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Advances of injectable hydrogel-based scaffolds for cartilage regeneration

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Regenerative Biomaterials 2019年第3期6卷 129-140页

作者： Jiawei Li guojun Chen Xingquan Xu Peter Abdou Qing Jiang Dongquan Shi zhen gu Department of Sports Medicine and Adult Reconstructive Surgery Drum Tower HospitalSchool of MedicineNanjing University321 Zhongshan RoadNanjing 210008JiangsuP.R.China Department of Bioengineering University of CaliforniaLos Angeles410 Westwood PlazaLos AngelesCA 90095USA California NanoSystems Institute University of CaliforniaLos Angeles570 Westwood PlazaLos AngelesCA 90095USA Jonsson Comprehensive Cancer Center University of CaliforniaLos Angeles8-684 Factor BuildingLos AngelesCA 90095USA Center for Minimally Invasive Therapeutics University of CaliforniaLos Angeles570 Westwood PlazaLos AngelesCA 90095USA

Articular cartilage is an important load-bearing tissue distributed on the surface of diarthrodial *** to its avascular,aneural and non-lymphatic features,cartilage has limited self-regenerative *** date,the utilization of biomaterials to aid in cartilage regeneration,especially through the use of injectable scaffolds,has attracted considerable *** materials,therapeutics and fabrication approaches have emerged with a focus on manipulating the cartilage microenvironment to induce the formation of cartilaginous structures that have similar properties to the native *** particular,the design and fabrication of injectable hydrogel-based scaffolds have advanced in recent years with the aim of enhancing its therapeutic efficacy and improving its ease of *** review summarizes recent progress in these efforts,including the structural improvement of scaffolds,network cross-linking techniques and strategies for controlled release,which present new opportunities for the development of injectable scaffolds for cartilage regeneration.

关键词： drug delivery tissue engineering injectable hydrogel cartilage regeneration

量子多尺度融合的高分卫星影像建筑物变化检测

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测绘通报 2024年第6期 65-70,126页

作者：张燕平张卡赵立科陶厦张帮王玉军顾桢刘浩林江苏省测绘产品质量监督检验站江苏南京210013 虚拟地理环境教育部重点实验室(南京师范大学) 江苏南京210023 南京师范大学地理科学学院江苏南京210023 江苏省地理信息资源开发与利用协同创新中心江苏南京210023 镇江市精勤测绘有限公司江苏镇江212009 江苏省地质调查研究院江苏南京210018 自然资源江苏省卫星应用技术中心江苏南京210018 苏州市消防救援支队江苏苏州215000

为了提高传统基于像元的高分辨率卫星影像变化检测方法的精度,本文提出了一种基于量子多尺度融合的高分卫星影像建筑物变化检测算法。首先,对双时相高分辨率卫星影像进行多尺度分割,构成多尺度影像数据集;然后,对多尺度影像数据集进行... 详细信息

为了提高传统基于像元的高分辨率卫星影像变化检测方法的精度,本文提出了一种基于量子多尺度融合的高分卫星影像建筑物变化检测算法。首先,对双时相高分辨率卫星影像进行多尺度分割,构成多尺度影像数据集;然后,对多尺度影像数据集进行迭代慢特征变换,得到不同尺度的变化强度图,再利用量子理论对多尺度变化强度图进行融合,以得到融合后的变化强度图;最后,通过最大类间方差法完成变化强度图的阈值分割,得到二值化变化检测结果。利用两组不同时相的实际高分卫星影像,对本文算法进行了试验验证。试验结果表明,与单一尺度面向对象变化检测方法和熵权法多尺度融合方法相比,本文算法可以取得更高的建筑物变化检测精度。

关键词：高分卫星影像建筑物变化检测量子理论迭代慢特征分析多尺度融合

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基于微针的治疗性细胞递释系统

药学进展 2024年第4期48卷 269-279页

作者：罗心怡张子儒张颖顾臻张宇琪浙江大学药学院先进药物递释系统全国重点实验室浙江省先进递药系统重点实验室浙江杭州310058 沈阳药科大学无涯创新学院辽宁沈阳110016

微针作为新型经皮给药技术,具有操作便捷、递送高效等优势,广泛应用于小分子、核酸、多肽、蛋白质等药物的递送。近期研究表明,微针也可以用于递送治疗性细胞等新型生物药物,如干细胞、免疫细胞等,以改善细胞疗法的系统毒性和副作用、... 详细信息

微针作为新型经皮给药技术,具有操作便捷、递送高效等优势,广泛应用于小分子、核酸、多肽、蛋白质等药物的递送。近期研究表明,微针也可以用于递送治疗性细胞等新型生物药物,如干细胞、免疫细胞等,以改善细胞疗法的系统毒性和副作用、增效局部治疗、提升患者依从性等。综述微针递送干细胞、免疫细胞等治疗性细胞的最新进展,讨论了基于微针的细胞递释系统的潜在挑战和未来前景。

