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Correlation analysis of interstitial maturity and prognosis of colorectal cancer:Meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2816-2825页

作者： zhen-Jun Liu Xu-Wen Zhang Qi-Qi Liu Shao-zhao Wang Department of Gastrointestinal Surgery Feicheng People's HospitalFeicheng 271600Shandong ProvinceChina Department of Hepatobiliary Surgery Feicheng People's HospitalFeicheng 271600Shandong ProvinceChina Department of Gastrointestinal Surgery Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Department of Anorectal Word Central Hospital Affiliated Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND To investigate the relationship between interstitial maturity and prognosis of colorectal *** To examine the correlation between interstitial maturity and the prognosis of colorectal *** The paper database PubMed,EMBASE,Cochranelibrary,Springerlink,CNKI,and Wanfang database were searched until December 2023."tumor stroma maturity""desmoplastic stroma reaction""desmoplastic reaction""stroma reaction""degree of stroma reaction""stroma classification""stroma density""colorectal cancer""colon cancer""rectal cancer""prognosis"were searched for the search *** system assessors independently screened the literature quality according to the inclusion exclusion criteria,Quality evaluation and data extraction were performed for the included literatures,and meta-analysis was performed for randomized control trials included at using Review Manager 5.2 *** Finally,data of 9849 patients with colorectal cancer from 19 cosets in 15 literatures were included,including 4339 patients with mature type(control group),3048 patients with intermediate type(intermediate group)and 2456 patients with immature type(immature group).The results of meta-analysis showed:Relapse-free survival[hazard ratio(HR)=2.66,95%confidence interval(CI):2.30-3.08;P<0.00001],disease-free survival(HR=3.68,95%CI:2.33-5.81;P<0.00001)and overall survival(HR=1.70,95%CI:1.53-1.87;P<0.00001)were significantly lower than those in mature group(control group);relapse-free survival(HR=1.36,95%CI:1.17-1.59;P<0.0001)and disease-free survival rate(HR=1.85,95%CI:1.53-2.24;P<0.0001)was significantly lower than the mature group(control group).CONCLUSION There is the correlation between tumor interstitial maturity and survival prognosis of colorectal cancer,and different degrees of tumor interstitial maturity have a certain impact on the quality of life of colorectal cancer patients.

关键词： Colorectal tumor Survival prognosis Tumor interstitial maturity Systematic review Meta-analysis

A Novel Trajectory Tracking Control of AGV Based on Udwadia-Kalaba Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1069-1071页

作者： Rongrong Yu Han zhao Shengchao zhen Kang Huang Xianmin Chen Hao Sun Ke Shao the School of Mechanical Engineering Hefei University of TechnologyHefei 230009China the College of Mechanical and Electronic Engineering Shandong University of Science and TechnologyQingdao 266590China the University of Science and Technology of China Hefei 230026China

Dear Editor,This letter is about an automated guided vehicle(AGV)trajectory tracking control method based on Udwadia-Kalaba(U-K)*** method provides a novel,concise and explicit motion equation for constrained mechanical systems with holonomic and/or nonholonomic constraints as well as constraints that may be ideal or *** this letter.

关键词： letter constraints constrained

Biosensing strategies for amyloid-like protein aggregates

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BMEMat(BioMedical Engineering Materials) 2024年第1期2卷 130-145页

作者： Yuhang Zhou Shijun Yan Wanting Dong Chenyao Wu zhen zhao Renzhi Wang Yanhong Duo Yongzhi Huang Ding Xu cheng Jiang School of Medicine The Chinese University of Hong Kong(Shenzhen)ShenzhenChina Nuffield Department of Clinical Neurosciences John Radcliffe HospitalUniversity of OxfordOxfordUK Materials Interfaces Center Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina Wyss Institute for Biologically Inspired Engineering Harvard UniversityBostonMAUSA Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Shenzhen Hicontac Technologies Co. LTD.ShenzhenChina

