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Application of the sodium hyaluronate-CNTF scaffolds in repairing adult rat spinal cord injury and facilitating neural network formation

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Science China(Life Sciences) 2018年第5期61卷 559-568页

作者： Yabin Xie Wei Song Wen Zhao Yudan Gao Junkui Shang peng Hao zhaoyang Yang Hongmei Duan Xiaoguang Li Department of Neurobiology School of Basic Medical Sciences Capital Medical University Beijing 100069 China Sehool of Rehabilitation Medicine China Rehabilitation Research Centre Capital Medical University Beijing 100069 China

The present study aimed to explore the potential of the sodium hyaluronate-CNTF (ciliary neurotrophic factor) scaffold in activating endogenous neurogenesis and facilitating neural network re-formation after the adult rat spinal cord injury (SCI). After completely cutting and removing a 5-mm adult rat T8 segment, a sodium hyaluronate-CNTF scaffold was implanted into the lesion area. Dil tracing and immunofluorescence staining were used to observe the proliferation, differentiation and integration of neural stem cells (NSCs) after SCI. A planar multielectrode dish system (MED64) was used to test the electrophysiological characteristics of the regenerated neural network in the lesioned area. Electrophysiology and behavior evaluation were used to evaluate functional recovery of paraplegic rat hindlimbs. The Dil tracing and immunofluorescence results suggest that the sodium hyaluronate-CNTF scaffold could activate the NSCs originating from the spinal cord ependymal, and facilitate their migration to the lesion area and differentiation into mature neurons, which were capable of forming synaptic contact and receiving glutamatergic excitatory synaptic input. The MED64 results suggest that functional synapsis could be established among regenerated neurons as well as between regenerated neurons and the host tissue, which has been evidenced to be glutamatergic excitatory synapsis. The electrophysiology and behavior evaluation results indicate that the paraplegic rats’ sensory and motor functions were recovered in some degree. Collectively, this study may shed light on paraplegia treatment in clinics.

关键词： spinal cord injury endogenous neural stem cells neural network reconstruction CNTF new born neuron

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Highly adaptive triboelectric tactile sensor on the foot of autonomous wall-climbing robots for detecting the adhesion state and avoiding the hazard

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Nano Research 2024年第7期17卷 6518-6526页

作者： zhaoyang Wang Jianhua Liu Ziyu Wang Chang Liu Qingyu Chen Chaofan Zhang Wenbo Zhang Jicang Si Xiu Xiao peng Xu Minyi Xu Dalian Key Lab of Marine Micro/Nano Energy and Self-powered System Marine Engineering CollegeDalian Maritime UniversityDalian 116026China Information Science and Technology College Dalian Maritime UniversityDalian 116026China Navigation College Dalian Maritime UniversityDalian 116026China Intelligent Biomimetic Design Lab College of EngineeringPeking UniversityBeijing 100871China

Due to the excellent maneuverability and obstacle crossing of legged robots,it is possible for an autonomous legged wallclimbing robots to replace manual inspection of ship exterior ***,when the magnetic adsorption legged wallclimbing robot steps on the convex point or convex line of the wall,or even when the robot missteps,the robot is likely to detach from the ferromagnetic ***,this paper proposes a tactile sensor for the legged magnetic adsorption wall-climbing robot to detect the magnetic adsorption state and improve the safety of the autonomous crawling of the *** tactile sensor mainly comprises a three-dimensional(3D)-printed shell,a tactile slider,and three isometric sensing units,with an optimized *** experiment shows that the triboelectric tactile sensor can monitor the sliding depth of the tactile slider and control the light-emitting device(LED)signal *** addition,in the demonstration experiment of detecting the adsorption state of the robot's foot,the triboelectric tactile sensor has strong adaptability to various ferromagnetic wall ***,this study establishes a robot gait control system to verify the feedback control ability of the triboelectric tactile *** results show that the robot equipped with the triboelectric tactile sensor can recognize the dangerous area on the crawling wall and autonomously avoid the ***,the proposed triboelectric tactile sensor has great potential in realizing the tactile sensing ability of robots and enhancing the safety and intelligent inspection of ultra-large vessels.

