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LRRK2 regulates actin assembly for spindle migration and mitochondrial function in mouse oocyte meiosis

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Journal of Molecular Cell Biology 2022年第1期14卷 21-31页

作者： zhen-nan pan Jing-Cai Liu Jia-Qian Ju Yue Wang Shao-Chen Sun College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China

Leucine-rich-repeat kinase 2 (LRRK2) belongs to the Roco GTPase family and is a large multidomain protein harboring both GTPase and kinase activities. LRRK2 plays indispensable roles in many processes, such as autophagy and vesicle trafficking in mitosis. In this study, we showed the critical roles of LRRK2 in mammalian oocyte meiosis. LRRK2 is mainly accumulated at the meiotic spindle periphery during oocyte maturation. Depleting LRRK2 led to the polar body extrusion defects and also induced large polar bodies in mouse oocytes. Mass spectrometry analysis and co-immunoprecipitation results showed that LRRK2 was associated with several actin-regulating factors, such as Fascin and Rho-kinase (ROCK), and depletion of LRRK2 affected the expression of ROCK, phosphorylated cofilin, and Fascin. Further analysis showed that LRRK2 depletion did not affect spindle organization but caused the failure of spindle migration, which was largely due to the decrease of cytoplasmic actin filaments. Moreover, LRRK2 showed a similar localization pattern to mitochondria, and LRRK2 was associated with several mitochondria-related proteins. Indeed, mitochondrial distribution and function were both disrupted in LRRK2-depleted oocytes. In summary, our results indicated the critical roles of LRRK2 in actin assembly for spindle migration and mitochondrial function in mouse oocyte meiosis.

关键词： actin spindle LRRK2 oocyte meiosis

SC-GAN:A Spectrum Cartography with Satellite Internet Based on Pix2Pix Generative Adversarial Network

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China Communications 2025年第2期22卷 47-61页

作者： zhen pan Zhang Bangning Wang Heng MaWenfeng Guo Daoxing College of Communications Engineering Army Engineering UniversityNanjing 210007China

The increasing demand for radioauthorized applications in the 6G era necessitates enhanced monitoring and management of radio resources,particularly for precise control over the electromagnetic *** radio map serves as a crucial tool for describing signal strength distribution within the current electromagnetic ***,most existing algorithms rely on sparse measurements of radio strength,disregarding the impact of building *** this paper,we propose a spectrum cartography(SC)algorithm that eliminates the need for relying on sparse ground-based radio strength measurements by utilizing a satellite network to collect data on buildings and *** algorithm leverages Pix2Pix Generative Adversarial Network(GAN)to construct accurate radio maps using transmitter information within real geographical ***,simulation results demonstrate that our algorithm exhibits superior accuracy compared to previously proposed methods.

关键词： electromagnetic situation Pix2Pix generative adversarial network radio map satellite internet spectrum cartography

Synergistic effect of silicon availability and salinity on metal adsorption in a common estuarine diatom

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Journal of Environmental Sciences 2025年第2期148卷 364-374页

作者： Fengyuan Chen Jie Ma Ke pan SZU-HKUST Joint PhD Program in Marine Environmental Science Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Marine Microbiome Engineering Institute for Advanced StudyShenzhen UniversityShenzhen 518060China Department of Ocean Science The Hong Kong University of Science and TechnologyHong Kong 999077China

Increasing nitrogen and phosphorus discharge and decreasing sediment input have made silicon(Si)a limiting element for diatoms in *** in nutrient structure and salinity fluctuation can greatly affect metal uptake by estuarine ***,the combined effects of Si and salinity on metal accumulation in these diatoms have not been *** this study,we aimed to investigate how salinity and Si availability combine to influence the adsorption of metals by a widely distributed diatom Phaeodactylum *** data indicate that replete Si and low salinity in seawater can enhance cadmium and copper adsorption onto the diatom *** the single-cell level,surface potential was a dominant factor determining metal adsorption,while surface roughness also contributed to the highermetal loading capacity at lower *** a combination of noninvasive micro-test technology,atomic force microscopy,X-ray photoelectron spectroscopy,and Fourier transform infrared spectroscopy,we demonstrate that the diversity and abundance of the functional groups embedded in diatom cell walls vary with salinity and Si *** results in a change in the cell surface potential and transient metal *** study provides novel mechanisms to explain the highly variable metal adsorption capacity of a model estuarine diatom.

