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心律失常机制的建模仿真和理论研究

中国科学基金 2022年第2期36卷 245-254页

作者：宋震鹏城实验室数学和基础理论部深圳518066

心血管疾病是全球自然死亡的头号杀手。心律失常一直都是心血管疾病致死的一种主要形式。随着实验和临床数据的积累、非线性动力学的理论应用、计算机算法的优化和算力的提升,通过建立生理生化层面精细的心脏电生理数学模型,开展生理及... 详细信息

心血管疾病是全球自然死亡的头号杀手。心律失常一直都是心血管疾病致死的一种主要形式。随着实验和临床数据的积累、非线性动力学的理论应用、计算机算法的优化和算力的提升,通过建立生理生化层面精细的心脏电生理数学模型,开展生理及病理条件下高性能计算仿真已成为探究心律失常机制的一种有效技术手段。本文简要介绍了造成心律失常的几种典型机制,回顾了心脏电生理建模仿真的发展过程并指出了目前面临的主要挑战,包括如何更系统深入地理解心律失常这一可激发介质上多尺度多物理态的复杂时空行为,如何运用电生理建模仿真辅助抗心律失常特效药物研发以及完善一般性药物的心脏安全评估。针对以上的挑战,本文提出如下研究建议:发展计算上可行的多尺度群体化心脏电生理数学模型;进行基于药物与蛋白/离子通道相互作用的虚拟抗心律失常药物靶点的筛查;建立一般性药物心脏毒性检测的虚拟仿真平台。通过深度结合实验和临床数据发展高性能多尺度群体化的心脏电生理虚拟仿真,有望进一步发掘多学科交叉的研究潜力,推动心脏病学发展。

关键词：心血管疾病心律失常多尺度建模虚拟药物靶点筛查虚拟药物心脏毒性检测

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Strain Tunable Berry Curvature Dipole, Orbital Magnetization and Nonlinear Hall Effect in WSe_(2) Monolayer

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Chinese Physics Letters 2021年第1期38卷 99-104页

作者： Mao-Sen Qin Peng-Fei Zhu Xing-Guo Ye Wen-zheng Xu zhen-Hao song Jing Liang Kaihui Liu Zhi-Min Liao State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China

The electronic topology is generally related to the Berry curvature,which can induce the anomalous Hall effect in time-reversal symmetry breaking *** monolayer transition metal dichalcogenides possesses two nonequivalent K and K’ valleys,having Berry curvatures with opposite signs,and thus vanishing anomalous Hall effect in this *** we report the experimental realization of asymmetrical distribution of Berry curvature in a single valley in monolayer WSe_(2) via applying uniaxial strain to break C_(3v) *** a result,although the Berry curvature itself is still opposite in K and K’ valleys,the two valleys would contribute equally to nonzero Berry curvature *** applying electric field E,the emergent Berry curvature dipole D would lead to an out-of-plane orbital magnetization M ∝ D·E,which further induces an anomalous Hall effect with a linear response to E^(2),known as nonlinear Hall *** show the strain modulated transport properties of nonlinear Hall effect in monolayer WSe_(2) with moderate hole-doping by *** second-harmonic Hall signals show quadratic dependence on electric field,and the corresponding orbital magnetization per current density M/J can reach as large as *** contrast to the conventional Rashba-Edelstein effect with in-plane spin polarization,such current-induced orbital magnetization is along the out-of-plane direction,thus promising for high-efficient electrical switching of perpendicular magnetization.

关键词： Berry curvature magnetization

Parasitic Motion Based Optimal Design of Parallel Manipulators

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Effective time, correction speed and termination time of hemiepiphysiodesis in children

第15届中国系统仿真技术及其应用学术会议（15th CCSSTA2014）

作者： Zhang song-zhen Lou Yun-jiang Liao Bin Key Lab for Advanced Motion Control Technology and Modern Automation Equipments Harbin Institute of Technology Shenzhen Graduate School

Parasitic motion is widely believed a drawback of lower mobility parallel *** researchers tried to eliminate or reduce it by kinematic optimization or by special architectural ***,the parasitic motion enables the implementation of a higher degrees-of-freedom(DoF)motion task with a lower DoF parallel manipulator to a certain *** contrast to the traditional elimination of parasitic motion,in this paper we first propose to take advantage of parasitic motion/By the example of planar five-bar parallel manipulator,we demonstrate to maximize the parasitic rotation so that it is able to accomplish planar manipulation of workpieces with their orientations in a given *** new design concept will lead to lower cost,lower complexity of kinematics and control.

