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3D printed grafts with gradient structures for organized vascular regeneration

International Journal of Extreme Manufacturing 2024年第3期6卷 505-520页

作者： Yuewei Chen Zhongfei Zou Tao Fu Zhuang Li zhaojie zhang Meng Zhu Qing Gao Shaofei Wu Guosheng Fu Yong He Jiayin Fu State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China School of Mechanical Engineering Guizhou UniversityGuiyang 550025People’s Republic of China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalZhejiang UniversityHangzhou 310016People’s Republic of China School of Mechanical Engineering Guizhou Institute of TechnologyGuiyang 550003People’s Republic of China Department of Oral and Maxillofacial Surgery The Second Affiliated Hospital of Zhejiang University School of MedicineSchool of Stomatologyand Key Laboratory of Oral Biomedical Research of Zhejiang ProvinceHangzhouZhejiang 310006People’s Republic of China

Synthetic vascular grafts suitable for small-diameter arteries(<6 mm) are in great ***,there are still no commercially available small-diameter vascular grafts(SDVGs) in clinical practice due to thrombosis and stenosis after in vivo *** designing SDVGs,many studies emphasized reendothelization but ignored the importance of reconstruction of the smooth muscle layer(SML).To facilitate rapid SML regeneration,a high-resolution 3D printing method was used to create a novel bilayer SDVG with structures and mechanical properties mimicking natural *** by the collagen alignment of SML,the inner layer of the grafts had larger pore sizes and high porosity to accelerate the infiltration of cells and their circumferential alignment,which could facilitate SML reconstruction for compliance restoration and spontaneous *** outer layer was designed to induce fibroblast recruitment by low porosity and minor pore size and provide SDVG with sufficient mechanical *** month after implantation,the arteries regenerated by 3D-printed grafts exhibited better pulsatility than electrospun grafts,with a compliance(8.9%) approaching that of natural arteries(11.36%) and significantly higher than that of electrospun ones(1.9%).The 3D-printed vascular demonstrated a three-layer structure more closely resembling natural arteries while electrospun grafts showed incomplete endothelium and immature *** study shows the importance of SML reconstruction during vascular graft regeneration and provides an effective strategy to reconstruct blood vessels through 3D-printed structures rapidly.

关键词： small-diameter vascular graft smooth muscle layer 3D printing endothelialization

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盐酸氨溴索联合纤维支气管镜肺泡灌洗治疗重症肺炎患者的效果

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中国医药科学 2024年第3期14卷 191-194页

作者：张炤杰南京市溧水区人民医院重症医学科江苏南京211200

目的研究在治疗重症肺炎患者中,联合使用盐酸氨溴索、纤维支气管镜肺泡灌洗的效果。方法选取2021年1月至2022年12月南京市溧水区人民医院收治的70例重症肺炎患者,采用随机抽样法划分为两组,对照组(n=35)给予盐酸氨溴索治疗,试验组(n=... 详细信息

目的研究在治疗重症肺炎患者中,联合使用盐酸氨溴索、纤维支气管镜肺泡灌洗的效果。方法选取2021年1月至2022年12月南京市溧水区人民医院收治的70例重症肺炎患者,采用随机抽样法划分为两组,对照组(n=35)给予盐酸氨溴索治疗,试验组(n=35)在上述治疗基础上给予纤维支气管镜肺泡灌洗疗法,比较分析两组间临床症状消失时间、临床疗效、炎症因子水平[C反应蛋白(CRP)、白细胞计数(WBC)、白介素-1(IL-1)、白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子α(TNF-α)]、动脉血气分析指标[p H值、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]。结果试验组总有效率高于对照组,差异有统计学意义(P0.05);治疗后试验组炎症因子指标低于对照组,差异有统计学意义(P0.05);治疗后试验组PaO_(2)、p H值高于对照组,PaCO_(2)低于对照组,差异有统计学意义(P<0.05)。结论盐酸氨溴索联合纤维支气管镜肺泡灌洗治疗能有效改善炎症反应与动脉血气分析指标,缩短症状消失时间。