关键词： legged wall-climbing robot ship inspection tactile perception triboelectric sensor

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Highly stable lead-free Cs3Bi2I9 perovskite nanoplates for photodetection applications

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Nano Research 2019年第8期12卷 1894-1899页

作者： zhaoyang Qi Xianwei Fu Tiefeng Yang Dong Li peng Fan Honglai Li Feng Jiang Lihui Li Ziyu Luo Xiujuan Zhuang Anlian Pan Key Laboratory for Micro-Nano Physics and Technology of Hunan Province College of Materials and EngineeringSchool of Physics and Electronic Scienceand State Key Laboratory of Chemo/Biosensing and ChemometricsHunan UniversityChangsha 410082China

Lead halide perovskites have received tremendous attentions recently for their excellent properties such as high light absorption coefficient and long charge carrier diffusion length. However, the stability issues and the existence of toxic lead cations have largely limited their applications in optoelectronic area. Herein, we report the synthesis and investigation of highly stable and lead-free Cs3Bi2I9 perovskite nanoplates for visible light photodetection applications. The Cs3Bi2I9 nanoplates were synthesized through a facile solution-processed method, which is also applicable to various substrates. The achieved nanoplates present very good crystal quality and exhibit excellent long-term stability even exposed in moist air for several months. Photodetectors were constructed based on these high-quality perovskite nanoplates for the first time, and display a maximum photoresponsivity of 33.1 mA/W under the illumination of 450 nm laser, which is six times higher than the solution-synthesized CH3NH3PbI3 nanowire photodetectors. The specific detectivity of these devices can reach up to 10^10 Jones. Additionally, the devices exhibit fast rise and decay time of 10.2 and 37.2 ms, respectively, and highly stable photoswitching behavior with their photoresponse well retaining under alternating light and darkness. This work opens up a new opportunity for stable and low-toxic perovskite-based optoelectronic applications.

关键词： bismuth inorganic perovskite lead-free highly stable nanoplates photodetector

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Room Temperature Synthesis of Vertically Aligned Amorphous Ultrathin NiCo-LDH Nanosheets Bifunctional Flexible Supercapacitor Electrodes

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Energy & Environmental Materials 2024年第2期7卷 277-286页

作者： Kwadwo Asare Owusu zhaoyang Wang Ali Saad Felix Ofori Boakye Muhammad Asim Mushtaq Muhammad Tahir Ghulam Yasin Dongqing Liu Zhengchun peng Xingke Cai Institute for Advanced Study Shenzhen UniversityShenzhen 518060China College of Physics and Optoelectronics Shenzhen University3688 Nanhai BoulevardNanshan DistrictShenzhen 518060China School of Chemistry and Materials Science Hubei Engineering UniversityNo.272 Traffic AvenueXiaogan 432000China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyNo.122 Luoshi RoadWuhan 430070China Key Laboratory of Green Printing CAS Research Centre for Excellence in Molecular ScienceInstitute of Chemistry Chinese Academy of Sciences(ICCAS)Beijing 100190China College of Mechatronics and Control Engineering Shenzhen University3688 Nanhai BoulevardNanshan DistrictShenzhen 518050China

Developing a simple scalable method to fabricate electrodes with high capacity and wide voltage range is desired for the real use of electrochemical ***,we synthesized amorphous NiCo-LDH nanosheets vertically aligned on activated carbon cloth substrate,which was in situ transformed from Co-metal-organic framework materials nano-columns by a simple ion exchange process at room *** to the amorphous and vertically aligned ultrathin structure of NiCo-LDH,the NiCo-LDH/activated carbon cloth composites present high areal capacities of 3770 and 1480 mF cm^(-2)as cathode and anode at 2 mA cm^(-2),and 79.5%and 80%capacity have been preserved at 50 mA cm^(-2).In the meantime,they all showed excellent cycling performance with negligible change after>10000 *** fabricating them into an asymmetric supercapacitor,the device achieves high energy densities(5.61 mWh cm^(-2)and 0.352 mW cm^(-3)).This work provides an innovative strategy for simplifying the design of supercapacitors as well as providing a new understanding of improving the rate capabilities/cycling stability of NiCo-LDH materials.

