检索结果-南通市图书馆

Oral nanoparticles containing naringenin suppress atherosclerotic progression by targeting delivery to plaque macrophages

引用

Nano Research 2023年第1期16卷 925-937页

作者： Mengran Guo Zhongshan He zhaohui jin Lingjing Huang jingmei Yuan Shugang Qin Xinchun Wang Lili Cao Xiangrong Song Department of Critical Care Medicine Department of Anesthesiology and Translational Neuroscience CenterDepartment of Clinical PharmacyFrontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610000China First Affiliated Hospital of the Medical College Shihezi UniversityShihezi 832008China College of Medicine Chengdu UniversityChengdu 610000China

Atherosclerosis is the main cause of ischemic stroke and myocardial infarction *** have shown unique benefits for atherosclerosis treatment by targeting the lesional macrophages of ***,most of the nanocarriers are administered intravenously,which is inconvenient and may cause ***,we developed an oral lipid-polymer based nanoparticles(FA-LNPs)decorated with folic acid,which can not only effectively overcome intestinal mucosal-epithelial barrier by increasing the transmembrane transport through intestinal epithelial and the accumulation in Peyer’s patches but also actively target to the aortic plaque sites and accumulate in lesional ***,naringenin(Nrg),one of the antiinflammation drugs,was designed to be the oral nanomedicine(FA-LNPs/Nrg)for the first time via the encapsulation of ***-LNPs/Nrg presented highly anti-atherosclerotic *** the atherosclerotic ApoE−/−mice were treated by FALNPs/Nrg via oral administration for three months,the aortic lesion area,plaque area,and necrotic core area of the aortic root were significantly ***,the lipid-related blood parameters recovered to normal *** study provides a promising approach to atherosclerosis treatment based on the novel oral targeting delivery system.

关键词： atherosclerosis macrophages Peyer’s patches oral delivery folic acid naringenin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

HES1在神经胶质瘤中的研究进展

引用

临床神经外科杂志 2024年第3期21卷 337-340页

作者：汤磊李阳洋金朝晖王冉杨坤南京医科大学附属脑科医院神经外科南京210029

神经胶质细胞瘤是常见的颅内原发恶性肿瘤,现有的治疗方案存在局限,高级别神经胶质瘤经手术及放化疗后无法完全治愈。HES1属于前神经元碱性螺旋-环-螺旋基因(BHLH)家族的转录因子,在细胞发育、分化和增殖中起重要作用。在胶质瘤发展和... 详细信息

神经胶质细胞瘤是常见的颅内原发恶性肿瘤,现有的治疗方案存在局限,高级别神经胶质瘤经手术及放化疗后无法完全治愈。HES1属于前神经元碱性螺旋-环-螺旋基因(BHLH)家族的转录因子,在细胞发育、分化和增殖中起重要作用。在胶质瘤发展和恶化过程中HES1的角色备受瞩目。本文旨在通过回顾相关研究,探究HES1在胶质瘤发展过程中的作用机制以及其对治疗方式的影响,对这一领域的进展进行综述。

关键词：胶质瘤 HES1 Notch信号通路肿瘤发展

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Core-shell lipid-polymeric nanoparticles for enhanced oral bioavailability and antihypertensive efficacy of KY5 peptide

引用

Chinese Chemical Letters 2023年第4期34卷 158-163页

作者： jingmei Yuan Mengran Guo Shengnan Zhao jinhua Li Xinchun Wang Jian Yang zhaohui jin Xiangrong Song Department of Critical Care Medicine Department of Clinical PharmacyFrontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China School of Applied Chemistry and Biological Technology Shenzhen PolytechnicShenzhen 518055China First Affiliated Hospital of the Medical College Shihezi UniversityShihezi 832008China

Hypertension is the leading risk factor for death and disability, and hypertensive patients always need long-term oral antihypertensive drugs. Some bioactive peptides that extracted from animals or plants have shown excellent advantages on antihypertension. However, the oral delivery of these peptides is always failure on account of instability and poor absorption in the gastrointestinal tract. Herein, we developed a core-shell lipid-polymeric nanoparticle for oral delivery of a highly efficient antihypertensive peptide KY5(KY5-CSs). KY5-CSs had a particle size of 216.7 ± 2.5 nm, with a narrow PDI of 0.07 ± *** zeta potential was-4.1 ± 0.1 m V. It exhibited good stability in 4 ℃ and possessed a controlled release behavior in gastrointestinal tract. The cellular uptake study proved that the lipid shell imparted unique capability of permeation across the mucus layer and internalization by Caco-2/HT-29 cells. In addition, KY5-CSs enhanced in situ intestinal absorption in SD rats. The pharmacokinetic studies and antihypertensive efficacy showed a superior oral absorption and antihypertensive effect of KY5-CSs than KY5-NPs. In conclusion, the core-shell lipid-polymeric nanoparticles will provide attractive potential for oral delivery of antihypertensive peptides.

