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Differential bonding behaviors of sodium/potassium-ion storage in sawdust waste carbon derivatives

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Chinese Chemical Letters 2024年第4期35卷 496-501页

作者： Jun-Ming Cao Kai-Yang Zhang Jia-Lin Yang zhen-Yi gu Xing-Long Wu MOE Key Laboratory for UV Light-Emitting Materials and Technology Northeast Normal UniversityChangchun 130024China Department of Chemistry Northeast Normal UniversityChangchun 130024China

Sodium-ion batteries(SIBs) and potassium-ion batteries(PIBs) are the most promising alternatives to lithium-ion batteries, and thus have drawn intensive research attention. Porous carbon materials from different precursors have been widely used as anode materials owing to their compatible storage effectiveness of both larger radii sodium and potassium ions. However, the differential bonding behaviors of Na and K ions with porous carbon-based anode are the significant one worth investigating, which could provide a clean picture of alkali ions storage mechanism. Therefore, in this work, we prepare a porous carbon network derived from sawdust(SDC) wastes, to further analyze the differences on sodium and potassium ions storage behaviors in terms of bond-forming process. It is found that, as-prepared SDC anodes could deliver stable sodium and potassium storage capacities, however, there are notable distinctions in terms of electrochemical behaviors and diffusion processes. By virtue of ex-situ XRD and Raman spectroscopy, the phase transition reaction of potassium ions could be well-observed, and the results shows that the multiple intercalated compounds was formed in SDC network during ions insertion, further resulting in slower diffusion kinetics and larger resistance compared to non-bonded process of sodium ions storage. This study provides more insights into the differences between sodium and potassium ions storage, as well as the energy storage mechanism of porous carbon as anodes for secondary batteries.

关键词： Porous carbon Sodium-ion storage Potassium-ion storage Bonding behaviors Batteries

Ability of Helicobacter pylori to internalize into Candida

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World Journal of Gastroenterology 2024年第16期30卷 2281-2284页

作者： zheng-Hong Chen Jian-Chao Sun Ting-Xiu Yang gu-zhen Cui Key Laboratory of Microbiology and Parasitology of Education Department of guizhou Guizhou Medical UniversityGuiyang 561113Guizhou ProvinceChina Key Laboratory of Endemic and Ethnic Diseases of Ministry of Education Guizhou Medical UniversityGuiyang 561113Guizhou ProvinceChina Joint Laboratory of Helicobacter Pylori and Intestinal Microecology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550009Guizhou ProvinceChina Department of Quality Control Guizhou Provincial Center for Clinical LaboratoryGuiyang 550002Guizhou ProvinceChina Department of Hospital Infection and Management Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina

The following are our views regarding the“letter to the editor”(Helicobacter is preserved in yeast vacuoles!Does Koch’s postulates confirm it?)by Alipour and Gaeini,and the response“letter to the editor”(Candida accommodates nonculturable Helicobacter pylori in its vacuole-Koch’s postulates aren’t applicable)by Siavoshi and *** and Gaeini rejected the methods,results,discussion,and conclusions summarized in a review article by Siavoshi and *** present article reviews and discusses evidence on the evolutionary adaptation of Helicobacter pylori(***)to thrive in Candida cell vacuoles and concludes that Candida could act as a Trojan horse,transporting potentially infectious *** into the stomach of humans.

关键词： Helicobacter pylori Candida yeast Intracellular presence Helicobacter pylori-specific gene Helicobacter pylori transmission

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu zhen gu Hua Yan Dingding Shen Xiaosong gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

Structural regulation of coal-derived hard carbon anode for sodium-ion batteries via pre-oxidation

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Rare Metals 2024年第6期43卷 2585-2596页

作者： Meng-Yuan Su Kai-Yang Zhang Edison Huixiang Ang Xue-Li Zhang Yan-Ning Liu Jia-Lin Yang zhen-Yi gu Faaz A.Butt Xing-Long Wu Faculty of Chemistry Northeast Normal UniversityChangchun 130024China MOE Key Laboratory for UV Light-Emiting Materials and Technology.Northeast Normal University.Ministry of Education Changchun 130024China Natural Sciences and Science Education National Institute of EducationNanyang Technological UniversitySingapore 637616Singapore Materials Engineering Department NED University of Engineering and TechnologyKarachi 75300Pakistan

Hard carbon(HC)is broadly recognized as an exceptionally prospective candidate for the anodes of sodium-ion batteries(SIBs),but their practical implementation faces substantial limitations linked to precursor factors,such as reduced carbon yield and increased ***,a cost-effective approach is proposed to prepare a coal-derived HC anode with simple pre-oxidation followed by a post-carbonization process which effectively expands the d_(002)layer spacing,generates closed pores and increases defect *** these modifications,the resulting HC anode attains a delicate equilibrium between plateau capacity and sloping capacity,showcasing a remarkable reversible capacity of 306.3 mAh·g^(-1)at 0.03 A·g^(-1).Furthermore,the produ ced HC exhibits fast reaction kinetics and exceptional rate performance,achieving a capacity of 289 mAh·g^(-1)at 0.1 A·g^(-1),equivalent to~94.5%of that at 0.03 A·g^(-1).When implemented in a full cell configuration,the impressive electrochemical performance is evident,with a notable energy density of 410.6 Wh·kg^(-1)(based on cathode mass).In short,we provide a straightforward yet efficient method for regulating coal-derived HC,which is crucial for the widespread use of SIBs anodes.