关键词： amorphous nanosheets aqueous supercapacitor high volumetric/areal energy density NiCo-LDH room temperature synthesis

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Chronic spinal cord injury repair by NT3-chitosan only occurs after clearance of the lesion scar

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2568-2580页

作者： Can Zhao Jia-Sheng Rao Hongmei Duan peng Hao Junkui Shang Yubo Fan Wen Zhao Yudan Gao zhaoyang Yang Yi Eve Sun Xiaoguang Li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Institute of Rehabilitation Engineering China Rehabilitation Science InstituteBeijing 100068China Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Beijing Advanced Innovation Centre for Biomedical Engineering Key Laboratory for Biomechanics and Mechanobiology of Chinese Education MinistrySchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 10083China School of Engineering Medicine Beihang UniversityBeijing 10083China Shanghai Institute of Stem Cell Research and Clinical Translation Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of Psychiatry and Biobehavioral Sciences UCLA Medical SchoolLos AngelesCA 90095USA

Spinal cord injury(SCI)is a severe damage usually leading to limb dysesthesia,motor dysfunction,and other physiological *** have previously shown that NT3-chitosan could trigger an acute SCI repairment in rats and non-human *** to the negative effect of inhibitory molecules in glial scar on axonal regeneration,however,the role of NT3-chitosan in the treatment of chronic SCI remains *** with the fresh wound of acute SCI,how to handle the lesion core and glial scars is a major issue related to chronic-SCI *** we report,in a chronic complete SCI rat model,establishment of magnetic resonancediffusion tensor imaging(MR-DTI)methods to monitor spatial and temporal changes of the lesion area,which matched well with anatomical *** of the lesion core via suction of cystic tissues and trimming of solid scar tissues before introducing NT3-chitosan using either a rigid tubular scaffold or a soft gel form led to robust neural regeneration,which interconnected the severed ascending and descending axons and accompanied with electrophysiological and motor functional *** contrast,cystic tissue extraction without scar trimming followed by NT3-chitosan injection,resulted in little,if any *** together,after lesion core clearance,NT3-chitosan can be used to enable chronic-SCI repair and MR-DTI-based mapping of lesion area and monitoring of ongoing regeneration can potentially be implemented in clinical studies for subacute/chronic-SCI repair.

关键词： scar NT3 wound

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Cellular regeneration treatments for traumatic brain injury

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Medicine in Novel Technology and Devices 2022年第4期16卷 285-292页

作者： Hao Fan Hongmei Duan peng Hao Yudan Gao Wen Zhao Fei Hao Xiaoguang Li zhaoyang Yang Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijing100069China Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijing100083China Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China

Different types of traumatic brain injury(TBI)have posed a hazard to human health for a while,and their aftereffects have a significant negative impact on patients'quality of *** the increased attention that TBI has received recently,the clinical treatment plan that is currently in place only consists of palliative therapy for neuroprotection or the mitigation of secondary injury,which has only a minimally positive impact on the prognosis and quality of life in TBI *** TBI,regenerative therapy seeks to improve the patient's *** therapy,which has become one of the hottest research fields,is expected to improve the therapeutic effect of this *** article will briefly discuss recent developments in research of TBI and available treatments,and then give a general assessment of the outlook.

关键词： Traumatic brain injury Nerve regeneration Endogenous neurogenesis Cell replacement therapy

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Regeneration and functional recovery of the completely transected optic nerve in adult rats by CNTF-chitosan

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Signal Transduction and Targeted Therapy 2023年第3期8卷 912-915页

作者： Xiao Liu Fei Hao peng Hao Jingxue Zhang Liqiang Wang Si-Wei You Ningli Wang zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical University100069 BeijingChina School of Engineering Medicine Beijing Key Laboratory for Biomaterials and Neural RegenerationBeihang University100083 BeijingChina Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key Laboratory100005 BeijingChina Department of Ophthalmology The Third Medical CenterChinese PLA General Hospital100089 BeijingChina Department of Ophthalmology Xijing HospitalThe Fourth Military Medical University710032 Xi’anShanxi ProvinceChina Guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan University510632 GuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) 510530 GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong Kong999077 Hong KongChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay Area510515 GuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong University226001 NantongJiangsu ProvinceChina Beijing International Cooperation Bases for Science and Technology on Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Big Data-Based Precision MedicineBeihang University100083 BeijingChina

Dear Editor,The optic nerve,which belongs to the central nervous system(CNS),cannot regenerate when injured in adult mammals.1 Up to now,no readily translatable measures are available for repairing a severely injured optic *** we demonstrated that ciliary neurotrophic factor(CNTF)-chitosan enabled the reconstruction and functional recovery of the adult rat visual system,thus shedding light on the clinical potential for repairing the severely injured optic nerve.