关键词：微针经皮递送细胞疗法干细胞免疫细胞

Macroencapsulation Devices for Cell Therapy

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Engineering 2022年第6期8卷 53-70页

作者： Wei Liu Yanfang Wang Jinqiang Wang Olivia LLanier Marissa EWechsler Nicholas A.Peppas zhen gu Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Department of Biomedical Engineering The University of Texas at AustinAustinTX 78712USA Department of Biomedical Engineering and Chemical Engineering The University of Texas at San AntonioSan AntonioTX 78249USA Division of Molecular Pharmaceutics and Drug Delivery College of PharmacyThe University of Texas at AustinAustinTX 78712USA Zhejiang Laboratory of Systems and Precision Medicine Zhejiang University Medical CenterHangzhou 311121China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Macroencapsulation has been widely used in cell therapy due to its capability to provide immune-privileged sites for implanted allogeneic or xenogeneic *** also serves to provide mechanical and physiochemical support for maintaining cell expansion and promoting therapeutic *** devices such as membrane-controlled release systems,hydrogels,micronee-dle(MN)array patches,and three-dimensional(3D)stents have shown promising in-lab and preclinical results in the maintenance of long-term cell survival and the strengthening of treatment *** studies focus on expanding the applications of these devices to new cell-based areas such as chimeric antigen receptor(CAR)-T cell delivery,cardiovascular disease therapy,and the exploration of new materials,construction methods,and working principles to augment treatment efficacy and prolong therapy ***,we survey innovative platforms and approaches,as well as translation outcomes,for advancing the performance and applications of macrodevices for cell-based therapies.A discussion and critique regarding future opportunities and challenges is also provided.

关键词： Drug delivery Cell encapsulation Cell therapy Cell transplantation Biomedical devices

The Luminescence Properties of M' type of YTaO_4∶Eu

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Chemical Research in Chinese Universities 1999年第3期15卷 226-231页

作者： LI Bo gu zhen-nan DONG Yi LIN Jian-hua SU Mian-zeng Chemistry Department State key Laboratory of Rare Earth Materials Chemistry and ApplicationsPeking UniversityBejing 100871P.R.China

A series of Eu 3+ doped of Mtype of yttrium orthotantalate Y 1-x Eu x TaO 4( x =0-0.30) was sythesized. The influence of activator concentration on luminescence properties was studied in detail. The strong evidence from excitation spectra, emission spectra and diffusive reflection spectra of this system shows that there is energy transfer from TaO 3- 4 to Eu 3+ via the charge transfer and spectral overlap.

关键词： Tantalate Rare earth Luminescence

Enhanced electrode kinetics and electrochemical properties of low-cost NaFe_(2)PO_(4)(SO_(4))_(2)via Ca~(2+)doping as cathode material for sodium-ion batteries

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Journal of Materials Science & Technology 2021年第19期78卷 176-182页

作者： Shao-Fang Li zhen-Yi gu Jin-Zhi guo Xian-Kun Hou Xu Yang Bo Zhao Xing-Long Wu National fy Local United Engineering Laboratory for Power Batteries Faculty of ChemistryNortheast Normal UniversityChangchun130024China Key Laboratory for UV Light-Emitting Materials and Technology Northeast Normal UniversityMinistry of EducationChangchun130024China

In recent years,sodium-ion batteries(SIBs)have been considered as one of the most promising alternatives to lithium-ion batteries(LIBs).Here,a new Na-super-ionic conductor(NASICON)cathode material Na Fe_(2)PO_(4)(SO_(4))_(2)is successfully prepared through solid state method for *** the poor electronic conductivity of iron-based materials results in its poor rate and cycle *** the electrochemical is effectively promoting via Ca^(2+)***_(0.84)Ca_(0.08)Fe_(2)PO_(4)(SO_(4))_(2)have achieved considerable electrochemical *** first discharge specific capacity is 121.6 m A h g^(-1)at 25 m A g^(-1)with the voltage platform(-3.1 V)corresponding to Fe^(2+/3+).After 100 cycles,the capacity retention is 55.1%.The excellent electrochemical performance is caused by some Na^(+)is substituted by Ca^(2+)and leading to the fast sodium kinetics,which is well proved by the powder X-ray diffraction pattern and well corresponding to the galvanostatic intermittent titration technique and cyclic voltammetry testing result(the diffusivity values are around at 10^(-12)cm^(2)s^(-1)).

