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三角网数字地面模型的生成及其在路线设计中的应用

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铁道学报 2000年第3期22卷 74-77页

作者：蒲浩宋占峰蒋红斐詹振炎长沙铁道学院土木建筑学院长沙410075

论述了一种形成离散点三角形格网 (TIN)数字地面模型的方法 ,在生成初始三角形后 ,采用队列及平衡二叉树等数据结构进行三角网的扩展 ,通过点集分块改进点的搜索方法 ,减少了搜索时间 ,并用 L OP算法优化网形。用这种方法生成的带状数... 详细信息

论述了一种形成离散点三角形格网 (TIN)数字地面模型的方法 ,在生成初始三角形后 ,采用队列及平衡二叉树等数据结构进行三角网的扩展 ,通过点集分块改进点的搜索方法 ,减少了搜索时间 ,并用 L OP算法优化网形。用这种方法生成的带状数字地面模型已成功地应用于铁路和公路的勘测设计中。

关键词：数字地面模型路线设计铁路选线 CAD 三角网

Association among lifestyle, clinical examination, polymorphisms in CDH1 gene and Traditional Chinese Medicine syndrome differentiation of gastric cancer

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Journal of Traditional Chinese Medicine 2013年第5期33卷 572-579页

作者： Junfeng zhang zhen zhan Juan Wu Chunbing zhang Yaping Yang Shujuan Tong Ruiping Wang Xuewen Yang Wei Dong Department of Pathogen and Immunology Discipline of Chinese and Western Integrative Medicine College of Basic Medicine Nanjing University of Chinese Medicine Department of Statistics and Preventive Medicine Discipline of Chinese and Western Integrative Medicine College of Basic Medicine Nanjing University of Chinese Medicine Department of Clinical Laboratory First Affiliated Hospital of Nanjing University of Chinese Medicine Department of Traditional Chinese Medicine Diagnostics College of Basic Medicine Nanjing University of Chinese Medicine Department of Traditional Chinese Medicine Oncology First Affiliated Hospital of Nanjing University of Chinese Medicine

OBJECTIVE:To explore the association among lifestyle,clinical examination,polymorphisms in CDH1 gene and Traditional Chinese Medicine(TCM)syndrome differentiation of gastric cancer(GC). METHODS:A hospital-based population of 387 GC patients was investigated in Jiangsu *** information regarding lifestyle and clinical examination were collected by a standard *** known single nucleotide polymorphisms(SNPs)in CDH1 were investigated by polymerase chain reaction-ligation detection reaction *** analysis was conducted by SPSS 16.0 ***:The results showed that meal duration and the status of glutamic pyruvic transaminase were significantly associated with TCM syndrome differentiation of GC(both P0.05).However,significant differences were observed in rs13689 genotype distributions between several pairs of syndrome types of GC,suggesting that rs13689 is correlated with the syndrome differentiation of ***:Integrated analysis of lifestyle,clinical examination and CDH1 gene polymorphisms can contribute to a better understanding of the GC syndrome types and may improve the efficacy of interventions by stratifying disease according to TCM criteria.

关键词： Cadherins Stomach neoplasms Polymorphism single nucleotide Syndrome differentiation Clinical examination

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现代路线CAD系统关键技术研究

中国铁道科学 2005年第4期26卷 136-138页

作者：蒲浩詹振炎中南大学土建学院

This thesis applied synthetically the theories and technologies of computer graphics, computational (geometry) and geometrical modeling, scientific (computation) visualization, interactive, virtual reality, computer animation etc to research thoroughly and carefully on several critical technologies of computer aided alignment design, such as digital terrain model, interactive alignment, 3D modeling of route entity, simplification of 3D model, showing realistic image and dynamic and real time display of 3D route scene etc. By thoroughly analyzing the relationship between the 2D horizontal, vertical and cross-section (design) and the 3D visual design, the conclusion could be reached that both are not substituted mutually (this being advocated and the other being cut down), but are mutually replenishing, and supplementing and complementing each other. They should be combined closely and applied synthetically. Based on this idea, the research work was carried out and closely centered on the theories and methods whose characteristic was combining 2D design with 3D design. Consequently not only the improvement of traditional methods of the 2D horizontal, vertical and cross section (design) but also the researches and applications of some new technologies such as 3D visualization, virtual reality etc, had been laid stress on in this thesis .The chief research contents and achievements could be summarized as follows: 1) Based on the theories of Delaunay triangulation and constrained Delaunay triangulation, the (algorithm) for fast and integrally creating irregular (triangulation) net adapted to railway and highway alignment design was put forward and realized. It adopted an integral creating TIN technology which need not divide an enormous sum of topography points into some pieces in advance and could build a whole continuous strip triangle net without seams. Benefit from that, the question of bordering caused by dividing the points into pieces was avoided. The building spe

关键词：计算机辅助设计道路工程三维可视化模型简化

Establishing prognostic models for intrahepatic cholangiocarcinoma based on immune cells

