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不同中主应力条件下粗粒土应力变形特性试验研究

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岩土工程学报 2016年第11期38卷 2078-2084页

作者：潘家军程展林余挺江洎洧左永振徐晗长江水利委员会长江科学院湖北武汉430010 水利部岩土力学与工程重点实验室湖北武汉430010 中国电建集团成都勘测设计研究院四川成都610072

采用长江科学院大型真三轴仪,对粗粒土进行了一系列不同中主应力系数条件下的真三轴试验和平面应变试验,研究了中主应力对粗粒土的应力变形的影响规律。试验结果表明,中主应力比b一定时,应力–应变关系曲线的斜率和峰值强度随着固结压... 详细信息

采用长江科学院大型真三轴仪,对粗粒土进行了一系列不同中主应力系数条件下的真三轴试验和平面应变试验,研究了中主应力对粗粒土的应力变形的影响规律。试验结果表明,中主应力比b一定时,应力–应变关系曲线的斜率和峰值强度随着固结压力的增大而增加,在低围压条件下,体变关系曲线在加载过程中表现为先剪缩后剪胀的特性,而在高围压下,整个加载过程中表现剪缩的特性;固结压力一定时,随着b值的增大,应力在峰值后的软化现象愈加明显,体变全过程曲线表现出剪胀特征对应的固结压力越来越低,小主应变–大主应变关系曲线的斜率绝对值增大。研究成果可为进一步研究粗粒土的本构模型奠定基础。

关键词：粗粒土真三轴中主应力试验应力应变

CuCl_2对催化合成碳酸二甲酯反应的影响

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天津大学学报（自然科学与工程技术版） 2003年第5期36卷 631-634页

作者：马新宾李振花韩森许根慧天津大学化工学院一碳化学与化工国家重点实验室天津300072

探讨了焙烧温度、铜含量和催化剂制备时n(OH)/n(Cu)比值等对甲醇氧化羰基化合成碳酸二甲酯反应中铜基催化剂反应活性的影响.对催化剂进行了比表面、孔分布、SEM和XRD测试.结果表明,高温焙烧降低了催化剂的比表面积,有利于活性组分铜在... 详细信息

探讨了焙烧温度、铜含量和催化剂制备时n(OH)/n(Cu)比值等对甲醇氧化羰基化合成碳酸二甲酯反应中铜基催化剂反应活性的影响.对催化剂进行了比表面、孔分布、SEM和XRD测试.结果表明,高温焙烧降低了催化剂的比表面积,有利于活性组分铜在活性炭载体的分布,提高了反应活性.研究表明,Cu2OCl2是甲醇氧化羰基化合成碳酸二甲酯反应的活性物种.

关键词：碳酸二甲酯酯化反应 CuCl2 催化剂氯化铜甲醇焙烧温度催化活性

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen zhen Wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai xu zhen Gu Hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu xue han Yan Su Yiming Zhou Minhui xu Jiyan xu zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing He zhen Wang Yuchen Wang Mengjie Zhu Zhile Liang Kanghong Zhang Yuge xu Gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu xu Shaocong Yan Ting Liang Jia Jia Shengjie Yuan Dongxing Kou zhengji Zhou Wenhui Zhou Yafang Qi Yuena Meng Litao han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： CIGS solar cells Solution-processed method Ag doping Crystal growth Defects engineering

SUDS胶束中维生素C生物抗氧化反应动力学的停流ESR研究

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武汉大学学报（自然科学版） 2001年第2期47卷 177-181页

作者：俞开潮周锦兰刘中立陈平韩正旭华中科技大学化学系湖北武汉430074 武汉工业学院饲料系湖北武汉430022 兰州大学应用有机化学国家重点实验室甘肃兰州730000

用停止 -流动 ESR实验技术研究了在近中性条件下 ,1-十一烷基 -十二烷基硫酸钠 (SU DS)负离子胶束的形成及在此胶束中 ,维生素 C还原 4-羟基 - 2 ,2 ,6 ,6 -四甲基哌啶 - 1-氧自由基 (HO- TEMPO)及其亲脂性衍生物4-己酰氧基 - TEMPO(C6 ... 详细信息

用停止 -流动 ESR实验技术研究了在近中性条件下 ,1-十一烷基 -十二烷基硫酸钠 (SU DS)负离子胶束的形成及在此胶束中 ,维生素 C还原 4-羟基 - 2 ,2 ,6 ,6 -四甲基哌啶 - 1-氧自由基 (HO- TEMPO)及其亲脂性衍生物4-己酰氧基 - TEMPO(C6 - TEMPO)和 4-棕榈酰氧基 - TEMPO(C1 6 - TEMPO)的反应活性 ,测得 3个反应的二级速率常数依次为 4.9,1.6 ,0 .2 2 L· m ol- 1· s- 1 .动力学分析表明 :VC的抗氧化活性与氧化剂的侧链长度有关。

关键词：停止-流动ESR技术胶束氮氧自由基维生素C 生物抗氧化反应动力学 1,-十一烷基一十二烷基硫酸钠

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现行增值税类型存在问题及对策研究

商丘职业技术学院学报 2003年第4期2卷 25-27页

作者：张玉珍徐寒陕西财经职业技术学院会计系陕西咸阳712000

我国现行的生产型增值税存在严重的缺陷,已经不能适应市场经济发展的需要,应实行消费型增值税。

关键词：增值税类型生产型增值税消费型增值税税制改革