关键词： Diatom Metal adsorption Silicon Salinity Functional group Surface potential

Seismic isolation design and resilience improvement of railway station considering the influence of near-fault pulse-like ground motions

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Earthquake Engineering and Engineering Vibration 2025年第1期24卷 257-270页

作者： pan Yi Song Jiayu Chen Qi Liu Yongxin School of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China Key Laboratory of Seismic Engineering of Sichuan Province Chengdu 610031China

To improve the resilience of railway stations,a typical station was selected as the research object,and an isolation design was ***-four groups of near-fault pulse-like ground motions were *** seismic resilience of the no-isolation railway stations(NIRS)and the isolation railway stations(IRS)were compared to provide a numerical result of the improvement in *** results show that in the station isolation design,the station's functional requirements and structural characteristics should be considered and the appropriate placement of isolation bearings is under the waiting *** the action of a rare earthquake,the repair cost,repair time,rate of harm and death of the IRS were decreased by 8.04 million,18.30 days,6.93×10^(-3)and 1.21×10^(-3),respectively,when compared to the *** IRS received a seismic resilience grade of three-stars and the NIRS only one-star,indicating that rational isolation design improves the seismic resilience of ***,for the design of stations close to earthquake faults,it is suggested to utilize appropriate isolation techniques to improve their seismic resilience.

关键词： railway station near-fault pulse-like ground motion isolation design seismic resilience resilience improvement

Neuromodulation with chemicals: Opportunities and challenges

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Fundamental Research 2025年第1期5卷 55-62页

作者： pan, Yifei pan, Cong Mao, Lanqun Yu, Ping Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China College of Chemistry Beijing Normal University Beijing 100875 China

Chemicals play a crucial role in neurophysiological and neuropathological processes. By regulating the concentration of specific chemicals, receptors on the neuron cell membrane can be modulated to activate or inhibit, thereby influencing specific ion channels and facilitating neuromodulation. This review introduces several chemical modulation techniques, such as microinjection, electrode/nanoparticle-based chemical delivery methods, in situ electrochemical synthesis and chemogenetics. While these techniques show promise in expanding the application of chemical neuromodulation, they currently exhibit different degrees of shortcomings and room for improvement. This review summarizes the opportunities and challenges for chemical neuromodulation methods and provide an outlook for their prospects in the future. © 2024

关键词： Brain chemistry Chemical delivery In vivo Neurochemistry Neuromodulation

Engineering atomic Rb-N configurations to tune radical pathways for highly selective photocatalytic H_(2)O_(2) synthesis coupled with biomass valorization

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Journal of Energy Chemistry 2025年第1期100卷 215-225页

作者： Jiaye Li Shuang pan Yihuang Chen Qiong Liu College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325035ZhejiangChina Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology(China) Institute of AnalysisGuangdong Academy of Sciences(China National Analytical CenterGuangzhou)Guangzhou 510070GuangdongChina