Protein aggregate species play a pivotal role in the pathology of various degenerative *** dynamic changes are closely correlated with disease progression,making them promising candidates as diagnostic *** the prevalence of degenerative diseases,growing attention is drawn to develop pragmatic and accessible protein aggregate species detection ***,the performance of current detection methods is far from satisfying the requirements of extensive clinical *** this review,we focus on the design strategies,merits,and potential shortcomings of each class of detection *** review is organized into three major parts:native protein sensing,seed amplification,and intricate program,which embody three different but interconnected *** the best of our knowledge,no systematic review has encompassed the entire workflow,from the molecular level to the apparatus *** review emphasizes the feasibility of the methods instead of theoretical detection *** conclude that high selectivity does play a pivotal role,while signal compilation,multilateral profiling,and other patient-oriented strategies(*** invasiveness and assay speed)are also important.

关键词： biomarker degenerative disease protein aggregates sensor

Research on Transmission Line Tower Tilting and Foundation State Monitoring Technology Based onMulti-Sensor Cooperative Detection and Correction

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Energy Engineering 2024年第1期121卷 169-185页

作者： Guangxin Zhang Minghui Liu Shichao cheng Minzhen Wang Changshun zhao Hongdan zhao Gaiming Zhong College of Science and Technology(CST) Ningbo UniversityNingbo315000China Dadong Power Supply Company State Grid Liaoning Electric Power Co.Ltd.Dandong118000China Dalian Power Supply Company State Grid Liaoning Electric Power Co.Ltd.Dalian116000China Yanbian Power Supply Company State Grid Jilin Electric Power Co.Ltd.Yanji133000China Liaoyuan Power Supply Company State Grid Jilin Electric Power Co.Ltd.Liaoyuan136200China

The transmission line tower will be affected by bad weather and artificial subsidence caused by the foundation and other factors in the power *** tower’s tilt and severe deformation will cause the building to *** small changes caused the tower’s collapse,but the early staff often could not intuitively notice the changes in the tower’s *** the current tower online monitoring system,terminal equipment often needs to replace batteries frequently due to premature exhaustion of *** to the need for real-time measurement of power line tower,this research designed a real-time monitoring device monitoring the transmission tower attitude tilting and foundation state based on the inertial sensor,the acceleration of 3 axis inertial sensor and angular velocity raw data to pole average filtering pre-processing,and then through the complementary filtering algorithm for comprehensive calculation of tilt angle,the system meets the demand for inclined online monitoring of power line poles and towers regarding measurement accuracy,with low cost and power *** optimization multi-sensor cooperative detection and correction measured tilt angle result relative accuracy can reach 1.03%,which has specific promotion and application value since the system has the advantages of unattended and efficient calculation.

关键词： Transmission line tower tilting multi-sensor foundation state monitoring collaborative detection

Hollow structured Fe@C nanorods for boosting dehydrogenation properties of α-AlH_(3)

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Nano Research 2024年第9期17卷 8184-8191页

作者： Yuan zhao Qingshuang Wang Dongming Yin Xiaoli Wang Shouliang Li Chunli Wang Long Liang Shaolei zhao Limin Wang Yong cheng School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Shandong Provincial Key Laboratory of Monocrystalline Silicon Semiconductor Materials and Technology College of Chemistry and Chemical EngineeringDezhou UniversityDezhou 253023China Henan Nayu New Material Co. Ltd.Xinxiang 453000China

α-AlH_(3)is regarded as one of the most promising hydrogen storage materials due to its high hydrogen storage capacity(10.1 wt.%,148 kg·m^(-3)).However,in practical applications,the associated hydrogen release temperature remains relatively *** effectively address this issue,hollow structured Fe@C nanorods derived from Fe-MOF are introduced as highly efficient catalyst to optimize the dehydrogenation properties ofα-AlH_(3).Comparatively,the initial hydrogen release temperature ofα-AlH_(3)+3 wt.%Fe@C is reduced to 94.2℃,which is significantly lower than that of pureα-AlH_(3)(137.8℃).At 100 and 120℃,it exhibits hydrogen capacities of 5.38 wt.%and 7.47 wt.%,respectively,whereas pureα-AlH_(3)only delivers hydrogen capacities of 0.24 wt.%and 5.94 wt.%under the same *** density functional theory(DFT)calculations further indicate that the existence of Fe@C catalyst can make the length of Al-H bond increase,which is more conducive to the release of *** results show that the synergistic effect of Fe and porous carbon in Fe@C nanorods can improve the hydrogen desorption kinetics ofα-AlH_(3),providing a good prospect for the application ofα-AlH_(3)in hydrogen storage fields.

