检索结果-南通市图书馆

Association and prognostic significance of alpha-L-fucosidase-1 and matrix metalloproteinase 9 expression in esophageal squamous cell carcinoma

引用

World Journal of Gastrointestinal Oncology 2022年第2期14卷 498-510页

作者： Xiang-Yang yu Sheng-Cheng Lin Meng-Qi Zhang Xiao-Tong Guo Kai Ma Li-Xu Wang Wen-Ting Huang Zhe Wang Xin yu Chun-Guang Wang Lan-Jun Zhang zhen-tao yu Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518116Guangdong ProvinceChina Department of Pathology Shenzhen Maternity and Child Healthcare HospitalShenzhen 518038Guangdong ProvinceChina Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518116Guangdong ProvinceChina Department of Thoracic Surgery Sun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Alpha-L-fucosidase-1(FUCA1)has been demonstrated to play opposing regulatory roles in adenocarcinoma and non-adenocarcinoma.Moreover,recent studies reported that FUCA1 could decrease the invasion capability by downregulating matrix metalloproteinase 9(MMP-9)expression.However,the potential role and prognostic significance of FUCA1 in esophageal squamous cell carcinoma(ESCC)have not yet been explored.AIM To evaluate the status,association,and prognostic value of FUCA1 and MMP-9 expression in ESCC.METHODS Patients who underwent esophagectomy for ESCC between January 1,2014,and December 31,2014 at Sun Yat-Sen University Cancer Center were enrolled.The expression status of FUCA1 and MMP-9 in cancerous tissues was detected using immunohistochemistry.In addition,the expression profiles of the FUCA1 and MMP-9 genes in non-metastatic ESCC were extracted from The Cancer Genome Atlas(TCGA)database.RESULTS High expression of FUCA1 and MMP-9 was found in 90 patients(75.6%)and 62 patients(52.1%),respectively.In the high FUCA1 expression group,the constituent ratios of patients with stage III disease(61.1%vs 37.9%,P=0.029),lymphatic invasion(62.2%vs 31.0%,P=0.003),and high MMP-9 expression(60.0%vs 27.6%,P=0.002)were significantly higher than those in the low FUCA1 expression group.In Kaplan-Meier univariate analysis,advanced tumor-nodemetastasis stage(III,P=0.001),positive regional lymph node metastasis(N+,P=0.002),high FUCA1 expression(P=0.001),and high MMP-9 expression(P=0.002)were potential predictors of shorter overall survival(OS),which was similar to the results analyzed based on the TCGA database.Further Cox multivariate regression analyses still demonstrated that FUCA1 and MMP-9 expression levels were independent prognostic factors of OS[hazard ratio(HR):0.484,95%confidence interval(CI):0.239-0.979;P=0.044;and HR:0.591,95%CI:0.359-0.973,P=0.039,respectively].CONCLUSION FUCA1 cooperation with MMP-9 may have a major role in affecting the ESCC invasion and metastatic capability,and serve as a valuable prognosti

关键词： Esophageal squamous cell carcinoma Alpha-L-fucosidase-1 Matrix metalloproteinase-9 Immunohistochemistry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neoadjuvant chemoradiotherapy for resectable esophageal cancer:an in-depth study of randomized controlled trials and literature review

引用

Cancer Biology & Medicine 2014年第3期11卷 191-201页

作者： Xiao-Feng Duan Peng Tang zhen-tao yu Department of Esophageal Cancer Tianjin Medical University Cancer Institute and Hospital

Surgery following neoadjuvant chemoradiotherapy(NCRT) is a common multidisciplinary treatment for resectable esophageal cancer(EC). After analyzing 12 randomized controlled trials(RCTs), we discuss the key issues of surgery in the management of resectable EC. Along with chemoradiotherapy, NCRT is recommended for patients with squamous cell carcinoma(SCC) and adenocarcinoma(AC), and most chemotherapy regimens are based on cisplatin, fluorouracil(FU), or both(CF). However, taxane-based schedules or additional studies, together with newer chemotherapies, are warranted. In nine clinical trials, post-operative complications were similar without significant differences between two treatment groups. In-hospital mortality was significantly different in only 1 out of 10 trials. Half of the randomized trials that compare NCRT with surgery in EC demonstrate an increase in overall survival or disease-free survival. NCRT offers a great opportunity for margin negative resection, decreased disease stage, and improved loco-regional control. However, NCRT does not affect the quality of life when combined with esophagectomy. Future trials should focus on the identification of optimum regimens and selection of patients who are most likely to benefit from specific treatment options.

