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三氧自体血疗法联合三氧皮下注射辅助治疗老年急性带状疱疹的疗效分析

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中国疼痛医学杂志 2024年第7期30卷 509-514页

作者：秦佳文高伊丽李娜张永庆焦国华李慧杨园园王祥瑞廖丽君俞海萍同济大学医学院上海200082 同济大学附属东方医院疼痛科上海200123 桐乡市中医医院疼痛科桐乡314500 同济大学附属东方医院护理部上海200123

目的:探讨三氧自体血疗法联合三氧皮下注射在辅助治疗老年急性期带状疱疹中的疗效。方法:选取2023年1月至2023年10月同济大学附属东方医院疼痛科收治的老年急性期带状疱疹病人,采用随机数字表法分为药物治疗组(对照组)和药物联合三氧治... 详细信息

目的:探讨三氧自体血疗法联合三氧皮下注射在辅助治疗老年急性期带状疱疹中的疗效。方法:选取2023年1月至2023年10月同济大学附属东方医院疼痛科收治的老年急性期带状疱疹病人,采用随机数字表法分为药物治疗组(对照组)和药物联合三氧治疗组(三氧组),每组各30例。药物治疗组采用口服盐酸伐昔洛韦、甲钴胺、普瑞巴林等常规药物治疗;药物联合三氧组在对照组治疗的基础上加用三氧自体血疗法联合三氧皮下注射治疗。比较两组病人治疗前、治疗后1周、2周、1个月的疼痛视觉模拟评分法(visual analogue scale,VAS)评分、睡眠状况自评量表(self-rating scale of sleep,SRSS)、抑郁-焦虑-压力评分量表(depressionanxietystressscale,DASS),并记录两组病人的疱疹愈合时间、不良反应发生率及带状疱疹后神经痛的发病率。结果:60例病人全部完成试验,与对照组相比,三氧组治疗后1周、2周和1个月的VAS评分下降更为显著(P<0.05),三氧组病人治疗后SRSS和DASS量表评分均有显著下降(P<0.05),三氧组的疱疹愈合时间(天数)明显缩短(P<0.01),三氧组带状疱疹后神经痛的发病率更低(P<0.05),治疗期间两组病人的不良反应发生率差异无统计学意义。结论:三氧自体血疗法联合三氧皮下注射在辅助治疗老年急性期带状疱疹中可显著减轻病人疼痛,提高睡眠质量,改善情绪状态,加速疱疹愈合并降低带状疱疹后神经痛的发病率,可为老年急性带状疱疹病人提供安全有效的辅助治疗方案。

关键词：三氧自体血疗法三氧皮下注射老年带状疱疹

Long noncoding RNA X-inactive specific transcript regulates NLR family pyrin domain containing 3/caspase-1-mediated pyroptosis in diabetic nephropathy

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World Journal of Diabetes 2022年第4期13卷 358-375页

作者： Jia Xu Qin Wang yi-Fan Song Xiao-Hui Xu He Zhu Pei-Dan Chen Ye-ping Ren Department of Nephrology Shenzhen University General HospitalShenzhen 518000Guangdong ProvinceChina

BACKGROUND NLRP3-mediated pyroptosis is recognized as an essential modulator of renal disease *** noncoding RNAs(lncRNAs)are active participators of diabetic nephropathy(DN).X inactive specific transcript(XIST)expression has been reported to be elevated in the serum of DN *** To evaluate the mechanism of lncRNA XIST in renal tubular epithelial cell(RTEC)pyroptosis in *** A DN rat model was established through streptozotocin injection,and XIST was knocked down by tail vein injection of the lentivirus LV *** metabolic and biochemical indices were detected,and pathological changes in the renal tissue were *** expression of indicators related to inflammation and pyroptosis was also *** glucose(HG)was used to treat HK2 cells,and cell viability and lactate dehydrogenase(LDH)activity were detected after silencing *** subcellular localization and downstream mechanism of XIST were ***,a rescue experiment was carried out to verify that XIST regulates NLR family pyrin domain containing 3(NLRP3)/caspase-1-mediated RTEC pyroptosis through the microRNA-15-5p(miR-15b-5p)/Toll-like receptor 4(TLR4)*** XIST was highly expressed in the DN *** silencing improved renal metabolism and biochemical indices and mitigated renal *** expression of inflammation and pyroptosis indicators was significantly increased in DN rats and HG-treated HK2 cells;cell viability was decreased and LDH activity was increased after HGtreatment. Silencing XIST inhibited RTEC pyroptosis by inhibiting NLRP3/caspase-1. Mechanistically,XIST sponged miR-15b-5p to regulate TLR4. Silencing XIST inhibited TLR4 by promotingmiR-15b-5p. miR-15b-5p inhibition or TLR4 overexpression averted the inhibitory effect ofsilencing XIST on HG-induced RTEC *** XIST inhibits TLR4 by upregulating miR-15b-5p and ultimately inhibits renal injury inDN by inhibiting NLRP3/caspase-1-mediated RTEC pyroptosis.