关键词： Parallel Manipulator Parasitic Motion Optimal Design

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World Journal of Orthopedics 2024年第1期15卷 1-10页

作者： Jian-Fa Zeng Yu-Yin Xie Can Liu zhen-Qi song zheng Xu Zhong-Wen Tang Jie Wen Sheng Xiao Department of Pediatric Orthopedics Hunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina Department of Anatomy Hunan Normal University school of MedicineChangsha 410003Hunan ProvinceChina

In children with asymmetric growth on the medial and lateral side of limbs,if there still remains growth potential,the guided growth technique of hemiepiphysiodesis on one side of the epiphysis is recognized as a safe and effective ***,when the hemi-epiphysiodesis start to correct the deformities,how many degrees could hemi-epiphysiodesis bring every month and when to remove the hemi-epiphysiodesis implant without rebound phenomenon are still on *** article reviews the current studies focus on the effective time,correction speed and termination time of hemi-epiphysiodesis.

关键词： Hemi-epiphysiodesis Percutaneous epiphysiodesis Transphyseal screws Eight plate

Roles of combined femoral and acetabular anteversion in pathological changes of hip dysplasia and hip reconstructive surgery

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World Journal of Orthopedics 2024年第5期15卷 390-399页

作者： Can Liu zheng Xu Jian-Fa Zeng zhen-Qi song Yu-Yin Xie Zhong-Wen Tang Jie Wen Sheng Xiao Department of Anatomy Hunan Normal University School of MedicineChangsha 410003Hunan ProvinceChina Department of Pediatric Orthopedics Hunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina

Combined femoral and acetabular anteversion is the sum of femoral and acetabular anteversion,representing their morphological relationship in the axial *** with the increasing understanding of hip dysplasia in recent years,numerous scholars have confirmed the role of combined femoral and acetabular anteversion in the pathological changes of hip *** present,the reconstructive surgery for hip dysplasia includes total hip replacement and redirectional hip preservation *** an important surgery index,combined femoral and acetabular anteversion have a crucial role in these ***,we discuss the role of combined femoral and acetabular anteversion in pathological changes of hip dysplasia,total hip replacement,and redirectional hip preservation surgery.

关键词： Combined anteversion Femoral anteversion Acetabular anteversion Hip dysplasia Hip preservation surgery Total hip replacement

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基于混沌理论的铁路客货运量预测研究

铁道学报 2011年第6期33卷 1-7页

作者：朱子虎翁振松铁道部经济规划研究院运输咨询部北京100038

应用混沌理论的相空间重构方法,分析与铁路运量相关的12组时间序列,分别计算它们的嵌入延迟时间、嵌入维数、关联维数、最大Lyapunov指数等混沌统计量,并以此为依据判断12组时间序列的混沌特性。结果显示:铁路客货运量及周转量不具有混... 详细信息

应用混沌理论的相空间重构方法,分析与铁路运量相关的12组时间序列,分别计算它们的嵌入延迟时间、嵌入维数、关联维数、最大Lyapunov指数等混沌统计量,并以此为依据判断12组时间序列的混沌特性。结果显示:铁路客货运量及周转量不具有混沌特性,对应的4组时间序列不是混沌的;铁路客货运量、周转量的增量及增长率都具有明显的混沌特性,它们对应的8组时间序列是混沌的。在识别是否混沌的基础上,应用基于最大Lyapunov指数预测方法,对铁路客货运量、周转量进行预测检验及预测结果分析。