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4092-4103页

作者： Zhuo-Ran Wang Cun-zhen zhang zhan Ding Yi-Zhuo Li Jian-Hua Yin Nan Li Department of Hepatic Surgery I(Ward I)Shanghai Eastern Hepatobiliary Surgery Hospital Navy Medical UniversityShanghai 200433China Key Laboratory of Biological Defense Ministry of EducationNavy Medical UniversityShanghai 200433China Shanghai Key Laboratory of Medical Bioprotection Navy Medical UniversityShanghai 200433China Department of Epidemiology Faculty of Navy MedicineNavy Medical UniversityShanghai 200433China Department of Oncology 905 Hospital of People’s Liberation Army NavyShanghai 200050China Department of Hepatobiliary Surgery The Second Affiliated HospitalWenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Intrahepatic cholangiocarcinoma(ICC)is a malignant liver tumor that is challenging to treat and manage and current prognostic models for the disease are inefficient or ***-associated immune cells are critical for tumor development and *** main goal of this study was to establish models based on tumor-associated immune cells for predicting the overall survival of patients undergoing surgery for *** To establish 1-year and 3-year prognostic models for ICC after surgical *** Immunohistochemical staining was performed for CD4,CD8,CD20,pan-cytokeratin(CK),and CD68 in tumors and paired adjacent tissues from 141 patients with ICC who underwent curative *** of variables was based on regression diagnostic procedures and goodness-of-fit tests(PH assumption).Clinical parameters and pathological diagnoses,combined with the distribution of immune cells in tumors and paired adjacent tissues,were utilized to establish 1-and 3-year prognostic *** This is an important application of immune cells in the tumor ***4,CD8,CD20,and CK were included in the establishment of our prognostic model by stepwise selection,whereas CD68 was not significantly associated with the prognosis of *** integrating clinical data associated with ICC,distinct prognostic models were derived for 1-and 3-year survival outcomes using variable *** 1-year prediction model yielded a C-index of 0.7695%confidence interval(95%CI):0.65-0.87 and the 3-year prediction model produced a C-index of 0.69(95%CI:0.65-0.73).Internal validation yielded a C-index of 0.761(95%CI:0.669-0.853)for the 1-year model and 0.693(95%CI:0.642-0.744)for the 3-year *** We developed Cox regression models for 1-year and 3-year survival predictions of patients with ICC who underwent resection,which has positive implications for establishing a more comprehensive prognostic model for ICC based on tumor immune microenvironment an

关键词： Intrahepatic cholangiocarcinoma Tumor immune cells Biomarkers Prognosis Prediction models

脑白质疏松(LA)病人Fazekas分级与营养状况的相关性分析

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肠外与肠内营养 2022年第6期29卷 337-341页

作者：詹贞潘杨南京医科大学附属脑科医院老年医学科江苏南京210029

目的:探讨脑白质疏松(LA)病人Fazekas分级与相关营养状况的关系。方法:回顾性研究2020年1月至2022年1月南京医科大学附属脑科医院神经内科收治的100例住院病人,根据Fazekas分级将脑白质疏松病人分为对照组LA0,(n=30例),LA1(n=28例),LA2(... 详细信息

目的:探讨脑白质疏松(LA)病人Fazekas分级与相关营养状况的关系。方法:回顾性研究2020年1月至2022年1月南京医科大学附属脑科医院神经内科收治的100例住院病人,根据Fazekas分级将脑白质疏松病人分为对照组LA0,(n=30例),LA1(n=28例),LA2(n=24例)和LA3(n=18例)。并对4组病人的基本信息(性别,年龄,BMI,吸烟和饮酒情况),临床资料,营养指标(ALB、PA、RBP)及营养状态(NRS 2002评分)进行统计分析。结果:LA分级越高,营养指标呈下降趋势(P<0.05);LA病人严重程度升高,病人的同型半胱氨酸氨酸水平呈升高趋势(P<0.05)。LA等级越高,MMSE和MoCA的评分越低,认知功能障碍越严重(P<0.05)。LA分级越高存在营养风险越多(P<0.05)。结论:LA病人的营养指标与LA严重程度相关,同时LA病情越严重,LA病人认知功能障碍越严重,并且营养风险越多。

关键词：脑白质疏松营养指标营养风险危险因素

山东省林业产业集群成长能力影响因素实证分析

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林业经济问题 2013年第4期33卷 312-318页

作者：张占贞青岛科技大学经济与管理学院山东青岛266061

从核心生产能力、生产性服务能力和政策环境影响能力的视角,构建了山东省林业产业集群成长能力指标体系,在问卷调查和实地调查的基础上,采用因子分析法对林业产业集群成长能力的影响因素进行定量分析。研究结果表明:各因素对产业集群成... 详细信息

从核心生产能力、生产性服务能力和政策环境影响能力的视角,构建了山东省林业产业集群成长能力指标体系,在问卷调查和实地调查的基础上,采用因子分析法对林业产业集群成长能力的影响因素进行定量分析。研究结果表明:各因素对产业集群成长的影响按其重要性依次为:企业发展能力、生产性服务、政策法律、企业间关联性、集群发展软环境、集群发展硬环境、专业市场建设等。在现有4个集群中,木材加工产业集群的成长能力最强,种苗花卉产业集群次之。