关键词： Fe@C α-AlH_(3) dehydrogenation catalyst

Recent advances in Pt catalysts and membrane electrode assemblies fabrication for proton exchange membrane fuel cells

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Rare Metals 2024年第9期43卷 4198-4221页

作者： Miao Ma Li-Xiao Shen Jing Liu Bin Xu Yun-Long Zhang Lei zhao zhen-Bo Wang School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001China College of Environmental and Chemical Engineering Yanshan UniversityQinhuangdao 066004China Unipower Hydrogen Technology(Jiangsu)Corporation Changzhou 213176China

Proton exchange membrane fuel cells(PEMFCs)have been identified as a highly promising means of achieving sustainable energy conversion.A crucial factor in enhancing the performance of PEMFCs for further potential energy applications is the advancement in the field of catalyst engineering that has led to remarkable performance enhancement in facilitating the oxygen reduction reaction(ORR).Subsequently,it is important to acknowledge that the techniques used in preparation of membrane electrode assemblies(MEAs),the vital constituents of PEMFCs,also possess direct and critical influence on exhibiting the full catalytic activity of meticulously crafted ***,a succinct summary of the most recent advancements in Pt catalysts for ORR was offered and their underly catalytic mechanism were ***,both laboratory-scale and industrial-scale MEA fabrication techniques of Pt catalysts were ***,a detailed analysis of the connections between materials,process,and performance in MEA fabrication was presented in order to facilitate the development of optimal catalyst layers.

关键词： Pt catalysts Oxygen reduction reaction Membrane electrode assemblies MEA fabrication techniques

In Situ Raman Monitoring of Trace Antibiotics in Different Harsh Water Environments

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Energy & Environmental Materials 2024年第1期7卷 284-293页

作者： Chundong Liu Fengcai Lei Maogang Gong Xiaoming Zhou Xiaofei zhao zhen Li Chao Zhang Baoyuan Man Jing Yu School of Physics and Electronics Institute of Materials and Clean EnergyShandong Normal UniversityJinan 250014China College of Chemistry Chemical Engineering and Materials ScienceInstitute of Biomedical SciencesShandong Normal UniversityJinan 250014China Department of Physics and Astronomy University of KansasLawrenceKansas 66045USA Shandong Provincial Hospital Shandong First Medical UniversityJinan 250021China

In situ surface-enhanced Raman scattering(SERS)is a widely used operando analytical technique,while facing numerous complex factors in applications under aqueous environment,such as low detection sensitivity,poor anti-interference capability,etc.,resulting in unreliable *** address these issues,herein a new hydrophobic SERS strategy has been *** comprehensively designing and researching a SERS-active structure of superhydrophobic ZnO/Ag nanowires,we demonstrate that hydrophobicity can not only draw analytes from water onto substrate,but also adjust"hottest spot"from the bottom of the nanowires to the *** a result,the structure can simultaneously concentrate the dispersed molecules in water and the enhanced electric field in structure into a same zone,while perfecting its own anti-interference *** underwater in situ analytical enhancement factor of this platform is as high as 1.67×10^(11),and the operando limited of detection for metronidazole(MNZ)reaches to 10^(-9)*** importantly,we also successfully generalized this structure to various real in situ detection scenarios,including on-site detection of MNZ in corrosive urine,real-time warning of wrong dose of MNZ during intravenous therapy,in situ monitoring of MNZ in flowing wastewater with particulate interference,etc.,demonstrating the great application potential of this hydrophobic *** work realizes a synergistic promotion for in situ SERS performance under aqueous environment,and also provides a novel view for improving other in situ analytical techniques.