关键词： Diabetic nephropathy Pyroptosis Renal tubular epithelial cell Long noncoding RNA X-inactive specific transcript microRNA-15b-5p Toll-like receptor 4 NLR family pyrin domain containing 3/caspase-1 pathway

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冻融作用下锚固裂隙岩体力学响应研究综述

煤炭科技 2024年第2期45卷 19-26页

作者：张新宙李聪吴亮亮谢天赵凯艺蔡玮珍张荣堂武汉轻工大学土木工程与建筑学院湖北武汉430023

冻融循环作用下锚固岩体力学响应与裂隙岩体存在显著区别,研究锚固岩体冻融力学响应对寒区锚固边坡长期安全控制具有重要意义。在裂隙岩体冻融响应研究的基础上,综述了冻融循环作用下裂隙边坡锚固岩体力学响应行为研究进展;从裂隙冻胀... 详细信息

冻融循环作用下锚固岩体力学响应与裂隙岩体存在显著区别,研究锚固岩体冻融力学响应对寒区锚固边坡长期安全控制具有重要意义。在裂隙岩体冻融响应研究的基础上,综述了冻融循环作用下裂隙边坡锚固岩体力学响应行为研究进展;从裂隙冻胀力、锚固结构预应力等方面综述了锚固岩体对冻融作用的力学响应研究成果;对锚固岩体冻融力学响应问题研究的发展趋势进行了展望,并指出冻融条件下锚固岩体中冻胀力与锚固力的演变规律是下一步研究的重点。

关键词：冻融循环裂隙冻胀力锚固结构预应力力学响应

Effect of N,N-Dimethylglycine on Homocysteine Metabolism in Rats Fed Folate-Sufficient and Folate-Deficient Diets

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Biomedical and Environmental Sciences 2021年第5期34卷 356-363页

作者： LIU yi Qun HUANG Ling He LIU Pei Pei XING Qing Bin HAN Feng WANG Qin CHEN Shu Rong SUGIYAMA Kimio XIANG Xue Song HUANG zhen Wu Key Laboratory of Trace Element Nutrition of National Health Commission National Institute of Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China Chinese Nutrition Society Beijing 100022China Beijing Dietetic Association Beijing 100050China Department of Applied Biological Chemistry Faculty of AgricultureShizuka University836 OhyaSuruga-kuShizuoka 422-8529Japan

Objective This study aimed to investigate the effects of N,N-dimethylglycine(DMG) on the concentration and metabolism of plasma homocysteine(pHcy) in folate-sufficient and folate-deficient *** In this study, 0.1% DMG was supplemented in 20% casein diets that were either folatesufficient(20 C) or folate-deficient(20 CFD). Blood and liver of rats were subjected to assays of Hcy and its metabolites. Hcy and its related metabolite concentrations were determined using a liquid chromatographic *** Folate deprivation significantly increased pHcy concentration in rats fed 20 C diet(from 14.19 ±0.39 μmol/L to 28.49 ± 0.50 μmol/L;P < 0.05). When supplemented with DMG, pHcy concentration was significantly decreased(12.23 ± 0.18 μmol/L) in rats fed 20 C diet but significantly increased(31.56 ±0.59 μmol/L) in rats fed 20 CFD. The hepatic methionine synthase activity in the 20 CFD group was significantly lower than that in the 20 C group;enzyme activity was unaffected by DMG supplementation regardless of folate sufficiency. The activity of hepatic cystathionine β-synthase(CBS) in the 20 CFD group was decreased but not in the 20 C group;DMG supplementation enhanced hepatic CBS activity in both groups, in which the effect was significant in the 20 C group but not in the other *** DMG supplementation exhibited hypohomocysteinemic effects under folate-sufficient conditions. By contrast, the combination of folate deficiency and DMG supplementation has deleterious effect on pHcy concentration.