关键词：林业产业集群成长能力影响因素问卷调查因子分析

青蒿素生物合成关键酶CYP71AV1的表达纯化和晶体培养

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中国中药杂志 2018年第15期43卷 3064-3069页

作者：史超邓洁常振战北京大学基础医学院生物物理系

疟疾是一种严重危害人类健康的世界性流行疾病,在青蒿素广泛应用之前,全世界每年约4亿人次感染疟疾,至少有100万人的死亡病例。因此疟疾被世界卫生组织列为世界三大死亡疾病之一。青蒿素的发现,开创了疟疾治疗新方法,全球数亿人因这种... 详细信息

疟疾是一种严重危害人类健康的世界性流行疾病,在青蒿素广泛应用之前,全世界每年约4亿人次感染疟疾,至少有100万人的死亡病例。因此疟疾被世界卫生组织列为世界三大死亡疾病之一。青蒿素的发现,开创了疟疾治疗新方法,全球数亿人因这种＂中国神药＂而受益。紫穗槐-4,11-二烯氧化酶是一种植物细胞色素P450蛋白（CYP71AV1）,参与催化紫穗槐-4,11-二烯生成青蒿酸的三步氧化反应,是青蒿素生物合成途径上的关键酶。作者拟通过p CW Ori（＋）-CYP71AV1重组质粒在原核表达系统中的可溶性表达及蛋白纯化,采用一氧化碳差式光谱分析和基于血红素辅基的生物活性测定,验证CYP71AV1蛋白的活性,培养该蛋白的晶体。结果表明,构建的重组基因p CW Ori（＋）-CYP71AV1在大肠杆菌中得以功能性表达,经过亲和层析和凝胶过滤层析纯化得到了毫克级、有活性的目的蛋白,筛选出了重组CYP71AV1蛋白的晶体生长条件。这些研究为解析青蒿素生物合成关键酶CYP71AV1的晶体结构,以及通过合成生物学方法批量生产青蒿素奠定了基础,同时为其他植物来源的P450蛋白的表达纯化与结晶提供参考。

关键词：青蒿素 CYP71AV1 植物P450蛋白生物合成结晶

Fast and Robust Control of Excitation Systems: A Finite-time Method

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Journal of Systems Science and Systems Engineering 2001年第2期13卷 148-161页

作者： WANG Yu-zhen, CHENG Dai-zhan, HONG Yi-guang, QIN Hua-shuInstitute of Systems Science, Academy of Mathematics and System Sciences,Chinese Academy of Sciences, Beijing 100080, China Institute of Systems Science Academy of Mathematics and System Sciences Chinese Academy of Sciences Beijing 100080 China

Using finite-time control approach, this paper proposes a new design method for nonlinear robust excitation control of a widely used 5th-order model of synchronous generators. The finite-time excitation controller achieved here can improve the system′s behaviors in some aspects such as quick convergence and robustness for uncertainties. Simulations demonstrate that the finite-time excitation controller is more effective than some other excitation controllers.

关键词： finite-time control homogeneity excitation control robustness

Spin order and dynamics in the topological rare-earth germanide semimetals

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 113-127页

作者： Yuhao Wang Zhixuan zhen Jing Meng Igor Plokhikh Delong Wu Dariusz J.Gawryluk Yang Xu Qingfeng zhan Ming Shi Ekaterina Pomjakushina Toni Shiroka Tian Shang Key Laboratory of Polar Materials and Devices(MOE) School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China Laboratory for Multiscale Materials and Experiments Paul Scherrer InstitutVilligen PSI CH-5232Switzerland Center for Correlated Matter and School of Physics Zhejiang UniversityHangzhou 310058China Laboratory for Muon-Spin Spectroscopy Paul Scherrer InstitutVilligen PSI CH-5232Switzerland Laboratorium für Festkörperphysik ETH ZürichZürich CH-8093Switzerland

The REAl(Si,Ge)(RE=rare earth)family,known to break both the inversion-and time-reversal symmetries,represents one of the most suitable platforms for investigating the interplay between correlated-electron phenomena and topologically nontrivial ***,we report on systematic magnetic,transport,and muon-spin rotation and relaxation(μSR)measurements on(Nd,Sm)AlGe single crystals,which exhibit antiferromagnetic(AFM)transitions at T_(N)=6.1 and 5.9 K,*** addition,NdAlGe undergoes also an incommensurate-to-commensurate ferrimagnetic transition at 4.5 *** transverse-fieldμSR measurements confirm the AFM transitions,featuring a~90%magnetic volume ***-field(ZF)μSR measurements reveal a more disordered internal field distribution in NdAlGe than in SmAlGe,reflected in a larger transverse muon-spin relaxation rateλTat T<

关键词： magneticWeyl semimetals topological Hall effect spin fluctuations μSR