bi)nanospheres coated with carbon(Bi@C)is constructed by utilizing a novel Bi-based complex(1,4,5,8-naphthalenetetracarboxylic dianhydride as the ligand)as the precursor,which provides an effective template to fabricate Bi-based ***-40℃,the Bi@C anode achieves a high capacity,which is equivalent to 96%of that at 25℃,benefitting from the core-shell nanostructured engineering and Na^(+)-ether-solvent cointercalation *** special Na+-diglyme cointercalation behavior may effectively reduce the activation energy and accelerate the Na+diffusion kinetics,enabling the excellent low-temperature performance of the Bi@C *** expected,the fabricated Na_(3)V_(2)(PO_(4))_(3)//Bi@C full-cell delivers impressive rechargeability in the ether-based electrolyte at-40℃.Density functional theory calculations and electrochemical tests also reveal the fast reaction kinetic mechanism at LT,thanks to a much lower diffusion energy barrier(167 meV)and a lower reaction activation energy(32.2 kJ mol^(-1))of Bi@C anode in comparison with that of bulk *** work provides a rational design of Bi-based electrodes for rechargeable SIBs under extreme conditions.

关键词： bismuth core-shell structure low-temperature conditions sodium-ion batteries

Mass spectrometry analysis of intact protein N-glycosylation signatures of cells and sera in pancreatic adenocarcinomas

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第1期25卷 51-64页

作者： Mingming XU Zhaoliang LIU Wenhua HU Ying han zhen WU Sufeng CHEN Peng XIA Jing DU Xumin ZhanG Piliang HAO Jun XIA Shuang YANG Center for Clinical Mass Spectrometry College of Pharmaceutical SciencesSoochow UniversitySuzhou215123China School of Life Science and Technology ShanghaiTech UniversityShanghai201210China State Key Laboratory of Genetic Engineering Department of BiochemistrySchool of Life SciencesFudan UniversityShanghai200438China Department of Clinical Laboratory Center Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou310014China

Pancreatic cancer is among the most malignant cancers,and thus early intervention is the key to better survival ***,no methods have been derived that can reliably identify early precursors of development into ***,it is urgent to discover early molecular changes during pancreatic *** aberrant glycosylation is closely associated with cancer progression,numerous efforts have been made to mine glycosylation changes as biomarkers for diagnosis;however,detailed glycoproteomic information,especially site-specific N-glycosylation changes in pancreatic cancer with and without drug treatment,needs to be further ***,we used comprehensive solid-phase chemoenzymatic glycoproteomics to analyze glycans,glycosites,and intact glycopeptides in pancreatic cancer cells and patient *** profiling of N-glycans in cancer cells revealed an increase in the secreted glycoproteins from the primary tumor of MIA PaCa-2 cells,whereas human sera,which contain many secreted glycoproteins,had significant changes of glycans at their specific *** results indicated the potential role for tumor-specific glycosylation as disease *** also found that AMG-510,a small molecule inhibitor against Kirsten rat sarcoma viral oncogene homolog(KRAS)G12C mutation,profoundly reduced the glycosylation level in MIA PaCa-2 cells,suggesting that KRAS plays a role in the cellular glycosylation process,and thus glycosylation inhibition contributes to the anti-tumor effect of AMG-510.

关键词： Pancreatic cancer Glycosylation Biomarker Glycoproteomics Mass spectrometry

Evolution of template-assisted two-dimensional porphyrin chiral grating structure by directed self-assembly using chiral second harmonic generation microscopy

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Chinese Chemical Letters 2024年第10期35卷 170-174页

作者： Changhui Yu Peng Shang Huihui Hu Yuening Zhang Xujin Qin Linyu han Caihe Liu Xiaohan Liu Minghua Liu Yuan Guo zhen Zhang Beijing National Laboratory for Molecular Sciences State Key Laboratory of Molecular Reaction DynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Beijing National Laboratory for Molecular Science CAS Key Laboratory of ColloidInterface and Chemical ThermodynamicsInstitute of ChemistryChinese Academyof SciencesBeijing100190China

Directed self-assembly has been used to create micro-nano scale patterns,including chiral periodic structures of organic molecules,for potential applications in optics,photonics,metamaterials,and medical and sensing *** study presents a straightforward approach for fabricating large-scale chiral grating porphyrin assemblies through template-assisted *** solution of tetrakis(4-sulfonatophenyl)porphyrin(TPPS)was induced by chiral amino acids(L/D-arginine and L/D-serine)to selfassemble into highly ordered chiral grating structures with the assistance of sodium dodecyl sulfate(SDS).The structures show precise line widths(5.5μm)and gaps(18μm).Using in situ optical microscopy and second harmonic generation(SHG)microscopy,the chiral characteristics and dynamic evolution of the template-assisted self-assembly are *** is found that the chirality of amino acids induced TPPS self-assembled into chiral structures and the liquid contraction interface significantly enhanced the chirality of the *** study is significant for understanding the mechanism of chiral evolution and designing novel micro-nano materials with predetermined chiral properties.