关键词： Folate deficiency N,N-Dimethylglycine 5-methyltetrahydrofolate Plasma homocysteine

Fifteen-year mortality and prognostic factors in patients with dilated cardiomyopathy:persistent standardized application of drug therapy and strengthened management may bring about encouraging change in an aging society

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Journal of Geriatric Cardiology 2022年第5期19卷 335-342页

作者： Xiao-Rong XU Meng-Meng HAN yi-zhen YANG Xin WANG Dong-Yan HOU Xian-Chen MENG Hua WANG Wen-Shu ZHAO Lin ZHANG Lin XU Heart Center and Beijing Key Laboratory of Hypertension Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Intensive Care Units Beijing Longfu HospitalBeijingChina Statistics Department Information CenterBeijing Chaoyang HospitalCapital Medical UniversityBeijingChina

BACKGROUND There is scarce data on the long-term mortality and associated prognostic factors in patients with dilated car-diomyopathy(DCM).The study aimed to investigate the all-cause mortality up to 15 years(mean 7.9±5.7 years)in such patients,and the independent prognostic factors influencing their long-term *** One hundred and sixty-six consecutive patients with DCM were prospectively enrolled from 2002 to *** mean age of patients was 59.5±10.4 years,and approximately 57%were *** were followed up by telephone or outpa-tient visit at least every three months until 2019 or all-cause death *** of mortality were identified using mul-tivariate logistic regression *** During the 15 years of follow-up,five patients were lost to follow-up,and the complete data records of 161 patients were included in the *** were treated with angiotensin-converting-enzyme inhibitors(ACEI)or angiotensin-recept-or blocker(ARB),β-blockers,mineralocorticoid receptor antagonist(MRA),diuretics and digitalis from 2002 to 2004,and main-tained at the maximum tolerated doses between 2004 and *** safety targets to maintain heart rate and blood pressure at 60-80 beats/min and 90-120/60-80 mmHg,***-cause mortality in the first five years was 55.9%.The independent risk factors for the 5-year mortality were age≥70 years old(OR=5.45,P=0.006),systolic blood pressure(SBP)>120 mmHg(OR=3.63,P=0.004),6-minute walk distance(6MWD)120 mmHg(OR=9.56,P<0.001).CONCLUSIONS This study was the first to demonstrate the 15-year survival rate of 34%in DCM *** DCM patients’first five-year all-cause mortality decreased significantly after continuous standardized treatment and intensive *** mortality then plateaued in the following 10

关键词： patients doses strengthened

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砂卵(砾)石层中注浆模拟试验研究

岩土工程学报 2006年第12期28卷 2134-2138页

作者：杨坪唐益群彭振斌陈安同济大学地下建筑与工程系上海200092 中南大学地学与环境工程学院湖南长沙410083

通过在模拟的砂卵(砾)石层中进行注浆试验,研究分析注浆压力p、注浆时间t、浆液水灰比m、地层渗透系数k、孔隙度n的单因素和多因素对浆液扩散半径R、注浆后结石体抗压强度P的影响规律及它们之间的相互关系。试验结果表明:R随着p、t、k、... 详细信息

通过在模拟的砂卵(砾)石层中进行注浆试验,研究分析注浆压力p、注浆时间t、浆液水灰比m、地层渗透系数k、孔隙度n的单因素和多因素对浆液扩散半径R、注浆后结石体抗压强度P的影响规律及它们之间的相互关系。试验结果表明:R随着p、t、k、m的增加而增大,影响R的显著因素是p,其次是k,t和m;P随着p、t、n的增加而增大,随着m的减小而增加,p对注浆后P有较大的影响,n、t次之,而m则占有明显的优势。利用计算机优化回归实验数据,得出了它们之间的关系式。

关键词：砂卵(砾)石注浆模拟实验扩散半径抗压强度

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不同地区牛背最长肌营养成分对比分析

中国牛业科学 2024年第1期50卷 14-18页

作者：王一然杨亮高雨姚康雨魏勇任万平新疆农业大学新疆肉乳用草食动物营养实验室乌鲁木齐市830052 新疆天润乳业股份公司乌鲁木齐市830000

探索不同地区牛背最长肌的氨基酸、脂肪酸、微量元素等营养成分含量的差异。试验选取贵州、内蒙、新疆地区各6头36月龄左右公牛的牛背最长肌进行营养成分测定。结果表明:(1)内蒙地区牛背最长肌中甘氨酸、脯氨酸、丙氨酸等含量均显著高... 详细信息