关键词：随机对照试验食管癌化疗文献综述治疗方案鳞状细胞癌氟尿嘧啶临床试验

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microstructural adjustments and mechanical properties of a cold-rolled biomedical near β-Ti alloy sheet

引用

Rare Metals 2018年第10期37卷 846-851页

作者： Xi-Qun Ma Hong-Zhi Niu zhen-tao yu Sen yu Chang Wang Northwest Institute for Nonferrous Metal Research Xi'an 710016 China School of Materials Science and Engineering Northeastern University Shenyang 110819 China

In this study, microstructural adjustments and mechanical properties of a cold-rolled near β-type alloy Ti-25Nb-3Zr-3Mo-2Sn （wt%） sheet were investigated. Microstructures and phase transformation products strongly depended on aging temperatures. Solution treatments within single β-phase field removed the stress-induced at martensites and produced a few new lath-shaped ones, but metastable β phase still dominated. This is exactly the reason why current alloy exhibits the lowest modulus （54 GPa） and best elongation to fracture （39 %）, but the worst yield strength of only 340 MPa, at solutiontreated state. A fairly large number of ellipsoidal ω phase nanoparticles precipitated throughout parent β phase during aging at 380℃. These ω nanoparticles possess remarkable strengthening effect, but deteriorate ductility seriously. A novel post-aging process was proposed to remove brittle ω phase. By contrast, aging at 450 ℃ resulted in sufficient precipitation of fine needle-like α phase. This brought about the best combination of high yield strength （770 MPa） and moderate elastic modulus （75 GPa） and good elongation （15 %） for biomedical implants.

关键词： Near β-Ti alloy Microstructures Phase transformation Mechanical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prognostic significance of preoperative and postoperative CK19 and CEA m RNA levels in peripheral blood of patients with gastric cardia cancer

引用

World Journal of Gastroenterology 2017年第8期23卷 1424-1433页

作者： yu-Feng Qiao Chuan-Gui Chen Jie yue Ming-Quan Ma Zhao Ma zhen-tao yu Department of Esophageal Cancer Tianjin Medical University Cancer Institute and HospitalKey Laboratory of Cancer Prevention and Therapy of Tianjin CityTianjin 300060China

AIM To evaluate the clinical and prognostic significance of preoperative and postoperative cytokeratin 19(CK19) and carcinoembryonic antigen(CEA) m RNA levels in peripheral blood of patients with gastric cardia cancer(GCC).METHODS We detected the preoperative and postoperative mR NA levels of CK19 and CEA in peripheral blood of 129 GCC patients by using reverse transcription-polymerase chain reaction and evaluated their clinical and prognostic significance by univariate Kaplan-Meier survival analysis and multivariate Cox proportional hazard analysis. A new prognostic model which stratified patients into three different risk groups was established based on the independent prognostic factors.RESULTS Elevated preoperative and postoperative CK19 and CEA mR NA levels in peripheral blood of GCC patients were associated with lymph node metastasis. Univariate analysis showed that tumor size, histological grade, depth of tumor invasion, lymph node metastasis, preoperative CK19 m RNA, and preoperative and postoperative CEA m RNA levels were correlated with the prognosis of GCC patients. The multivariate analysis showed that lymph node status(P = 0.018), preoperative CK19(P = 0.035) and CEA(P = 0.011) m RNA levels were independent prognostic factors for overall survival(OS). The 5-year OS rates for the low-, intermediate-, and high-risk groups were 48.3%, 22.6%, and 4.6%, respectively(P < 0.001).CONCLUSION Elevated preoperative CK19 and CEA mR NA levels may be regarded as promising biomarkers for predicting lymph node metastasis and poor prognosis in patients with GCC. This new prognostic model may help us identify the subpopulations of GCC patients with the highest risk.