关键词： Second harmonic generation microscopy Chiral assembly Porphyrin Chiral evolution Template-assisted self-assembly Micro-nano structure

Planning and construction of Xiong’an New Area(city of over 5 million people):Contributions of China’s geologists and urban geology

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China Geology 2024年第3期7卷 382-408页

作者： Bo han zhen Ma Liang-jun Lin Hong-wei Liu Yi-hang Gao Yu-bo Xia Hai-tao Li Xu Guo Feng Ma Yu-shan Wang Ya-long Zhou Hong-qiang Li Tianjin Center China Geological Survey(North China Center of Geoscience Innovation)Ministry of Natural ResourcesTianjin 300170China Xiong’an Urban Geological Research Center China Geological SurveyMinistry of Natural ResourcesTianjin 300170China Tianjin Key Laboratory of Coast Geological Processes and Environmental Safety Tianjin 300170China China Institute of Geo-Environment Monitoring Beijing 100081China Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Center for Hydrogeology and Environmental Geology China Geological SurveyMinistry of Natural ResourcesBaoding 071051China Institute of Geophysical&Geochemical Exploration Chinese Academy of Geological SciencesLangfang 065000China Chinese Academy of Geological Sciences Beijing 10037China

China established Xiong’an New Area in Hebei Province in 2017,which is planned to accommodate about 5 million people,aiming to relieve Beijing City of the functions non-essential to its role as China’s capital and to expedite the coordinated development of the Beijing-Tianjin-Hebei *** 2017 to 2021,the China Geological Survey(CGS)took the lead in multi-factor urban geological surveys involving space,resources,environments,and disasters according to the general requirements of“global vision,international standards,distinctive Chinese features,and future-oriented goals”in Xiong’an New Area,identifying the engineering geologic conditions and geologic environmental challenges of this *** achievements also include a 3D engineering geological structure model for the whole area,along with“one city proper and five clusters”,insights into the ecology and the background endowment of natural resources like land,geothermal resources,groundwater,and wetland of the area before engineering construction,a comprehensive monitoring network of resources and environments in the area,and the“Transparent Xiong’an”geological information platform that is open,shared,dynamically updated,and three-dimensionally ***’s geologists and urban geology have played a significant role in the urban planning and construction of Xiong’an New Area,providing whole-process geological solutions for urban planning,construction,operation and *** future urban construction of Xiong’an New Area will necessitate the theoretical and technical support of earth system science(ESS)from various aspects,and the purpose is to enhance the resilience of the new type of city and to provide support for the green,low-carbon,and sustainable development of this area.

关键词： Low Carbon New City Planning and construction Land Geothermal resources Groundwater Wetland Underground space Geologic disasters Site stability Natural resource Ecosystem Geological safety Transparent Xiong’an Resilient city Xiong’an New Area

High-strength antiswelling adhesive achieves both hemostasis and wound healing

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Journal of Pharmaceutical Analysis 2024年第6期14卷 781-784页

作者： Xin Zhao Jinlong Luo Ying Huang Lei Mu Jueying Chen zhen Liang Zhanhai Yin Dake Chu Yong han Baolin Guo State Key Laboratory for Mechanical Behavior of Materials Frontier Institute of Science and TechnologyXi'an Jiaotong UniversityXi'an710049China Department of Plastic Surgery Xijing HospitalAir Force Medical UniversityXi'an710032China Department of Orthopaedics The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China Department of Gastroenterology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi'an Jiaotong UniversityXi'an710049China

Skin is one of the most vulnerable tissues,but there is a lack of injectable bioactive hydrogel dressings,which possess high strength,antiswelling capacity,and wet tissue adhesiveness,but also a rapid gelling process to enable rapid hemostasis,sutureless wound closure,and scarless healing of infected skin wounds[1e5].A new injectable,antibacterial,and multifunctional hydrogel dressings based on poly(citric acid-co-polyethylene glycol)-g-dopamine(PCPD)and amino-terminated Pluronic F127(APF)mi-celles loaded with astragaloside IV(AS)was developed for this pur-pose,as shown in Fig.1A[6].

关键词： healing wound stasis

FAST unveils a new era in the discovery of long-period pulsars in globular clusters

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 185-186页

作者： Zhanwen han International Centre of Supernovae Yunnan Key LaboratoryYunnan ObservatoriesChinese Academy of SciencesKunming 650011China

Globular clusters(GC)are among the oldest celestial bodies in the Milky *** possessing millions of stars and have been going through abundant stellar interactions,GCs are futile ground for hunting for compact objects,particularly,neutron stars.A significant number of fast-spinning millisecond pulsars(MSPs)have been discovered,comprising the majority of known GC pulsars.

关键词： stars pulsars abundant

Molecular Characterization of Coxsackievirus B1 Strains Isolated from Patients with hand Foot and Mouth Disease in Yunnan,Southwest China

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Biomedical and Environmental Sciences 2024年第5期37卷 543-548页

作者： XU Dan han ZhanG Ming CHEN Jun wei Feng Chang Zeng LIU Yu han CHU Zhao Yang LIU Wen Jing LI Li MA Shao Hui Institute of Medical Biology Chinese Academy of Medical Sciencesand Peking Union Medical CollegeKunming 650118YunnanChina Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease Kunming 650118YunnanChina School of Life Sciences Yunnan UniversityKunming 650504YunnanChina School of Medicine Yunnan UniversityKunming 650504YunnanChina Department of Clinical Laboratory Kunming Maternal and Child Health hospital Kunming 650031YunnanChina

Coxsackievirus(CV)B belongs to the species Enterovirus B,genus Enterovirus of the family *** B(EV-B)includes 63 serotypes:CVB1-6;CVA9;echoviruses E1-7,9,11-21,24-27,and 29-33;EV-B69,EV-B 73-75,EV-B77-88,EV-B 93,EV-B 9... 详细信息

关键词： Coxsackievirus Patients belongs