关键词： Hypertension Core-shell lipid-polymeric nanoparticles KY5 Antihypertensive peptides Oral delivery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis of nanoiron by microemulsion with Span/Tween as mixed surfactants for reduction of nitrate in water

引用

Frontiers of Environmental Science & Engineering 2007年第4期1卷 466-470页

作者： ZHANG Yunxia LI Tielong jin zhaohui WANG Wei WANG Shuaima College of Environmental Science and Engineering Nankai UniversityTianjin 300071China

Denitrification of nitrate in groundwater using iron nanoparticles has received increasing interest in recent *** order to fabricate iron nanoparticles with homoge-neously spherical shape and narrow size distribution,a simple and“green”method was developed to synthesize iron *** conventional microemulsion methods were modified by applying Span 80 and Tween 60 as mixed *** maximum content of water in the Water-in-oil(W/O)microemulsion and its appropriate forming conditions were found,and then the microemulsion system consisting of saturated Fe^(2+)solution was used to synthesizeα-Fe ultrafine particles by redox *** nanoparticles were characterized by using powder X-ray diffraction(XRD)and transmission electron microscopy(TEM).The results show that the average diameter of the particle is about 80-90 *** chemical activity of the obtained iron nanoparticles was studied by the denitrification experiment of *** results show that under the experimental conditions,iron removed most of the 80 mg/L nitrate within 30 *** mass balance of nitrate reduction with nanoscale Fe indicates that endproducts are mainly *** possible reaction pathways for nitrate reduction by nanoscale iron particles have been proposed in this work.

关键词： mixed surfactants microemulsion iron nanoparticles nitrate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Basal-plane stacking-fault energies of Mg alloys: A first-principles study of metallic alloying effects

引用

Journal of Materials Science & Technology 2018年第10期34卷 1773-1780页

作者： Qing Dong Zhe Luo Hong Zhu Leyun Wang Tao Ying zhaohui jin Dejiang Li Wenjiang Ding Xiaoqin Zeng National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite School of Materials Science and Engineering Shanghai Jiao Tong Universit University of Michigan–Shanghai Jiao Tong University Joint Institute Shanghai Jiao Tong University

Generalized stacking-fault energies （GSFEs） of basal-plane stacking faults 11 and 12 in Mg alloys have been studied based on first-principles calculations, where 43 alloying elements were considered. It is found that the most contributing features of alloying elements to GSFEs are bulk modulus, equilibrium volume, binding energy, atomic radius and ionization energy. Both bulk modulus and ionization energy exhibit positive relationships with GSFEs, and the others show opposite relationships. Multiple regressions have been performed to offer a quantitative prediction for basal-plane GSFEs in Mg-X systems. GSFEs, alloying effects of elements and the prediction model established within this work may provide guidelines for new Mg alloys design with better ductility.

关键词： First-principles calculations Magnesium alloys Stacking-fault energy Alloying effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Studies on catalytic reduction of nitrate in groundwater

引用

Frontiers of Environmental Science & Engineering 2007年第3期1卷 357-361页

作者： GENG Bing ZHU Yanfang jin zhaohui LI Tielong KANG Haiyan WANG Shuaima College of Environmental Science and Engineering Nankai UniversityTianjin 300071China

Catalytic reduction of nitrate in groundwater by sodium formate over the catalyst was ***-Cu/c-Al2O3 catalyst was prepared by impregnation and charac-terized by brunauer-emmett-teller(BET),inductive coupled plasma(ICP),X-ray diffraction(XRD),transmission electron microscopy(TEM)and energy dispersive X-ray(EDX).It was found that total nitrogen was effectively removed from the nitrate solution(100 mg/L)and the removal efficiency was 87%.The catalytic activity was affected by pH,catalyst amount used,concentration of sodium formate,and initial concentration of *** sodium formate was used as reductant,precise control in the initial pH was ***-sively high or low initial pH(7.0 or 3.0)reduced catalytic *** initial pH of 4.5,catalytic activity was enhanced by reducing the amount of catalyst,while concentrations of sodium formate increased with a considerable decrease in N2 *** which case,catalytic reduction followed the first order kinetics.

关键词： catalytic reduction nitrate ammonium catalysis sodium formate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A lipid-based LMP2-mRNA vaccine to treat nasopharyngeal carcinoma

引用

Nano Research 2023年第4期16卷 5357-5367页

作者： Mengran Guo Xing Duan Xingchen Peng zhaohui jin Hai Huang Wen Xiao Qian Zheng Yongqi Deng Na Fan Kepan Chen Xiangrong Song Department of Critical Care Medicine Department of Clinical PharmacyFrontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610000China West China School of Pharmacy Sichuan UniversityChengdu 610000China

Nasopharyngeal carcinoma(NPC)is a serious and highly invasive epithelial malignancy that is closely associated with Epstein‒Barr virus(EBV).Due to the lack of therapeutic vaccines for NPC,we selected EBV latent membrane protein 2(LMP2)as a preferable targeting antigen to develop a lipid-based LMP2-mRNA(mLMP2)***-length mLMP2 expressing LMP2 was first synthesized using an in vitro transcription method and then encapsulated into(2,3-dioleacyl propyl)trimethylammonium chloride(DOTAP)-based cationic liposomes to obtain the mRNA vaccine(LPX-mLMP2).The cell assays showed that the antigenpresenting cells were capable of highly efficient uptake of LPX-mLMP2 and expression of ***2 could subsequently be presented to form the peptide-major histocompatibility complex(pMHC).Furthermore,LPX-mLMP2 could accumulate in the spleen,express antigens,promote the maturation of dendritic cells and stimulate antigen-specific T-cell responses in *** dramatically inhibited the tumor growth of the LMP2-expressing tumor model after three doses of ***,the proliferation of antigen-specific T cells in the tumor site made a good sign for the promise of mRNA vaccines in virus-induced ***,we provided a newly developed antigen-encoding mRNA vaccine with advantages against *** also demonstrated that mRNA vaccines are attractive candidates for cancer immunotherapy.