关键词： antibiotic detection hydrophobic structure In situ Raman metronidazole wettability

Atmospheric chemistry of 2-nitrobenzaldehyde:Initiated by photo-excitation,OH-oxidation,and small TiO_(2) clusters adsorption catalysis

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Journal of Environmental Sciences 2024年第5期139卷 123-137页

作者： Feng-Yang Bai Xiang-Huan Liu Ting-Ting Meng Zhou Yu Yi-Chen Wang Shuang Ni zhen zhao Institute of Catalysis for Energy and Environment College of Chemistry and Chemical EngineeringShenyang Normal UniversityShenyang 110034China

The fate of 2-nitrobenzaldehyde(2-NBA)is of interest in atmospheric chemistry as it is a semi-volatile organic compound with high *** study presents a quantum chemical study of the gas-phase reactions of 2-NBA photo-excitation and OH-oxidation in the absence and presence of small TiO_(2) *** further understand the unknown photolysis mechanism,the photo-reaction pathways of ground singlet state and the lying excited triplet state of 2-NBA were investigated including the initial and subsequent reactions of proton transfer,direct CO,NO_(2),and HCO elimination routes in the presence of O_(2) and ***,the OH-mediated degradation of 2-NBA proceeded via five H-extraction and six OH-addition channels by indirect mechanism,which follows a succession of reaction steps initiated by the formation of weakly stable intermediate *** H-extraction from the-CHO group was the dominant pathway with a negative activation energy of-1.22 kcal/*** calculated rate coefficients at 200–600 K were close to the experimental data in literature within 308-352 K,and the kinetic negative temperature independence was found in both experimental literature and computational ***,2-NBA was favored to be captured onto small TiO_(2) clusters via six adsorption configurations formed via various combination of three types of bonds of Ti…O,Ti…C,and O…H between the molecularly adsorbed 2-NBA and TiO_(2) *** indicted that the chemisorptions of aldehyde oxygen have largest *** results suggested adsorption conformations have a respectable impact on the catalysis *** study is significant for understanding the atmospheric chemistry of 2-nitrobenzaldehyde.

关键词： 2-nitrobenzaldehyde OH radical oxidation Rate coefficient Photolysis mechanism Adsorption catalysis

Nitro-oleic acid ameliorates erectile dysfunction in a streptozotocin-induced rat model of diabetes by inhibiting oxidative stress and apoptosis and activating the NO/cGMP pathway

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Asian Journal of Andrology 2024年第1期26卷 57-66页

作者： Chang-Bo zhao Wei-Bo Chen Wen-zhen Wang Fang-Xin Gong Cui-Qin Fan Ye Li Tian Lan Wen-Jing Wang Ming-zhen Yuan Department of Urology Shandong Provincial HospitalShandong UniversityJinan 250012China Department of Andrology Liaocheng People's HospitalShandong UniversityLiaocheng 252000China Department of Urology The Second Hospital of Shandong UniversityJinan 250012China Department of Physiology School of Basic Medical SciencesShandong UniversityJinan 250012China

The major vascular complications associated with diabetes make the management of diabetic mellitus erectile dysfunction(DMED)a challenging *** factors contributing to DMED include oxidative stress,nitric oxide(NO)/cyclic guanosine monophosphate(cGMP)pathway activation,and apoptosis,while nitro-oleic acid(NO,-OA)has been shown to be beneficial in treating these aspects of this ***,herein,investigated the effects and possible mechanisms of NO,-OA on erectile function as assessed in a streptozotocin-induced rat model of *** results revealed that the erectile function of DMED rats was significantly impaired compared with that of the control ***,in response to 4 weeks of NO,-OA treatment,there was an improvement in erectile *** expression of oxidative stress-related indicators was significantly increased and the NO/cGMP pathway was impaired in the DMED *** expression of proapoptotic factors was increased,while that of antiapoptotic factors was decreased in the DMED ***,the cell morphology in the cavernous tissue of the DMED group also changed ***,-OA treatment significantly reversed all these changes observed in the DMED *** conclusion,NO,-OA treatment partially improved erectile function in DMED rats through mechanisms that included inhibition of oxidative stress,activation of the NO/cGMP pathway,and a reduction in apoptosis.

关键词： apoptosis diabetic mellitus erectile dysfunction nitro-oleic acid NO/cGMP pathway oxidative stress