Photocatalytic oxygen reduction for hydrogen peroxide(H_(2)O_(2))synthesis presents a green and costeffective production ***,achieving highly selective H_(2)O_(2)synthesis remains challenging,necessitating precise control over free radical reaction pathways and minimizing undesirable oxidative ***,we report for the visible light-driven simultaneous co-photocatalytic reduction of O2to H_(2)O_(2)and oxidation of biomass using the atomic rubidium-nitride modified carbon nitride(CNRb).The optimized CNRb catalyst demonstrates a record photoreduction rate of 8.01 mM h^(-1)for H_(2)O_(2)generation and photooxidation rate of 3.75 mM h^(-1)for furfuryl alcohol to furoic acid,achieving a remarkable solar-to-chemical conversion(SCC)efficiency of up to 2.27%.Experimental characterizations and DFT calculation disclosed that the introducing atomic Rb–N configurations allows for the high-selective generation of superoxide radicals while suppressing hydroxyl free radical *** is because the Rb–N serves as the new alternative site to perceive a stronger connection position for O2adsorption and reinforce the capability to extract protons,thereby triggering a high selective redox product *** study holds great potential in precisely regulating reactive radical processes at the atomic level,thereby paving the way for efficient synthesis of H_(2)O_(2)coupled with biomass valorization.

关键词： Atomic economy Radical pathway regulation Photocatalytic H_(2)O_(2)synthesis Rubidium atom coordination Biomass valorization

Airborne fungal communities are more susceptible to anthropogenic activities than bacteria

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Journal of Environmental Sciences 2025年第3期149卷 564-573页

作者： Yuanyuan pan Zhiwei Zuo Xueyun Huang Renguo Zhu School of Water Resources&Environmental Engineering East China University of TechnologyNanchang 330013China Jiangxi Province Key Laboratory of the Causes and Control of Atmospheric Pollution East China University of TechnologyNanchang 330013China

Airborne microorganisms(AM)have significant environmental and health *** studies have been conducted to investigate the factors influencing the composition and diversity of ***,the knowledge of AM with anthropogenic activities has not reach a *** this study,we took advantage of the dramatic decline of outdoor anthropogenic activities resulting from COVID-19 lockdown to reveal their *** collected airborne particulate matter before and during the lockdown period in two *** results showed that it was fungal diversity and communities but not bacteria obviously different between pre-lockdownand lockdown samples,suggesting that airborne fungiwere more susceptible to anthropogenic activities than ***,after the implementation of lockdown,the co-occurrence networks of both bacterial and fungal community became more complex,whichmight be due to the variation of microbial ***,Mantel test and correlation analysis showed that air pollutants also partly contributed to microbial *** fungal community was more affected by air pollutants than bacterial ***,some human pathogens like Nigrospora and Arthrinium were negatively correlated with air ***,our study highlighted the more impacts of anthropogenic activities on airborne fungal community than bacterial community and advanced the understanding of associations between anthropogenic activities and AM.

关键词： COVID-19 lockdown Anthropogenic activities Airborne microorganisms Response Air pollutants

The role of axon guidance molecules in the pathogenesis of epilepsy

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Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： zheng Liu Chunhua pan Hao Huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

Recent progress in flexible sensors based on 2D materials

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Journal of Semiconductors 2025年第1期46卷 130-142页

作者： Xiang Li Guancheng Wu Caofeng pan Rongrong Bao School of Physics Beihang UniversityBeijing 100191China Institute of Atomic Manufacturing Beihang UniversityBeijing 100191China Beijing Institute of nanoenergy and nanosystems Chinese Academy of SciencesBeijing 101400China School of nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049China

With the rapid development of the internet of things(IoT)and wearable electronics,the role of flexible sensors is becoming increasingly irreplaceable,due to their ability to process and convert information ***-dimensional(2D)materials have been widely welcomed by researchers as sensitive layers,which broadens the range and application of flexible sensors due to the advantages of their large specific surface area,tunable energy bands,controllable thickness at the atomic level,stable mechanical properties,and excellent optoelectronic *** review focuses on five different types of 2D materials for monitoring pressure,humidity,sound,gas,and so on,to realize the recognition and conversion of human body and environmental ***,the main problems and possible solutions of flexible sensors based on 2D materials as sensitive layers are summarized.

关键词： 2D materials flexible sensors layered structure solution method