关键词： NaFe_(2)PO_(4)(SO_(4))_(2) Na-super-ionic conductor Sodium-ion batteries Cathode Ca~(2+)doping

Ultrasound-triggered noninvasive regulation of blood glucose levels using microgels integrated with insulin nanocapsules

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Nano Research 2017年第4期10卷 1393-1402页

作者： Jin Di Jicheng Yu Qun Wang Shanshan Yao Yanqi Ye Matthew Pless Yong Zhu Yun Jing zhen gu Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill and North Carolina State University Raleigh NC27695 USA Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics UNC Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA Department of Chemical and Biological Engineering Iowa State University Ames IA 50011 USA Department of Mechanical and Aerospace Engineering North Carolina State University Raleigh NC 27695 USA Department of Medicine University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA

Diabetes is a serious public health problem affecting 422 million people worldwide. Traditional diabetes management often requires multiple daily insulin injections, associated with pain and inadequate glycemia control. Herein, we have developed an ultrasound-triggered insulin delivery system capable of pulsatile insulin release that can provide both long-term sustained and fast on-demand responses. In this system, insulin-loaded poly（lactic-co-glycolic acid）（PLGA） nanocapsules are encapsulated within chitosan microgels. The encapsulated insulin in nanocapsules can passively diffuse from the nanoparticle but remain restricted within the microgel. Upon ultrasound treatment, the stored insulin in microgels can be rapidly released to regulate blood glucose levels. In a chemically-induced type I diabetic mouse model, we demonstrated that this system, when activated by 30 s ultrasound administration, could effectively achieve glycemic control for up to one week in a noninvasive, localized, and pulsatile manner.

关键词： controlled drug delivery focused ultrasound diabetes nanocapsule microgel

Glucose-responsive oral insulin delivery for postprandial glycemic regulation

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Nano Research 2019年第7期12卷 1539-1545页

作者： Jicheng Yu Yuqi Zhang Jinqiang Wang Di Wen Anna R. Kahkoska John B. Buse zhen gu Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill and North Carolina State UniversityRaleighNC 27695USA Department of Bioengineering University of California lx>s AngelesLos AngelesCA 90095USA Department of Medicine University of North Carolina at Chapel HillChapel HillNC 27599USA California NanoSystems Institute (CNSI) Jonsson Comprehensive Cancer CenterCenter for Minimally Invasive TherapeuticsUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA

Controlling postprandial glucose levels for diabetic patients is critical to achieve the tight glycemic control that decreases the risk for developing long-term micro- and macrovascular ***,we report a glucose-responsive oral insulin delivery system based on Fc receptor (FcRn)-targeted liposomes with glucose-sensitive hyaluronic acid (HA) shell for postprandial glycemic *** oral administration,the HA shell can quickly detach in the presence of increasing intestinal glucose concentration due to the competitive binding of glucose with the phenylboronic acid groups conjugated with *** exposed Fc groups on the surface of liposomes then facilitate enhanced intestinal absorption in an FcRn-mediated transport *** vivo studies on chemically-induced type 1 diabetic mice show this oral glucose-responsive delivery approach can effectively reduce postprandial blood glucose *** work is the first demonstration of an oral insulin delivery system directly triggered by increasing postprandial glucose concentrations in the intestine to provide an on-demand insulin release with ease of administration.

关键词： diabetes drug delivery glucose-responsive insulin nanomedicine

Functional dyspepsia of ulcer-dysmotility type:clinical incidence and therapeutic strategy

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World Journal of Gastroenterology 1998年第4期4卷 95-96页

作者： WANG XiaoZhong and LIN guzhen

Ｆｕｎｃｔｉｏｎａｌｄｙｓｐｅｐｓｉａｏｆｕｌｃｅｒｄｙｓｍｏｔｉｌｉｔｙｔｙｐｅ：ｃｌｉｎｉｃａｌｉｎｃｉｄｅｎｃｅａｎｄｔｈｅｒａｐｅｕｔｉｃｓｔｒａｔｅｇｙＷＡＮＧＸｉａｏＺｈｏｎｇａｎｄＬＩＮＧｕＺｈｅ... 详细信息

Ｆｕｎｃｔｉｏｎａｌｄｙｓｐｅｐｓｉａｏｆｕｌｃｅｒｄｙｓｍｏｔｉｌｉｔｙｔｙｐｅ：ｃｌｉｎｉｃａｌｉｎｃｉｄｅｎｃｅａｎｄｔｈｅｒａｐｅｕｔｉｃｓｔｒａｔｅｇｙＷＡＮＧＸｉａｏＺｈｏｎｇａｎｄＬＩＮＧｕＺｈｅｎＳｕｂｊｅｃｔｈｅａａｄｉｎｇｓ...

关键词： dyspepsia/drug therapy famotidine/therapeutic use cisapride/therapeutic use peptic ulcer gastrointestinal motility