探索不同地区牛背最长肌的氨基酸、脂肪酸、微量元素等营养成分含量的差异。试验选取贵州、内蒙、新疆地区各6头36月龄左右公牛的牛背最长肌进行营养成分测定。结果表明:(1)内蒙地区牛背最长肌中甘氨酸、脯氨酸、丙氨酸等含量均显著高于贵州和新疆地区(P<0.05);(2)内蒙地区牛背最长肌中硬脂酸、油酸等含量极显著高于贵州和新疆地区(P<0.01);(3)贵州地区牛背最长肌中牛磺酸含量显著高于内蒙和新疆地区(P<0.05);(4)新疆地区牛背最长肌中总胆固醇含量极显著低于贵州和内蒙地区(P<0.01)。综上所述,内蒙地区氨基酸、脂肪酸含量高;贵州地区牛磺酸含量高;新疆地区胆固醇含量低。

关键词：氨基酸脂肪酸微量元素不同地区牛背最长肌

威廉环毛蚓中8种核苷提取工艺优化及含量测定

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中成药 2024年第8期46卷 2526-2530页

作者：宇泉霖吴雪纯邱旖宋嘉佳蒋巧萍孙常胜吴婧楠蔡程科王洪飞北京中医药大学中药学院北京102400 北京量子高科制药有限公司北京102200

目的优化威廉环毛蚓中尿嘧啶、次黄嘌呤、黄嘌呤、尿苷、胸腺嘧啶、肌苷、鸟苷、2′-脱氧鸟苷提取工艺,并测定其含量。方法以料液比、超声时间、超声温度为影响因素,次黄嘌呤、总核苷含量为评价指标,正交试验优化提取工艺。HPLC法测定... 详细信息

目的优化威廉环毛蚓中尿嘧啶、次黄嘌呤、黄嘌呤、尿苷、胸腺嘧啶、肌苷、鸟苷、2′-脱氧鸟苷提取工艺,并测定其含量。方法以料液比、超声时间、超声温度为影响因素,次黄嘌呤、总核苷含量为评价指标,正交试验优化提取工艺。HPLC法测定各核苷含量,分析采用Agilent C_(18)色谱柱(4.6 mm×250 mm,5μm);流动相甲醇-水,梯度洗脱;体积流量1 mL/min;柱温30℃;检测波长260 nm。结果最佳条件为料液比1∶250,超声时间30 min,超声温度60℃。8种核苷在各自范围内线性关系良好(R^(2)>0.9990),平均加样回收率99.11%~103.27%,RSD 0.85%~2.89%。结论该方法稳定可靠,可用于威廉环毛蚓中核苷的提取与含量测定。

关键词：威廉环毛蚓核苷提取工艺含量测定正交试验 HPLC

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胎盘绒毛膜血管瘤病17例临床病理分析

诊断病理学杂志 2024年第6期31卷 537-539,550页

作者：张爱格王莉萍杨毅斌陈菠郑良楷厦门大学附属妇女儿童医院厦门市妇幼保健院病理科福建厦门361003

目的研究和探讨胎盘绒毛膜血管瘤病(CM)的临床病理特征、诊断、鉴别诊断及对围生儿结局的影响。方法收集厦门市妇幼保健院病理科2021年6月至2023年3月确诊CM 17例,回顾性分析其临床及病理资料,并进行分析总结。结果17例CM中局限型占15例... 详细信息

目的研究和探讨胎盘绒毛膜血管瘤病(CM)的临床病理特征、诊断、鉴别诊断及对围生儿结局的影响。方法收集厦门市妇幼保健院病理科2021年6月至2023年3月确诊CM 17例,回顾性分析其临床及病理资料,并进行分析总结。结果17例CM中局限型占15例(占88.2%),包括局灶性7例,阶段性8例(2例见终末绒毛累及);弥漫型2例(占11.8%,均见终末绒毛累及);围生儿影响方面,CM、非CM在生长发育迟缓、早产、死胎的总体分布上存在着统计学差异(P<0.05)。结论CM是比较少见的一种胎盘绒毛血管病变,除了累及干绒毛和未成熟中间型绒毛,还可累及终末绒毛,对围生儿结局有不良影响,需引起临床重视,胎盘的准确评估具有临床意义。

关键词：绒毛膜血管瘤病胎盘病理分析围生儿