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Alternate disinfection approaches or raise disinfectant dosages for sewage treatment plants to address the COVID-19 pandemic?From disinfection efficiency,DBP formation,and toxicity perspectives

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Frontiers of Environmental Science & Engineering 2024年第9期18卷 115-128页

作者： Xiaobin Liao xinyue Liu Yueyun He Xueping Tang Ruanjunjie Xia Yongjun Huang Wenhua Li Jing Zou zhenming Zhou Mazhan Zhuang Institute of Municipal and Environmental Engineering College of Civil EngineeringHuaqiao UniversityXiamen 361021China Xiamen Institute of Environmental Science Xiamen 361021China College of Biomedical Sciences Huaqiao UniversityXiamen 361021China

During the COVID-19 pandemic,most sewage treatment plants increased disinfectant dosages to inactivate pathogenic viruses and microorganisms more ***,this approach also led to the production of more disinfection by-products(DBPs).To ensure both disinfection efficiency and a reduction in DBP formation,new disinfection protocols are *** this study,the disinfection efficiency,DBP amounts,and toxicity changes resulting from ozone(O_(3)),ultraviolet(UV),chlorine(Cl_(2)),and their combined processes were *** results demonstrated that the O_(3)/UV/Cl_(2)combination achieved the highest disinfection *** produced the most DBPs,whereas UV treatment reduced the formation of trihalomethane(THM),halogenated ketones(HKs),haloacetic acids(HAA),dichloroacetonitrile(DCAN)and N-nitrosodimethylamine(NDMA)by 45.9%,52.6%,82.0%,67.95%,and 47%,respectively.O_(3)also significantly reduced their production by 99.1%,91.1%,99.5%,100%,and 35%.Intracellular organic matter(IOM)was identified as the primary DBP precursors,producing 2.94 times more DBPs than extracellular organic matter(EOM).The increased DBP formation during chlorination was attributed to IOM leakage and cell membrane damage,which was verified using scanning electron microscopy(SEM).The toxicities of DBPs were evaluated for six disinfection methods,revealing inconsistent *** overall toxicities were assessed using zebrafish embryo *** evaluations indicated that chlorination alone was the least favorable *** addition,the toxicities followed a sequence:Cl_(2)≈O_(3)/Cl_(2)>O_(3)>O_(3)/UV/Cl_(2)>UV>UV/Cl_(2).These findings can serve as a reference for sewage treatment plants in selecting appropriate disinfection methods to manage the COVID-19 epidemic from comprehensive perspective.

关键词： Sewage bacteria Disinfection by-products Toxicity Ozonation UV Chlorination

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Recent advances and applications of single atom catalysts based electrochemical sensors

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Nano Research 2024年第4期17卷 2994-3013页

作者： Mingyue Wang Mingfu Ye Jieyue Wang Yong Xu zhendong Wang xinyue Tong Xinya Han Kui Zhang Wenhai Wang Konglin Wu Xianwen Wei Institute of Clean Energy and Advanced Nanocatalysis(iClean) School of Chemistry and Chemical EngineeringAnhui University of TechnologyMaanshan 243002China School of Materials Science and Engineering Anhui University of TechnologyMaanshan 243002China Anhui International Research Center of Energy materials green manufacturing and biotechnology School of Chemistry and Chemical EngineeringAnhui University of TechnologyMaanshan 243002China Carbon Cycle and Emission Control Research Center Low-Carbon Research InstituteAnhui University of TechnologyMaanshan 243002China

Single atom catalysts(SACs)have attracted considerable attention due to their unique structures and excellent catalytic performance,especially in the area of catalysis science and energy conversion and *** recent years,SACs have emerged as a new type of sensing material for constructing electrochemical sensors(ECSs),presenting excellent sensitivity,selectivity,and ***,we review the recent advances of SACs in electrochemical sensing and discuss the status quo of current SAC-based ***,the fundamentals of SAC-based ECSs are outlined,including the involved central metal atoms and various supports of SACs in this field,the detection mechanisms,and improving strategies of SAC-based ***,the important applications of SAC-based ECSs are listed and classified,covering the detection of reactive oxygen and nitrogen species,environmental pollutants,disease biomarkers,and ***,based on abundant reported cases,the current conundrums of SAC-based ECSs are summarized,and the prediction of their future developing trends is also put forward.

关键词： single atom catalysts(SACs) electrochemical sensors(ECSs) reactive oxygen and nitrogen species environmental pollutants disease biomarkers pharmaceuticals

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Narrative review of latest research progress about robotic percutaneous coronary intervention

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Journal of Geriatric Cardiology 2024年第8期21卷 816-825页

作者： zhen-Yu LIU Guang-Yao ZHAI Department of Clinical Medicine Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Cardiology Beijing Luhe HospitalCapital Medical UniversityBeijingChina

Robotic percutaneous coronary intervention(R-PCI)is a novel technology in which operators can manipulate guidewires and catheter devices in interventional *** approach provides great benefits to interventional cardiologists in terms of reducing both radiation exposure and orthopedic *** large,high-quality cohort studies have confirmed the short-term safety and high technical success rate of ***,randomized long-term data are still needed before adopting them as part of standard coronary ***,tele-stenting for complex coronary lesions has significant potential for *** need to overcome the present relevant challenges for its application such as inherent delays,bedside care for unstable patients from R-PCIs to manual PCIs(M-PCIs),incompatibility for a thrombus aspiration catheter and heavily calcified *** is a great future in laboratory workflow teams,3D-printed anatomical models and multiple joint collaborative control *** narrative review summarizes the latest developments in R-PCI,with a focus on developments in robotic technology,and discusses the current and future potential use of R-PCI in clinical practice globally.