关键词：重症肺炎盐酸氨溴索纤维支气管镜肺泡灌洗炎症因子

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青岛主城区等时交通圈的构建及空间格局研究

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山东大学学报（工学版） 2024年第2期54卷 27-35页

作者：刘冰王新雨陈丽张艺曦张照杰陆邹妍梁蕾山东科技大学计算机科学与工程学院山东青岛266590 山东科技大学测绘与空间信息学院山东青岛266590 山东科技大学审计处山东青岛266590 山东正元地球物理信息技术有限公司山东济南250101 浙江正元地理信息有限责任公司浙江湖州313203

以青岛市主城区交通圈为对象,分析青岛主城区交通圈层,弥补青岛市交通圈空间格局研究的缺失。依据地价均衡理论识别青岛主城区;采用核密度分析法和中心服务区算法,辅以源点终点(origin-destination, OD)矩阵分析法、成本距离分析法,生... 详细信息

以青岛市主城区交通圈为对象,分析青岛主城区交通圈层,弥补青岛市交通圈空间格局研究的缺失。依据地价均衡理论识别青岛主城区;采用核密度分析法和中心服务区算法,辅以源点终点(origin-destination, OD)矩阵分析法、成本距离分析法,生成青岛主城区等时交通圈;将青岛主城区交通圈分为核心区、过渡区与边缘区,并对青岛主城区空间范围、圈层形态等空间格局特征进行分析、评价;根据分析结果提出交通规划的具体建议。研究结果表明:青岛主城区内基于职能的平均时间成本为0.58 h,不同区域的时间成本差异明显,其中核心区有较高的路网密度,呈南北狭长分布;过渡区在核心区周围,道路里程较短,路网密度最低,空间分布格局不规则;边缘区时间成本最高,但路网密度比过渡区高,空间形态呈组团式分布。

关键词：交通圈网络分析方法城市职能空间格局青岛都市圈核密度分析法

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Cenozoic Exhumation and Thrusting in the Northern Qilian Shan,Northeastern Margin of the Tibetan Plateau:Constraints from Sedimentological and Apatite Fission-Track Data

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Acta Geologica Sinica(English Edition) 2009年第3期83卷 562-579页

作者： GUO zhaojie LU Jiemin zhang Zhicheng Key Laboratory of Orogenic Belts and Crustal Evolution Peking University Beijing 100871 China

The Qilian Shan lies along the northeastern edge of the Tibetan Plateau. To constrain its deformation history, we conducted integrated research on Mesozoic-Cenozoic stratigraphic sections in the Jiuxi Basin immediately north of the mountain range. Paleocurrent measurements, sandstone compositional data, and facies analysis of Cenozoic stratigraphic sections suggest that the Jiuxi Basin received sediments from the Altyn Tagh Range in the northwest, initially in the Oligocene （-33 Ma）, depositing the Huoshaogou Formation in the northern part of the basin. Later, the source area of the Jiuxi Basin changed to the Qilian Shan in the south during Late Oligocene （-27 Ma）, which led to the deposition of the Baiyanghe Formation. We suggest that uplift of the northern Qilian Shan induced by thrusting began no later than the Late Oligocene. Fission-track analysis of apatite from the Qilian Shan yields further information about the deformation history of the northern Qilain Shan and the Jiuxi Basin. It shows that a period of rapid cooling, interpreted as exhumation, initiated in the Oligocene. We suggest that this exhumation marked the initial uplift of the Qilian Shan resulting from the India-Asia collision.