关键词： mRNA vaccine latent membrane protein 2(LMP2) nasopharyngeal carcinoma Epstein-Barr virus(EBV) tumorinfiltrating lymphocytes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research and development strategy for biodegradable magnesium-based vascular stents:a review

引用

Biomaterials Translational 2021年第3期2卷 236-247页

作者： Jialin Niu Hua Huang Jia Pei zhaohui jin Shaokang Guan Guangyin Yuan National Engineering Research Center of Light Alloy Net Forming and Key State Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghaiChina School of Materials Science and Engineering Zhengzhou UniversityZhengzhouHenan ProvinceChina

Magnesium alloys are an ideal material for biodegradable vascular stents,which can be completely absorbed in the human body,and have good biosafety and mechanical ***,the rapid corrosion rate and excessive localized corrosion,as well as challenges in the preparation and processing of microtubes for stents,are restricting the clinical application of magnesium-based vascular *** the present work we will give an overview of the recent progresses on biodegradable magnesium based vascular stents including magnesium alloy design,high-precision microtubes processing,stent shape optimisation and functional coating *** particular,the Triune Principle in biodegradable magnesium alloy design is proposed based on our research experience,which requires three key aspects to be considered when designing new biodegradable magnesium alloys for vascular stents application,*** and biosafety,mechanical properties,and *** review hopes to inspire the future studies on the design and development of biodegradable magnesium alloy-based vascular stents.

关键词： biodegradable magnesium alloy vascular stents functional coatings synthesis high-precision microtubes processing magnesium alloy design stent shape optimisation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dechlorination of Trichloroethylene in Groundwater by Nanoscale Bimetallic Fe/Pd Particles

引用

Journal of Water Resource and Protection 2009年第2期1卷 78-83页

作者： Tielong LI Shujing LI Yongchao LI zhaohui jin 不详

Palladium/iron bimetallic nanoparticles were synthesized using microemulsion method in the water-in-oil (W/O) microemulsion system, which was made up of iso-octane, cetyltrimethyl-ammonium bromide (CTAB), butanol and water and characterized by measuring the conductivity of the solution. Transmission electron microscope (TEM) and energy dispersive X-ray microanalysis (EDX) analysis showed that the av-erage diameter of synthesized palladium/iron bimetallic nanoparticles was less than 80 nm, which was much smaller than the particles produced by the solution method. The palladium/iron bimetallic nanoscale particles produced in the laboratory showed better performance on dechlorinating TCE than the other materials. The nanoscale Fe/Pd particles exhibited high reactivity. When Pd content is 0.5%, the best TCE dechlorination efficiency is achieved within 30min. And Fe/Pd nanoparticles show persistent reaction activity in some sense.

关键词： Trichloroethylene Microemulsion Nanoscale Pd/Fe Particles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Estimate of ammonia transfer from Lake Dianchi water to the air

引用

Journal of Environmental Sciences 1995年第4期7卷 478-483页

作者： Dai Shugui Zhuang Yuanyi jin zhaohui(Department of Environmental Science, Nankai University/, Tianjin 300071 , China)Zhang Mingshun(China Environmental Protection Management Cadre College,Qinhuangdao 066000 , China)

ＥｓｔｉｍａｔｅｏｆａｍｍｏｎｉａｔｒａｎｓｆｅｒｆｒｏｍＬａｋｅＤｉａｎｃｈｉｗａｔｅｒｔｏｔｈｅａｉｒＤａｉＳｈｕｇｕｉ；ＺｈｕａｎｇＹｕａｎｙｉ；ＪｉｎＺｈａｏｈｕｉ（ＤｅｐａｒｔｍｅｎｔｏｆＥｎｖｉｒｏｎｍｅ... 详细信息

ＥｓｔｉｍａｔｅｏｆａｍｍｏｎｉａｔｒａｎｓｆｅｒｆｒｏｍＬａｋｅＤｉａｎｃｈｉｗａｔｅｒｔｏｔｈｅａｉｒＤａｉＳｈｕｇｕｉ；ＺｈｕａｎｇＹｕａｎｙｉ；ＪｉｎＺｈａｏｈｕｉ（ＤｅｐａｒｔｍｅｎｔｏｆＥｎｖｉｒｏｎｍｅｎｔａｌＳｃｉｅｎｃｅ，Ｎａｎｋａ...

关键词： ammonia transfer Lake Dianchi.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：