关键词： Sodium-ion batteries Hard carbon Anode Coal Pre-oxidation

Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor

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National Science Review 2024年第4期11卷 206-215页

作者： Ziyan Liao Jie Jiang Wei Wu Jiaqi Shi Yanfang Wang Yuejun Yao Tao Sheng Feng Liu Wei Liu Peng Zhao Feifei Lv Jie Sun Hongjun Li zhen gu National Key Laboratory of Advanced Drug Delivery and Release Systems College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang University Liangzhu Laboratory Zhejiang University Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology Zhejiang University School of Medicine Department of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University Department of Laboratory Medicine The First Affiliated Hospital Zhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang University Jinhua Institute of Zhejiang University MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang University Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

The limited infiltration and persistence of chimeric antigen receptor(CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell proliferation in lymph nodes. This scaffold gathers the function of loading,delivery, activation and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) by a microfluidic technique with the modification of T-cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 30 days in a cervical tumor model and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors.

关键词： drug delivery cell therapy bioinspired biomaterials cancer immunotherapy

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受自体材料启发的药物递送系统

Science China Materials 2024年第8期67卷 2427-2446页

作者：冯慧珩程伊安柳扶摇顾臻李洪军 State Key Laboratory of Advanced Drug Delivery and Release Systems and Liangzhu LaboratoryCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China

随着个性化医疗理念的深入研究,基于自体来源材料的药物递送系统受到越来越多的关注并快速发展.自体来源材料具有保留其体内天然生理学特性和优良的生物相容性等特点,这为其在材料功能化和药物递送方面开辟了广泛的研究空间,也为疾病治... 详细信息

随着个性化医疗理念的深入研究,基于自体来源材料的药物递送系统受到越来越多的关注并快速发展.自体来源材料具有保留其体内天然生理学特性和优良的生物相容性等特点,这为其在材料功能化和药物递送方面开辟了广泛的研究空间,也为疾病治疗提供了坚实的基础.借助这些优势,受自体来源材料启发的药物递送系统有望在疾病治疗方面实现减毒增效.本文对基于人源蛋白、细胞材料及细胞外基质支架的药物递送系统的最新研究进行了全面回顾,重点关注了这类药物递送系统的载药策略和应用场景,深入分析了它们在疾病治疗中的优势和限制.此外,本文还探讨了受自体来源材料启发的药物递送系统在临床转化过程中面临的潜在机遇和挑战.

关键词：生理学特性药物递送疾病治疗减毒增效个性化医疗生物相容性功能化

农村水利工程中河道治理项目实践--以野麻村大化子沟山洪沟道治理工程为例

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价值工程 2024年第2期43卷 54-56页

作者：顾振红白银市平川区水务局白银730913

目前在农村河道治理中需综合采用多样化治理手段,提高治理水平,从而发挥河道在农村地区的重要作用。目前我国农村地区越发注重河道治理项目,每年在此类项目中投入了较大的资金,给予了政策、技术等支持,但许多河道的治理效果不佳,未来还... 详细信息

目前在农村河道治理中需综合采用多样化治理手段,提高治理水平,从而发挥河道在农村地区的重要作用。目前我国农村地区越发注重河道治理项目,每年在此类项目中投入了较大的资金,给予了政策、技术等支持,但许多河道的治理效果不佳,未来还需继续积极采用生态治理等新技术。基于此,本文以野麻村大化子沟山洪沟道治理工程为例,重点分析了河道治理的相关技术及措施,以期为同类型项目提供借鉴。

关键词：农村水利工程河道治理可持续发展

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水利工程施工管理的重要性和对策探析

全面腐蚀控制 2024年第8期38卷 75-77页

作者：顾振红白银市平川区水务局甘肃白银730913

水利工程作为基础设施的重要组成部分,对国家的经济发展和人民生活水平有着深远的影响。随着全球气候变化和人口增长,对水资源的管理利用提出更高的要求,使得水利工程的设计建设变得尤为关键。在这一背景下,水利工程施工管理的效率和效... 详细信息

水利工程作为基础设施的重要组成部分,对国家的经济发展和人民生活水平有着深远的影响。随着全球气候变化和人口增长,对水资源的管理利用提出更高的要求,使得水利工程的设计建设变得尤为关键。在这一背景下,水利工程施工管理的效率和效果直接关系到工程的成功与否,进而影响到水资源的合理利用。本文从水利工程施工管理的重要性出发,分析a目前水利工程施工管理中存在的问题,提出相应解决办法。

关键词：水利工程施工管理对策探析

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红色旅游资源提升企业全要素生产率探析

边疆经济与文化 2024年第1期 53-60页

作者：顾振华上海商学院商务经济学院上海200235

红色旅游资源的开发帮助了参与红色旅游的企业员工树立正确的价值观,从而影响企业的生产经营。以2003—2019年我国244个城市3017家上市公司为样本,不仅检验了红色旅游资源的生产溢出效应,还提出了商业模式创新和交通基础设施改善两大影... 详细信息

红色旅游资源的开发帮助了参与红色旅游的企业员工树立正确的价值观,从而影响企业的生产经营。以2003—2019年我国244个城市3017家上市公司为样本,不仅检验了红色旅游资源的生产溢出效应,还提出了商业模式创新和交通基础设施改善两大影响机制。研究结果表明:红色旅游资源所在城市中的企业全要素生产率较高;该效应在非国有和中西部地区企业中更突出;在红色旅游资源的影响过程中,商业模式创新和高铁站点的开通发挥了媒介作用;为增强文化自信提供一个可行的思路。

关键词：红色旅游资源企业价值观商业模式创新全要素生产率