关键词： Cenozoic uplift sandstone composition apatite fission-track dating Jiuxi Basin QilianShan

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疏筋整复手法治疗寰枢关节紊乱症的运动学量化研究

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中国中医骨伤科杂志 2024年第4期32卷 24-28页

作者：张琰朕刘洋李锐杨灿胡滟琦张兆杰中国中医科学院望京医院北京100102 北京中医药大学东方医院

目的:量化疏筋整复手法治疗寰枢关节紊乱症运动学参数,初步探究手法与疾病治疗的量效关系,规范操作要领,丰富手法内涵并推广应用。方法:2022年10月至2023年5月就诊的寰枢关节紊乱症患者18例,其中男10例,女8例;年龄为24~27岁,平均为(25.5... 详细信息

目的:量化疏筋整复手法治疗寰枢关节紊乱症运动学参数,初步探究手法与疾病治疗的量效关系,规范操作要领,丰富手法内涵并推广应用。方法:2022年10月至2023年5月就诊的寰枢关节紊乱症患者18例,其中男10例,女8例;年龄为24~27岁,平均为(25.50±1.10)岁。选取一位有着丰富临床经验且手法操作娴熟的脊柱科主任医师对患者进行操作,通过运动捕捉系统量化疏筋整复手法的被动旋转角度、旋扳角度及运动学曲线。结果:旋扳整复操作时被动旋转角度为72.21°±5.06°,患侧和对侧的被动旋转角度相比差异无统计学意义(P>0.05),患侧的旋扳角度为7.34°±1.90°,对侧为5.61°±1.76°,两侧相比差异有统计学意义(P<0.001)。结论:疏筋整复手法在治疗寰枢关节紊乱症时应把握到达旋转稳定状态时的被动旋转角度和旋扳角度,同时注重对齿状突偏歪侧进行旋扳。

关键词：疏筋整复手法寰枢关节紊乱症运动捕捉系统运动学参数量效关系

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Image super‐resolution via dynamic network

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CAAI Transactions on Intelligence Technology 2024年第4期9卷 837-849页

作者： Chunwei Tian Xuanyu zhang Qi zhang Mingming Yang zhaojie Ju School of Software Northwestern Polytechnical UniversityXi'anChina National Engineering Laboratory for Integrated Aero‐Space‐Ground‐Ocean Big Data Application Technology Xi'anChina Research&Development Institute Northwestern Polytechnical UniversityShenzhenChina School of Economics and Management Harbin Institute of Technology at WeihaiWeihaiChina Tencent AI Lab ShenzhenChina School of Computing University of PortsmouthPortsmouthUK

Convolutional neural networks depend on deep network architectures to extract accurate information for image super‐***,obtained information of these con-volutional neural networks cannot completely express predicted high‐quality images for complex scenes.A dynamic network for image super‐resolution(DSRNet)is presented,which contains a residual enhancement block,wide enhancement block,feature refine-ment block and construction *** residual enhancement block is composed of a residual enhanced architecture to facilitate hierarchical features for image super‐*** enhance robustness of obtained super‐resolution model for complex scenes,a wide enhancement block achieves a dynamic architecture to learn more robust information to enhance applicability of an obtained super‐resolution model for varying *** prevent interference of components in a wide enhancement block,a refine-ment block utilises a stacked architecture to accurately learn obtained ***,a residual learning operation is embedded in the refinement block to prevent long‐term dependency ***,a construction block is responsible for reconstructing high‐quality *** heterogeneous architecture can not only facilitate richer structural information,but also be lightweight,which is suitable for mobile digital *** results show that our method is more competitive in terms of performance,recovering time of image super‐resolution and *** code of DSRNet can be obtained at https://***/hellloxiaotian/DSRNet.