关键词：胃的贲门癌症 Cytokeratin 19 Carcinoembryonic 抗原 Clinicopathological 因素预后

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Designation and development of biomedical Ti alloys with finer biomechanical compatibility in long-term surgical implants

引用

Frontiers of Materials Science 2014年第3期8卷 219-229页

作者： zhen-tao yu Ming-Hua ZHANG yu-Xing TIAN Jun CHENG Xi-Qun MA Han-yuan LIU Chang WANG Northwest Institute for Nonferrous Metal Research Xi'an 710016 China Tangdu Hospital The Fourth Military Medical University Xi'an 710038 China

与优秀 biomechanical 相容性开发新钛合金是一个重要研究方向外科植入材料。现在的纸总结生物医学的钛合金的国际研究和开发。瞄准增加 biomechanical 相容性，它也介绍合金设计的探索和改进，机械处理，微观结构和阶段转变，并且以后... 详细信息

与优秀 biomechanical 相容性开发新钛合金是一个重要研究方向外科植入材料。现在的纸总结生物医学的钛合金的国际研究和开发。瞄准增加 biomechanical 相容性，它也介绍合金设计的探索和改进，机械处理，微观结构和阶段转变，并且以后最后为关于生物医学的钛合金的科学研究构画出方向。

关键词：生物力学生物医学相容性植入物外科开发金具 Ti

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于井筒-地层定压实验的重力置换窗口研究

引用

科学技术与工程 2024年第6期24卷 2330-2338页

作者：陶振宇樊洪海罗胜刘玉含邓嵩叶宇光中国石油大学石油工程学院北京102249 中国石油华北油田巴彦勘探开发分公司巴彦淖尔015000 中国石油集团工程技术研究院有限公司北京102206 常州大学石油工程学院常州213164

为了处理重力置换引起的溢漏事故,首先需要了解重力置换发生的条件,分析重力置换窗口,判断井下是否发生重力置换,并采取对应的处理方法。通过自主研制的井筒-地层重力置换实验装置,开展气液、液液重力置换临界点实验,基于理论及实验分析... 详细信息

为了处理重力置换引起的溢漏事故,首先需要了解重力置换发生的条件,分析重力置换窗口,判断井下是否发生重力置换,并采取对应的处理方法。通过自主研制的井筒-地层重力置换实验装置,开展气液、液液重力置换临界点实验,基于理论及实验分析,定量计算地层重力置换窗口,并拟合了重力置换窗口临界点压力曲线,拟合公式与实测值误差小于10%。在该实验条件下,当钻井液密度为0.998 g/cm3时,气液重力置换窗口为-5 800~10.6 Pa,液液地层重力置换的窗口为-1 192~16.6 Pa。结果表明,气液、液液重力置换窗口与流体密度差基本呈线性关系;现场实际井下重力置换窗口远高于此,所以需要在钻进时考虑重力置换窗口的影响。据此,提出了预防重力置换发生的方法,以及发生重力置换溢漏事故后对应的处理方法。

关键词：重力置换实验装置地层重力置换窗口井筒-地层定压实验抑制措施

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thermal stability of bimodal grain structure in a cobalt-based superalloy subjected to high-temperature exposure

引用

Rare Metals 2021年第4期40卷 877-884页

作者： Cheng-Lin Li Jeong Mok Oh Seong-Woo Choi Xin-Ming Mei Jae-Keun Hong Jong-Taek Yeom Qing-Song Mei zhen-tao yu Chan Hee Park School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea Institute of Advanced Wear and Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou 510632China

The present work investigates the thermal stability and mechanical properties of a Co-20 Cr-15 W-10 Ni(wt%) alloy with a bimodal grain(BG) structure.The BG structure consisting of fine grains(FGs) and coarse grains(CGs) is thermally stable under high-temperature exposure treatments of 760℃ for 100 h and 870℃ for 100-1000 h.The size of both FGs and CGs remains no significant changes after thermal exposure treatments.The microstructural stability is associated with the slow kinetics of grain growth and the pinning of carbides.The thermal stability enables to maintain the BG structures,leading to the same mechanical properties as the sample without thermal exposure treatment.In particular,the BG alloy samples after thermal exposure treatment exhibit superior mechanical properties of both high strength and high ductility compared to the unimodal grain(UG) structured ones.The BG structure of the alloy samples after thermal exposure is capable of avoiding severe loss of ductility and retaining high strength.More specifically,the ductility of the BG alloy samples after thermal exposure treatments of 870℃ for 500-1000 h is ten times higher(44.6% vs.3.5% and 52.6% vs.5.0%) than that of the UG ones.The finding in the present work may give new insights into high-temperature applications of the Co-20 Cr-15 W-10 Ni alloy and other metallic materials with a BG structure.