关键词： coronary injuries unstable

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Energy-Preserving Parareal-RKN Algorithms for Hamiltonian Systems

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Numerical Mathematics(Theory,Methods and Applications) 2024年第1期17卷 121-144页

作者： zhen Miao Bin Wang Yaolin Jiang School of Mathematics and Statistics Northwestern Polytechnical UniversityXi’an 710072P.R.China School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an 710049P.R.China

In this paper,we formulate and analyse a kind of parareal-RKN algo-rithms with energy conservation for Hamiltonian *** proposed algorithms are constructed by using the ideas of parareal methods,Runge-Kutta-Nystr¨om(RKN)methods and projection *** is shown that the algorithms can exactly pre-serve the energy of Hamiltonian ***,the convergence of the integra-tors is rigorously *** numerical experiments are carried out to support the theoretical results presented in this paper and show the numerical behaviour of the derived algorithms.

关键词： Parareal methods Runge-Kutta-Nystr¨om methods Hamiltonian systems energy conservation

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Scaling Laws Behind Penetrative Turbulence:History and Perspectives

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Advances in Atmospheric Sciences 2024年第10期41卷 1881-1900页

作者： Zijing DING Ruiqi HUANG zhen OUYANG School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150006China

An unstably stratified flow entering into a stably stratified flow is referred to as penetrative convection,which is crucial to many physical processes and has been thought of as a key factor for extreme weather *** theoretical,numerical,and experimental studies on penetrative convection are reviewed,along with field studies providing insights into turbulence *** physical factors that initiate penetrative convection,including internal heat sources,nonlinear constitutive relationships,centrifugal forces and other complicated factors are ***-edge methods for understanding transport mechanisms and statistical properties of penetrative turbulence are also documented,e.g.,the variational approach and quasilinear approach,which derive scaling laws embedded in penetrative *** these scaling laws in penetrative convection can improve our understanding of large-scale geophysical and astrophysical *** better the model of penetrative turbulence towards a practical situation,new directions,e.g.,penetrative convection in spheres,and radiation-forced convection,are proposed.

关键词： thermal convection penetrative convection scaling law turbulence

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Regulation of aging by NELF-A and RNA polymerase Ⅱ elongation

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Neural Regeneration Research 2024年第7期19卷 1415-1416页

作者： Chin-Tong Ong zhen-Kai Ngian Temasek Life Sciences Laboratory and Department of Biological Sciences National University of SingaporeSingaporeSingapore Department of Genetics Harvard Medical SchoolBostonMAUSA Institute of Molecular and Cell Biology Agency for ScienceTechnology and ResearchSingaporeSingapore

Epigenetic regulation of aging:Aging is defined as the gradual decline of physiological function and cellular integrity,causing o rganismal vulnerability to age-onset diseases and *** in different animal models have l... 详细信息

关键词： aging twelve integrity

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Collaborative Charging Scheduling in Wireless Charging Sensor Networks

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Computers, Materials & Continua 2024年第4期79卷 1613-1630页

作者： Qiuyang Wang zhen Xu Lei Yang School of Electrical and Electronic Engineering Wuhan Polytechnic UniversityWuhan430048China

Wireless sensor networks (WSNs) have the trouble of limited battery power, and wireless charging provides apromising solution to this problem, which is not easily affected by the external environment. In this paper, we studythe recharging of sensors in wireless rechargeable sensor networks (WRSNs) by scheduling two mobile chargers(MCs) to collaboratively charge sensors. We first formulate a novel sensor charging scheduling problem with theobjective of maximizing the number of surviving sensors, and further propose a collaborative charging schedulingalgorithm(CCSA) for WRSNs. In the scheme, the sensors are divided into important sensors and ordinary *** can adaptively collaboratively charge the sensors based on the energy limit ofMCs and the energy demandof sensors. Finally, we conducted comparative simulations. The simulation results show that the proposed algorithmcan effectively reduce the death rate of the sensor. The proposed algorithm provides a solution to the uncertaintyof node charging tasks and the collaborative challenges posed by multiple MCs in practical scenarios.