关键词： CNN dynamic network image super‐resolution lightweight network

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Joint Biomedical Entity and Relation Extraction Based on Multi-Granularity Convolutional Tokens Pairs of Labeling

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Computers, Materials & Continua 2024年第9期80卷 4325-4340页

作者： zhaojie Sun Linlin Xing Longbo zhang Hongzhen Cai Maozu Guo Department of Computer Science and Technology Shandong University of TechnologyZibo255000China Department of Agricultural Engineering and Food Science Shandong University of TechnologyZibo255000China Department of Electrical and Information Engineering Beijing University of Civil Engineering and ArchitectureBeijing100044China

Extracting valuable information frombiomedical texts is one of the current research hotspots of concern to a wide range of *** biomedical corpus contains numerous complex long sentences and overlapping relational triples,making most generalized domain joint modeling methods difficult to apply effectively in this *** a complex semantic environment in biomedical texts,in this paper,we propose a novel perspective to perform joint entity and relation extraction;existing studies divide the relation triples into several steps or ***,the three elements in the relation triples are interdependent and inseparable,so we regard joint extraction as a tripartite classification *** the same time,fromthe perspective of triple classification,we design amulti-granularity 2D convolution to refine the word pair table and better utilize the dependencies between biomedical word ***,we use a biaffine predictor to assist in predicting the labels of word pairs for relation *** model(MCTPL)Multi-granularity Convolutional Tokens Pairs of Labeling better utilizes the elements of triples and improves the ability to extract overlapping triples compared to previous ***,we evaluated our model on two publicly accessible *** experimental results show that our model’s ability to extract relation triples on the CPI dataset improves the F1 score by 2.34%compared to the current optimal *** the DDI dataset,the F1 value improves the F1 value by 1.68%compared to the current optimal *** model achieved state-of-the-art performance compared to other baseline models in biomedical text entity relation extraction.

关键词： Deep learning biomedical joint extraction triple classification multi-granularity 2D convolution

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筋柔骨正理论指导下运用单纯疏筋手法治疗寰枢关节错缝30例

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中国中医骨伤科杂志 2024年第4期32卷 59-63,67页

作者：李锐刘洋张世民杨灿张琰朕王毅黎作旭刘昱彰靳蛟郝俊涛林海张兆杰中国中医科学院望京医院北京100102 北京中医药大学东方医院

目的:回顾性分析单纯疏筋手法治疗30例寰枢关节错缝患者,观察其主要症状及影像学指标的改善情况。方法:选取2022年1月至2022年10月就诊的寰枢关节错缝患者30例,采用单纯疏筋手法进行治疗,每周3次,共治疗3周,分别于治疗前、首次治疗后3周... 详细信息

目的:回顾性分析单纯疏筋手法治疗30例寰枢关节错缝患者,观察其主要症状及影像学指标的改善情况。方法:选取2022年1月至2022年10月就诊的寰枢关节错缝患者30例,采用单纯疏筋手法进行治疗,每周3次,共治疗3周,分别于治疗前、首次治疗后3周、6周采用视觉模拟量表(VAS)评分和颈性眩晕症状和功能评估量表评估患者的主观症状,并于治疗前和首次治疗后3周测定颈椎CT片中的寰枢椎相对旋转角度、齿突侧块间距、寰齿前间距以及屈伸功能位X线片中的寰枢关节活动度。结果:30例患者均完成3周共9次手法治疗,首次治疗后3周和6周与治疗前相比,患者的颈痛VAS评分、颈性眩晕症状与功能量表评分均明显改善,差异有统计学意义(P0.05)。结论:筋柔骨正理论指导下运用单纯疏筋手法能够改善患者的临床症状及影像学表现,并且治疗过程中无颈椎扳动类操作,具有较好的安全性。

关键词：寰枢关节错缝手法筋柔骨正寰枢椎相对旋转角度齿突侧块间距

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Nature of the Precambrian metamorphic blocks in the eastern segment of Central Tianshan:Constraint from geochronology and Nd isotopic geochemistry

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Science China Earth Sciences 2004年第12期47卷 1085-1094页