关键词： Regeneration functional CNTF

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Histone deacetylases:Regulation of vascular homeostasis via endothelial cells and vascular smooth muscle cells and the role in vascular pathogenesis

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Genes & Diseases 2024年第6期11卷 351-366页

作者： Hanyi Yang Kai Guo peng Ding Jiayi Ning Yimeng Zhang Yuanyong Wang zhaoyang Wang Guanglin Liu Changjian Shao Minghong Pan Zhiqiang Ma Xiaolong Yan Jing Han Department of Ophthalmology Tangdu HospitalThe Air Force Military Medical UniversityXi'anShaanxi 710038China Xi'an Medical University Xi'anShaanxi 710086China Department of Thoracic Surgery Shaanxi Provincial People's HospitalThe Third Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxi 710068China Department of Thoracic Surgery Tangdu HospitalThe Air Force Military Medical UniversityXi'anShaanxi710038China Department of Medical Oncology Senior Department of OncologyChinese PLA General HospitalThe FifthMedical CenterBeijing100853China

tHistone deacetylases(HDACs)are proteases that play a key role in chromosome structural modification and gene expression regulation,and the involvement of HDACs in can-cer,the nervous system,and the metabolic and immune system has been well *** understanding of the function of HDACs in the vascular system has recently progressed,and a significant variety of HDAC inhibitors have been shown to be effective in the treatment of vascular ***,few reviews have focused on the role of HDACs in the vascular *** this study,the role of HDACs in the regulation of the vascular system mainly involving endothelial cells and vascular smooth muscle cells was discussed based on recent updates,and the role of HDACs in different vascular pathogenesis was summarized as ***,the therapeutic effects and prospects of HDAC inhibitors were also addressed in this review.

关键词： Deacetylation Endothelial cells Histone deacetylase Vascular disease Vascular smooth muscle cells

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Activation of endogenous neurogenesis and angiogenesis by basic fibroblast growth factor-chitosan gel in an adult rat model of ischemic stroke

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Neural Regeneration Research 2024年第2期19卷 409-415页

作者： Hongmei Duan Shulun Li peng Hao Fei Hao Wen Zhao Yudan Gao Hui Qiao Yiming Gu Yang Lv Xinjie Bao Kin Chiu Kwok-Fai So zhaoyang Yang Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Department of Epidemiology and Statistics School of Public Health and ManagementNingxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina Department of Physical Education Capital University of Economics and BusinessmBeijingChina Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Psychology State Key Lab of Brain and Cognitive SciencesThe University of Hong KongHong Kong Special Administration RegionChina Guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

Attempts have been made to use cell transplantation and biomaterials to promote cell proliferation,differentiation,migration,and survival,as well as angiogenesis,in the context of brain ***,whether bioactive materials can repair the damage caused by ischemic stroke by activating endogenous neurogenesis and angiogenesis is still *** this study,we applied chitosan gel loaded with basic fibroblast growth factor to the stroke cavity 7 days after ischemic stroke in *** gel slowly released basic fibroblast growth factor,which improved the local microenvironment,activated endogenous neural stem/progenitor cells,and recruited these cells to migrate toward the penumbra and stroke cavity and subsequently differentiate into neurons,while enhancing angiogenesis in the penumbra and stroke cavity and ultimately leading to partial functional *** study revealed the mechanism by which bioactive materials repair ischemic strokes,thus providing a new strategy for the clinical application of bioactive materials in the treatment of ischemic stroke.

关键词： adult endogenous neurogenesis angiogenesis basic fibroblast growth factor-chitosan gel chitosan functional recovery ischemic stroke neural stem cell newborn neuron

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Synthesis of Benzazepines via Ag(I)-Catalyzed Three-component Reaction of 2-Alkynylbenzaldehydes,Amines and Diazo Compounds

Synthesis of Benzazepines via Ag(I)-Catalyzed Three-componen...

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第十八届全国金属有机化学学术研讨会

作者： Tiebo Xiao Pai peng zhaoyang Wang Lei Zhou School of Chemistry and Chemical Engineering Sun Yat-sen University School of Chemistry and Environment South China Normal UniversityKey Laboratory of Theoretical Chemistry of EnvironmentMinistry of Education

Development of synthetic methods of benzazepine derivatives from easily accessible reactants is highly significant because it is a scaffold for potential medicinal agents in several therapeutic applications. Herein we reported an efficient method for the synthesis of 3-benzazepines via Ag(I)-catalyzed three-component reaction of 2-alkynylbenzaldehydes,amines and diazo *** reaction probobaly proceeds through the following pathway:1)silver-catalyzed cyclization of N′-

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