关键词：铁路运量预测混沌理论相空间重构时间延迟嵌入维数最大Lyapunov指数

Identification of four novel mutations in the HNF-1A gene in Chinese early-onset and/or multiplex diabetes pedigrees

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Chinese Medical Journal 2006年第13期119卷 1072-1078页

作者： YANG zhen WU song-hua zhenG Tai-shan LU Hui-juan XIANG Kun-san Shanghai Diabetes Institute Department of Endocrinology and Metabolism Shanghai No. 6 People＇s Hospital Shanghai Jiaotong University Shanghai 200233 China

Background Mutations in the hepatocyte nuclear factor-lA gene cause the type 3 form of maturity-onset diabetes of the young （MODY3）. This study was undertaken to determine mutations and sequence variations of the HN... 详细信息

关键词： maturity-onset diabetes of the young hepatocyte nuclear factor-1A gene direct sequencing

Peripheral radial chop technique for phacoemulsification of hard cataracts

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Chinese Medical Journal 2007年第4期120卷 284-286页

作者： LI Shao-wei XIE Li-xin song zhen-hua MENG Li JIANG Jian Shandong Eye Institute Qingdao 266071 China

Background Phacoemulsification yields successful outcomes in eyes with standard cataract. Though techniques have been improved, it is still challenging to perform phacoemulsification in cases of hard cataracts for difficulty in nuclear management and much more complications. This study aimed at describing and evaluating the efficacy and safety of a peripheral radial chop technique to remove hard cataracts. Methods In this prospective study conducted between January 2003 and January 2004, 107 consecutive eyes with hard cataract underwent modified phacoemulsification surgery with peripheral radial chop technique by the Bausch ＆ Lomb Millennium phacoemulsifler with preset parameters of power less than 30%; vaccum, 150 mmHg; and bottle height, 85 cm when a DP8145 phaco tip was used, and vaccum, 380 mmHg; bottle height, 95 cm when a DP8245 phaco tip was used. Results The mean ultrasonic power was 14.7% （range 9% to 19%）, ultrasonic time was 1.98 minutes （range 1.55 to 3.18 minutes）. At 1, 7 and 30 days postoperatively, the eyes with uncorrected visual acuity 0.5 or better accounted for 76.42%, 87.16% and 90.67% respectively. At 1 month, the endothelial cell loss rate was 9.74% （range 8% to 17%）. There were 6 cases of posterior capsule rupture in an early period of study. No serious intraoperaUve or postoperative complications were noted. Conclusions The peripheral radial chop technique was effective without serious complications in hands of an experienced surgeon.

关键词： phacoemulsification chop technique hard cataract

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信息本体论与信息科学范式的建构

自然辩证法研究 2018年第7期34卷 108-114页

作者：王振嵩广西安交通大学人文社会科学学院陕西西安710049

一个统一的科学范式需要一个与之相适应的本体论理论。正在形成的信息科学范式的本体论理论是什么?这是当代信息哲学研究的问题。霍基奇奈尔设想了一个信息科学范式蓝图,由于缺乏对信息本质的探索,他的范式更像是一个复杂系统科学范式框... 详细信息

一个统一的科学范式需要一个与之相适应的本体论理论。正在形成的信息科学范式的本体论理论是什么?这是当代信息哲学研究的问题。霍基奇奈尔设想了一个信息科学范式蓝图,由于缺乏对信息本质的探索,他的范式更像是一个复杂系统科学范式框架,但其提出的本体论规律却具有很强的时代创新性。当代物理主义信息哲学对传统本体论的妥协和计算主义信息哲学搁置本体的态度,使它们无法为信息科学范式提供合适的本体论内核。但辩证唯物主义信息哲学依据其对存在领域的根本变革,不仅提供了一个最大外延的且具有强大解释力的哲学信息概念,还十分契合于霍基奇奈尔提出的信息科学范式的本体论规律。因而,在双重批判(哲学对科学的批判与哲学对自身的批判)的基础上,辩证唯物主义的信息哲学能够提供信息科学范式所需的本体论内核。

关键词：信息科学范式信息哲学存在实在非严格决定论进化系统本体论