作者： LIU Shuwen,GUO zhaojie,zhang Zhicheng,LI Qiugen & ZHENG Haifei The Key Laboratory of Orogenic Belts and Crustal Evolution,Ministry of Education,China School of Earth and Space Sciences,Peking University,Beijing 100871,China The Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of Education China School of Earth and Space Sciences Peking University Beijing China

Granitoid gneisses are widespread in Precambrian metamorphic blocks of eastern segment of the Central Tianshan Tectonic Zone, and they have intrusive contact relationships with their metamorphic sedimentary country rocks of Proterozoic Xingxingxia and Kawabulag groups. Zircon U-Pb ages from a granodioritic gneiss (IW11-1) and a parametamorphic schist (W05-9) are determined at the Weiya area. Euhedral prismatic zircons from the granodioritic gneiss (IW11-1) provide U-Pb isotopic discordia intercept ages of 1218±17 Ma and 426±26 Ma, respectively, and euhedral prismatic zircons from the parametamorphic schist (W05-9) display U-Pb isotopic discordia intercept ages of 1216±74 Ma and 290±15 Ma, respectively. A whole-rock Sm-Nd isotopic isochron is determined in augen granitoid gneiss samples at the Gang- gou-Kumishi area and we obtain the isochron age of 1142±120 Ma, and its ε Nd (t) = -4.3. These geochronological data suggest that these Precambrian metamorphic basement blocks within eastern segment of the Central Tianshan Tectonic Zone can be produced during 1140—1220 Ma, and occur a nearly homochronous metamorphism. Integrated to these geochronological data, Nd depleted mantle model ages (T DM ) and epsilon Nd(t) values of these granitoid gneiss samples indicate that they can derive from mixing in various scales both magmas from mantle and crust sources at a late Mesoproterozoic active continental margin tectonic environment. Similarity in geochronology, Sm-Nd isotopic geochemistry between Weiya-Xingxingxia, Pargangtag and Ganggou-Kumishi areas suggests that they could be a bigger uniform metamorphic basement block, which could be formed by the assembly of the supercontinent Rodinia and be separated by late geological processes.

关键词： Central Tianshan Tectonic Zone, Precambrian metamorphic blocks, granitoid gneisses, isotopic chronolo-gy, active continental margin, supercontinent Rodinia.

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基于三维有限元分析寰枢关节紊乱症对上颈椎生物力学平衡的影响

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中国中医骨伤科杂志 2024年第3期32卷 59-64页

作者：李锐张兆杰张琰朕张世民王朝鲁刘劲松黎作旭刘昱彰马明靳蛟杨灿黄菊英中国中医科学院望京医院北京100102 首都医科大学生物工程学院

目的:分析寰枢关节紊乱症患者上颈椎的生物力学特征,探讨骨错缝在寰枢关节紊乱症发病中的作用。方法:基于1例寰枢关节紊乱症患者的影像资料构建有限元模型并验证其有效性,分析关节面、椎间盘、肌肉的应力情况,并与正常颈椎的有限元模型... 详细信息

目的:分析寰枢关节紊乱症患者上颈椎的生物力学特征,探讨骨错缝在寰枢关节紊乱症发病中的作用。方法:基于1例寰枢关节紊乱症患者的影像资料构建有限元模型并验证其有效性,分析关节面、椎间盘、肌肉的应力情况,并与正常颈椎的有限元模型进行比较。结果:与正常模型相比,寰枢关节紊乱症模型的整体应力分布不均,模型右侧应力大于左侧;寰枢关节紊乱症有限元模型的寰枢外侧关节、椎间盘、肌肉有明显的应力分布不均匀现象,偏歪侧的寰枢侧方关节、椎间盘后侧、头后大直肌止点处有明显的应力集中现象。结论:寰枢关节紊乱症会破坏上颈椎整体的力学平衡,导致关节面、椎间盘和肌肉的应力分布不均匀,可能导致颈痛和脊柱退变。

关键词：有限元寰枢关节紊乱症生物力学寰枢侧方关节骨错缝

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