关键词： Thermal stability Bimodal grain structure High-temperature exposure Cobalt-based superalloy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Elevated serum levels of human relaxin-2 in patients with esophageal squamous cell carcinoma

引用

World Journal of Gastroenterology 2013年第15期19卷 2412-2418页

作者： Peng Ren zhen-tao yu Li Xiu Mei Wang Hua-Min Liu Department of Esophageal Cancer Tianjin Medical University Cancer Institute and Hospital and Key Laboratory of Cancer Prevention and Therapy

AIM: To assess the prognostic value of serum human relaxin 2 (H2 RLN) level in patients with esophageal squamous cell carcinoma (ESCC). METHODS: From October 1998 to September 2009, 146 patients with histopathologically confirmed ESCC were enrolled in this study. One hundred patients underwent en bloc esophagectomy, and 46 patients with unresectable tumors underwent palliative surgery. Five of the 146 patients died of surgical complications. Serum levels of H2 RLN were measured by enzyme linked immunosorbent assay. The relationship between serum H2 RLN level and each of the clinicopathological parameters was analyzed using the χ2 test. Patients were classified into two groups according to their H2 RLN level (< 0.462 ng/mL vs ≥ 0.462 ng/mL). When any analysis cell had fewer than five cases, the Fisher's exact test was used. The statistical difference between groups A and B in each clinicopathological category was determined by the Student's t test (two-tailed) or analysis of variance. Survival curves were plotted using the Kaplan-Meier method. The statistical difference in survival between the different groups was compared using the log-rank test. Survival correlation with the prognostic factors was further investigated by multivariate analysis using the Cox proportional hazards model with backward stepwise likelihood ratio. RESULTS: ESCC patients tended to have significantly higher serum H2 RLN concentrations (0.48 ± 0.17 ng/ mL, n=141) compared with the healthy control group (0.342 ± 0.12 ng/mL, n=112). There was a significant difference between patients with lymph node involvement (0.74 ± 0.15 ng/mL, n=90), distant metastasis (0.90 ± 0.19 ng/mL, n=32) and those without lymph node involvement (0.45 ± 0.12 ng/mL, n=51), and distant metastasis (0.43 ± 0.14 ng/mL, n=109), respectively (P < 0.01). Patients with high H2 RLN levels (≥ 0.462 ng/mL) had a poorer prognosis than patients with low serum H2 RLN levels (< 0.462 ng/mL; P=0.0056). The H2 RLN level was also correlated with survival and tumor-node-metastasis sta

关键词： Esophageal squamous cell carcinoma Re- laxin Tumor markers Metastasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Finite-Time Convergent Analysis of Continuous Action Iterated Dilemma

引用

IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 563-565页

作者： zhen Wang Xiaoyue Jin tao Zhang Dengxiu yu Northwestern Polytechnical University

Dear Editor,In this letter, a finite-time convergent analysis of continuous action iterated dilemma(CAID) is proposed. In traditional evolutionary game theory, the strategy of the player is binary(cooperation or defec... 详细信息

关键词： lemma letter convergent

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecular dynamics study of hydrogen-induced cracking behavior of ferrite–pearlite gas transmission pipeline steel

引用

Journal of Iron and Steel Research(International) 2024年第2期31卷 488-500页

作者： tao-long Xu Si-han Guo Gong-zhen He Hao-yu Han Petroleum Engineering School Southwest Petroleum UniversityChengdu610500SichuanChina Sichuan East Gas Transmission Sales Center of Sinopec Natural Gas Branch Wuhan430074HubeiChina

Hydrogen embrittlement of pipelines depends on the hydrogen-induced cracking behavior of the pipeline steel microstructure.Based on molecular dynamics analysis,the ferrite–cementite(α-Fe/Fe3C)lamellar atomic structure with the Bagaryatskii orientation relationship was established,and stepwise relaxation of the conjugate gradient energy minimization and constant-temperature and constant-pressure relaxation were performed under NPT(the isothermal–isobaric)conditions.The mechanical property curves of theα-Fe/Fe3C models were obtained under different cementite terminal plane structures,and the evolution of the atomic structure was analyzed in detail.In addition,the influence of different hydrogen concentrations,different temperatures,different strain rates,changes in voids,and different micro-degrees of freedom on the deformation and failure mechanism of the model was investigated,aiming to provide a reliable way to explore the micro-mechanism of macro-cracking behavior of pipeline steel.

关键词： Ferrite-cementite lamellar structure Pipeline steel Failure mechanism Crack propagation Molecular dynamics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：