关键词： Wireless rechargeable sensor network mobile charger collaborative charging adaptive charging

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SemiSynBio:A new era for neuromorphic computing

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Synthetic and Systems Biotechnology 2024年第3期9卷 594-599页

作者： Ruicun Liu Tuoyu Liu Wuge Liu Boyu Luo Yuchen Li xinyue Fan Xianchao Zhang Wei Cui Yue Teng State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAcademy of Military Medical SciencesBeijing100071China Institute of Information Network and Artificial Intelligence Jiaxing UniversityJiaxing314001China South China University of Technology Guangzhou510641China

Neuromorphic computing has the potential to achieve the requirements of the next-generation artificial intelligence(AI)systems,due to its advantages of adaptive learning and parallel ***,biocomputing has seen ongoing development with the rise of synthetic biology,becoming the driving force for new generation semiconductor synthetic biology(SemiSynBio)***-based biomolecules could potentially perform the functions of Boolean operators as logic gates and be used to construct artificial neural networks(ANNs),providing the possibility of executing neuromorphic computing at the molecular ***,we briefly outline the principles of neuromorphic computing,describe the advances in DNA computing with a focus on synthetic neuromorphic computing,and summarize the major challenges and prospects for synthetic neuromorphic *** believe that constructing such synthetic neuromorphic circuits will be an important step toward realizing neuromorphic computing,which would be of widespread use in biocomputing,DNA storage,information security,and national defense.

关键词： Neuromorphic computing Synthetic biology Biocomputing Artificial intelligence Neuromorphic genetic circuits

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Gain deeper insights into traditional Chinese medicines using multidimensional chromatography combined with chemometric approaches

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Chinese Herbal Medicines 2024年第1期16卷 27-41页

作者： xinyue Yang Pingping Zeng Jin Wen Chuanlin Wang Liangyuan Yao Min He Department of Pharmaceutical Engineering School of Chemical EngineeringXiangtan UniversityXiangtan 411105China Hunan Qianjin Xiangjiang Pharmaceutical Joint Stock Co. Ltd.Zhuzhou 412000China

Traditional Chinese medicines(TCMs)possess a rich historical background,unique theoretical framework,remarkable therapeutic efficacy,and abundant ***,the modernization and internationalization of TCMs have faced significant obstacles due to their diverse ingredients and unknown *** gain deeper insights into the phytochemicals and ensure the quality control of TCMs,there is an urgent need to enhance analytical ***,two-dimensional(2D)chromatography,which incorporates two independent separation mechanisms,demonstrates superior separation capabilities compared to the traditional one-dimensional(1D)separation system when analyzing TCMs *** the past decade,new techniques have been continuously developed to gain actionable insights from complex *** review presents the recent advancements in the application of multidimensional chromatography for the quality evaluation of TCMs,encompassing 2D-gas chromatography(GC),2D-liquid chromatography(LC),as well as emerging three-dimensional(3D)-GC,3D-LC,and their associated data-processing *** studies highlight the promising potential of multidimensional chromatographic separation for future phytochemical ***,the increased separation capability has resulted in higher-order data sets and greater demands for data-processing *** that multidimensional chromatography is still a relatively nascent research field,further hardware enhancements and the implementation of chemometric methods are necessary to foster its robust development.

关键词： chemometrics multidimensional separation off-line two-dimensional liquid chromatography on-line two-dimensional liquid chromatography quality control traditional chinese medicines two-dimensional gas chromatography

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STING mediates microglial pyroptosis via interaction with NLRP3 in cerebral ischaemic stroke

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Stroke & Vascular Neurology 2024年第2期9卷 153-164页

作者： Wenyu Li Nan Shen Lingqi Kong Hongmei Huang xinyue Wang Yan Zhang Guoping Wang Pengfei Xu Wei Hu Department of Neurology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhuiChina

background Ischaemia-evoked neuroinflammation is a critical pathogenic event following ischaemic *** D(GSDMD)-associated pyroptosis represents a type of inflammation-associated programmed cell death,which can exacerbate neuroinflammatory responses and brain *** of interferon genes(STING)was recently described as a vital innate immune adaptor protein associated with ***,the regulatory effects of STING on microglial pyroptosis post-stroke have not been well *** STING-knockout and wild-type(WT)mice were subjected to middle cerebral artery occlusion(MCAO).STING small interfering RNA(siRNA)was transfected into BV2 cells before oxygen-glucose deprivation/reoxygenation(OGD/R).STING-overexpressing adeno-associated virus(AAV)and NOD-like receptor family pyrin domain containing 3(NLRP3)siRNA were administered by stereotaxic injection.2,3,5-Triphenyl tetrazolium chloride(TTC)staining,TdT-mediated dUTP nick end labeling(TUNEL)staining,Fluoro-Jade C(FJC)staining,neurobehavioural tests,immunohistochemistry,cytokine antibody array assay,transmission electron microscopy,immunoblot,Enzyme-linked immunosorbent assay(ELISA)and quantitative real-time polymerase chain reaction(qRT-PCR)were carried ***-immunoprecipitation assays were used to investigate the interplay between STING and *** STING expression was increased after MCAO and mainly detected on *** deletion alleviated brain infarction,neuronal damage and neurobehavioural impairment in mice subjected to *** knockout suppressed microglial activation and the secretion of inflammatory chemokines,accompanied by mitigation of microglial *** upregulation of microglial STING by AAV-F4/80-STING aggravated brain injury and microglial ***,co-immunoprecipitation showed that STING bound to NLRP3 in *** of NLRP3 siRNA reversed AAV-F4/80-STING-induced deterioration of microglial pyropt

关键词： NLRP3 cerebral inflammation

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